{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T12:54:02Z","timestamp":1790945642761,"version":"4.1.0"},"reference-count":13,"publisher":"American Chemical Society (ACS)","issue":"25","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Org. Chem."],"published-print":{"date-parts":[[2003,12,1]]},"DOI":"10.1021\/jo035356i","type":"journal-article","created":{"date-parts":[[2003,12,5]],"date-time":"2003-12-05T05:46:55Z","timestamp":1070603215000},"page":"9861-9864","source":"Crossref","is-referenced-by-count":25,"title":["New Synthesis of Optically Active 5-Isoxazolidinones and \u03b2-Amino Acids"],"prefix":"10.1021","volume":"68","author":[{"given":"Renzo","family":"Luisi","sequence":"first","affiliation":[{"name":"Dipartimento Farmaco-Chimico, Universit\u00e0 degli Studi di Bari, Via E. Orabona 4, I-70126 Bari, Italy, and C.N.R., Istituto di Chimica dei Composti Organometallici \u201cICCOM\u201d, Sezione di Bari, Italy %florio@farmchim.uniba.it"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vito","family":"Capriati","sequence":"additional","affiliation":[{"name":"Dipartimento Farmaco-Chimico, Universit\u00e0 degli Studi di Bari, Via E. Orabona 4, I-70126 Bari, Italy, and C.N.R., Istituto di Chimica dei Composti Organometallici \u201cICCOM\u201d, Sezione di Bari, Italy %florio@farmchim.uniba.it"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saverio","family":"Florio","sequence":"additional","affiliation":[{"name":"Dipartimento Farmaco-Chimico, Universit\u00e0 degli Studi di Bari, Via E. Orabona 4, I-70126 Bari, Italy, and C.N.R., Istituto di Chimica dei Composti Organometallici \u201cICCOM\u201d, Sezione di Bari, Italy %florio@farmchim.uniba.it"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Vista","sequence":"additional","affiliation":[{"name":"Dipartimento Farmaco-Chimico, Universit\u00e0 degli Studi di Bari, Via E. Orabona 4, I-70126 Bari, Italy, and C.N.R., Istituto di Chimica dei Composti Organometallici \u201cICCOM\u201d, Sezione di Bari, Italy %florio@farmchim.uniba.it"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2003,11,15]]},"reference":[{"key":"jo035356ib00001\/jo035356ib00001_1","first-page":"4184","volume":"3","author":"Sibi M. P.","year":"2001","journal-title":"Org. Lett."},{"key":"jo035356ib00002\/jo035356ib00002_1","first-page":"4370","volume":"40","author":"Baldwin J. E.","year":"1984","journal-title":"J. Tetrahedron"},{"key":"jo035356ib00003\/jo035356ib00003_1","first-page":"2448","volume":"54","author":"Ishikawa T.","year":"1998","journal-title":"Tetrahedron"},{"key":"jo035356ib00004\/jo035356ib00004_1","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1016\/S0040-4039(00)99509-1","volume":"30","author":"Panfil I.","year":"1989","journal-title":"Tetrahedron Lett."},{"key":"jo035356ib00005\/jo035356ib00005_1","doi-asserted-by":"crossref","first-page":"3121","DOI":"10.1021\/ol0264455","volume":"4","author":"Shindo M.","year":"2002","journal-title":"Org. Lett."},{"key":"jo035356ib00006\/jo035356ib00006_1","doi-asserted-by":"crossref","first-page":"9186","DOI":"10.1016\/S0040-4039(01)02025-1","volume":"42","author":"Capriati V.","year":"2001","journal-title":"Tetrahedron Lett."},{"key":"jo035356ib00006\/jo035356ib00006_2","first-page":"2969","volume":"2961","author":"Capriati V.","year":"2002","journal-title":"Eur. J. Org. Chem."},{"key":"jo035356ib00008\/jo035356ib00008_1","first-page":"3172","volume":"81","author":"In","year":"1959","journal-title":"J. Am. Chem. Soc."},{"key":"jo035356ib00009\/jo035356ib00009_1","doi-asserted-by":"crossref","first-page":"3116","DOI":"10.1021\/jo971161x","volume":"63","author":"Kamata K.","year":"1998","journal-title":"J. Org. Chem."},{"key":"jo035356ib00010\/jo035356ib00010_1","unstructured":"Hydroxylamine (R,R)-10was isolated and characterized after column chromatography by FT-IR analysis (bands at 3373 cm-1, OH, and 1690 cm-1, CN) and13C NMR (see the Supporting Information). Compound (R,R)-10was found to equilibrate in CDCl3or acidic solution to the corresponding spirocyclic form whose hydrolysis gave the 5-isoxazolidinone (\u2212)-6a (er determinated by chiral GC, see the Supporting Information)."},{"key":"jo035356ib00011\/jo035356ib00011_1","unstructured":"The X-ray analysis of (R,R,R)-12aallowed the determination of the absolute configuration at the newly created stereogenic centers. CCDC-213766 contain the supplementary crystallographic data for compound (R,R,R)-12a. These data can be obtained free of charge at www.ccdc.ac.uk\/conts\/retrieving.html or from the Cambridge Crystallographic Data Centre, 12 Union Road, Cambridge CB2 1EZ, UK; Fax:\u2009 (int) +44-1223\/336-033; E-mail:\u2009 deposit@ccdc.cam.ac.uk."},{"key":"jo035356ib00014\/jo035356ib00014_1","unstructured":"The presence of two bands at 3272 (OH stretching) and at 1697 cm-1(CN stretching) in the FT-IR spectrum and a carbon at 168 ppm in the13C NMR spectrum are diagnostic of the presence of the hydroxylamino form (S,S)-14."},{"key":"jo035356ib00017\/jo035356ib00017_1","doi-asserted-by":"crossref","first-page":"983","DOI":"10.2174\/092986730610220401161510","volume":"6","author":"For","year":"1999","journal-title":"Curr. Med. 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