{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T23:12:28Z","timestamp":1787958748567,"version":"build-2784847793"},"reference-count":26,"publisher":"American Chemical Society (ACS)","issue":"31","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Phys. Chem. B"],"published-print":{"date-parts":[[2014,8,7]]},"DOI":"10.1021\/jp503256k","type":"journal-article","created":{"date-parts":[[2014,7,19]],"date-time":"2014-07-19T03:51:15Z","timestamp":1405741875000},"page":"9180-9190","source":"Crossref","is-referenced-by-count":25,"title":["Mechanochemical Synthesis of Bumetanide\u20134-Aminobenzoic Acid Molecular Cocrystals: A Facile and Green Approach to Drug Optimization"],"prefix":"10.1021","volume":"118","author":[{"given":"Giovanna","family":"Bruni","sequence":"first","affiliation":[{"name":"C.S.G.I.\r- Department of Chemistry, Physical-Chemistry Section, University of Pavia, Viale Taramelli 16, 27100 Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariarosa","family":"Maietta","sequence":"additional","affiliation":[{"name":"C.S.G.I.\r- Department of Chemistry, Physical-Chemistry Section, University of Pavia, Viale Taramelli 16, 27100 Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vittorio","family":"Berbenni","sequence":"additional","affiliation":[{"name":"C.S.G.I.\r- Department of Chemistry, Physical-Chemistry Section, University of Pavia, Viale Taramelli 16, 27100 Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piercarlo","family":"Mustarelli","sequence":"additional","affiliation":[{"name":"C.S.G.I.\r- Department of Chemistry, Physical-Chemistry Section, University of Pavia, Viale Taramelli 16, 27100 Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Ferrara","sequence":"additional","affiliation":[{"name":"C.S.G.I.\r- Department of Chemistry, Physical-Chemistry Section, University of Pavia, Viale Taramelli 16, 27100 Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Freccero","sequence":"additional","affiliation":[{"name":"Department of Chemistry,\rOrganic Chemistry Section, University of Pavia, Viale Taramelli\r10, 27100 Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Grande","sequence":"additional","affiliation":[{"name":"Department of Chemistry,\rOrganic Chemistry Section, University of Pavia, Viale Taramelli\r10, 27100 Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauretta","family":"Maggi","sequence":"additional","affiliation":[{"name":"Department of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Milanese","sequence":"additional","affiliation":[{"name":"C.S.G.I.\r- Department of Chemistry, Physical-Chemistry Section, University of Pavia, Viale Taramelli 16, 27100 Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Girella","sequence":"additional","affiliation":[{"name":"C.S.G.I.\r- Department of Chemistry, Physical-Chemistry Section, University of Pavia, Viale Taramelli 16, 27100 Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amedeo","family":"Marini","sequence":"additional","affiliation":[{"name":"C.S.G.I.\r- Department of Chemistry, Physical-Chemistry Section, University of Pavia, Viale Taramelli 16, 27100 Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2014,7,25]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.tips.2012.12.003","volume":"34","author":"Steed J. W.","year":"2013","journal-title":"Trends Pharmacol. Sci."},{"key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1517\/17425247.2013.747508","volume":"10","author":"Sun C. C.","year":"2013","journal-title":"Expert Opin. Drug Delivery"},{"key":"ref3\/cit3","unstructured":"FDA.Guidance for Industry: Regulatory Classification of Pharmaceutical Co-crystals, 2013."},{"key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"2537","DOI":"10.1021\/cg800183v","volume":"8","author":"Ter Horst J. H.","year":"2008","journal-title":"Cryst. Growth Des."},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1016\/j.ejpb.2013.02.007","volume":"85","author":"Chun N. H.","year":"2013","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ejps.2009.05.010","volume":"38","author":"Padrela L.","year":"2009","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.ijpharm.2008.10.006","volume":"368","author":"Dhumal R. S.","year":"2009","journal-title":"Int. J. Pharm."},{"key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"7638","DOI":"10.1039\/c3cs60014a","volume":"42","author":"Braga D.","year":"2013","journal-title":"Chem. Soc. Rev."},{"key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1039\/B815174A","volume":"11","author":"Friscic T.","year":"2009","journal-title":"CrystEngComm"},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1021\/cg800936d","volume":"9","author":"Weyna D. R.","year":"2009","journal-title":"Cryst. Growth Des."},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"2350","DOI":"10.1039\/c2ce06582g","volume":"14","author":"Delori A.","year":"2012","journal-title":"CrystEngComm"},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1136\/bmj.1.5794.211","volume":"1","author":"Asbury M. J.","year":"1972","journal-title":"Br. Med. J."},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1038\/clpt.1986.112","volume":"39","author":"Lau H. S. H.","year":"1986","journal-title":"Clin. Pharmacol. Ther."},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"426","DOI":"10.2165\/00003495-198428050-00003","volume":"28","author":"Ward A.","year":"1984","journal-title":"Drugs"},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.addr.2007.05.010","volume":"59","author":"Serajuddin A. T. M.","year":"2007","journal-title":"Adv. Drug Delivery Rev."},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"2428","DOI":"10.1039\/c2ce06631a","volume":"14","author":"Winston O.","year":"2012","journal-title":"CrystEngComm"},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1039\/C1CE05571B","volume":"14","author":"Bruni G.","year":"2012","journal-title":"CrystEngComm"},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"8113","DOI":"10.1021\/jp404273x","volume":"117","author":"Bruni G.","year":"2013","journal-title":"J. Phys. Chem. B"},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"4079","DOI":"10.1002\/jps.23721","volume":"102","author":"Bruni G.","year":"2013","journal-title":"J. Pharm. Sci."},{"key":"ref20\/cit20","first-page":"205","volume":"14","author":"Borka L.","year":"1977","journal-title":"Acta Pharm. Suec."},{"key":"ref21\/cit21","first-page":"3","volume":"50","author":"Kuhnert-Brandstaetter M.","year":"1982","journal-title":"Sci. Pharm."},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"2950","DOI":"10.1021\/cg900129f","volume":"9","author":"Schultheiss N.","year":"2009","journal-title":"Cryst. Growth Des."},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"6035","DOI":"10.1039\/c2ce25846c","volume":"14","author":"Bruni G.","year":"2012","journal-title":"CrystEngComm."},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.molstruc.2004.11.063","volume":"744","author":"Samsonowicz M.","year":"2005","journal-title":"J. Mol. Struct."},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1021\/cg8007014","volume":"9","author":"Vogt F. G.","year":"2009","journal-title":"Cryst. Growth Des."},{"key":"ref26\/cit26","unstructured":"http:\/\/www.hmdb.ca\/metabolites\/HMDB15024, Human Metabolome Database, version 3.5, Bumetanide, HMDB15024, accessed Dec 17, 2013."}],"container-title":["The Journal of Physical Chemistry B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jp503256k","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,23]],"date-time":"2023-04-23T03:05:13Z","timestamp":1682219113000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jp503256k"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,25]]},"references-count":26,"journal-issue":{"issue":"31","published-print":{"date-parts":[[2014,8,7]]}},"alternative-id":["10.1021\/jp503256k"],"URL":"https:\/\/doi.org\/10.1021\/jp503256k","relation":{},"ISSN":["1520-6106","1520-5207"],"issn-type":[{"value":"1520-6106","type":"print"},{"value":"1520-5207","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,25]]}}}