{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T10:21:29Z","timestamp":1768472489620,"version":"3.49.0"},"reference-count":41,"publisher":"American Chemical Society (ACS)","issue":"13","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Med. Chem."],"published-print":{"date-parts":[[1998,6,1]]},"DOI":"10.1021\/jm970791o","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T05:23:55Z","timestamp":1027661035000},"page":"2319-2332","source":"Crossref","is-referenced-by-count":49,"title":["Comprehensive Study on Structure\u2212Activity Relationships of Rifamycins:\u2009 Discussion of Molecular and Crystal Structure and Spectroscopic and Thermochemical Properties of Rifamycin O"],"prefix":"10.1021","volume":"41","author":[{"given":"Alessia","family":"Bacchi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giancarlo","family":"Pelizzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marino","family":"Nebuloni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pietro","family":"Ferrari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[1998,5,23]]},"reference":[{"key":"jm970791ob00001\/jm970791ob00001_1","first-page":"600","volume-title":"Structure\u2212activity relationship among the semisynthetic antibiotics","author":"Lancini G.","year":"1977"},{"key":"jm970791ob00002\/jm970791ob00002_1","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/0022-2836(74)90094-1","volume":"87","author":"Brufani M.","year":"1974","journal-title":"J. Mol. Biol."},{"key":"jm970791ob00003\/jm970791ob00003_1","first-page":"703","volume":"14","author":"Brufani M.","year":"1978","journal-title":"Mol. Pharmacol."},{"key":"jm970791ob00004\/jm970791ob00004_1","first-page":"399","volume":"21","author":"Brufani M.","year":"1982","journal-title":"Mol. Pharmacol."},{"key":"jm970791ob00005\/jm970791ob00005_1","first-page":"140","volume":"23","author":"Arora S. K","year":"1983","journal-title":"Mol. Pharmacol."},{"key":"jm970791ob00006\/jm970791ob00006_1","doi-asserted-by":"crossref","first-page":"181","DOI":"10.7164\/antibiotics.37.178","volume":"37","author":"Arora S. K.","year":"1984","journal-title":"J. Antibiot."},{"key":"jm970791ob00007\/jm970791ob00007_1","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1021\/jm00146a021","volume":"28","author":"Arora S. K","year":"1985","journal-title":"J. Med. Chem."},{"key":"jm970791ob00008\/jm970791ob00008_1","first-page":"623","volume":"47","author":"Bacchi A.","year":"1995","journal-title":"Mol. Pharmacol."},{"key":"jm970791ob00009\/jm970791ob00009_1","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1021\/ar00089a002","volume":"16","author":"Buergi H. B.","year":"1983","journal-title":"Acc. Chem. Res."},{"key":"jm970791ob00010\/jm970791ob00010_1","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1007\/BF00674135","volume":"1","author":"Klebe G","year":"1990","journal-title":"Struct. Chem."},{"key":"jm970791ob00011\/jm970791ob00011_1","first-page":"157","volume":"37","author":"Arora S. K","year":"1981","journal-title":"Acta Crystallogr. Sect. B"},{"key":"jm970791ob00012\/jm970791ob00012_1","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1002\/hlca.19900730122","volume":"73","author":"Bartolucci C.","year":"1990","journal-title":"Helv. Chim. Acta"},{"key":"jm970791ob00013\/jm970791ob00013_1","doi-asserted-by":"crossref","first-page":"2661","DOI":"10.1021\/jo00134a028","volume":"47","author":"Cellai L.","year":"1982","journal-title":"J. Org. Chem."},{"key":"jm970791ob00014\/jm970791ob00014_1","first-page":"1640","volume":"1633","author":"Cellai L.","year":"1982","journal-title":"J. Chem. Soc., Perkin Trans. 2"},{"key":"jm970791ob00015\/jm970791ob00015_1","first-page":"1462","volume":"31","author":"Gadret M.","year":"1975","journal-title":"Acta Crystallogr. Sect. B"},{"key":"jm970791ob00016\/jm970791ob00016_1","first-page":"1627","volume":"37","author":"Brufani M.","year":"1984","journal-title":"J. Antibiot."},{"key":"jm970791ob00017\/jm970791ob00017_1","first-page":"329","volume":"328","author":"Cellai L.","year":"1987","journal-title":"J. Chem. Res. (S)"},{"key":"jm970791ob00018\/jm970791ob00018_1","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1107\/S010827018700934X","volume":"44","author":"Cerrini S.","year":"1988","journal-title":"Acta Crystallogr. Sect. C."},{"key":"jm970791ob00019\/jm970791ob00019_1","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1002\/hlca.19910740211","volume":"74","author":"Leger J. M.","year":"1991","journal-title":"Helv. Chim. Acta"},{"key":"jm970791ob00020\/jm970791ob00020_1","doi-asserted-by":"crossref","first-page":"431","DOI":"10.7164\/antibiotics.45.428","volume":"45","author":"Arora S. K.","year":"1992","journal-title":"J. Antibiot."},{"key":"jm970791ob00021\/jm970791ob00021_1","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1002\/hlca.19920750112","volume":"75","author":"Bartolucci C.","year":"1992","journal-title":"Helv. Chim. Acta"},{"key":"jm970791ob00022\/jm970791ob00022_1","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1002\/hlca.19930760406","volume":"76","author":"Bartolucci C.","year":"1993","journal-title":"Helv. Chim. Acta"},{"key":"jm970791ob00023\/jm970791ob00023_1","first-page":"59","volume":"3","author":"Murray-Rust P.","year":"1985","journal-title":"J. Mol. Graphics"},{"key":"jm970791ob00024\/jm970791ob00024_1","first-page":"696","volume":"30","author":"Ferrari P.","year":"1975","journal-title":"Farmaco Ed. Sci."},{"key":"jm970791ob00025\/jm970791ob00025_1","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1021\/jo00384a027","volume":"52","author":"Arora S. K.","year":"1987","journal-title":"J. Org. Chem."},{"key":"jm970791ob00026\/jm970791ob00026_1","first-page":"681","volume":"36","author":"Martinelli G.","year":"1981","journal-title":"Farmaco Ed. Sci."},{"key":"jm970791ob00027\/jm970791ob00027_1","first-page":"435","volume":"27","author":"Altomare A.","year":"1994","journal-title":"J. Appl. Crystallogr."},{"key":"jm970791ob00028\/jm970791ob00028_1","volume-title":"Program for structure refinement","author":"Sheldrick G.","year":"1993"},{"key":"jm970791ob00029\/jm970791ob00029_1","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1107\/S0021889895007138","volume":"28","author":"Nardelli M.","year":"1995","journal-title":"J. Appl. Crystallogr."},{"key":"jm970791ob00030\/jm970791ob00030_1","volume-title":"ORTEP original program modified for PC","author":"Zsolnai L.","year":"1994"},{"key":"jm970791ob00031\/jm970791ob00031_1","volume-title":"Program for plotting molecular and crystal structures","author":"Motherwell W. D. S.","year":"1976"},{"key":"jm970791ob00032\/jm970791ob00032_1","first-page":"1","volume":"8","author":"Allen F. H.","year":"1993","journal-title":"Chem. Des. Automation News"},{"key":"jm970791ob00033\/jm970791ob00033_1","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1002\/hlca.19960790611","volume":"79","author":"Bartolucci C.","year":"1996","journal-title":"Helv. Chim. Acta"},{"key":"jm970791ob00034\/jm970791ob00034_1","doi-asserted-by":"crossref","first-page":"6256","DOI":"10.1021\/ja00854a057","volume":"97","author":"Dampier M. F.","year":"1975","journal-title":"J. Am. Chem. Soc."},{"key":"jm970791ob00035\/jm970791ob00035_1","first-page":"29","volume":"182","author":"Wherli W.","year":"1969","journal-title":"Biochem. Biophys. Acta"},{"key":"jm970791ob00036\/jm970791ob00036_1","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1021\/jm00167a029","volume":"33","author":"Cavalleri B.","year":"1990","journal-title":"J. Med. Chem."},{"key":"jm970791ob00037\/jm970791ob00037_1","unstructured":"SAS; SAS Institute Inc.\u2009 Cary, NC, 1989."},{"key":"jm970791ob00038\/jm970791ob00038_1","unstructured":"SYBYL 6.3; TRIPOS Assoc. Inc.\u2009 St. Louis, MO, 1991\u22121996."},{"key":"jm970791ob00039\/jm970791ob00039_1","unstructured":"Frisch, M. J.; Trucks, G. W.; Head-Gordon, M.; Gill, P. M. W.; Wong, M. W.; Foresman, J. B.; Johnson, B. G.; Schlegel, H. B.; Robb, M. A.; Replogle, R. S.; Gomperts, R.; Andres, J. L.; Raghavachari, K.; Binkley, J. S.; Gonzalez, C.; Martin, R. L.; Fox, D. J.; Defrees, D. J.; Baker, J.; Stewart, J. J. P.; Pople, J. A. Gaussian92; Gaussian, Inc.\u2009 Pittsburgh, PA, 1992."},{"key":"jm970791ob00040\/jm970791ob00040_1","first-page":"3288","volume":"36","author":"Gesteiger J.","year":"1980","journal-title":"Tetrahedron"},{"key":"jm970791ob00041\/jm970791ob00041_1","volume-title":"Theoretical Models of Chemical Bonding, IV","author":"Tomasi J.","year":"1990"}],"container-title":["Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jm970791o","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,7]],"date-time":"2023-04-07T14:32:48Z","timestamp":1680877968000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jm970791o"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,5,23]]},"references-count":41,"journal-issue":{"issue":"13","published-print":{"date-parts":[[1998,6,1]]}},"alternative-id":["10.1021\/jm970791o"],"URL":"https:\/\/doi.org\/10.1021\/jm970791o","relation":{},"ISSN":["0022-2623","1520-4804"],"issn-type":[{"value":"0022-2623","type":"print"},{"value":"1520-4804","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,5,23]]}}}