{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T13:24:48Z","timestamp":1791206688070,"version":"4.1.0"},"reference-count":24,"publisher":"American Chemical Society (ACS)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Med. Chem. Lett."],"published-print":{"date-parts":[[2012,11,8]]},"DOI":"10.1021\/ml300197h","type":"journal-article","created":{"date-parts":[[2012,9,9]],"date-time":"2012-09-09T10:42:17Z","timestamp":1347187337000},"page":"920-924","source":"Crossref","is-referenced-by-count":17,"title":["Nonpeptidic Lysosomal Modulators Derived from Z-Phe-Ala-Diazomethylketone for Treating Protein Accumulation Diseases"],"prefix":"10.1021","volume":"3","author":[{"given":"Kishore","family":"Viswanathan","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical\rSciences, University of Connecticut, Storrs,\rConnecticut 06269, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis J.","family":"Hoover","sequence":"additional","affiliation":[{"name":"Synaptic Dynamics Inc., Farmington, Connecticut 06032, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeannie","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical\rSciences, University of Connecticut, Storrs,\rConnecticut 06269, United States"},{"name":"William C. Friday Laboratory,\rBiotechnology Research and Training Center, University of North Carolina\u2014Pembroke, Pembroke, North Carolina\r28372, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meagan L.","family":"Wisniewski","sequence":"additional","affiliation":[{"name":"William C. Friday Laboratory,\rBiotechnology Research and Training Center, University of North Carolina\u2014Pembroke, Pembroke, North Carolina\r28372, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uzoma S.","family":"Ikonne","sequence":"additional","affiliation":[{"name":"William C. Friday Laboratory,\rBiotechnology Research and Training Center, University of North Carolina\u2014Pembroke, Pembroke, North Carolina\r28372, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben A.","family":"Bahr","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical\rSciences, University of Connecticut, Storrs,\rConnecticut 06269, United States"},{"name":"William C. Friday Laboratory,\rBiotechnology Research and Training Center, University of North Carolina\u2014Pembroke, Pembroke, North Carolina\r28372, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis L.","family":"Wright","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical\rSciences, University of Connecticut, Storrs,\rConnecticut 06269, United States"},{"name":"Synaptic Dynamics Inc., Farmington, Connecticut 06032, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2012,9,11]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1111\/j.1471-4159.2006.04426.x","volume":"101","author":"Walsh D. M.","year":"2007","journal-title":"J. Neurochem."},{"key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1001\/archneurol.2011.69","volume":"68","author":"Schneider L. S.","year":"2011","journal-title":"Arch. Neurol."},{"key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1093\/jnen\/61.7.640","volume":"61","author":"Bendiske J.","year":"2002","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1046\/j.1471-4159.2002.01192.x","volume":"83","author":"Bahr B. A.","year":"2002","journal-title":"J. Neurochem."},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/0896-6273(95)90324-0","volume":"14","author":"Cataldo A. M.","year":"1995","journal-title":"Neuron"},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1097\/00005072-199903000-00007","volume":"58","author":"Callahan L. M.","year":"1999","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1002\/1531-8249(200007)48:1<77::AID-ANA12>3.0.CO;2-A","volume":"48","author":"Ginsberg S. D.","year":"2000","journal-title":"Ann. Neurol."},{"key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"97","DOI":"10.3233\/JAD-2001-3114","volume":"3","author":"Nixon R. A.","year":"2001","journal-title":"J. Alzheimer's Dis."},{"key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"2207","DOI":"10.1111\/j.1471-4159.1992.tb10965.x","volume":"58","author":"Banay-Schwartz M.","year":"1992","journal-title":"J. Neurochem."},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/S0306-4522(00)00021-X","volume":"97","author":"Bi X.","year":"2000","journal-title":"Neuroscience (Oxford)"},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1093\/jnen\/62.5.451","volume":"62","author":"Bendiske J.","year":"2003","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1089\/rej.2005.8.227","volume":"8","author":"Butler D.","year":"2005","journal-title":"Rejuvenation Res."},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.neuron.2006.07.027","volume":"51","author":"Mueller-Steiner S.","year":"2006","journal-title":"Neuron"},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"438","DOI":"10.2174\/156720509789207903","volume":"6","author":"Bahr B. A.","year":"2009","journal-title":"Curr. Alzheimer Res."},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s12031-007-9009-7","volume":"34","author":"Ryzhikov S.","year":"2008","journal-title":"J. Mol. Neurosci."},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1089\/rej.2011.1282","volume":"15","author":"Bahr B. A.","year":"2012","journal-title":"Rejuvenation Res."},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"e20501","DOI":"10.1371\/journal.pone.0020501","volume":"6","author":"Butler D.","year":"2011","journal-title":"PLoS One"},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"2300","DOI":"10.1021\/jm00068a006","volume":"36","author":"Ghosh A. K.","year":"1993","journal-title":"J. Med. Chem."},{"key":"ref19\/cit19","first-page":"137","author":"Dubey A. K.","year":"2010","journal-title":"ARKIVOC (Gainesville, FL, U. S.)"},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.5012\/bkcs.2008.29.5.1073","volume":"29","author":"Park S.","year":"2008","journal-title":"Bull. Korean Chem. Soc."},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"14025","DOI":"10.1074\/jbc.275.19.14025","volume":"275","author":"Turner M. D.","year":"2000","journal-title":"J. Biol. Chem."},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"e20501","DOI":"10.1371\/journal.pone.0020501","volume":"6","author":"Butler D.","year":"2011","journal-title":"PLoS One"},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"8125","DOI":"10.1021\/bi00150a004","volume":"31","author":"Parris K. D.","year":"1992","journal-title":"Biochemistry"},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1021\/jm00150a007","volume":"28","author":"Boger J.","year":"1985","journal-title":"J. Med. Chem."}],"container-title":["ACS Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/ml300197h","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,14]],"date-time":"2023-04-14T13:32:02Z","timestamp":1681479122000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/ml300197h"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9,11]]},"references-count":24,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2012,11,8]]}},"alternative-id":["10.1021\/ml300197h"],"URL":"https:\/\/doi.org\/10.1021\/ml300197h","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.717955885.793460786","asserted-by":"object"}]},"ISSN":["1948-5875","1948-5875"],"issn-type":[{"value":"1948-5875","type":"print"},{"value":"1948-5875","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,9,11]]}}}