{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T20:30:49Z","timestamp":1762374649053},"reference-count":20,"publisher":"American Chemical Society (ACS)","issue":"21","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Med. Chem."],"published-print":{"date-parts":[[1998,10,1]]},"DOI":"10.1021\/jm980384s","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T05:23:55Z","timestamp":1027661035000},"page":"4177-4180","source":"Crossref","is-referenced-by-count":13,"title":["7-Arylidenenaltrexones as Selective \u03b4<sub>1<\/sub> Opioid Receptor Antagonists"],"prefix":"10.1021","volume":"41","author":[{"given":"Shigenori","family":"Ohkawa","sequence":"first","affiliation":[{"name":"Department of Medicinal Chemistry, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota 55455"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip S.","family":"Portoghese","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota 55455"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[1998,9,18]]},"reference":[{"key":"jm980384sb00001\/jm980384sb00001_1","first-page":"592","volume":"48","author":"Dhawan B. N.","year":"1996","journal-title":"Pharmacol. Rev."},{"key":"jm980384sb00002\/jm980384sb00002_1","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/0014-2999(92)90167-3","volume":"218","author":"Portoghese P. S.","year":"1992","journal-title":"Eur. J. Pharmacol."},{"key":"jm980384sb00003\/jm980384sb00003_1","first-page":"680","volume":"275","author":"Sofuoglu M.","year":"1991","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"jm980384sb00004\/jm980384sb00004_1","first-page":"1075","volume":"257","author":"Jiang Q.","year":"1991","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"jm980384sb00005\/jm980384sb00005_1","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/j.1749-6632.1977.tb41843.x","volume":"297","author":"Schwyzer R.","year":"1977","journal-title":"Ann. NY Acad. Sci."},{"key":"jm980384sb00006\/jm980384sb00006_1","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/0165-6147(89)90267-8","volume":"10","author":"Portoghese P. S","year":"1989","journal-title":"Trends Pharmacol. Sci."},{"key":"jm980384sb00007\/jm980384sb00007_1","first-page":"2574","volume":"36","author":"Portoghese P. S.","year":"1993","journal-title":"J. Med. Chem."},{"key":"jm980384sb00008\/jm980384sb00008_1","first-page":"1725","volume":"40","author":"Ohkawa S.","year":"1997","journal-title":"J. Med. Chem."},{"key":"jm980384sb00009\/jm980384sb00009_1","first-page":"1296","volume":"34","author":"Portoghese P. S.","year":"1991","journal-title":"J. Med. Chem."},{"key":"jm980384sb00010\/jm980384sb00010_1","first-page":"585","volume":"37","author":"Portoghese P. S.","year":"1994","journal-title":"J. Med. Chem."},{"key":"jm980384sb00011\/jm980384sb00011_1","first-page":"753","volume":"40","author":"Palmer R. B.","year":"1997","journal-title":"J. Med. Chem."},{"key":"jm980384sb00012\/jm980384sb00012_1","first-page":"365","volume":"22","author":"Rang H. B","year":"1964","journal-title":"Br. J. Pharmacol."},{"key":"jm980384sb00013\/jm980384sb00013_1","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/267499a0","volume":"267","author":"Lord J. A. H.","year":"1977","journal-title":"Nature"},{"key":"jm980384sb00014\/jm980384sb00014_1","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/0024-3205(85)90202-4","volume":"36","author":"Portoghese P. S.","year":"1985","journal-title":"Life Sci."},{"key":"jm980384sb00015\/jm980384sb00015_1","first-page":"491","volume":"20","author":"Fournie-Zaluski M.-C.","year":"1981","journal-title":"Mol. Pharmacol."},{"key":"jm980384sb00016\/jm980384sb00016_1","first-page":"400","volume":"190","author":"Tulunay F. C.","year":"1974","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"jm980384sb00017\/jm980384sb00017_1","first-page":"12","volume":"224","author":"von Voigtlander P. F.","year":"1983","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"jm980384sb00018\/jm980384sb00018_1","doi-asserted-by":"crossref","first-page":"5874","DOI":"10.1073\/pnas.80.19.5871","volume":"80","author":"Mosberg H. I.","year":"1983","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"jm980384sb00019\/jm980384sb00019_1","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/0014-2999(81)90364-2","volume":"70","author":"Handa B. K.","year":"1981","journal-title":"Eur. J. Pharmacol."},{"key":"jm980384sb00020\/jm980384sb00020_1","first-page":"838","volume":"264","author":"Wild K. D.","year":"1993","journal-title":"J. Pharmacol. Exp. Ther."}],"container-title":["Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jm980384s","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,7]],"date-time":"2023-04-07T14:10:57Z","timestamp":1680876657000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jm980384s"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,9,18]]},"references-count":20,"journal-issue":{"issue":"21","published-print":{"date-parts":[[1998,10,1]]}},"alternative-id":["10.1021\/jm980384s"],"URL":"https:\/\/doi.org\/10.1021\/jm980384s","relation":{},"ISSN":["0022-2623","1520-4804"],"issn-type":[{"value":"0022-2623","type":"print"},{"value":"1520-4804","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,9,18]]}}}