{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T19:23:09Z","timestamp":1769628189819,"version":"3.49.0"},"reference-count":35,"publisher":"American Chemical Society (ACS)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol. Pharmaceutics"],"published-print":{"date-parts":[[2013,11,4]]},"DOI":"10.1021\/mp400179v","type":"journal-article","created":{"date-parts":[[2013,6,10]],"date-time":"2013-06-10T17:21:35Z","timestamp":1370884895000},"page":"3989-3996","source":"Crossref","is-referenced-by-count":31,"title":["Ion Pairing with Bile Salts Modulates Intestinal Permeability and Contributes to Food\u2013Drug Interaction of BCS Class III Compound Trospium Chloride"],"prefix":"10.1021","volume":"10","author":[{"given":"Christian A.","family":"Heinen","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Technology & Biopharmaceutics, Johannes Gutenberg University, Staudingerweg 5, 55128 Mainz, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Reuss","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, University Medical Center, Johannes Gutenberg University, Langenbeckstr. 1, 55101 Mainz, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gordon L.","family":"Amidon","sequence":"additional","affiliation":[{"name":"College of Pharmacy, The University of Michigan, 428 Church Street, Ann\rArbor, Michigan 48109-1065, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Langguth","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology & Biopharmaceutics, Johannes Gutenberg University, Staudingerweg 5, 55128 Mainz, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2013,7,12]]},"reference":[{"issue":"3","key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"233","DOI":"10.2165\/00003088-199936030-00004","volume":"36","author":"Fleisher D.","year":"1999","journal-title":"Clin. Pharmacokinet."},{"issue":"3","key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1517\/17425255.2011.553189","volume":"7","author":"Hanley M. J.","year":"2011","journal-title":"Expert Opin. Drug Metab. Toxicol."},{"issue":"2","key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/S0190-9622(85)80041-4","volume":"12","author":"Leyden J. J.","year":"1985","journal-title":"J. Am. Acad. Dermatol."},{"issue":"5","key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1021\/mp0499407","volume":"1","author":"Yu L. X.","year":"2004","journal-title":"Mol. Pharmaceutics"},{"issue":"6","key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.addr.2007.08.043","volume":"60","author":"Custodio J. M.","year":"2008","journal-title":"Adv. Drug Delivery Rev."},{"issue":"6","key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1007\/s11095-007-9236-1","volume":"24","author":"Gu C. H.","year":"2007","journal-title":"Pharm. Res."},{"issue":"2","key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1208\/s12248-008-9025-8","volume":"10","author":"Lentz K. A.","year":"2008","journal-title":"AAPS J."},{"issue":"7","key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"701","DOI":"10.2165\/00003088-200544070-00003","volume":"44","author":"Doroshyenko O.","year":"2005","journal-title":"Clin. Pharmacokinet."},{"issue":"13","key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.jchromb.2010.02.028","volume":"878","author":"Hotha K. K.","year":"2010","journal-title":"J. Chromatogr., B"},{"issue":"12","key":"ref10\/cit10","first-page":"1362","volume":"37","author":"Langguth P.","year":"1987","journal-title":"Arzneim.-Forsch."},{"issue":"7","key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1002\/bdd.1798","volume":"33","author":"Radwan A.","year":"2012","journal-title":"Biopharm. Drug Dispos."},{"issue":"12","key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1023\/A:1015877929381","volume":"8","author":"Bakatselou V.","year":"1991","journal-title":"Pharm. Res."},{"issue":"5","key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1023\/A:1011910801212","volume":"15","author":"Galia E.","year":"1998","journal-title":"Pharm. Res."},{"issue":"6","key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1023\/A:1018965328626","volume":"10","author":"Lennernas H.","year":"1993","journal-title":"Pharm. Res."},{"issue":"4","key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1023\/A:1015827624296","volume":"7","author":"Poelma F. G.","year":"1990","journal-title":"Pharm. Res."},{"issue":"1","key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.ijpharm.2008.10.001","volume":"368","author":"Sugano K.","year":"2009","journal-title":"Int. J. Pharmaceutics"},{"issue":"1","key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1023\/A:1018870712463","volume":"16","author":"Sj\u00f6str\u00f6m M.","year":"1999","journal-title":"Pharm. Res."},{"issue":"1","key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1021\/mp200201y","volume":"9","author":"Yang L.","year":"2011","journal-title":"Mol. Pharmaceutics"},{"issue":"2","key":"ref19\/cit19","first-page":"G515","volume":"281","author":"Song I. S.","year":"2001","journal-title":"Am. J. Physiol."},{"issue":"5","key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1007\/s11095-010-0075-0","volume":"27","author":"Song I. S.","year":"2010","journal-title":"Pharm. Res."},{"issue":"9","key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1002\/bdd.580","volume":"28","author":"Choi M. K.","year":"2007","journal-title":"Biopharm. Drug Dispos."},{"issue":"1","key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s12272-008-1127-4","volume":"31","author":"Chae H. W.","year":"2008","journal-title":"Arch. Pharmacal Res."},{"issue":"12","key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.1007\/s11095-005-8192-x","volume":"22","author":"Persson E. M.","year":"2005","journal-title":"Pharm. Res."},{"issue":"1","key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0009-8981(76)90007-3","volume":"70","author":"Mashige F.","year":"1976","journal-title":"Clin. Chim. Acta"},{"issue":"5","key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1021\/bm701337q","volume":"9","author":"Grube S.","year":"2008","journal-title":"Biomacromolecules"},{"issue":"3","key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1021\/js970218s","volume":"87","author":"Ungell A. L.","year":"1998","journal-title":"J. Pharm. Sci."},{"issue":"5","key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1023\/A:1012121632357","volume":"14","author":"Lennernas H.","year":"1997","journal-title":"Pharm. Res."},{"issue":"4","key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1023\/A:1023294715483","volume":"20","author":"Song I. S.","year":"2003","journal-title":"Pharm. Res."},{"issue":"3","key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/0305-0491(86)90295-6","volume":"83","author":"Alvaro D.","year":"1986","journal-title":"Comp. Biochem. Physiol. B"},{"issue":"4","key":"ref30\/cit30","first-page":"623","volume":"73","author":"Nakayama F.","year":"1969","journal-title":"J. Lab. Clin. Med."},{"issue":"1","key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1002\/jps.21093","volume":"97","author":"Tsutsumi K.","year":"2008","journal-title":"J. Pharm. Sci."},{"issue":"1","key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1208\/s12249-009-9203-8","volume":"10","author":"Dhiman M. K.","year":"2009","journal-title":"AAPS PharmSciTech"},{"issue":"10","key":"ref33\/cit33","doi-asserted-by":"crossref","first-page":"6362","DOI":"10.1016\/S0021-9258(18)32418-9","volume":"258","author":"Roda A.","year":"1983","journal-title":"J. Biol. Chem."},{"issue":"1","key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0169-409X(92)90015-I","volume":"8","author":"Scott Swenson E.","year":"1992","journal-title":"Adv. Drug Delivery Rev."},{"issue":"9","key":"ref35\/cit35","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1023\/A:1015874906665","volume":"8","author":"TenHoor C. N.","year":"1991","journal-title":"Pharm. Res."}],"container-title":["Molecular Pharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/mp400179v","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,16]],"date-time":"2023-04-16T09:02:28Z","timestamp":1681635748000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/mp400179v"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7,12]]},"references-count":35,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2013,11,4]]}},"alternative-id":["10.1021\/mp400179v"],"URL":"https:\/\/doi.org\/10.1021\/mp400179v","relation":{},"ISSN":["1543-8384","1543-8392"],"issn-type":[{"value":"1543-8384","type":"print"},{"value":"1543-8392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,12]]}}}