{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T04:18:31Z","timestamp":1790309911817,"version":"4.1.0"},"reference-count":35,"publisher":"American Chemical Society (ACS)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Med. Chem. Lett."],"published-print":{"date-parts":[[2011,12,8]]},"DOI":"10.1021\/ml200202y","type":"journal-article","created":{"date-parts":[[2011,9,29]],"date-time":"2011-09-29T19:00:33Z","timestamp":1317322833000},"page":"924-928","source":"Crossref","is-referenced-by-count":18,"title":["Toward Overcoming <i>Staphylococcus aureus<\/i> Aminoglycoside Resistance Mechanisms with a Functionally Designed Neomycin Analogue"],"prefix":"10.1021","volume":"2","author":[{"given":"Stephen","family":"Hanessian","sequence":"first","affiliation":[{"name":"Department of Chemistry, Universit\u00e9 de Montr\u00e9al, C.P. 6128, Succ. Centre-Ville, Montr\u00e9al, Quebec H3C 3J7, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Gigu\u00e8re","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Universit\u00e9 de Montr\u00e9al, C.P. 6128, Succ. Centre-Ville, Montr\u00e9al, Quebec H3C 3J7, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justyna","family":"Grzyb","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Universit\u00e9 de Montr\u00e9al, C.P. 6128, Succ. Centre-Ville, Montr\u00e9al, Quebec H3C 3J7, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Pablo","family":"Maianti","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Universit\u00e9 de Montr\u00e9al, C.P. 6128, Succ. Centre-Ville, Montr\u00e9al, Quebec H3C 3J7, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar M.","family":"Saavedra","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Universit\u00e9 de Montr\u00e9al, C.P. 6128, Succ. Centre-Ville, Montr\u00e9al, Quebec H3C 3J7, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James B.","family":"Aggen","sequence":"additional","affiliation":[{"name":"Achaogen Inc., 7000 Shoreline Court, Suite 371, South San Francisco, California 94080, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin S.","family":"Linsell","sequence":"additional","affiliation":[{"name":"Achaogen Inc., 7000 Shoreline Court, Suite 371, South San Francisco, California 94080, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam A.","family":"Goldblum","sequence":"additional","affiliation":[{"name":"Achaogen Inc., 7000 Shoreline Court, Suite 371, South San Francisco, California 94080, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darin J.","family":"Hildebrandt","sequence":"additional","affiliation":[{"name":"Achaogen Inc., 7000 Shoreline Court, Suite 371, South San Francisco, California 94080, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy R.","family":"Kane","sequence":"additional","affiliation":[{"name":"Achaogen Inc., 7000 Shoreline Court, Suite 371, South San Francisco, California 94080, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Dozzo","sequence":"additional","affiliation":[{"name":"Achaogen Inc., 7000 Shoreline Court, Suite 371, South San Francisco, California 94080, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micah J.","family":"Gliedt","sequence":"additional","affiliation":[{"name":"Achaogen Inc., 7000 Shoreline Court, Suite 371, South San Francisco, California 94080, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rowena D.","family":"Matias","sequence":"additional","affiliation":[{"name":"Achaogen Inc., 7000 Shoreline Court, Suite 371, South San Francisco, California 94080, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee Ann","family":"Feeney","sequence":"additional","affiliation":[{"name":"Achaogen Inc., 7000 Shoreline Court, Suite 371, South San Francisco, California 94080, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliana S.","family":"Armstrong","sequence":"additional","affiliation":[{"name":"Achaogen Inc., 7000 Shoreline Court, Suite 371, South San Francisco, California 94080, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2011,9,29]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1001\/jama.298.15.1763","volume":"298","author":"Klevens R. M.","year":"2007","journal-title":"JAMA"},{"key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1086\/499632","volume":"193","author":"Kuehnert M. J.","year":"2006","journal-title":"J. Infect. Dis."},{"key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1086\/346207","volume":"36","author":"Fridkin S. K.","year":"2003","journal-title":"Clin. Infect. Dis."},{"key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"S344","DOI":"10.1086\/533590","volume":"46","author":"Boucher H. W.","year":"2008","journal-title":"Clin. Infect. Dis."},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1086\/595011","volume":"48","author":"Boucher H. W.","year":"2009","journal-title":"Clin. Infect. Dis."},{"key":"ref6\/cit6","doi-asserted-by":"crossref","DOI":"10.1002\/9780470149676","volume-title":"Aminoglycoside Antibiotics: From Chemical Biology to Drug Discovery","author":"Arya D. P.","year":"2007","edition":"1"},{"key":"ref7\/cit7","doi-asserted-by":"crossref","DOI":"10.1128\/9781555817886","volume-title":"Antibiotics: Actions, Origins, Resistance","author":"Walsh C.","year":"2003"},{"key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1038\/35030019","volume":"407","author":"Carter A. P.","year":"2000","journal-title":"Nature"},{"key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1146\/annurev.biochem.74.061903.155440","volume":"74","author":"Ogle J. M.","year":"2005","journal-title":"Annu. Rev. Biochem."},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"5677","DOI":"10.1093\/nar\/gki862","volume":"33","author":"Francois B.","year":"2005","journal-title":"Nucleic Acids Res."},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S1097-2765(04)00005-X","volume":"13","author":"Gromadski K. B.","year":"2004","journal-title":"Mol. Cell"},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"393","DOI":"10.3109\/10409230903307311","volume":"44","author":"Wilson D. N.","year":"2009","journal-title":"Crit. Rev. Biochem. Mol. Biol."},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1021\/cr0301088","volume":"105","author":"Magnet S.","year":"2005","journal-title":"Chem. Rev."},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1128\/AAC.48.4.1124-1127.2004","volume":"48","author":"Kim H. B.","year":"2004","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1093\/jac\/43.2.253","volume":"43","author":"Schmitz F.-J.","year":"1999","journal-title":"J. Antimicrob. Chemother."},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1128\/mr.57.1.138-163.1993","volume":"57","author":"Shaw K. J.","year":"1993","journal-title":"Microbiol. Rev."},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/0002-9343(86)90499-7","volume":"80","author":"Price K. E.","year":"1986","journal-title":"Am. J. Med."},{"key":"ref18\/cit18","author":"Battistini C.","journal-title":"J. Antibiot. (Tokyo)"},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"58","DOI":"10.7164\/antibiotics.35.58","volume":"35","author":"Torii T.","year":"1982","journal-title":"J. Antibiot."},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1246\/bcsj.50.1580","volume":"50","author":"Nishimura T.","year":"1977","journal-title":"Bull. Chem. Soc. Jpn."},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0008-6215(82)84044-5","volume":"109","author":"Matsuno T.","year":"1982","journal-title":"Carbohydr. Res."},{"key":"ref22\/cit22a","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1081\/CAR-200059968","volume":"24","author":"Rai R.","year":"2005","journal-title":"J. Carbohydr. Chem."},{"key":"ref22\/cit22a1","unstructured":"1982, 35, 98\u2013101."},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"7097","DOI":"10.1016\/j.bmcl.2010.09.084","volume":"20","author":"Hanessian S.","year":"2010","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref24\/cit24","unstructured":"Naito, T.; Nakagawa, S.Paromomycin antibiotic derivatives. U.S. Patent 3,897,412, July 29, 1975."},{"issue":"10","key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1055\/s-1979-28843","author":"Garegg P. J.","year":"1979","journal-title":"Synthesis"},{"issue":"2","key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1080\/07328308408058814","volume":"3","author":"Garegg P. J.","year":"1984","journal-title":"J. Carbohydr. Chem."},{"key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1039\/p19820000681","author":"Garegg P. J.","year":"1982","journal-title":"J. Chem. Soc., Perkin Trans. 1"},{"key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1002\/cmdc.200700113","volume":"2","author":"Kondo J.","year":"2007","journal-title":"ChemMedChem"},{"key":"ref30\/cit30","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/S0008-6215(00)80401-2","volume":"92","author":"Paulsen H.","year":"1981","journal-title":"Carbohydr. Res."},{"key":"ref31\/cit31","volume-title":"CLSI document M7-A7","year":"2006","edition":"7"},{"key":"ref32\/cit32","volume-title":"CLSI document M100-S18","year":"2008"},{"key":"ref33\/cit33","doi-asserted-by":"crossref","first-page":"2598","DOI":"10.1021\/jo01045a028","volume":"28","author":"Haskell T. H.","year":"1963","journal-title":"J. Org. Chem."},{"key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"3049","DOI":"10.1128\/AAC.00062-09","volume":"53","author":"Fong D. H.","year":"2009","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref35\/cit35","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1093\/emboj\/21.10.2323","volume":"21","author":"Fong D. H.","year":"2002","journal-title":"EMBO J."}],"container-title":["ACS Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/ml200202y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T07:30:33Z","timestamp":1682321433000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/ml200202y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9,29]]},"references-count":35,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2011,12,8]]}},"alternative-id":["10.1021\/ml200202y"],"URL":"https:\/\/doi.org\/10.1021\/ml200202y","relation":{},"ISSN":["1948-5875","1948-5875"],"issn-type":[{"value":"1948-5875","type":"print"},{"value":"1948-5875","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,9,29]]}}}