{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:49:10Z","timestamp":1777668550873,"version":"3.51.4"},"reference-count":19,"publisher":"American Chemical Society (ACS)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Med. Chem. Lett."],"published-print":{"date-parts":[[2012,7,12]]},"DOI":"10.1021\/ml300068r","type":"journal-article","created":{"date-parts":[[2012,6,14]],"date-time":"2012-06-14T14:33:30Z","timestamp":1339684410000},"page":"540-543","source":"Crossref","is-referenced-by-count":20,"title":["Identification of New Snake Venom Metalloproteinase Inhibitors Using Compound Screening and Rational Peptide Design"],"prefix":"10.1021","volume":"3","author":[{"given":"Fabi\u00e1n","family":"Villalta-Romero","sequence":"first","affiliation":[{"name":"Escuela de Qu\u00edmica, Universidad de Costa Rica, San Jos\u00e9, Costa Rica"},{"name":"Instituto Clodomiro Picado,\rFacultad de Microbiolog\u00eda, Universidad de Costa Rica, San Jos\u00e9, Costa Rica"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Gortat","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Pr\u00edncipe Felipe, E-46012 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9s E.","family":"Herrera","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Pr\u00edncipe Felipe, E-46012 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebeca","family":"Arguedas","sequence":"additional","affiliation":[{"name":"Escuela de Qu\u00edmica, Universidad de Costa Rica, San Jos\u00e9, Costa Rica"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Quesada","sequence":"additional","affiliation":[{"name":"Escuela de Qu\u00edmica, Universidad de Costa Rica, San Jos\u00e9, Costa Rica"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robson Lopes","family":"de Melo","sequence":"additional","affiliation":[{"name":"Center for Applied Toxinology, Instituto Butantan, Sao Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan J.","family":"Calvete","sequence":"additional","affiliation":[{"name":"Instituto de Biomedicina, IBV-CSIC, E-46010 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mavis","family":"Montero","sequence":"additional","affiliation":[{"name":"Escuela de Qu\u00edmica, Universidad de Costa Rica, San Jos\u00e9, Costa Rica"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renato","family":"Murillo","sequence":"additional","affiliation":[{"name":"Escuela de Qu\u00edmica, Universidad de Costa Rica, San Jos\u00e9, Costa Rica"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Rucavado","sequence":"additional","affiliation":[{"name":"Instituto Clodomiro Picado,\rFacultad de Microbiolog\u00eda, Universidad de Costa Rica, San Jos\u00e9, Costa Rica"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Mar\u00eda","family":"Guti\u00e9rrez","sequence":"additional","affiliation":[{"name":"Instituto Clodomiro Picado,\rFacultad de Microbiolog\u00eda, Universidad de Costa Rica, San Jos\u00e9, Costa Rica"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrique","family":"P\u00e9rez-Pay\u00e1","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Pr\u00edncipe Felipe, E-46012 Valencia, Spain"},{"name":"Instituto de Biomedicina, IBV-CSIC, E-46010 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2012,6,20]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0140-6736(09)61754-2","volume":"375","author":"Warrell D. A.","year":"2010","journal-title":"Lancet"},{"key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1016\/j.toxicon.2009.01.038","volume":"54","author":"Gutierrez J. M.","year":"2009","journal-title":"Toxicon"},{"key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"e150","DOI":"10.1371\/journal.pmed.0030150","volume":"3","author":"Gutierrez J. M.","year":"2006","journal-title":"PLoS Med."},{"key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1126\/science.1067100","volume":"295","author":"Coussens L. M.","year":"2002","journal-title":"Science"},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1002\/cmdc.200600204","volume":"2","author":"Jacobsen F. E.","year":"2007","journal-title":"ChemMedChem"},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"6166","DOI":"10.1021\/bi9002315","volume":"48","author":"Lingott T.","year":"2009","journal-title":"Biochemistry"},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"14194","DOI":"10.1074\/jbc.M313474200","volume":"279","author":"Lukacova V.","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"3423","DOI":"10.1021\/ic026029g","volume":"42","author":"Puerta D. T.","year":"2003","journal-title":"Inorg. Chem."},{"key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1110\/ps.03102403","volume":"12","author":"Watanabe L.","year":"2003","journal-title":"Protein Sci."},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1016\/S0960-894X(98)00218-2","volume":"8","author":"Pratt L. M.","year":"1998","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s10555-006-7894-9","volume":"25","author":"Fisher J. F.","year":"2006","journal-title":"Cancer Metastasis Rev."},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/S1359-6446(99)01408-7","volume":"4","author":"Gutierrez J. M.","year":"1999","journal-title":"Drug Discovery Today"},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/j.toxicon.2006.11.020","volume":"49","author":"Howes J. M.","year":"2007","journal-title":"Toxicon"},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0006-2952(00)00302-6","volume":"60","author":"Escalante T.","year":"2000","journal-title":"Biochem. Pharmacol."},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"3517","DOI":"10.1111\/j.1582-4934.2008.00660.x","volume":"13","author":"Suter D. M.","year":"2009","journal-title":"J. Cell Mol. Med."},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1016\/S0960-894X(98)00396-5","volume":"8","author":"Steinman D. H.","year":"1998","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"3042","DOI":"10.1046\/j.1432-1327.2001.02199.x","volume":"268","author":"Valente R. H.","year":"2001","journal-title":"Eur. J. Biochem."},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S1093-3263(03)00153-0","volume":"22","author":"Hu X.","year":"2003","journal-title":"J. Mol. Graphics Modell."},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.jmb.2009.03.003","volume":"388","author":"Peterson Q. P.","year":"2009","journal-title":"J. Mol. Biol."}],"container-title":["ACS Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/ml300068r","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T07:41:59Z","timestamp":1680507719000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/ml300068r"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6,20]]},"references-count":19,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2012,7,12]]}},"alternative-id":["10.1021\/ml300068r"],"URL":"https:\/\/doi.org\/10.1021\/ml300068r","relation":{},"ISSN":["1948-5875","1948-5875"],"issn-type":[{"value":"1948-5875","type":"print"},{"value":"1948-5875","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,6,20]]}}}