{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:49:16Z","timestamp":1790804956508,"version":"4.1.0"},"reference-count":7,"publisher":"American Chemical Society (ACS)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Org. Chem."],"published-print":{"date-parts":[[2011,3,18]]},"DOI":"10.1021\/jo102262k","type":"journal-article","created":{"date-parts":[[2011,2,4]],"date-time":"2011-02-04T09:50:54Z","timestamp":1296813054000},"page":"1653-1661","source":"Crossref","is-referenced-by-count":32,"title":["POCl\n                    <sub>3<\/sub>\n                    Chlorination of 4-Quinazolones"],"prefix":"10.1021","volume":"76","author":[{"given":"Euan A.","family":"Arnott","sequence":"first","affiliation":[{"name":"AstraZeneca, Pharmaceutical Development, Silk Road Business Park, Charter Way, Macclesfield, Cheshire SK10 2NA, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lai C.","family":"Chan","sequence":"additional","affiliation":[{"name":"AstraZeneca, Pharmaceutical Development, Silk Road Business Park, Charter Way, Macclesfield, Cheshire SK10 2NA, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian G.","family":"Cox","sequence":"additional","affiliation":[{"name":"AstraZeneca, Pharmaceutical Development, Silk Road Business Park, Charter Way, Macclesfield, Cheshire SK10 2NA, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Meyrick","sequence":"additional","affiliation":[{"name":"AstraZeneca, Pharmaceutical Development, Silk Road Business Park, Charter Way, Macclesfield, Cheshire SK10 2NA, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andy","family":"Phillips","sequence":"additional","affiliation":[{"name":"AstraZeneca, Pharmaceutical Development, Silk Road Business Park, Charter Way, Macclesfield, Cheshire SK10 2NA, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2011,2,4]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1126\/science.1095920","volume":"303","author":"Noble M. E. M.","year":"2004","journal-title":"Science"},{"key":"ref2\/cit2","doi-asserted-by":"crossref","DOI":"10.1002\/9780470186916","volume-title":"The Chemistry of Heterocyclic Compounds, 24, Fused Pyrimidines: Part 1: Quinazolines","author":"Armarego W. L. F.","year":"1967"},{"issue":"17","key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"2601","DOI":"10.1139\/v81-374","volume":"59","author":"Robins M. J.","year":"1981","journal-title":"Can. J. Chem."},{"issue":"4","key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1021\/op970213h","volume":"1","author":"Anderson N. G.","year":"1997","journal-title":"Org. Process Res. Dev."},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"2523","DOI":"10.1063\/1.1673336","volume":"52","author":"Tanner J. E.","year":"1970","journal-title":"J. Chem. Phys."},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/zaac.19633240102","volume":"324","author":"Grunze H.","year":"1963","journal-title":"Z., Anorg. Allgem. Chem."},{"key":"ref8\/cit8","unstructured":"For example, reaction of related 5,7-difluoroquinazolin-4-ol with the less reactive P-Cl species (PhO)\n                      2\n                      P(O)Cl forms initially predominantly the (\n                      \n                        N\n                      \n                      )-substituted quinazolone, which then equilibrates with the (\n                      \n                        O\n                      \n                      )-substituted species;Pointon, S.Unpublished work."}],"container-title":["The Journal of Organic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jo102262k","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,5]],"date-time":"2023-04-05T00:45:49Z","timestamp":1680655549000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jo102262k"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,2,4]]},"references-count":7,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011,3,18]]}},"alternative-id":["10.1021\/jo102262k"],"URL":"https:\/\/doi.org\/10.1021\/jo102262k","relation":{},"ISSN":["0022-3263","1520-6904"],"issn-type":[{"value":"0022-3263","type":"print"},{"value":"1520-6904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,2,4]]}}}