{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T05:58:39Z","timestamp":1778565519110,"version":"3.51.4"},"reference-count":42,"publisher":"American Chemical Society (ACS)","issue":"42","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Phys. Chem. B"],"published-print":{"date-parts":[[2009,10,22]]},"DOI":"10.1021\/jp906593c","type":"journal-article","created":{"date-parts":[[2009,9,24]],"date-time":"2009-09-24T13:33:15Z","timestamp":1253799195000},"page":"13998-14005","source":"Crossref","is-referenced-by-count":12,"title":["Dissecting the Inhibition Mechanism of Cytosolic versus Transmembrane Carbonic Anhydrases by ESR"],"prefix":"10.1021","volume":"113","author":[{"given":"Laura","family":"Ciani","sequence":"first","affiliation":[{"name":"Dipartimento di Chimica and CSGI, and Laboratorio di Chimica Bioinorganica, Rm. 188, Universit\u00e0 degli Studi di Firenze, Via della Lastruccia 3, I-50019 Sesto Fiorentino (Firenze), Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Cecchi","sequence":"additional","affiliation":[{"name":"Dipartimento di Chimica and CSGI, and Laboratorio di Chimica Bioinorganica, Rm. 188, Universit\u00e0 degli Studi di Firenze, Via della Lastruccia 3, I-50019 Sesto Fiorentino (Firenze), Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Temperini","sequence":"additional","affiliation":[{"name":"Dipartimento di Chimica and CSGI, and Laboratorio di Chimica Bioinorganica, Rm. 188, Universit\u00e0 degli Studi di Firenze, Via della Lastruccia 3, I-50019 Sesto Fiorentino (Firenze), Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudiu T.","family":"Supuran","sequence":"additional","affiliation":[{"name":"Dipartimento di Chimica and CSGI, and Laboratorio di Chimica Bioinorganica, Rm. 188, Universit\u00e0 degli Studi di Firenze, Via della Lastruccia 3, I-50019 Sesto Fiorentino (Firenze), Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Ristori","sequence":"additional","affiliation":[{"name":"Dipartimento di Chimica and CSGI, and Laboratorio di Chimica Bioinorganica, Rm. 188, Universit\u00e0 degli Studi di Firenze, Via della Lastruccia 3, I-50019 Sesto Fiorentino (Firenze), Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2009,9,24]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"3475","DOI":"10.1016\/j.bmcl.2008.05.051","volume":"18","author":"Cecchi A.","year":"2008","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/nrd2467","volume":"7","author":"Supuran C. T.","year":"2008","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1021\/cr050262p","volume":"108","author":"Krishnamurthy V. M.","year":"2008","journal-title":"Chem. Rev."},{"key":"ref4\/cit4a","doi-asserted-by":"crossref","unstructured":"aSupuran, C. T.; Scozzafava, A.; Conway, J.Carbonic Anhydrase\u2014Its Inhibitors and Activators;CRC Press:Boca Raton, FL, 2004; pp1\u2212363;","DOI":"10.4324\/9780203475300"},{"key":"ref4\/cit4b","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1002\/med.20112","volume":"28","author":"Winum J. Y.","year":"2008","journal-title":"Med. Res. Rev."},{"key":"ref4\/cit4c","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1002\/med.10025","volume":"23","author":"Supuran C. T.","year":"2003","journal-title":"Med. Res. Rev."},{"key":"ref5\/cit5a","doi-asserted-by":"crossref","first-page":"8329","DOI":"10.1021\/ja061574s","volume":"128","author":"Alterio V.","year":"2006","journal-title":"J. Am. Chem. Soc."},{"key":"ref5\/cit5b","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.tips.2006.09.002","volume":"27","author":"Thiry A.","year":"2006","journal-title":"Trends Pharmacol. Sci."},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.radonc.2007.04.018","volume":"83","author":"Dubois L.","year":"2007","journal-title":"Radiother. Oncol."},{"key":"ref6\/cit6b","doi-asserted-by":"crossref","first-page":"3230","DOI":"10.1021\/jm800121c","volume":"51","author":"D\u2019Ambrosio K.","year":"2008","journal-title":"J. Med. Chem."},{"key":"ref6\/cit6c","doi-asserted-by":"crossref","first-page":"3051","DOI":"10.1021\/jm701526d","volume":"51","author":"Thiry A.","year":"2008","journal-title":"J. Med. Chem."},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"685","DOI":"10.2174\/138161208783877893","volume":"14","author":"Pastorekova S.","year":"2008","journal-title":"Curr. Pharm. Des."},{"key":"ref8\/cit8a","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1016\/j.bmcl.2005.01.086","volume":"15","author":"Di Fiore A.","year":"2005","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref8\/cit8b","doi-asserted-by":"crossref","first-page":"7697","DOI":"10.1002\/anie.200701189","volume":"46","author":"K\u00f6hler K.","year":"2007","journal-title":"Angew. Chem., Int. Ed. Engl."},{"key":"ref8\/cit8c","doi-asserted-by":"crossref","first-page":"2567","DOI":"10.1016\/j.bmcl.2008.03.051","volume":"18","author":"Temperini C.","year":"2008","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref8\/cit8d","doi-asserted-by":"crossref","first-page":"5721","DOI":"10.1021\/jm050333c","volume":"48","author":"Menchise V.","year":"2005","journal-title":"J. Med. Chem."},{"key":"ref8\/cit8e","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1021\/jm030912m","volume":"47","author":"Weber A.","year":"2004","journal-title":"J. Med. Chem."},{"key":"ref9\/cit9a","doi-asserted-by":"crossref","first-page":"6942","DOI":"10.1021\/ja802214x","volume":"130","author":"Aaron J. A.","year":"2008","journal-title":"J. Am. Chem. Soc."},{"key":"ref9\/cit9b","doi-asserted-by":"crossref","first-page":"2286","DOI":"10.1021\/jm00013a004","volume":"38","author":"Boriack P. A.","year":"1995","journal-title":"J. Med. Chem."},{"key":"ref9\/cit9c","doi-asserted-by":"crossref","first-page":"12125","DOI":"10.1021\/ja002627n","volume":"122","author":"Kim C. Y.","year":"2000","journal-title":"J. Am. Chem. Soc."},{"key":"ref9\/cit9d","unstructured":"dAntel, J.; Weber, A.; Sotriffer, C. A.; Klebe, G.InCarbonic Anhydrase\u2014Its Inhibitors and Activators;Supuran, C. T.; Scozzafava, A.; Conway, J., Eds.CRC Press:Boca Raton, FL, 2004; pp45\u221265."},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1002\/prot.22144","volume":"74","author":"Di Fiore A.","year":"2009","journal-title":"Proteins"},{"key":"ref11\/cit11a","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.bmcl.2003.09.062","volume":"14","author":"Abbate F.","year":"2004","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref11\/cit11b","first-page":"1075","volume":"5","author":"Supuran C. T.","year":"2002","journal-title":"IDrugs"},{"key":"ref11\/cit11c","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1517\/13543784.12.2.283","volume":"12","author":"Supuran C. T.","year":"2003","journal-title":"Expert Opin. Investig. Drugs"},{"key":"ref12\/cit12","unstructured":"Marsh, D.; Horvath, L. I.InAdvanced EPR: Applications in Biology and Biochemistry,Hoff, A. J., Ed.Elsevier:Amsterdam, 1989; pp707\u2212752."},{"key":"ref13\/cit13","unstructured":"Freed, J. H.InEPR in the 21st Century;Kawamori, A.; Yamauchi, J.; Ohta, H., Eds.Elsevier Science:Amsterdam, 2002; pp719\u2212730."},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1126\/science.291.5502.266","volume":"291","author":"Borbat P. P.","year":"2001","journal-title":"Science"},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1021\/ci049748h","volume":"2","author":"\u0160trancar J.","year":"2005","journal-title":"J. Chem. Inform. Model."},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/j.sbi.2006.08.008","volume":"16","author":"Fanucci G.","year":"2006","journal-title":"Curr. Opin. Struct. Biol."},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"7807","DOI":"10.1021\/jp044538t","volume":"109","author":"Baute D.","year":"2005","journal-title":"J. Phys. Chem. B"},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"10238","DOI":"10.1021\/la0485881","volume":"20","author":"Ottaviani M. F.","year":"2004","journal-title":"Langmuir"},{"key":"ref19\/cit19","doi-asserted-by":"crossref","DOI":"10.1002\/047005350X","volume-title":"Advanced ESR Methods in Polymer Research","author":"Schlick S.","year":"2006"},{"key":"ref20\/cit20","volume-title":"Biological Magnetic Resonance","author":"Schneider D. J.","year":"1989"},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"3703","DOI":"10.1021\/jp054738k","volume":"110","author":"David E. K.","year":"2006","journal-title":"J. Phys. Chem. A"},{"key":"ref22\/cit22","doi-asserted-by":"crossref","unstructured":"Freed, J. H.InSpin Labeling: Theory and Application;Berliner, L. J., Ed.Academic:New York, 1976; pp53\u2212132.","DOI":"10.1016\/B978-0-12-092350-2.50008-4"},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1006\/jmra.1996.0113","volume":"120","author":"Budil D. E.","year":"1996","journal-title":"J. Magn. Reson. A"},{"key":"ref24\/cit24","volume-title":"CrysAlis RED. Version 1.171.32.2","year":"2006"},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1107\/S0108767390010224","volume":"47","author":"Jones T.A,","year":"1991","journal-title":"Acta Crystallogr."},{"key":"ref26\/cit26","first-page":"2126","volume":"60","author":"Emsley P.","year":"2004","journal-title":"Acta Crystallogr."},{"key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1107\/S0021889892009944","volume":"26","author":"Laskowski R. A.","year":"1993","journal-title":"J. Appl. Crystallogr."},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"893","DOI":"10.2174\/156802607780636672","volume":"7","author":"Hilvo M.","year":"2007","journal-title":"Curr. Top. Med. Chem."}],"container-title":["The Journal of Physical Chemistry B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jp906593c","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,6]],"date-time":"2023-04-06T05:43:46Z","timestamp":1680759826000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jp906593c"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,9,24]]},"references-count":42,"journal-issue":{"issue":"42","published-print":{"date-parts":[[2009,10,22]]}},"alternative-id":["10.1021\/jp906593c"],"URL":"https:\/\/doi.org\/10.1021\/jp906593c","relation":{},"ISSN":["1520-6106","1520-5207"],"issn-type":[{"value":"1520-6106","type":"print"},{"value":"1520-5207","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,9,24]]}}}