{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T19:18:25Z","timestamp":1788290305722,"version":"build-2803163510"},"reference-count":45,"publisher":"American Chemical Society (ACS)","issue":"19","license":[{"start":{"date-parts":[[2015,9,22]],"date-time":"2015-09-22T00:00:00Z","timestamp":1442880000000},"content-version":"vor","delay-in-days":365,"URL":"https:\/\/pubs.acs.org\/page\/policy\/authorchoice_termsofuse.html"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["CA-19033"],"award-info":[{"award-number":["CA-19033"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,10,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The evolution of an enantioselective total synthesis of (+)-18-epi-latrunculol A, a congener of the marine-sponge-derived latrunculins A and B, is reported. Key steps include a late-stage Mitsunobu macrolactonization to construct the 16-membered macrolactone, a mild Carreira alkynylation to unite the northern and southern hemispheres, a diastereoselective, acid-mediated \u03b4-hydroxy enone cyclization\/equilibration sequence, and a functional-group-tolerant cross-metathesis to access the enone cyclization precursor.<\/jats:p>","DOI":"10.1021\/jo501733m","type":"journal-article","created":{"date-parts":[[2014,9,22]],"date-time":"2014-09-22T15:07:28Z","timestamp":1411398448000},"page":"9284-9296","source":"Crossref","is-referenced-by-count":14,"title":["Total Synthesis of (+)-18-\n                    <i>epi<\/i>\n                    -Latrunculol\nA: Development of a Synthetic Route"],"prefix":"10.1021","volume":"79","author":[{"given":"Brett D.","family":"Williams","sequence":"first","affiliation":[{"name":"University of Pennsylvania , , , ,","place":["Philadelphia, Pennsylvania, United States, 19104"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"Amos B.","family":"Smith","sequence":"additional","affiliation":[{"name":"University of Pennsylvania , , , ,","place":["Philadelphia, Pennsylvania, United States, 19104"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2014,9,22]]},"reference":[{"key":"2026090115011640600_cit1","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/BF00390634","volume":"30","author":"Neeman","year":"1975","journal-title":"Mar. 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