{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T01:08:52Z","timestamp":1648775332115},"reference-count":21,"publisher":"American Geophysical Union (AGU)","issue":"12","license":[{"start":{"date-parts":[[1999,12,1]],"date-time":"1999-12-01T00:00:00Z","timestamp":944006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[1999,12]]},"DOI":"10.1021\/js990244l","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T09:40:54Z","timestamp":1030268454000},"page":"1259-1265","source":"Crossref","is-referenced-by-count":1,"title":["Diphenhydramine disposition in the sheep maternal\u2013Placental\u2013Fetal unit: Determinants of plasma drug concentrations in the mother and the fetus\u2020\u2020Abbreviations: DPHM, diphenhydramine; [2H10]DPHM, deuteriumlabeled diphenhydramine; CLmm, maternal total body clearance; CLff, fetal total body clearance; CLmf, maternal to fetal placental clearance; CLfm, fetal to maternal placental clearance; CLmo, maternal nonplacental clearance; CLfo, fetal nonplacental clearance; Cm, maternal plasma steady-state DPHM concentration after maternal administration; Cf, fetal plasma steady-state DPHM concentration after maternal administration; Cm\u2032, maternal plasma steady-state DPHM (or [2H10]-DPHM) concentration after fetal administration; Cf\u2032, fetal plasma steady-state DPHM (or [2H10]DPHM) concentration after fetal administration; ko, maternal drug infusion rate; ko\u2032, fetal drug infusion rate; M-UF, maternal steady-state plasma unbound fraction of the drug; F-UF, fetal steady-state plasma unbound fraction of the drug; r, Pearson correlation coefficient."],"prefix":"10.1029","volume":"88","author":[{"given":"Sanjeev","family":"Kumar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George R.","family":"Tonn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.Wayne","family":"Riggs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan W.","family":"Rurak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"13","reference":[{"key":"10.1021\/js990244l_bb0010","series-title":"Oxford Reviews of Reproductive Biology","first-page":"389","article-title":"Pharmacokinetics in pregnancy and placental drug transfer","author":"Reynolds","year":"1989"},{"key":"10.1021\/js990244l_bb0015","first-page":"33","article-title":"Drug disposition and effects in the fetus","volume":"15","author":"Rurak","year":"1991","journal-title":"J. Dev. Physiol."},{"key":"10.1021\/js990244l_bb0020","first-page":"382","article-title":"The contribution of trans-placental clearances and fetal clearance to drug disposition in the ovine maternal-fetal unit","volume":"10","author":"Szeto","year":"1982","journal-title":"Drug. Metab. Disp."},{"key":"10.1021\/js990244l_bb0025","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1002\/jps.2600820206","article-title":"Trans-placental and nonplacental clearances of diphenhydramine in the chronically instrumented pregnant sheep","volume":"82","author":"Yoo","year":"1993","journal-title":"J. Pharm. Sci."},{"key":"10.1021\/js990244l_bb0030","first-page":"617","article-title":"Estimation of transplacental and nonplacental diphenhydramine clearances in the fetal lamb: the impact of fetal first-pass hepatic drug uptake","volume":"282","author":"Kumar","year":"1997","journal-title":"J. Phamacol. Exp. Ther."},{"key":"10.1021\/js990244l_bb0035","first-page":"463","article-title":"Comparative formation, distribution and elimination kinetics of diphenyl-methoxyacetic acid (a diphenhydramine metabolite) in maternal and fetal sheep","volume":"27","author":"Kumar","year":"1999","journal-title":"Drug Metab. Disp."},{"key":"10.1021\/js990244l_bb0040","first-page":"271","article-title":"Effects of diphenhydramine in the fetal lamb after maternal or fetal administration","volume":"247","author":"Rurak","year":"1988","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1021\/js990244l_bb0045","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S0378-4347(00)80734-3","article-title":"Determination of diphenhydramine in biological fluids by capillary gas chromatography using nitrogen-phosphorus detection","volume":"378","author":"Yoo","year":"1986","journal-title":"J. Chromatogr. (Biomed. Appl.)."},{"key":"10.1021\/js990244l_bb0050","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1002\/bms.1200221103","article-title":"Simultaneous Analysis of diphenhydramine and a stable isotope analogue (2H10) diphenhydramine using capillary gas chromatography with mass selective detection in biological fluids from chronically instrumented pregnant ewes","volume":"22","author":"Tonn","year":"1993","journal-title":"Biol. Mass Spectrom."},{"key":"10.1021\/js990244l_bb0055","series-title":"ADAPT II User's Guide: Pharmacokinetic\/Pharmacodynamic Systems Analysis Software","author":"D\u2032Argenio","year":"1997"},{"key":"10.1021\/js990244l_bb0060","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.2527\/jas1975.4141065x","article-title":"A description of the dynamics of fetal growth in sheep","volume":"41","author":"Koong","year":"1975","journal-title":"J. Anim. Sci."},{"key":"10.1021\/js990244l_bb0065","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1002\/cpt1975184377","article-title":"A physiologic approach to hepatic drug clearance","volume":"18","author":"Wilkinson","year":"1975","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1021\/js990244l_bb0070","doi-asserted-by":"crossref","first-page":"156","DOI":"10.2165\/00003088-198814030-00004","article-title":"The significance of plasma protein binding on the fetal\/maternal distribution of drugs at steady-state","volume":"14","author":"Hill","year":"1988","journal-title":"Clin. Pharmacokin."},{"key":"10.1021\/js990244l_bb0075","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1152\/jappl.1967.22.6.1171","article-title":"Theoretical and experimental study of transplacental diffusion","volume":"22","author":"Meschia","year":"1967","journal-title":"J. Appl. Physiol."},{"key":"10.1021\/js990244l_bb0080","first-page":"H429","article-title":"Placental transfer as a function of uterine blood flow","volume":"242","author":"Wilkening","year":"1982","journal-title":"Am. J. Physiol."},{"key":"10.1021\/js990244l_bb0085","first-page":"R539","article-title":"Transplacental diffusion and blood flow of gravid bovine uterus","volume":"249","author":"Reynolds","year":"1985","journal-title":"Am. J. Physiol."},{"key":"10.1021\/js990244l_bb0090","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1002\/jps.2600840905","article-title":"Determinants of placental drug transfer: studies in isolated perfused human placenta","volume":"84","author":"Bassily","year":"1995","journal-title":"J. Pharm. Sci."},{"key":"10.1021\/js990244l_bb0095","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1159\/000301534","article-title":"Fetal circulation times and their implications for tissue oxygenation","volume":"6","author":"Power","year":"1975","journal-title":"Gynecol. Invest."},{"key":"10.1021\/js990244l_bb0100","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1152\/ajplegacy.1969.216.4.946","article-title":"Simultaneous measurements of hepatic and portal venous blood flow in the sheep and dog","volume":"216","author":"Katz","year":"1969","journal-title":"Am. J. Physiol."},{"key":"10.1021\/js990244l_bb0105","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1161\/01.RES.42.3.426","article-title":"Liver and ductus venosus blood flows in the fetal lamb in utero","volume":"42","author":"Edelstone","year":"1978","journal-title":"Circ. Res."},{"key":"10.1021\/js990244l_bb0110","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/1071-5576(95)00029-E","article-title":"Changes in blood flow to the ovine chorion and amnion across gestation","volume":"2","author":"Hedriana","year":"1995","journal-title":"J. Soc. Gynecol. Invest."}],"container-title":["Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022354915330033?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022354915330033?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,7,20]],"date-time":"2021-07-20T05:42:41Z","timestamp":1626759761000},"score":1,"resource":{"primary":{"URL":"http:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022354915330033"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,12]]},"references-count":21,"journal-issue":{"issue":"12","published-print":{"date-parts":[[1999,12]]}},"alternative-id":["S0022354915330033"],"URL":"https:\/\/doi.org\/10.1021\/js990244l","relation":{},"ISSN":["0022-3549"],"issn-type":[{"value":"0022-3549","type":"print"}],"subject":[],"published":{"date-parts":[[1999,12]]}}}