{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T20:58:27Z","timestamp":1780433907921,"version":"3.54.1"},"reference-count":50,"publisher":"American Chemical Society (ACS)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Med. Chem."],"published-print":{"date-parts":[[1998,3,1]]},"DOI":"10.1021\/jm970568r","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T05:23:55Z","timestamp":1027661035000},"page":"902-912","source":"Crossref","is-referenced-by-count":103,"title":["Novel 17-Azolyl Steroids, Potent Inhibitors of Human Cytochrome 17\u03b1-Hydroxylase-C<sub>17,20<\/sub>-lyase (P450<sub>17<\/sub><sub>\u03b1<\/sub>):\u2009 Potential Agents for the Treatment of Prostate Cancer"],"prefix":"10.1021","volume":"41","author":[{"given":"Vincent C. O.","family":"Njar","sequence":"first","affiliation":[{"name":"Department of Pharmacology & Experimental Therapeutics, School of Medicine, University of Maryland, Baltimore, Maryland 21201"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuya","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Pharmacology & Experimental Therapeutics, School of Medicine, University of Maryland, Baltimore, Maryland 21201"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivo P.","family":"Nnane","sequence":"additional","affiliation":[{"name":"Department of Pharmacology & Experimental Therapeutics, School of Medicine, University of Maryland, Baltimore, Maryland 21201"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dmitry N.","family":"Grigoryev","sequence":"additional","affiliation":[{"name":"Department of Pharmacology & Experimental Therapeutics, School of Medicine, University of Maryland, Baltimore, Maryland 21201"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian J.","family":"Long","sequence":"additional","affiliation":[{"name":"Department of Pharmacology & Experimental Therapeutics, School of Medicine, University of Maryland, Baltimore, Maryland 21201"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela M. H.","family":"Brodie","sequence":"additional","affiliation":[{"name":"Department of Pharmacology & Experimental Therapeutics, School of Medicine, University of Maryland, Baltimore, Maryland 21201"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[1998,2,24]]},"reference":[{"key":"jm970568rb00001\/jm970568rb00001_1","doi-asserted-by":"crossref","first-page":"4042","DOI":"10.1021\/bi00517a014","volume":"20","author":"Nakajin S.","year":"1981","journal-title":"Biochemistry"},{"key":"jm970568rb00002\/jm970568rb00002_1","first-page":"6139","volume":"256","author":"Nakajin S.","year":"1981","journal-title":"J. Biol. Chem."},{"key":"jm970568rb00003\/jm970568rb00003_1","first-page":"532","volume":"40","author":"Hall P. F","year":"1991","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"jm970568rb00004\/jm970568rb00004_1","first-page":"267","volume":"263","author":"Akhtar M.","year":"1994","journal-title":"J. Chem. Soc., Perkin Trans. 1"},{"key":"jm970568rb00005\/jm970568rb00005_1","first-page":"2190","volume":"33","author":"Swinney M.","year":"1994","journal-title":"Biochemistry"},{"key":"jm970568rb00006\/jm970568rb00006_1","doi-asserted-by":"crossref","first-page":"4418","DOI":"10.1021\/bi00180a039","volume":"33","author":"Akhtar M.","year":"1994","journal-title":"Biochemistry"},{"key":"jm970568rb00007\/jm970568rb00007_1","unstructured":"Bossche, H. V.; Moereels, H. 17\u03b1-Hydroxylase\/17,20-Lyase. InDesign ofEnzyme Inhibitors as Drugs; Snadler, M., Smith, H. J., Eds.; Oxford University Press:\u2009 Oxford, U.K., 1994; Vol. 2, pp 438\u2212461."},{"key":"jm970568rb00008\/jm970568rb00008_1","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0960-0760(95)00230-8","volume":"56","author":"De Coster R.","year":"1996","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"jm970568rb00009\/jm970568rb00009_1","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1021\/jm00290a004","volume":"14","author":"Arth G. E.","year":"1971","journal-title":"J. Med. Chem."},{"key":"jm970568rb00010\/jm970568rb00010_1","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1016\/0006-291X(89)90854-1","volume":"162","author":"Angelastro M. R.","year":"1989","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"jm970568rb00011\/jm970568rb00011_1","first-page":"320","volume":"42","author":"Li J.","year":"1992","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"jm970568rb00012\/jm970568rb00012_1","first-page":"150","volume":"26","author":"Li J.","year":"1995","journal-title":"Prostate"},{"key":"jm970568rb00013\/jm970568rb00013_1","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.1021\/jm00013a022","volume":"38","author":"Potter G. A.","year":"1995","journal-title":"J. Med. Chem."},{"key":"jm970568rb00014\/jm970568rb00014_1","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1016\/0968-0896(96)00135-6","volume":"4","author":"Burkhart J. P.","year":"1996","journal-title":"Bioorg. Med. Chem."},{"key":"jm970568rb00015\/jm970568rb00015_1","first-page":"1453","volume":"4","author":"Njar V. C. O.","year":"1996","journal-title":"Bioorg. Med. Chem."},{"key":"jm970568rb00016\/jm970568rb00016_1","first-page":"4339","volume":"39","author":"Li J. S.","year":"1996","journal-title":"J. Med. Chem."},{"issue":"6","key":"jm970568rb00017\/jm970568rb00017_1","first-page":"4964","volume":"56","author":"Klus G. T.","year":"1996","journal-title":"Cancer Res."},{"key":"jm970568rb00018\/jm970568rb00018_1","first-page":"2782","volume":"6","author":"Njar V. C. O.","year":"1996","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"jm970568rb00019\/jm970568rb00019_1","first-page":"473","volume":"62","author":"Njar V. C. O.","year":"1997","journal-title":"Steroids"},{"key":"jm970568rb00020\/jm970568rb00020_1","doi-asserted-by":"crossref","first-page":"3304","DOI":"10.1021\/jm970337k","volume":"40","author":"Ling Y.","year":"1997","journal-title":"J. Med. Chem."},{"key":"jm970568rb00021\/jm970568rb00021_1","first-page":"531","volume":"28","author":"Ayub M.","year":"1987","journal-title":"J. Steroid Biochem."},{"key":"jm970568rb00022\/jm970568rb00022_1","first-page":"13","volume":"18","author":"Vanden Bossche H.","year":"1990","journal-title":"Biochem. Soc. Trans."},{"key":"jm970568rb00023\/jm970568rb00023_1","doi-asserted-by":"crossref","first-page":"3055","DOI":"10.1021\/jm00173a022","volume":"33","author":"McCague R.","year":"1990","journal-title":"J. Med. Chem."},{"key":"jm970568rb00024\/jm970568rb00024_1","first-page":"122","volume":"8","author":"Sergejew T.","year":"1994","journal-title":"J. Enzymol. Inhib."},{"key":"jm970568rb00025\/jm970568rb00025_1","first-page":"841","volume":"39","author":"Wacher G. A.","year":"1996","journal-title":"J. Med. Chem."},{"key":"jm970568rb00026\/jm970568rb00026_1","first-page":"575","volume":"328","author":"Hartmann R. W.","year":"1995","journal-title":"Arch. Pharm. (Weinheim)"},{"key":"jm970568rb00027\/jm970568rb00027_1","first-page":"261","volume":"329","author":"Hartmann R. W.","year":"1996","journal-title":"Arch. Pharm. Pharm. Med. Chem."},{"key":"jm970568rb00028\/jm970568rb00028_1","first-page":"63","volume":"132","author":"Trachtenberg J","year":"1984","journal-title":"J. Urol."},{"key":"jm970568rb00029\/jm970568rb00029_1","first-page":"51","volume":"58","author":"Williams G.","year":"1986","journal-title":"Br. J. Urol."},{"key":"jm970568rb00030\/jm970568rb00030_1","first-page":"1021","volume":"43","author":"Vanden Bossche H","year":"1992","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"jm970568rb00031\/jm970568rb00031_1","doi-asserted-by":"crossref","first-page":"2942","DOI":"10.1021\/jm00173a002","volume":"33","author":"Cole P. A.","year":"1990","journal-title":"J. Med. Chem."},{"key":"jm970568rb00032\/jm970568rb00032_1","first-page":"7608e","volume":"49","author":"Ronig K.","year":"1953","journal-title":"Chem. Abstr."},{"key":"jm970568rb00033\/jm970568rb00033_1","first-page":"1662","volume":"18","author":"Nambara T.","year":"1970","journal-title":"Chem. Pharm. Bull."},{"key":"jm970568rb00034\/jm970568rb00034_1","first-page":"663","volume":"13","author":"Wolff M. E.","year":"1970","journal-title":"J. Med. Chem."},{"key":"jm970568rb00035\/jm970568rb00035_1","first-page":"5657","volume":"59","author":"van Leuesn D.","year":"1994","journal-title":"J. Org. Chem."},{"key":"jm970568rb00036\/jm970568rb00036_1","doi-asserted-by":"crossref","first-page":"3199","DOI":"10.1021\/jo01348a024","volume":"31","author":"Doorenbos N. J.","year":"1966","journal-title":"J. Org. Chem."},{"key":"jm970568rb00037\/jm970568rb00037_1","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1002\/jhet.5570320159","volume":"32","author":"Siddiqui A. U.","year":"1995","journal-title":"J. Heterocycl. Chem."},{"key":"jm970568rb00038\/jm970568rb00038_1","doi-asserted-by":"crossref","first-page":"3199","DOI":"10.1021\/jo00191a028","volume":"49","author":"Meyer M. D.","year":"1984","journal-title":"J. Org. Chem."},{"key":"jm970568rb00039\/jm970568rb00039_1","unstructured":"March, J.Advanced Organic Chemistry\u2212Reactions, Mechanism andStructure, 4th ed.; John Wiley & Sons:\u2009 New York, 1992; pp 335\u2212338 and references cited therein."},{"key":"jm970568rb00040\/jm970568rb00040_1","first-page":"440","volume":"43","author":"Tasaka A.","year":"1995","journal-title":"Chem Pharm. Bull."},{"key":"jm970568rb00041\/jm970568rb00041_1","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1021\/jo00383a006","volume":"52","author":"Tadano K.","year":"1987","journal-title":"J. Org. Chem."},{"key":"jm970568rb00042\/jm970568rb00042_1","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1021\/jo01038a040","volume":"28","author":"Wecher W. J.","year":"1963","journal-title":"J. Org. Chem."},{"key":"jm970568rb00043\/jm970568rb00043_1","first-page":"257","volume":"250","author":"Bridgeman J. E.","year":"1970","journal-title":"J. Chem. Soc. C"},{"key":"jm970568rb00044\/jm970568rb00044_1","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1021\/jo00872a043","volume":"41","author":"Raggio M. L.","year":"1976","journal-title":"J. Org. Chem."},{"key":"jm970568rb00045\/jm970568rb00045_1","first-page":"301","volume":"61","author":"Morrison J. F.","year":"1988","journal-title":"Adv. Enzymol. Relat. Areas Mol. Biol."},{"key":"jm970568rb00046\/jm970568rb00046_1","first-page":"19689","volume":"268","author":"Imai T.","year":"1993","journal-title":"J. Biol. Chem."},{"key":"jm970568rb00047\/jm970568rb00047_1","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0076-6879(78)52030-2","volume":"52","author":"Jefcoate C. R","year":"1978","journal-title":"Methods Enzymol."},{"key":"jm970568rb00048\/jm970568rb00048_1","first-page":"3617","volume":"257","author":"Dawson J. H.","year":"1982","journal-title":"J. Biol. Chem."},{"key":"jm970568rb00049\/jm970568rb00049_1","doi-asserted-by":"crossref","first-page":"2925","DOI":"10.1021\/jo00408a041","volume":"43","author":"Still W. C.","year":"1978","journal-title":"J. Org. Chem."},{"key":"jm970568rb00050\/jm970568rb00050_1","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S0021-9258(19)52451-6","volume":"193","author":"Lowry O. H.","year":"1951","journal-title":"J. Biol. Chem."}],"container-title":["Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jm970568r","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,24]],"date-time":"2023-03-24T04:56:07Z","timestamp":1679633767000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jm970568r"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,2,24]]},"references-count":50,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1998,3,1]]}},"alternative-id":["10.1021\/jm970568r"],"URL":"https:\/\/doi.org\/10.1021\/jm970568r","relation":{},"ISSN":["0022-2623","1520-4804"],"issn-type":[{"value":"0022-2623","type":"print"},{"value":"1520-4804","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,2,24]]}}}