{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T16:10:50Z","timestamp":1746807050451,"version":"3.40.5"},"reference-count":50,"publisher":"American Chemical Society (ACS)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Org. Chem."],"published-print":{"date-parts":[[2008,6,1]]},"DOI":"10.1021\/jo8005528","type":"journal-article","created":{"date-parts":[[2008,5,9]],"date-time":"2008-05-09T06:01:38Z","timestamp":1210312898000},"page":"4205-4211","source":"Crossref","is-referenced-by-count":10,"title":["Intrinsic Conformational Preferences of C<sup>\u03b1,\u03b1<\/sup>-Dibenzylglycine"],"prefix":"10.1021","volume":"73","author":[{"given":"Jordi","family":"Casanovas","sequence":"first","affiliation":[{"name":"Departament de Qu\u00edmica, Escola Polit\u00e8cnica Superior, Universitat de Lleida, c\/Jaume II no. 69, Lleida E-25001, Spain, Basic Research Program, SAIC-Frederick, Inc., Center for Cancer Research Nanobiology Program, NCI, Frederick, Maryland 21702, Department of Human Genetics Sackler, Medical School, Tel Aviv University, Tel Aviv 69978, Israel, and Departament d\u2019Enginyeria Qu\u00edmica, E. T. S. d\u2019Enginyeria Industrial de Barcelona, Universitat Polit\u00e8cnica de Catalunya, Avda. Diagonal no. 647, Barcelona E-08028,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth","family":"Nussinov","sequence":"additional","affiliation":[{"name":"Departament de Qu\u00edmica, Escola Polit\u00e8cnica Superior, Universitat de Lleida, c\/Jaume II no. 69, Lleida E-25001, Spain, Basic Research Program, SAIC-Frederick, Inc., Center for Cancer Research Nanobiology Program, NCI, Frederick, Maryland 21702, Department of Human Genetics Sackler, Medical School, Tel Aviv University, Tel Aviv 69978, Israel, and Departament d\u2019Enginyeria Qu\u00edmica, E. T. S. d\u2019Enginyeria Industrial de Barcelona, Universitat Polit\u00e8cnica de Catalunya, Avda. Diagonal no. 647, Barcelona E-08028,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Alem\u00e1n","sequence":"additional","affiliation":[{"name":"Departament de Qu\u00edmica, Escola Polit\u00e8cnica Superior, Universitat de Lleida, c\/Jaume II no. 69, Lleida E-25001, Spain, Basic Research Program, SAIC-Frederick, Inc., Center for Cancer Research Nanobiology Program, NCI, Frederick, Maryland 21702, Department of Human Genetics Sackler, Medical School, Tel Aviv University, Tel Aviv 69978, Israel, and Departament d\u2019Enginyeria Qu\u00edmica, E. T. S. d\u2019Enginyeria Industrial de Barcelona, Universitat Polit\u00e8cnica de Catalunya, Avda. Diagonal no. 647, Barcelona E-08028,..."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2008,5,9]]},"reference":[{"key":"ref1\/cit1a","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1055\/s-2006-941573","author":"Toniolo C.","year":"2006","journal-title":"Synlett"},{"key":"ref1\/cit1b","doi-asserted-by":"crossref","first-page":"3131","DOI":"10.1021\/cr000053z","volume":"101","author":"Venkatraman J.","year":"2001","journal-title":"Chem. Rev."},{"key":"ref1\/cit1c","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1002\/1097-0282(2001)60:6<396::AID-BIP10184>3.0.CO;2-7","volume":"60","author":"Toniolo C.","year":"2001","journal-title":"Biopolymers (Pept. Sci.)"},{"key":"ref2\/cit2a","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0968-0896(98)00221-1","volume":"7","author":"Kaul R.","year":"1999","journal-title":"Bioorg. Med. Chem."},{"key":"ref2\/cit2b","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/(SICI)1097-0282(1996)40:1<3::AID-BIP2>3.0.CO;2-#","volume":"40","author":"Benedetti E.","year":"1996","journal-title":"Biopolymers (Pept. Sci.)"},{"key":"ref2\/cit2c","doi-asserted-by":"crossref","first-page":"4004","DOI":"10.1021\/ma00014a006","volume":"24","author":"Toniolo C.","year":"1991","journal-title":"Macromolecules"},{"key":"ref3\/cit3a","doi-asserted-by":"crossref","first-page":"6747","DOI":"10.1021\/bi00481a001","volume":"29","author":"Karle I. L.","year":"1990","journal-title":"Biochemistry"},{"key":"ref3\/cit3b","doi-asserted-by":"crossref","first-page":"7921","DOI":"10.1073\/pnas.87.20.7921","volume":"87","author":"Karle I. L.","year":"1990","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref3\/cit3c","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/0022-2836(90)90279-U","volume":"214","author":"Pavone V.","year":"1990","journal-title":"J. Mol. Biol."},{"key":"ref3\/cit3d","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1073\/pnas.86.3.765","volume":"86","author":"Karle I. L.","year":"1989","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref3\/cit3e","doi-asserted-by":"crossref","first-page":"307","DOI":"10.3109\/10409238409108718","volume":"16","author":"Prasad B. V. V.","year":"1984","journal-title":"CRC Crit. Rev. Biochem."},{"key":"ref4\/cit4a","doi-asserted-by":"crossref","first-page":"7550","DOI":"10.1021\/ma0106503","volume":"34","author":"Improta R.","year":"2001","journal-title":"Macromolecules"},{"key":"ref4\/cit4b","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1002\/bip.360340704","volume":"34","author":"Alem\u00e1n C.","year":"1994","journal-title":"Biopolymers"},{"key":"ref4\/cit4c","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1002\/bip.360340109","volume":"34","author":"Huston S. E.","year":"1994","journal-title":"Biopolymers"},{"key":"ref4\/cit4d","doi-asserted-by":"crossref","first-page":"11915","DOI":"10.1021\/ja00105a034","volume":"116","author":"Zhang L.","year":"1994","journal-title":"J. Am. Chem. Soc."},{"key":"ref4\/cit4e","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1002\/(SICI)1097-0134(199705)28:1<83::AID-PROT8>3.0.CO;2-K","volume":"28","author":"Alem\u00e1n C.","year":"1997","journal-title":"Proteins"},{"key":"ref4\/cit4f","doi-asserted-by":"crossref","first-page":"11849","DOI":"10.1021\/jp026381f","volume":"106","author":"Alem\u00e1n C.","year":"2002","journal-title":"J. Phys. Chem. B"},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"2174","DOI":"10.1021\/jo0624905","volume":"72","author":"Casanovas J.","year":"2007","journal-title":"J. Org. Chem."},{"key":"ref6\/cit6a","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1002\/bip.360341204","volume":"34","author":"Pavone V.","year":"1994","journal-title":"Biopolymers"},{"key":"ref6\/cit6b","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1002\/bip.360310608","volume":"31","author":"Crisma M.","year":"1991","journal-title":"Biopolymers"},{"key":"ref6\/cit6c","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1111\/j.1399-3011.1994.tb00408.x","volume":"44","author":"Toniolo C.","year":"1994","journal-title":"Int. J. Pept. Prot. Res."},{"key":"ref7\/cit7a","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1039\/P29900001481","author":"Valle G.","year":"1990","journal-title":"J. Chem. Soc., Perkin Trans. 2"},{"key":"ref7\/cit7b","first-page":"0527","volume":"60","author":"Damodharan L.","year":"2004","journal-title":"Acta Crystallogr."},{"key":"ref8\/cit8","unstructured":"Gaussian 03, Revision B.02:Frisch, M. J.; Trucks, G. W.; Schlegel, H. B.; Scuseria, G. E.; Robb, M. A.; Cheeseman, J. R.; Montgomery, J. A.; Vreven, T., Jr.; Kudin, K. N.; Burant, J. C.; Millam, J. M.; Iyengar, S. S.; Tomasi, J.; Barone, V.; Mennucci, B.; Cossi, M.; Scalmani, G.; Rega, N.; Petersson, G. A.; Nakatsuji, H.; Hada, M.; Ehara, M.; Toyota, K.; Fukuda, R.; Hasegawa, J.; Ishida, M.; Nakajima, T.; Honda, Y.; Kitao, O.; Nakai, H.; Klene, M.; Li, X.; Knox, J. E.; Hratchian, H. P.; Cross, J. B.; Adamo, C.; Jaramillo, J.; Gomperts, R.; Stratmann, R. E.; Yazyev, O.; Austin, A. J.; Cammi, R.; Pomelli, C.; Ochterski, J. W.; Ayala, P. Y.; Morokuma, K.; Voth, G. A.; Salvador, P.; Dannenberg, J. J.; Zakrzewski, V. G.; Dapprich, S.; Daniels, A. D.; C. Strain, M.; Farkas, O.; Malick, D. K.; Rabuck, A. D.; Raghavachari, K.; Foresman, J. B.; Ortiz, J. V.; Cui, Q.; Baboul, A. G.; Clifford, S.; Cioslowski, J.; Stefanov, B. B.; Liu, G.; Liashenko, A.; Piskorz, P.; Komaromi, I.; Martin, R. L.; Fox, D. J.; Keith, T.; Al-Laham, M. A.; Peng, C. Y.; Nanayakkara, A.; Challacombe, M.; Gill, P. M. W.; Johnson, B.; Chen, W.; Wong, M. W.; Gonzalez, C.; Pople, J. A.Gaussian, Inc., Pittsburgh, PA, 2003."},{"key":"ref9\/cit9a","doi-asserted-by":"crossref","first-page":"5046","DOI":"10.1021\/jp963339+","volume":"101","author":"Alem\u00e1n C.","year":"1997","journal-title":"J. Phys. Chem. B"},{"key":"ref9\/cit9b","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1007\/s002149900066","volume":"103","author":"G\u00f3mez-Catal\u00e1n J.","year":"2000","journal-title":"Theor. Chem. Acc."},{"key":"ref9\/cit9c","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.cplett.2006.08.062","volume":"429","author":"Casanovas J.","year":"2006","journal-title":"Chem. Phys. Lett."},{"key":"ref9\/cit9d","doi-asserted-by":"crossref","first-page":"21264","DOI":"10.1021\/jp062804s","volume":"110","author":"Alem\u00e1n C.","year":"2006","journal-title":"J. Phys. Chem. B"},{"key":"ref9\/cit9e","doi-asserted-by":"crossref","first-page":"7088","DOI":"10.1021\/jo034720a","volume":"68","author":"Casanovas J.","year":"2003","journal-title":"J. Org. Chem."},{"key":"ref9\/cit9f","doi-asserted-by":"crossref","first-page":"5762","DOI":"10.1021\/jp0542569","volume":"110","author":"Casanovas J.","year":"2006","journal-title":"J. Phys. Chem. B"},{"key":"ref10\/cit10a","doi-asserted-by":"crossref","first-page":"2950","DOI":"10.1021\/jo0478407","volume":"70","author":"Alem\u00e1n C.","year":"2005","journal-title":"J. Org. Chem."},{"key":"ref10\/cit10b","doi-asserted-by":"crossref","first-page":"7731","DOI":"10.1021\/jo051167j","volume":"70","author":"Alem\u00e1n C.","year":"2005","journal-title":"J. Org. Chem."},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1063\/1.464304","volume":"98","author":"Becke A. D.","year":"1993","journal-title":"J. Chem. Phys."},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1103\/PhysRevB.37.785","volume":"37","author":"Lee C.","year":"1993","journal-title":"Phys. Rev. B"},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"5639","DOI":"10.1063\/1.438980","volume":"72","author":"McLean A. D.","year":"1980","journal-title":"J. Chem. Phys."},{"key":"ref14\/cit14a","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/0301-0104(81)85090-2","volume":"55","author":"Miertus S.","year":"1981","journal-title":"Chem. Phys."},{"key":"ref14\/cit14b","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/0301-0104(82)85072-6","volume":"65","author":"Miertus S.","year":"1982","journal-title":"Chem. Phys."},{"key":"ref14\/cit14c","first-page":"2027","volume":"94","author":"Tomasi J.","year":"1994","journal-title":"Chem. Phys."},{"key":"ref14\/cit14d","doi-asserted-by":"crossref","first-page":"2999","DOI":"10.1021\/cr9904009","volume":"105","author":"Tomasi J.","year":"2005","journal-title":"Chem. Rev."},{"key":"ref15\/cit15a","doi-asserted-by":"crossref","first-page":"3257","DOI":"10.1021\/jp973306+","volume":"102","author":"Hawkins G. D.","year":"1998","journal-title":"J. Phys. Chem. B"},{"key":"ref15\/cit15b","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1021\/jp020774x","volume":"107","author":"Jang Y. H.","year":"2003","journal-title":"J. Phys. Chem. B"},{"key":"ref15\/cit15c","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.chemphys.2004.03.018","volume":"302","author":"Iribarren J. I.","year":"2004","journal-title":"Chem. Phys."},{"volume-title":"The Weak Hydrogen Bond in Stuctural Chemistry and Biology","year":"1999","author":"Desiraju G. R.","key":"ref16\/cit16"},{"key":"ref17\/cit17a","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1006\/jmbi.2000.4301","volume":"305","author":"Steiner T.","year":"2001","journal-title":"J. Mol. Biol."},{"key":"ref17\/cit17b","doi-asserted-by":"crossref","first-page":"17473","DOI":"10.1021\/j100048a025","volume":"99","author":"Worth G. A.","year":"1995","journal-title":"J. Phys. Chem."},{"key":"ref17\/cit17c","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1006\/jmbi.1994.1370","volume":"239","author":"Mitchell J. B. O.","year":"1994","journal-title":"J. Mol. Biol."},{"key":"ref17\/cit17d","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1038\/366413a0","volume":"366","author":"Mitchell J. B. O.","year":"1993","journal-title":"Nature"},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1021\/jo702107s","volume":"73","author":"Casanovas J.","year":"2008","journal-title":"J. Org. Chem."},{"key":"ref19\/cit19a","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1002\/bip.360330706","volume":"33","author":"Di Blasio B.","year":"1993","journal-title":"Biopolymers"},{"key":"ref19\/cit19b","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1002\/bip.360341012","volume":"34","author":"Benedetti E.","year":"1994","journal-title":"Biopolymers"}],"container-title":["The Journal of Organic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jo8005528","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,7]],"date-time":"2023-03-07T01:38:34Z","timestamp":1678153114000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jo8005528"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,5,9]]},"references-count":50,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2008,6,1]]}},"alternative-id":["10.1021\/jo8005528"],"URL":"https:\/\/doi.org\/10.1021\/jo8005528","relation":{},"ISSN":["0022-3263","1520-6904"],"issn-type":[{"type":"print","value":"0022-3263"},{"type":"electronic","value":"1520-6904"}],"subject":[],"published":{"date-parts":[[2008,5,9]]}}}