{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T11:14:32Z","timestamp":1697368472048},"reference-count":15,"publisher":"American Geophysical Union (AGU)","issue":"1","license":[{"start":{"date-parts":[[1998,1,1]],"date-time":"1998-01-01T00:00:00Z","timestamp":883612800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[1998,1]]},"DOI":"10.1021\/js9701115","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T09:40:54Z","timestamp":1030268454000},"page":"91-95","source":"Crossref","is-referenced-by-count":13,"title":["Photodegradation Products of Methylprednisolone Suleptanate in Aqueous Solution\u2014Evidence of a Bicyclo[3.1.0]hex-3-en-2-one Intermediate"],"prefix":"10.1029","volume":"87","author":[{"given":"Minoru","family":"Ogata","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukimi","family":"Noro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayumi","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsutomu","family":"Tahara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihide","family":"Nishimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"13","reference":[{"key":"10.1021\/js9701115_bb0005","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1002\/jps.2600740402","article-title":"Strategies in the Design of Solution-Stable, Water-Soluble Prodrugs I: A Physical-Organic Approach to Pro-Moiety Selection for 21- Esters of Corticosteroids","volume":"74","author":"Anderson","year":"1985","journal-title":"J. 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The data demonstrated that the 17-keto (3) and 11-keto (4) analogues increased only very slightly; that is, at most 0.2% after 3months of storage at 25\u00b0C (impurities other than 2 and 17-ester analogue: initial, 0.8% f 3months at 25\u00b0C, 1.0%)."},{"key":"10.1021\/js9701115_bb0025","unstructured":"Relative response factors are as follows: methylprednisolone (2), 1.8; 17-keto (3), 1.5; 11-keto (4), 0.9; 17-ester analogue, 1.0; N-demethyl analogue, 1.0. Relative response factor 1.0; was used for 6 because it had the similar chromophore to 1. Impurities observed (initial, and after 28days under 2000lx at 25\u00b0C) were 2 (0.2%\u21920.3%), 3 (not detected\u21920.5%), 4 (0.3%\u21921.2%), 6 (not detected\u21920.6%), 17-ester analogue (0.2%\u21920.3%), N-demethyl analogue (0.4%\u21920.4%), suleptanic acid (0.3%\u21920.6%), and other impurities (0.2%\u21920.4%). The assay results were calculated using the relative response factors. The relative response factor for 7 was determined to be 0.004 later and the amount of 7 was estimated to be ~5% in the photostability sample (2000lx, 28days). The formation of 7 (with its low relative response factor) and other uncharacterized minor compounds, eluting at the end in the wash, are presumably the cause of mass balance inconsistency."},{"key":"10.1021\/js9701115_bb0030","first-page":"809","article-title":"Structure and Physicochemical Properties of Methylprednisolone Suleptanate","volume":"24","author":"Kobayashi","year":"1993","journal-title":"Iyakuhin kenkyu (Japan)"},{"key":"10.1021\/js9701115_bb0035","series-title":"Abstract of The 30th NMR Toronkai (Symposium) (Japan)","first-page":"151","article-title":"The Comprehensive Role of NMR in the Analytical Laboratory","author":"Aoki","year":"1991"},{"key":"10.1021\/js9701115_bb0040","article-title":"Photochemical Transformations. Part IV. 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