{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T13:01:15Z","timestamp":1768827675457,"version":"3.49.0"},"reference-count":34,"publisher":"American Chemical Society (ACS)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol. Pharmaceutics"],"published-print":{"date-parts":[[2013,11,4]]},"DOI":"10.1021\/mp400210q","type":"journal-article","created":{"date-parts":[[2013,9,24]],"date-time":"2013-09-24T18:19:05Z","timestamp":1380046745000},"page":"4168-4175","source":"Crossref","is-referenced-by-count":36,"title":["Thrombin-Targeted Liposomes Establish a Sustained Localized Anticlotting Barrier against Acute Thrombosis"],"prefix":"10.1021","volume":"10","author":[{"given":"Rohun U.","family":"Palekar","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering, \u2021Department of Cell Biology and\rPhysiology, \u00a7Department of Medicine, and \u2225Department of Physics, Washington University in St. Louis, Consortium for Translational Research in Advanced Imaging and Nanomedicine, 4320 Forest Park Avenue, St. Louis, Missouri 63108, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacob W.","family":"Myerson","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, \u2021Department of Cell Biology and\rPhysiology, \u00a7Department of Medicine, and \u2225Department of Physics, Washington University in St. Louis, Consortium for Translational Research in Advanced Imaging and Nanomedicine, 4320 Forest Park Avenue, St. Louis, Missouri 63108, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul H.","family":"Schlesinger","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, \u2021Department of Cell Biology and\rPhysiology, \u00a7Department of Medicine, and \u2225Department of Physics, Washington University in St. Louis, Consortium for Translational Research in Advanced Imaging and Nanomedicine, 4320 Forest Park Avenue, St. Louis, Missouri 63108, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Evan","family":"Sadler","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, \u2021Department of Cell Biology and\rPhysiology, \u00a7Department of Medicine, and \u2225Department of Physics, Washington University in St. Louis, Consortium for Translational Research in Advanced Imaging and Nanomedicine, 4320 Forest Park Avenue, St. Louis, Missouri 63108, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, \u2021Department of Cell Biology and\rPhysiology, \u00a7Department of Medicine, and \u2225Department of Physics, Washington University in St. Louis, Consortium for Translational Research in Advanced Imaging and Nanomedicine, 4320 Forest Park Avenue, St. Louis, Missouri 63108, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel A.","family":"Wickline","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, \u2021Department of Cell Biology and\rPhysiology, \u00a7Department of Medicine, and \u2225Department of Physics, Washington University in St. Louis, Consortium for Translational Research in Advanced Imaging and Nanomedicine, 4320 Forest Park Avenue, St. Louis, Missouri 63108, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2013,10,10]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1124\/mi.11.2.9","volume":"11","author":"Choi J.","year":"2011","journal-title":"Mol. Interv."},{"key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.ejim.2009.09.005","volume":"20","author":"Franchini M.","year":"2009","journal-title":"Eur. J. Intern. Med."},{"key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1111\/j.1742-1241.2009.02058.x","volume":"63","author":"Siddique A.","year":"2009","journal-title":"Int. J. Clin. Pract."},{"key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.ccl.2008.07.002","volume":"26","author":"Lee L. V.","year":"2008","journal-title":"Cardiol. Clin."},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1038\/nature06797","volume":"451","author":"Mackman N.","year":"2008","journal-title":"Nature"},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/clpt.2009.98","volume":"86","author":"Gross P. L.","year":"2009","journal-title":"Clin. Pharmacol. Ther."},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1016\/j.thromres.2008.08.003","volume":"123","author":"Turpie A.","year":"2008","journal-title":"Thromb. Res."},{"key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1111\/j.1538-7836.2011.04339.x","volume":"9","author":"Myerson J.","year":"2011","journal-title":"J. Thrombosis Haemostasis"},{"key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1021\/nn900277t","volume":"3","author":"Shrivastava S.","year":"2009","journal-title":"ACS Nano"},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"9815","DOI":"10.1073\/pnas.0903369106","volume":"106","author":"Peters D.","year":"2009","journal-title":"Proc. Natl. Acad. Sci."},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"2731","DOI":"10.1021\/nn300172t","volume":"6","author":"Singh S. K. S.","year":"2012","journal-title":"ACS Nano"},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/nrd1632","volume":"4","author":"Torchilin V. P.","year":"2005","journal-title":"Nat. Rev. Drug Discovery"},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/0031-6865(95)00010-7","volume":"70","author":"Vemuri S.","year":"1995","journal-title":"Pharm. Acta Helv."},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"297","DOI":"10.2217\/17435889.1.3.297","volume":"1","author":"Immordino M. L.","year":"2006","journal-title":"Int. J. Nanomed."},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.peptides.2009.10.002","volume":"31","author":"Tan M. L.","year":"2010","journal-title":"Peptides"},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1111\/j.1527-3466.1992.tb00237.x","volume":"10","author":"Kaiser B.","year":"1992","journal-title":"Cardiovasc. Drug Rev."},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/0005-2736(79)90085-3","volume":"557","author":"Olson F.","year":"1979","journal-title":"Biochim. Biophys. Acta (BBA): Biomembr."},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"3792","DOI":"10.1158\/0008-5472.CAN-10-4455","volume":"71","author":"Hood J. L.","year":"2011","journal-title":"Cancer Res."},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/0003-2697(80)90269-9","volume":"104","author":"Stewart J. C. M.","year":"1980","journal-title":"Anal. Biochem."},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"3965","DOI":"10.1182\/blood-2004-02-0598","volume":"104","author":"Vicente C. P.","year":"2004","journal-title":"Blood"},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"4622","DOI":"10.1021\/bi00364a025","volume":"25","author":"Stone S. R.","year":"1986","journal-title":"Biochemistry"},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1309\/Y9EC63RW3XG1V313","volume":"123","author":"Zhou L.","year":"2005","journal-title":"Am. J. Clin. Pathol."},{"key":"ref23\/cit23","first-page":"65","volume":"272","author":"Jarvis G. E.","year":"2004","journal-title":"Methods Mol. Biol."},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1002\/path.1700900124","volume":"90","author":"Carstairs K. C.","year":"1965","journal-title":"J. Pathol. Bacteriol."},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1172\/JCI114723","volume":"86","author":"Weitz J. I. J.","year":"1990","journal-title":"J. Clin. Invest."},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"3619","DOI":"10.1073\/pnas.86.10.3619","volume":"86","author":"Hogg P. J.","year":"1989","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1161\/01.CIR.90.3.1522","volume":"90","author":"Lefkovits J.","year":"1994","journal-title":"Circulation"},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1016\/j.cellsig.2010.06.008","volume":"22","author":"Lova P.","year":"2010","journal-title":"Cell. Signal."},{"key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.thromres.2011.11.001","volume":"129","author":"De Candia E.","year":"2012","journal-title":"Thromb. Res."},{"key":"ref30\/cit30","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1055\/s-0037-1613473","volume":"89","author":"Dubois C.","year":"2003","journal-title":"Thromb. Haemost."},{"key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1038\/35025229","volume":"407","author":"Coughlin S. R.","year":"2000","journal-title":"Nature"},{"key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"6642","DOI":"10.1073\/pnas.95.12.6642","volume":"95","author":"Xu W. F. W.","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref33\/cit33","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1038\/29325","volume":"394","author":"Kahn M. L.","year":"1998","journal-title":"Nature"},{"key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1038\/35007085","volume":"404","author":"Nakanishi-Matsui M.","year":"2000","journal-title":"Nature"}],"container-title":["Molecular Pharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/mp400210q","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,16]],"date-time":"2023-04-16T09:07:55Z","timestamp":1681636075000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/mp400210q"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10,10]]},"references-count":34,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2013,11,4]]}},"alternative-id":["10.1021\/mp400210q"],"URL":"https:\/\/doi.org\/10.1021\/mp400210q","relation":{},"ISSN":["1543-8384","1543-8392"],"issn-type":[{"value":"1543-8384","type":"print"},{"value":"1543-8392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10,10]]}}}