{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T17:55:00Z","timestamp":1792000500690,"version":"4.4.0"},"reference-count":59,"publisher":"American Chemical Society (ACS)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol. Pharmaceutics"],"published-print":{"date-parts":[[2011,10,3]]},"DOI":"10.1021\/mp2000692","type":"journal-article","created":{"date-parts":[[2011,8,18]],"date-time":"2011-08-18T18:04:07Z","timestamp":1313690647000},"page":"1698-1708","source":"Crossref","is-referenced-by-count":51,"title":["Characterization of New Potential Anticancer Drugs Designed To Overcome Glutathione Transferase Mediated Resistance"],"prefix":"10.1021","volume":"8","author":[{"given":"Katarina","family":"Johansson","sequence":"first","affiliation":[{"name":"Institute of Environmental Medicine, Karolinska Institutet, SE-17177 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mika","family":"Ito","sequence":"additional","affiliation":[{"name":"Nano Medical Engineering Laboratory Discovery Research Institute, RIKEN Advanced Science Institute, 2-1 Hirosawa, Wako-Shi, Saitama 351-0198, Japan"},{"name":"Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolien M. S.","family":"Schophuizen","sequence":"additional","affiliation":[{"name":"Institute of Environmental Medicine, Karolinska Institutet, SE-17177 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherin","family":"Mathew Thengumtharayil","sequence":"additional","affiliation":[{"name":"Institute of Environmental Medicine, Karolinska Institutet, SE-17177 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanina D.","family":"Heuser","sequence":"additional","affiliation":[{"name":"Institute of Environmental Medicine, Karolinska Institutet, SE-17177 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Environmental Medicine, Karolinska Institutet, SE-17177 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miyuki","family":"Shimoji","sequence":"additional","affiliation":[{"name":"Institute of Environmental Medicine, Karolinska Institutet, SE-17177 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Vahter","sequence":"additional","affiliation":[{"name":"Institute of Environmental Medicine, Karolinska Institutet, SE-17177 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wee Han","family":"Ang","sequence":"additional","affiliation":[{"name":"Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J.","family":"Dyson","sequence":"additional","affiliation":[{"name":"Institut des Sciences et Ing\u00e9nierie Chimiques, Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aya","family":"Shibata","sequence":"additional","affiliation":[{"name":"Nano Medical Engineering Laboratory Discovery Research Institute, RIKEN Advanced Science Institute, 2-1 Hirosawa, Wako-Shi, Saitama 351-0198, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Shuto","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro,","family":"Ito","sequence":"additional","affiliation":[{"name":"Nano Medical Engineering Laboratory Discovery Research Institute, RIKEN Advanced Science Institute, 2-1 Hirosawa, Wako-Shi, Saitama 351-0198, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Abe","sequence":"additional","affiliation":[{"name":"Nano Medical Engineering Laboratory Discovery Research Institute, RIKEN Advanced Science Institute, 2-1 Hirosawa, Wako-Shi, Saitama 351-0198, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"Morgenstern","sequence":"additional","affiliation":[{"name":"Institute of Environmental Medicine, Karolinska Institutet, SE-17177 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2011,8,30]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/S1734-1140(09)70018-0","volume":"61","author":"Simunek T.","year":"2009","journal-title":"Pharmacol. Rep."},{"key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1038\/sj.ki.5002786","volume":"73","author":"Pabla N.","year":"2008","journal-title":"Kidney Int."},{"key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1097\/MOO.0b013e3282eee452","volume":"15","author":"Rybak L. P.","year":"2007","journal-title":"Curr. Opin. Otolaryngol. Head Neck Surg."},{"key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1158\/1535-7163.MCT-08-0840","volume":"8","author":"McWhinney S. R.","year":"2009","journal-title":"Mol. Cancer Ther."},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/nrd2468","volume":"7","author":"Rautio J.","year":"2008","journal-title":"Nat. Rev. Drug Discovery"},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.abb.2010.05.012","volume":"500","author":"Sau A.","year":"2010","journal-title":"Arch. Biochem. Biophys."},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"7369","DOI":"10.1038\/sj.onc.1206940","volume":"22","author":"Townsend D. M.","year":"2003","journal-title":"Oncogene"},{"key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.1200\/JCO.2008.19.2542","volume":"27","author":"Scotlandi K.","year":"2009","journal-title":"J. Clin. Oncol."},{"key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1093\/carcin\/bgl148","volume":"28","author":"Johansson K.","year":"2007","journal-title":"Carcinogenesis"},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1038\/sj.onc.1209373","volume":"25","author":"McIlwain C. C.","year":"2006","journal-title":"Oncogene"},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"157","DOI":"10.2165\/00129785-200303030-00002","volume":"3","author":"Townsend D.","year":"2003","journal-title":"Am. J. Pharmacogenomics"},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"445","DOI":"10.3109\/10409239509083491","volume":"30","author":"Hayes J. D.","year":"1995","journal-title":"Crit. Rev. Biochem. Mol. Biol."},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1111\/j.1432-1033.1983.tb07607.x","volume":"134","author":"Morgenstern R.","year":"1983","journal-title":"Eur. J. Biochem."},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/S1043-6618(03)00247-0","volume":"48","author":"Zhang J.","year":"2003","journal-title":"Pharmacol. Res."},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.cbi.2005.03.003","volume":"152","author":"Zhang J.","year":"2005","journal-title":"Chem.-Biol. Interact."},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/sj.neo.7900126","volume":"3","author":"Chaib H.","year":"2001","journal-title":"Neoplasia"},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1166\/gl.2002.005","volume":"1","author":"Futschik M.","year":"2002","journal-title":"Genome Lett."},{"key":"ref18\/cit18","first-page":"5403","volume":"59","author":"Lal A.","year":"1999","journal-title":"Cancer Res."},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1002\/ijc.20814","volume":"114","author":"Linnerth N. M.","year":"2005","journal-title":"Int. J. Cancer"},{"key":"ref20\/cit20","first-page":"49","volume":"23","author":"Tsunoda T.","year":"2003","journal-title":"Int. J. Oncol."},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"2702","DOI":"10.1096\/fj.01-0376com","volume":"15","author":"Goto S.","year":"2001","journal-title":"FASEB J."},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.bcp.2005.11.003","volume":"71","author":"Burg D.","year":"2006","journal-title":"Biochem. Pharmacol."},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1093\/emboj\/18.5.1321","volume":"18","author":"Adler V.","year":"1999","journal-title":"EMBO J."},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/1756-8722-2-20","volume":"2","author":"Raza A.","year":"2009","journal-title":"J. Hematol. Oncol."},{"key":"ref25\/cit25","first-page":"2568","volume":"58","author":"Morgan A. S.","year":"1998","journal-title":"Cancer Res."},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1517\/13543784.14.8.1047","volume":"14","author":"Tew K. D.","year":"2005","journal-title":"Expert Opin. Invest. Drugs"},{"key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1021\/ja0432618","volume":"127","author":"Ang W. H.","year":"2005","journal-title":"J. Am. Chem. Soc."},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"8060","DOI":"10.1021\/jm0506468","volume":"48","author":"Ang W. H.","year":"2005","journal-title":"J. Med. Chem."},{"key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1016\/0006-2952(90)90465-W","volume":"40","author":"Ploemen J. H.","year":"1990","journal-title":"Biochem. Pharmacol."},{"issue":"1","key":"ref30\/cit30","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1097\/MJT.0b013e318195e460","volume":"16","author":"Molnar J.","year":"2009","journal-title":"Am. J. Ther."},{"key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1016\/S0090-9556(24)15016-7","volume":"27","author":"Zhao Z.","year":"1999","journal-title":"Drug Metab. Dispos."},{"key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/S0090-9556(24)15015-5","volume":"27","author":"Koeplinger K. A.","year":"1999","journal-title":"Drug Metab. Dispos."},{"key":"ref33\/cit33","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1021\/bc700394s","volume":"19","author":"van Brakel R.","year":"2008","journal-title":"Bioconjugate Chem."},{"key":"ref34\/cit34","first-page":"305","volume":"36","author":"Yoo H.","year":"2003","journal-title":"J. Biochem. Mol. Biol."},{"key":"ref35\/cit35","doi-asserted-by":"crossref","first-page":"7130","DOI":"10.1016\/S0021-9258(19)42083-8","volume":"249","author":"Habig W. H.","year":"1974","journal-title":"J. Biol. Chem."},{"key":"ref36\/cit36","doi-asserted-by":"crossref","first-page":"2246","DOI":"10.1016\/j.bmcl.2008.03.014","volume":"18","author":"Shibata A.","year":"2008","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref37\/cit37","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.bbrc.2007.02.018","volume":"355","author":"Siritantikorn A.","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref38\/cit38","doi-asserted-by":"crossref","first-page":"11884","DOI":"10.1074\/jbc.271.20.11884","volume":"271","author":"Bunting K. D.","year":"1996","journal-title":"J. Biol. Chem."},{"key":"ref39\/cit39","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/S0014-5793(98)01291-5","volume":"438","author":"Sundberg K.","year":"1998","journal-title":"FEBS Lett."},{"key":"ref40\/cit40","doi-asserted-by":"crossref","first-page":"10510","DOI":"10.1021\/bi0505215","volume":"44","author":"Cogoi S.","year":"2005","journal-title":"Biochemistry"},{"key":"ref41\/cit41","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.ab.2009.03.046","volume":"390","author":"Alander J.","year":"2009","journal-title":"Anal. Biochem."},{"key":"ref42\/cit42","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/S0076-6879(05)01008-6","volume":"401","author":"Morgenstern R.","year":"2005","journal-title":"Methods Enzymol."},{"key":"ref43\/cit43","doi-asserted-by":"crossref","first-page":"9586","DOI":"10.1074\/jbc.M312320200","volume":"279","author":"Hegazy U. M.","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref44\/cit44","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","volume":"65","author":"Mosmann T.","year":"1983","journal-title":"J. Immunol. Methods"},{"key":"ref45\/cit45","doi-asserted-by":"crossref","first-page":"e8294","DOI":"10.1371\/journal.pone.0008294","volume":"4","author":"Lu D.","year":"2009","journal-title":"PLoS One"},{"key":"ref46\/cit46","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1016\/j.bcp.2009.06.104","volume":"78","author":"Nath N.","year":"2009","journal-title":"Biochem. Pharmacol."},{"key":"ref47\/cit47","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.1200\/JCO.2008.19.2542","volume":"27","author":"Scotlandi K.","year":"2009","journal-title":"J. Clin. Oncol."},{"key":"ref48\/cit48","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1016\/j.freeradbiomed.2004.09.002","volume":"37","author":"Kamada K.","year":"2004","journal-title":"Free Radical Biol. Med."},{"key":"ref49\/cit49","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1016\/j.freeradbiomed.2009.02.025","volume":"46","author":"Goto S.","year":"2009","journal-title":"Free Radical Biol. Med."},{"key":"ref50\/cit50","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1080\/10715769900301121","volume":"31","author":"Goto S.","year":"1999","journal-title":"Free Radical Res."},{"key":"ref51\/cit51","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1016\/S0022-3565(25)22526-5","volume":"270","author":"Lacreta F. P.","year":"1994","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref52\/cit52","first-page":"6059","volume":"51","author":"O\u2019Dwyer P. J.","year":"1991","journal-title":"Cancer Res."},{"key":"ref53\/cit53","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.biopha.2008.08.004","volume":"63","author":"Townsend D. M.","year":"2009","journal-title":"Biomed. Pharmacother."},{"key":"ref54\/cit54","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1111\/j.1464-410X.2005.05472.x","volume":"95","author":"Byun S. S.","year":"2005","journal-title":"BJU Int."},{"key":"ref55\/cit55","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/0009-2797(90)90044-N","volume":"74","author":"Mosialou E.","year":"1990","journal-title":"Chem.-Biol. Interact."},{"key":"ref56\/cit56","doi-asserted-by":"crossref","first-page":"3609","DOI":"10.1016\/0006-2952(84)90145-X","volume":"33","author":"Morgenstern R.","year":"1984","journal-title":"Biochem. Pharmacol."},{"key":"ref57\/cit57","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.1016\/j.ejmech.2008.10.009","volume":"44","author":"Axarli I.","year":"2009","journal-title":"Eur. J. Med. Chem."},{"key":"ref58\/cit58","doi-asserted-by":"crossref","first-page":"6671","DOI":"10.1016\/S0021-9258(18)68694-6","volume":"263","author":"Morgenstern R.","year":"1988","journal-title":"J. Biol. Chem."},{"key":"ref59\/cit59","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1021\/tx980013e","volume":"11","author":"Morgenstern R.","year":"1998","journal-title":"Chem. Res. Toxicol."}],"container-title":["Molecular Pharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/mp2000692","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,8]],"date-time":"2025-03-08T22:50:50Z","timestamp":1741474250000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/mp2000692"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8,30]]},"references-count":59,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2011,10,3]]}},"alternative-id":["10.1021\/mp2000692"],"URL":"https:\/\/doi.org\/10.1021\/mp2000692","relation":{},"ISSN":["1543-8384","1543-8392"],"issn-type":[{"value":"1543-8384","type":"print"},{"value":"1543-8392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,8,30]]}}}