{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T14:18:16Z","timestamp":1790518696238,"version":"4.1.0"},"reference-count":51,"publisher":"American Chemical Society (ACS)","issue":"39","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Phys. Chem. B"],"published-print":{"date-parts":[[2013,10,3]]},"DOI":"10.1021\/jp405389n","type":"journal-article","created":{"date-parts":[[2013,9,3]],"date-time":"2013-09-03T20:48:32Z","timestamp":1378241312000},"page":"11518-11529","source":"Crossref","is-referenced-by-count":38,"title":["Familial Alzheimer\u2019s Disease Osaka Mutant (\u0394E22) \u03b2-Barrels Suggest an Explanation for the Different A\u03b2<sub>1\u201340\/42<\/sub> Preferred Conformational States Observed by Experiment"],"prefix":"10.1021","volume":"117","author":[{"given":"Hyunbum","family":"Jang","sequence":"first","affiliation":[{"name":"Basic Science\rProgram, SAIC-Frederick, Inc., Cancer and Inflammation Program, National Cancer Institute, Frederick, Maryland 21702, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Teran Arce","sequence":"additional","affiliation":[{"name":"Departments\rof Bioengineering and of Mechanical and Aerospace Engineering, and Materials Science Program, University of California, San Diego, La Jolla, California 92093, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srinivasan","family":"Ramachandran","sequence":"additional","affiliation":[{"name":"Departments\rof Bioengineering and of Mechanical and Aerospace Engineering, and Materials Science Program, University of California, San Diego, La Jolla, California 92093, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce L.","family":"Kagan","sequence":"additional","affiliation":[{"name":"Department\rof Psychiatry, David Geffen School of Medicine, Semel\rInstitute for Neuroscience and Human Behavior, University of California, Los Angeles, California 90024, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ratnesh","family":"Lal","sequence":"additional","affiliation":[{"name":"Departments\rof Bioengineering and of Mechanical and Aerospace Engineering, and Materials Science Program, University of California, San Diego, La Jolla, California 92093, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Nussinov","sequence":"additional","affiliation":[{"name":"Basic Science\rProgram, SAIC-Frederick, Inc., Cancer and Inflammation Program, National Cancer Institute, Frederick, Maryland 21702, United States"},{"name":"Department\rof Human Molecular Genetics and Biochemistry, Sackler\rSchool of Medicine, Tel Aviv University, Tel Aviv 69978, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2013,9,13]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1002\/ana.21321","volume":"63","author":"Tomiyama T.","year":"2008","journal-title":"Ann. Neurol."},{"key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"957","DOI":"10.2353\/ajpath.2009.080480","volume":"174","author":"Nishitsuji K.","year":"2009","journal-title":"Am. J. Pathol."},{"key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"4845","DOI":"10.1523\/JNEUROSCI.5825-09.2010","volume":"30","author":"Tomiyama T.","year":"2010","journal-title":"J. Neurosci."},{"key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"98","DOI":"10.3109\/13506129.2011.580399","volume":"18","author":"Inayathullah M.","year":"2011","journal-title":"Amyloid"},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"2026","DOI":"10.1021\/bi1016217","volume":"50","author":"Cloe A. L.","year":"2011","journal-title":"Biochemistry"},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/j.jmb.2011.02.049","volume":"408","author":"Ovchinnikova O. Y.","year":"2011","journal-title":"J. Mol. Biol."},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1146\/annurev.genom.3.022502.103022","volume":"3","author":"Selkoe D. J.","year":"2002","journal-title":"Annu. Rev. Genomics Hum. Genet."},{"key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1126\/science.2111584","volume":"248","author":"Levy E.","year":"1990","journal-title":"Science"},{"key":"ref9\/cit9","first-page":"998","volume":"51","author":"Kamino K.","year":"1992","journal-title":"Am. J. Hum. Genet."},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1038\/nn0901-887","volume":"4","author":"Nilsberth C.","year":"2001","journal-title":"Nat. Neurosci."},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"27110","DOI":"10.1016\/S0021-9258(19)61486-9","volume":"275","author":"Miravalle L.","year":"2000","journal-title":"J. Biol. Chem."},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"e16248","DOI":"10.1371\/journal.pone.0016248","volume":"6","author":"Pifer P. M.","year":"2011","journal-title":"PLoS One"},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"46179","DOI":"10.1074\/jbc.M301874200","volume":"278","author":"Murakami K.","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"14126","DOI":"10.1073\/pnas.212206899","volume":"99","author":"Ma B.","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"17342","DOI":"10.1073\/pnas.0506723102","volume":"102","author":"L\u00fchrs T.","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1021\/bi051952q","volume":"45","author":"Petkova A. T.","year":"2006","journal-title":"Biochemistry"},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"4820","DOI":"10.1021\/cr900377t","volume":"110","author":"Miller Y.","year":"2010","journal-title":"Chem. Rev."},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.jmb.2011.11.023","volume":"421","author":"Ma B.","year":"2012","journal-title":"J. Mol. Biol."},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"8868","DOI":"10.1039\/c3cp00017f","volume":"15","author":"Jang H.","year":"2013","journal-title":"Phys. Chem. Chem. Phys."},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1096\/fj.09-145979","volume":"24","author":"Kajava A. V.","year":"2010","journal-title":"FASEB J"},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1074\/jbc.M504454200","volume":"281","author":"Zirah S.","year":"2006","journal-title":"J. Biol. Chem."},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1021\/ct200885r","volume":"8","author":"Capone R.","year":"2012","journal-title":"J. Chem. Theory Comput."},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1021\/jp2108126","volume":"116","author":"Connelly L.","year":"2012","journal-title":"J. Phys. Chem. B"},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1021\/bi2017427","volume":"51","author":"Capone R.","year":"2012","journal-title":"Biochemistry"},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"3031","DOI":"10.1021\/bi300257e","volume":"51","author":"Connelly L.","year":"2012","journal-title":"Biochemistry"},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/j.jmb.2010.10.025","volume":"404","author":"Jang H.","year":"2010","journal-title":"J. Mol. Biol."},{"key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/S0005-2736(02)00577-1","volume":"1565","author":"Schulz G. E.","year":"2002","journal-title":"Biochim. Biophys. Acta"},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1529\/biophysj.107.110148","volume":"93","author":"Jang H.","year":"2007","journal-title":"Biophys. J."},{"key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.tibs.2007.10.007","volume":"33","author":"Jang H.","year":"2008","journal-title":"Trends Biochem. Sci."},{"key":"ref30\/cit30","doi-asserted-by":"crossref","first-page":"3029","DOI":"10.1016\/j.bpj.2009.09.014","volume":"97","author":"Jang H.","year":"2009","journal-title":"Biophys. J."},{"key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"6538","DOI":"10.1073\/pnas.0914251107","author":"Jang H.","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"9445","DOI":"10.1021\/jp104073k","volume":"114","author":"Jang H.","year":"2010","journal-title":"J. Phys. Chem. B"},{"key":"ref33\/cit33","doi-asserted-by":"crossref","first-page":"14938","DOI":"10.1021\/ja9049299","volume":"131","author":"Mustata M.","year":"2009","journal-title":"J. Am. Chem. Soc."},{"key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"2644","DOI":"10.1016\/j.bpj.2010.02.024","volume":"98","author":"Capone R.","year":"2010","journal-title":"Biophys. J."},{"key":"ref35\/cit35","doi-asserted-by":"crossref","first-page":"4631","DOI":"10.1529\/biophysj.108.134551","volume":"95","author":"Jang H.","year":"2008","journal-title":"Biophys. J."},{"key":"ref36\/cit36","doi-asserted-by":"crossref","first-page":"10427","DOI":"10.1073\/pnas.0502066102","volume":"102","author":"Quist A.","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref37\/cit37","doi-asserted-by":"crossref","first-page":"11631","DOI":"10.1073\/pnas.91.24.11631","volume":"91","author":"Woolf T. B.","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref38\/cit38","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1002\/(SICI)1097-0134(199601)24:1<92::AID-PROT7>3.0.CO;2-Q","volume":"24","author":"Woolf T. B.","year":"1996","journal-title":"Proteins"},{"key":"ref39\/cit39","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s00232-005-7006-8","volume":"208","author":"Kucerka N.","year":"2005","journal-title":"J. Membr. Biol."},{"key":"ref40\/cit40","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/jcc.540040211","volume":"4","author":"Brooks B. R.","year":"1983","journal-title":"J. Comput. Chem."},{"key":"ref41\/cit41","doi-asserted-by":"crossref","first-page":"7830","DOI":"10.1021\/jp101759q","volume":"114","author":"Klauda J. B.","year":"2010","journal-title":"J. Phys. Chem. B"},{"key":"ref42\/cit42","doi-asserted-by":"crossref","first-page":"2198","DOI":"10.1021\/j100059a038","volume":"98","author":"Durell S. R.","year":"1994","journal-title":"J. Phys. Chem."},{"key":"ref43\/cit43","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.jmb.2008.11.060","volume":"386","author":"Wong P. T.","year":"2009","journal-title":"J. Mol. Biol."},{"key":"ref44\/cit44","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1002\/jcc.20289","volume":"26","author":"Phillips J. C.","year":"2005","journal-title":"J. Comput. Chem."},{"key":"ref45\/cit45","doi-asserted-by":"crossref","first-page":"16013","DOI":"10.1021\/ja2035859","volume":"133","author":"Bertini I.","year":"2011","journal-title":"J. Am. Chem. Soc."},{"key":"ref46\/cit46","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.jmb.2012.11.006","volume":"425","author":"Roychaudhuri R.","year":"2013","journal-title":"J. Mol. Biol."},{"key":"ref47\/cit47","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.jmb.2011.12.063","volume":"421","author":"Tofoleanu F.","year":"2012","journal-title":"J. Mol. Biol."},{"key":"ref48\/cit48","doi-asserted-by":"crossref","first-page":"339","DOI":"10.4161\/pri.21022","volume":"6","author":"Tofoleanu F.","year":"2012","journal-title":"Prion"},{"key":"ref49\/cit49","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1021\/ct300916f","volume":"9","author":"Jang H.","year":"2013","journal-title":"J. Chem. Theory Comput."},{"key":"ref50\/cit50","doi-asserted-by":"crossref","first-page":"2455","DOI":"10.1016\/S0006-3495(93)81293-1","volume":"65","author":"Smart O. S.","year":"1993","journal-title":"Biophys. J."},{"key":"ref51\/cit51","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1002\/prot.340230412","volume":"23","author":"Frishman D.","year":"1995","journal-title":"Proteins"}],"container-title":["The Journal of Physical Chemistry B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jp405389n","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,15]],"date-time":"2023-04-15T04:49:16Z","timestamp":1681534156000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jp405389n"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9,13]]},"references-count":51,"journal-issue":{"issue":"39","published-print":{"date-parts":[[2013,10,3]]}},"alternative-id":["10.1021\/jp405389n"],"URL":"https:\/\/doi.org\/10.1021\/jp405389n","relation":{},"ISSN":["1520-6106","1520-5207"],"issn-type":[{"value":"1520-6106","type":"print"},{"value":"1520-5207","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,9,13]]}}}