{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:04:34Z","timestamp":1791072274059,"version":"4.1.0"},"reference-count":16,"publisher":"American Chemical Society (ACS)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Med. Chem. Lett."],"published-print":{"date-parts":[[2013,12,12]]},"DOI":"10.1021\/ml400208v","type":"journal-article","created":{"date-parts":[[2013,10,4]],"date-time":"2013-10-04T11:46:32Z","timestamp":1380887192000},"page":"1148-1151","source":"Crossref","is-referenced-by-count":27,"title":["Discovery of Potent and Selective Inhibitors of\n                    <i>Toxoplasma gondii<\/i>\n                    Thymidylate Synthase for Opportunistic Infections"],"prefix":"10.1021","volume":"4","author":[{"given":"Nilesh","family":"Zaware","sequence":"first","affiliation":[{"name":"Division\rof Medicinal Chemistry, Graduate School of Pharmaceutical\rSciences, Duquesne University, 600 Forbes Avenue, Pittsburgh, Pennsylvania  15282, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitesh","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department\rof Pharmacology, Yale University School of Medicine, New Haven, Connecticut  06511, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Yang","sequence":"additional","affiliation":[{"name":"Division\rof Medicinal Chemistry, Graduate School of Pharmaceutical\rSciences, Duquesne University, 600 Forbes Avenue, Pittsburgh, Pennsylvania  15282, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi Kumar Vyas","family":"Devambatla","sequence":"additional","affiliation":[{"name":"Division\rof Medicinal Chemistry, Graduate School of Pharmaceutical\rSciences, Duquesne University, 600 Forbes Avenue, Pittsburgh, Pennsylvania  15282, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherry F.","family":"Queener","sequence":"additional","affiliation":[{"name":"Department\rof Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana 46202, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen S.","family":"Anderson","sequence":"additional","affiliation":[{"name":"Department\rof Pharmacology, Yale University School of Medicine, New Haven, Connecticut  06511, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleem","family":"Gangjee","sequence":"additional","affiliation":[{"name":"Division\rof Medicinal Chemistry, Graduate School of Pharmaceutical\rSciences, Duquesne University, 600 Forbes Avenue, Pittsburgh, Pennsylvania  15282, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2013,10,15]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1016\/S0140-6736(04)16412-X","volume":"363","author":"Montoya J. G.","year":"2004","journal-title":"Lancet"},{"key":"ref2\/cit2","volume":"58","author":"Kaplan J. E.","year":"2009","journal-title":"CDC, MMWR"},{"key":"ref3\/cit3","unstructured":"CDC. http:\/\/www.cdc.gov\/parasites\/toxoplasmosis\/(accessed May 2013) ."},{"key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1038\/clpt.2013.22","volume":"93","author":"Dudrand C. M.","year":"2013","journal-title":"Clin. Pharmacol. Ther."},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1086\/340577","volume":"185","author":"Aspinall T. V.","year":"2002","journal-title":"J. Infect. Dis."},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"325","DOI":"10.4269\/ajtmh.1984.33.325","volume":"33","author":"Chulay J. D.","year":"1984","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"31","DOI":"10.2174\/138945007779315524","volume":"8","author":"Hyde J. E.","year":"2007","journal-title":"Curr. Drug Targets"},{"key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.molbiopara.2005.02.016","volume":"143","author":"Pang C. K.","year":"2005","journal-title":"Mol. Biochem. Parasitol."},{"key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1002\/cmdc.200700215","volume":"3","author":"Ferrari S.","year":"2008","journal-title":"ChemMedChem"},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1038\/415926a","volume":"415","author":"Fox B. A.","year":"2002","journal-title":"Nature"},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1021\/jm00058a010","volume":"36","author":"Webber S. E.","year":"1993","journal-title":"J. Med. Chem."},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1021\/jm9011142","volume":"53","author":"Gangjee A.","year":"2010","journal-title":"J. Med. Chem."},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"5625","DOI":"10.1021\/jo800491k","volume":"73","author":"Sperotto E.","year":"2008","journal-title":"J. Org. Chem."},{"key":"ref14\/cit14","unstructured":"Molecular Operating Environment(MOE 2011.10);Chemical Computing Group, Inc.:Montreal, Quebec, Canada, 2008; www.chemcomp.com."},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1021\/jm950760y","volume":"39","author":"Piper J. R.","year":"1996","journal-title":"J. Med. Chem."},{"key":"ref16\/cit16","doi-asserted-by":"crossref","unstructured":"Sharma, H.; Landau, M. J.; Vargo, M. A.; Spasov, K. A.; Anderson, K. S.First Three-Dimensional Structure of\n                      Toxoplasma gondii\n                      Thymidylate Synthase-Dihydrofolate Reductase: Insights for Catalysis, Interdomain Interactions, and Substrate Channeling.Biochemistry 2013, submitted","DOI":"10.1021\/bi400576t"}],"container-title":["ACS Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/ml400208v","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,2]],"date-time":"2023-04-02T05:23:09Z","timestamp":1680412989000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/ml400208v"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10,15]]},"references-count":16,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2013,12,12]]}},"alternative-id":["10.1021\/ml400208v"],"URL":"https:\/\/doi.org\/10.1021\/ml400208v","relation":{},"ISSN":["1948-5875","1948-5875"],"issn-type":[{"value":"1948-5875","type":"print"},{"value":"1948-5875","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10,15]]}}}