{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T04:48:59Z","timestamp":1791089339785,"version":"4.1.0"},"reference-count":46,"publisher":"American Chemical Society (ACS)","issue":"20","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Org. Chem."],"published-print":{"date-parts":[[2011,10,21]]},"DOI":"10.1021\/jo201425q","type":"journal-article","created":{"date-parts":[[2011,9,7]],"date-time":"2011-09-07T13:53:02Z","timestamp":1315403582000},"page":"8262-8269","source":"Crossref","is-referenced-by-count":30,"title":["Direct, Metal-Free Amination of Heterocyclic Amides\/Ureas with NH-Heterocycles and N-Substituted Anilines in POCl<sub>3<\/sub>"],"prefix":"10.1021","volume":"76","author":[{"given":"Xiaohu","family":"Deng","sequence":"first","affiliation":[{"name":"Johnson & Johnson Pharmaceutical Research & Development, LLC, 3210 Merryfield Row, San Diego, California 92121, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armin","family":"Roessler","sequence":"additional","affiliation":[{"name":"PDMS API SM Development, Cilag AG, Hochstrasse 201, CH-8205 Schaffhausen, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivana","family":"Brdar","sequence":"additional","affiliation":[{"name":"PDMS API SM Development, Cilag AG, Hochstrasse 201, CH-8205 Schaffhausen, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"Faessler","sequence":"additional","affiliation":[{"name":"PDMS API SM Development, Cilag AG, Hochstrasse 201, CH-8205 Schaffhausen, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiejun","family":"Wu","sequence":"additional","affiliation":[{"name":"Johnson & Johnson Pharmaceutical Research & Development, LLC, 3210 Merryfield Row, San Diego, California 92121, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary S.","family":"Sales","sequence":"additional","affiliation":[{"name":"Johnson & Johnson Pharmaceutical Research & Development, LLC, 3210 Merryfield Row, San Diego, California 92121, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neelakandha S.","family":"Mani","sequence":"additional","affiliation":[{"name":"Johnson & Johnson Pharmaceutical Research & Development, LLC, 3210 Merryfield Row, San Diego, California 92121, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2011,9,7]]},"reference":[{"key":"ref1\/cit1","volume-title":"Heterocycles in Life and Society","author":"Pozharskii A. F.","year":"1997"},{"key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1021\/jm00157a010","volume":"29","author":"Iemura R.","year":"1986","journal-title":"J. Med. Chem."},{"key":"ref3\/cit3a","doi-asserted-by":"crossref","first-page":"4992","DOI":"10.1021\/jo00304a007","volume":"55","author":"Jameson D. L.","year":"1990","journal-title":"J. Org. Chem."},{"key":"ref3\/cit3b","doi-asserted-by":"crossref","first-page":"5687","DOI":"10.1016\/j.bmcl.2006.08.017","volume":"16","author":"Warshakoo N. C.","year":"2006","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref4\/cit4a","doi-asserted-by":"crossref","first-page":"3497","DOI":"10.1021\/ol000255h","volume":"2","author":"Lin X.","year":"2000","journal-title":"Org. Lett."},{"key":"ref4\/cit4b","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1021\/jo040281j","volume":"70","author":"Kang F-A","year":"2005","journal-title":"J. Org. Chem."},{"key":"ref4\/cit4c","doi-asserted-by":"crossref","first-page":"2425","DOI":"10.1021\/ol060815y","volume":"8","author":"Wan Z.-K","year":"2006","journal-title":"Org. Lett."},{"key":"ref4\/cit4d","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1021\/ja064682n","volume":"129","author":"Bae S.","year":"2007","journal-title":"J. Am. Chem. Soc."},{"key":"ref4\/cit4e","doi-asserted-by":"crossref","first-page":"10194","DOI":"10.1021\/jo7020373","volume":"72","author":"Wan Z.-K","year":"2007","journal-title":"J. Org. Chem."},{"key":"ref4\/cit4f","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1021\/ol8004084","volume":"10","author":"Levins C. G.","year":"2008","journal-title":"Org. Lett."},{"key":"ref4\/cit4g","doi-asserted-by":"crossref","first-page":"2203","DOI":"10.1021\/ol8006106","volume":"10","author":"Bae S.","year":"2008","journal-title":"Org. Lett."},{"key":"ref4\/cit4h","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1002\/ejoc.200801004","volume":"4","author":"Kang F.-A","year":"2009","journal-title":"Eur. J. Org. Chem."},{"key":"ref5\/cit5a","doi-asserted-by":"crossref","first-page":"6523","DOI":"10.1002\/anie.200601612","volume":"45","author":"Anderson K. W.","year":"2006","journal-title":"Angew. Chem., Int. Ed."},{"key":"ref5\/cit5b","doi-asserted-by":"crossref","first-page":"6338","DOI":"10.1002\/anie.200800497","volume":"47","author":"Surry D. S.","year":"2008","journal-title":"Angew. Chem., Int. Ed."},{"key":"ref5\/cit5c","doi-asserted-by":"crossref","first-page":"13848","DOI":"10.1021\/ja805810p","volume":"130","author":"Ogata T.","year":"2008","journal-title":"J. Am. Chem. Soc."},{"key":"ref6\/cit6a","doi-asserted-by":"crossref","first-page":"5578","DOI":"10.1021\/jo049658b","volume":"69","author":"Antilla J. C.","year":"2004","journal-title":"J. Org. Chem."},{"key":"ref6\/cit6b","doi-asserted-by":"crossref","first-page":"5164","DOI":"10.1021\/jo0504464","volume":"70","author":"Zhang H.","year":"2005","journal-title":"J. Org. Chem."},{"key":"ref6\/cit6c","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1002\/jhet.5570450640","volume":"45","author":"Hosseinzadeh R.","year":"2008","journal-title":"J. Heterocycl. Chem."},{"key":"ref6\/cit6d","doi-asserted-by":"crossref","first-page":"10585","DOI":"10.1002\/chem.200901014","volume":"15","author":"Li F.","year":"2009","journal-title":"Chem.\u2014Eur. J."},{"key":"ref7\/cit7a","doi-asserted-by":"crossref","first-page":"2282","DOI":"10.1002\/anie.200906750","volume":"49","author":"Armstrong A.","year":"2010","journal-title":"Angew. Chem., Int. Ed."},{"key":"ref7\/cit7b","doi-asserted-by":"crossref","first-page":"3674","DOI":"10.1021\/ja100354j","volume":"132","author":"Huang J.","year":"2010","journal-title":"J. Am. Chem. Soc."},{"key":"ref8\/cit8a","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.bmcl.2004.11.021","volume":"15","author":"Shao B.","year":"2005","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref8\/cit8b","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1016\/j.bmc.2005.09.063","volume":"14","author":"Rivara M.","year":"2006","journal-title":"Bioorg. Med. Chem."},{"key":"ref8\/cit8c","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1002\/ejoc.200800725","volume":"7","author":"Muniz F. M.","year":"2009","journal-title":"Eur. J. Org. Chem."},{"key":"ref9\/cit9a","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.1016\/j.bmcl.2005.02.076","volume":"15","author":"Verma S.","year":"2005","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref9\/cit9b","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1002\/jhet.5570450247","volume":"45","author":"Omar W. A. E.","year":"2008","journal-title":"J. Heterocycl. Chem."},{"key":"ref9\/cit9c","doi-asserted-by":"crossref","first-page":"5618","DOI":"10.1016\/j.bmcl.2008.08.104","volume":"18","author":"Zhang G.","year":"2008","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref9\/cit9d","doi-asserted-by":"crossref","first-page":"6691","DOI":"10.1016\/j.bmcl.2009.09.123","volume":"19","author":"Zhang G.","year":"2009","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref9\/cit9e","doi-asserted-by":"crossref","first-page":"6962","DOI":"10.1021\/jm9014197","volume":"52","author":"Pelletier J. C.","year":"2009","journal-title":"J. Med. Chem."},{"key":"ref9\/cit9f","doi-asserted-by":"crossref","first-page":"7950","DOI":"10.1021\/jm901543m","volume":"52","author":"Liu F.","year":"2009","journal-title":"J. Med. Chem."},{"key":"ref9\/cit9g","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1021\/ol902759k","volume":"12","author":"Shen Z.","year":"2010","journal-title":"Org. Lett."},{"key":"ref10\/cit10a","unstructured":"Schegk, E.; Gauss, W.Ger. Offen. 2130029, 1972."},{"key":"ref10\/cit10b","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/0223-5234(88)90204-8","volume":"23","author":"Vega S.","year":"1988","journal-title":"Eur. J. Med. Chem."},{"key":"ref10\/cit10c","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.3987\/COM-89-5036","volume":"29","author":"Lin P. K. T.","year":"1989","journal-title":"Heterocycles"},{"key":"ref10\/cit10d","doi-asserted-by":"crossref","first-page":"3618","DOI":"10.1021\/jo961901m","volume":"62","author":"Ohkanda J.","year":"1997","journal-title":"J. Org. Chem."},{"key":"ref10\/cit10e","doi-asserted-by":"crossref","first-page":"3375","DOI":"10.1021\/jo052443x","volume":"71","author":"Katritzky A. R.","year":"2006","journal-title":"J. Org. Chem."},{"key":"ref10\/cit10f","doi-asserted-by":"crossref","first-page":"263","DOI":"10.3998\/ark.5550190.0008.520","volume":"5","author":"Katritzky A. R.","year":"2007","journal-title":"ARKIVOC"},{"key":"ref10\/cit10g","first-page":"2682","author":"Rabilloud G.","year":"1975","journal-title":"Bull. Soc. Chim. Fr."},{"key":"ref10\/cit10h","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1002\/jhet.5570250247","volume":"25","author":"Shishoo C. J.","year":"1988","journal-title":"J. Heterocycl. Chem."},{"key":"ref10\/cit10i","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1080\/00397918908051016","volume":"19","author":"Sridevi G.","year":"1989","journal-title":"Synth. Commun."},{"key":"ref11\/cit11a","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1021\/ml100198y","volume":"1","author":"Rosen M. D.","year":"2010","journal-title":"ACS Med. Chem. Lett."},{"key":"ref11\/cit11b","doi-asserted-by":"crossref","first-page":"5742","DOI":"10.1021\/jo900912h","volume":"74","author":"Deng X.","year":"2009","journal-title":"J. Org. Chem."},{"key":"ref11\/cit11c","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1002\/ejoc.200901056","volume":"4","author":"Deng X.","year":"2010","journal-title":"Eur. J. Org. Chem."},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1080\/00397919808006874","volume":"28","author":"Hinkley J. M.","year":"1998","journal-title":"Synth. Commun."},{"key":"ref13\/cit13","first-page":"965","volume":"37","author":"Sharma S. D.","year":"1998","journal-title":"Indian J. Chem."},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1006\/jmre.1997.1110","volume":"125","author":"Stott K.","year":"1997","journal-title":"J. Magn. Reson."}],"container-title":["The Journal of Organic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jo201425q","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,22]],"date-time":"2023-04-22T00:57:29Z","timestamp":1682125049000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jo201425q"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9,7]]},"references-count":46,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2011,10,21]]}},"alternative-id":["10.1021\/jo201425q"],"URL":"https:\/\/doi.org\/10.1021\/jo201425q","relation":{},"ISSN":["0022-3263","1520-6904"],"issn-type":[{"value":"0022-3263","type":"print"},{"value":"1520-6904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,9,7]]}}}