{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T01:56:35Z","timestamp":1782698195910,"version":"3.54.5"},"reference-count":63,"publisher":"American Chemical Society (ACS)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Med. Chem."],"published-print":{"date-parts":[[2000,3,1]]},"DOI":"10.1021\/jm991056a","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T05:59:58Z","timestamp":1027663198000},"page":"1071-1084","source":"Crossref","is-referenced-by-count":64,"title":["Histaprodifens:\u2009 Synthesis, Pharmacological in Vitro Evaluation, and Molecular Modeling of a New Class of Highly Active and Selective Histamine H<sub>1<\/sub>-Receptor Agonists"],"prefix":"10.1021","volume":"43","author":[{"given":"Sigurd","family":"Elz","sequence":"first","affiliation":[{"name":"Institut f\u00fcr Pharmazie, Freie Universit\u00e4t Berlin, K\u00f6nigin-Luise-Strasse 2+4, D-14195 Berlin (Dahlem), Germany, Institut f\u00fcr Organische Chemie, Johannes Gutenberg-Universit\u00e4t, J.-J. Becherweg 18-20, D-55099 Mainz, Germany, and Forschungsinstitut f\u00fcr Molekulare Pharmakologie, Alfred-Kowalke-Strasse 4, D-10315 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Kramer","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Pharmazie, Freie Universit\u00e4t Berlin, K\u00f6nigin-Luise-Strasse 2+4, D-14195 Berlin (Dahlem), Germany, Institut f\u00fcr Organische Chemie, Johannes Gutenberg-Universit\u00e4t, J.-J. Becherweg 18-20, D-55099 Mainz, Germany, and Forschungsinstitut f\u00fcr Molekulare Pharmakologie, Alfred-Kowalke-Strasse 4, D-10315 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heinz H.","family":"Pertz","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Pharmazie, Freie Universit\u00e4t Berlin, K\u00f6nigin-Luise-Strasse 2+4, D-14195 Berlin (Dahlem), Germany, Institut f\u00fcr Organische Chemie, Johannes Gutenberg-Universit\u00e4t, J.-J. Becherweg 18-20, D-55099 Mainz, Germany, and Forschungsinstitut f\u00fcr Molekulare Pharmakologie, Alfred-Kowalke-Strasse 4, D-10315 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heiner","family":"Detert","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Pharmazie, Freie Universit\u00e4t Berlin, K\u00f6nigin-Luise-Strasse 2+4, D-14195 Berlin (Dahlem), Germany, Institut f\u00fcr Organische Chemie, Johannes Gutenberg-Universit\u00e4t, J.-J. Becherweg 18-20, D-55099 Mainz, Germany, and Forschungsinstitut f\u00fcr Molekulare Pharmakologie, Alfred-Kowalke-Strasse 4, D-10315 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton M.","family":"ter Laak","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Pharmazie, Freie Universit\u00e4t Berlin, K\u00f6nigin-Luise-Strasse 2+4, D-14195 Berlin (Dahlem), Germany, Institut f\u00fcr Organische Chemie, Johannes Gutenberg-Universit\u00e4t, J.-J. Becherweg 18-20, D-55099 Mainz, Germany, and Forschungsinstitut f\u00fcr Molekulare Pharmakologie, Alfred-Kowalke-Strasse 4, D-10315 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"K\u00fchne","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Pharmazie, Freie Universit\u00e4t Berlin, K\u00f6nigin-Luise-Strasse 2+4, D-14195 Berlin (Dahlem), Germany, Institut f\u00fcr Organische Chemie, Johannes Gutenberg-Universit\u00e4t, J.-J. Becherweg 18-20, D-55099 Mainz, Germany, and Forschungsinstitut f\u00fcr Molekulare Pharmakologie, Alfred-Kowalke-Strasse 4, D-10315 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Schunack","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Pharmazie, Freie Universit\u00e4t Berlin, K\u00f6nigin-Luise-Strasse 2+4, D-14195 Berlin (Dahlem), Germany, Institut f\u00fcr Organische Chemie, Johannes Gutenberg-Universit\u00e4t, J.-J. Becherweg 18-20, D-55099 Mainz, Germany, and Forschungsinstitut f\u00fcr Molekulare Pharmakologie, Alfred-Kowalke-Strasse 4, D-10315 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2000,3,4]]},"reference":[{"key":"jm991056ab00001\/jm991056ab00001_1","volume-title":"Agonists. XXVIth Meeting of the European Histamine Research Society","author":"Kramer K.","year":"1997"},{"key":"jm991056ab00002\/jm991056ab00002_1","volume-title":"XXVIIth Meeting of the European Histamine Research Society","author":"Kramer K.","year":"1998"},{"key":"jm991056ab00003\/jm991056ab00003_1","volume-title":"XIIIth International Congress of Pharmacology","author":"Elz S.","year":"1998"},{"key":"jm991056ab00004\/jm991056ab00004_1","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1016\/0028-3908(86)90029-8","volume":"25","author":"Tuomisto L.","year":"1986","journal-title":"Neuropharmacology"},{"key":"jm991056ab00005\/jm991056ab00005_1","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/BF00167568","volume":"346","author":"Yokoyama H.","year":"1992","journal-title":"Naunyn-Schmiedeberg's Arch. Pharmacol."},{"key":"jm991056ab00006\/jm991056ab00006_1","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/0014-2999(93)90263-H","volume":"237","author":"Oishi R.","year":"1993","journal-title":"Eur. J. Pharmacol."},{"key":"jm991056ab00007\/jm991056ab00007_1","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1161\/01.RES.61.2.280","volume":"61","author":"Toda N","year":"1987","journal-title":"Circ. Res."},{"key":"jm991056ab00008\/jm991056ab00008_1","first-page":"71","volume":"81","author":"Matsanuyama K.","year":"1990","journal-title":"Circulation"},{"key":"jm991056ab00009\/jm991056ab00009_1","first-page":"345","volume":"17","author":"Okumura K.","year":"1991","journal-title":"J. Am. Coll. Cardiol."},{"key":"jm991056ab00010\/jm991056ab00010_1","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/0924-977X(94)90293-3","volume":"4","author":"Monti J. M.","year":"1994","journal-title":"Eur. Neuropsychopharmacol."},{"key":"jm991056ab00011\/jm991056ab00011_1","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/276403a0","volume":"276","author":"Durant G. J.","year":"1978","journal-title":"Nature (London)"},{"key":"jm991056ab00012\/jm991056ab00012_1","doi-asserted-by":"crossref","first-page":"1970","DOI":"10.1021\/jm00128a045","volume":"32","author":"Buschauer A","year":"1989","journal-title":"J. Med. Chem."},{"key":"jm991056ab00013\/jm991056ab00013_1","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/327123a0","volume":"327","author":"Arrang J.-M.","year":"1987","journal-title":"Nature (London)"},{"key":"jm991056ab00014\/jm991056ab00014_1","first-page":"310","volume":"263","author":"Garbarg M.","year":"1992","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"jm991056ab00015\/jm991056ab00015_1","first-page":"278","volume":"49","author":"Hill S. J.","year":"1997","journal-title":"Pharmacol. Rev."},{"key":"jm991056ab00016\/jm991056ab00016_1","first-page":"85","volume":"44","author":"Zingel V.","year":"1995","journal-title":"Prog. Drug Res."},{"key":"jm991056ab00017\/jm991056ab00017_1","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1021\/jm00243a010","volume":"18","author":"Durant G. J.","year":"1975","journal-title":"J. Med. Chem."},{"key":"jm991056ab00018\/jm991056ab00018_1","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1002\/ardp.19793120718","volume":"312","author":"Hepp M.","year":"1979","journal-title":"Arch. Pharm. (Weinheim, Ger.)"},{"key":"jm991056ab00019\/jm991056ab00019_1","first-page":"133","volume":"10","author":"Dziuron P.","year":"1975","journal-title":"Eur. J. Med. Chem. Chim. Ther."},{"key":"jm991056ab00020\/jm991056ab00020_1","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/BF01921633","volume":"30","year":"1974","journal-title":"Experientia"},{"key":"jm991056ab00021\/jm991056ab00021_1","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1021\/jm00008a007","volume":"38","author":"Leschke C.","year":"1995","journal-title":"J. Med. Chem."},{"key":"jm991056ab00022\/jm991056ab00022_1","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1002\/ardp.19803130905","volume":"313","author":"Hepp M.","year":"1980","journal-title":"Arch. Pharm. (Weinheim, Ger.)"},{"key":"jm991056ab00023\/jm991056ab00023_1","doi-asserted-by":"crossref","first-page":"2588","DOI":"10.1016\/S0960-894X(98)00461-2","volume":"8","author":"Kramer K.","year":"1998","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"jm991056ab00024\/jm991056ab00024_1","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/0223-5234(96)89166-5","volume":"31","author":"Detert H.","year":"1996","journal-title":"Eur. J. Med. Chem."},{"key":"jm991056ab00025\/jm991056ab00025_1","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/S0223-5234(99)80037-3","volume":"34","author":"N\u00fcrnberg B.","year":"1999","journal-title":"Eur. J. Med. Chem."},{"key":"jm991056ab00026\/jm991056ab00026_1","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1358\/dof.1998.023.09.468507","volume":"23","author":"Handley D. A.","year":"1998","journal-title":"Drugs Future"},{"key":"jm991056ab00027\/jm991056ab00027_1","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1038\/38316","volume":"389","author":"Unger V. M.","year":"1997","journal-title":"Nature (London)"},{"key":"jm991056ab00028\/jm991056ab00028_1","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1002\/ardp.19733060505","volume":"306","author":"Dziuron P.","year":"1973","journal-title":"Arch. Pharm. (Weinheim, Ger.)"},{"key":"jm991056ab00029\/jm991056ab00029_1","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1248\/cpb.41.507","volume":"41","author":"Take K.","year":"1993","journal-title":"Chem. Pharm. Bull."},{"key":"jm991056ab00030\/jm991056ab00030_1","first-page":"1634","volume":"13","author":"Vorbr\u00fcggen H.","year":"1968","journal-title":"Tetrahedron Lett."},{"key":"jm991056ab00031\/jm991056ab00031_1","first-page":"79","volume":"596","author":"Reppe W. IV.","year":"1955","journal-title":"Justus Liebigs Ann. Chem."},{"key":"jm991056ab00032\/jm991056ab00032_1","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/0223-5234(90)90132-M","volume":"25","author":"Zingel V.","year":"1990","journal-title":"Eur. J. Med. Chem."},{"key":"jm991056ab00033\/jm991056ab00033_1","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1139\/y80-198","volume":"58","author":"Kenakin T. P.","year":"1980","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"jm991056ab00034\/jm991056ab00034_1","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1111\/j.1476-5381.1959.tb00928.x","volume":"14","author":"Arunlakshana O.","year":"1959","journal-title":"Br. J. Pharmacol. Chemother."},{"key":"jm991056ab00035\/jm991056ab00035_1","first-page":"525","volume":"198","author":"Marano M.","year":"1976","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"jm991056ab00036\/jm991056ab00036_1","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/BF00500480","volume":"318","author":"Kaumann A. J.","year":"1982","journal-title":"Naunyn-Schmiedeberg's Arch. Pharmacol."},{"key":"jm991056ab00037\/jm991056ab00037_1","first-page":"C413","volume":"37","author":"Dodel R.","year":"1992","journal-title":"Agents Actions"},{"key":"jm991056ab00038\/jm991056ab00038_1","first-page":"330","volume":"256","author":"Van der Voorde J.","year":"1982","journal-title":"Arch. Int. Pharmacodyn. Ther."},{"key":"jm991056ab00039\/jm991056ab00039_1","first-page":"120","volume":"87","author":"Van der Voorde J.","year":"1983","journal-title":"Eur. J. Pharmacol."},{"key":"jm991056ab00040\/jm991056ab00040_1","first-page":"183","volume":"21","author":"Carrier G. O.","year":"1984","journal-title":"Blood Vessels"},{"key":"jm991056ab00041\/jm991056ab00041_1","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1006\/bbrc.1994.2295","volume":"203","author":"Ohta K.","year":"1994","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"jm991056ab00042\/jm991056ab00042_1","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0014-2999(97)01620-8","volume":"345","author":"Nonaka H.","year":"1998","journal-title":"Eur. J. Pharmacol."},{"key":"jm991056ab00043\/jm991056ab00043_1","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1007\/BF00125173","volume":"9","author":"Ter Laak A. M.","year":"1995","journal-title":"J. Comput. Aided Mol. Des."},{"key":"jm991056ab00044\/jm991056ab00044_1","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1006\/bbrc.1994.1701","volume":"201","author":"Leurs R.","year":"1994","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"jm991056ab00045\/jm991056ab00045_1","doi-asserted-by":"crossref","first-page":"102","DOI":"10.3109\/10799899509045210","volume":"15","author":"Moguilevsky N.","year":"1995","journal-title":"J. Recept. Signal Transduction Res."},{"key":"jm991056ab00046\/jm991056ab00046_1","first-page":"12","volume":"35","author":"Elz S.","year":"2000","journal-title":"Eur. J. Med. Chem."},{"key":"jm991056ab00047\/jm991056ab00047_1","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1007\/PL00005316","volume":"359","author":"Malinowska B.","year":"1999","journal-title":"Naunyn-Schmiedeberg's Arch. Pharmacol."},{"key":"jm991056ab00048\/jm991056ab00048_1","first-page":"266","volume":"47","author":"Jenkinson D. H.","year":"1995","journal-title":"Pharmacol. Rev."},{"key":"jm991056ab00049\/jm991056ab00049_1","volume-title":"Catecholamines, Handbook of Experimental Pharmacology","volume":"335","author":"Furchgott R. F."},{"key":"jm991056ab00050\/jm991056ab00050_1","first-page":"330","volume":"143","author":"Van Rossum J. M","year":"1963","journal-title":"Arch. Int. Pharmacodyn. Ther."},{"key":"jm991056ab00051\/jm991056ab00051_1","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1111\/j.2042-7158.1995.tb05801.x","volume":"47","author":"Pertz H.","year":"1995","journal-title":"J. Pharm. Pharmacol."},{"key":"jm991056ab00052\/jm991056ab00052_1","first-page":"600","volume":"42","author":"Sasse A.","year":"1999","journal-title":"J. Med. Chem."},{"key":"jm991056ab00053\/jm991056ab00053_1","first-page":"594","volume":"328","author":"Elz S.","year":"1995","journal-title":"Arch. Pharm. Pharm. Med. Chem."},{"key":"jm991056ab00054\/jm991056ab00054_1","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1006\/jmbi.1997.1240","volume":"272","author":"Baldwin J. M.","year":"1997","journal-title":"J. Mol. Biol."},{"key":"jm991056ab00055\/jm991056ab00055_1","volume-title":"University of California","author":"Pearlman D. A.","year":"1995"},{"key":"jm991056ab00056\/jm991056ab00056_1","first-page":"3793","volume":"102","author":"Bayly C. I.","year":"1993","journal-title":"J. Phys. Chem."},{"key":"jm991056ab00057\/jm991056ab00057_1","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1002\/jcc.540141112","volume":"14","author":"Schmidt M. W.","year":"1993","journal-title":"J. Comput. Chem."},{"key":"jm991056ab00058\/jm991056ab00058_1","first-page":"3","volume":"12","author":"Schaftenaar G.","year":"1992","journal-title":"Quantum Chemical Program Exchange Bulletin"},{"key":"jm991056ab00059\/jm991056ab00059_1","volume-title":"Burger's Medicinal Chemistry and Drug Discovery, Therapeutic Agents","volume":"559","author":"Zhang M. Q.","edition":"5"},{"key":"jm991056ab00060\/jm991056ab00060_1","doi-asserted-by":"crossref","first-page":"6055","DOI":"10.1021\/bi990269z","volume":"38","author":"Anders J.","year":"1999","journal-title":"Biochemistry"},{"key":"jm991056ab00061\/jm991056ab00061_1","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1126\/science.274.5288.768","volume":"274","author":"Farrens D. L.","year":"1996","journal-title":"Science"},{"key":"jm991056ab00062\/jm991056ab00062_1","doi-asserted-by":"crossref","first-page":"28275","DOI":"10.1074\/jbc.270.47.28268","volume":"270","author":"Gether U.","year":"1995","journal-title":"J. Biol. Chem."},{"key":"jm991056ab00063\/jm991056ab00063_1","first-page":"308","volume":"6","author":"Ter Laak A. M.","year":"1999","journal-title":"Recept. Channels"}],"container-title":["Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jm991056a","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,7]],"date-time":"2024-12-07T08:07:24Z","timestamp":1733558844000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jm991056a"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,3,1]]},"references-count":63,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2000,3,1]]}},"alternative-id":["10.1021\/jm991056a"],"URL":"https:\/\/doi.org\/10.1021\/jm991056a","relation":{},"ISSN":["0022-2623","1520-4804"],"issn-type":[{"value":"0022-2623","type":"print"},{"value":"1520-4804","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,3,1]]}}}