{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T01:33:18Z","timestamp":1789695198554,"version":"4.0.1"},"reference-count":49,"publisher":"American Chemical Society (ACS)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol. Pharmaceutics"],"published-print":{"date-parts":[[2014,1,6]]},"DOI":"10.1021\/mp400400j","type":"journal-article","created":{"date-parts":[[2013,12,2]],"date-time":"2013-12-02T15:26:03Z","timestamp":1385997963000},"page":"102-111","source":"Crossref","is-referenced-by-count":93,"title":["Delivery of Chemically Glycosylated Cytochrome c Immobilized in Mesoporous Silica Nanoparticles Induces Apoptosis in HeLa Cancer Cells"],"prefix":"10.1021","volume":"11","author":[{"given":"Jessica","family":"M\u00e9ndez","sequence":"first","affiliation":[{"name":"Department\rof Chemistry, University of Puerto Rico, R\u00edo Piedras Campus, P.O. Box 23346, San Juan, Puerto Rico 00931-3346, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moraima","family":"Morales Cruz","sequence":"additional","affiliation":[{"name":"Department\rof Chemistry, University of Puerto Rico, R\u00edo Piedras Campus, P.O. Box 23346, San Juan, Puerto Rico 00931-3346, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yamixa","family":"Delgado","sequence":"additional","affiliation":[{"name":"Department\rof Chemistry, University of Puerto Rico, R\u00edo Piedras Campus, P.O. Box 23346, San Juan, Puerto Rico 00931-3346, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cindy M.","family":"Figueroa","sequence":"additional","affiliation":[{"name":"Department\rof Chemistry, University of Puerto Rico, R\u00edo Piedras Campus, P.O. Box 23346, San Juan, Puerto Rico 00931-3346, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elsie A.","family":"Orellano","sequence":"additional","affiliation":[{"name":"Department\rof Chemistry, University of Puerto Rico, R\u00edo Piedras Campus, P.O. Box 23346, San Juan, Puerto Rico 00931-3346, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myraida","family":"Morales","sequence":"additional","affiliation":[{"name":"Department\rof Chemistry, University of Puerto Rico, R\u00edo Piedras Campus, P.O. Box 23346, San Juan, Puerto Rico 00931-3346, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alina","family":"Monteagudo","sequence":"additional","affiliation":[{"name":"Department\rof Chemistry, University of Puerto Rico, R\u00edo Piedras Campus, P.O. Box 23346, San Juan, Puerto Rico 00931-3346, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Griebenow","sequence":"additional","affiliation":[{"name":"Department\rof Chemistry, University of Puerto Rico, R\u00edo Piedras Campus, P.O. Box 23346, San Juan, Puerto Rico 00931-3346, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2013,12,10]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"212","DOI":"10.3322\/caac.20121","volume":"61","author":"Siegel R.","year":"2011","journal-title":"Cancer J. Clin."},{"key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"5043","DOI":"10.1016\/j.bmc.2005.04.084","volume":"13","author":"Jaracz S.","year":"2005","journal-title":"Bioorg. Med. Chem."},{"key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","volume":"144","author":"Hanahan D.","year":"2011","journal-title":"Cell"},{"key":"ref4\/cit4","first-page":"1043","volume":"7","author":"Ranganathan R.","year":"2012","journal-title":"Int. J. Nanomed."},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.jconrel.2010.08.027","volume":"148","author":"Danhier F.","year":"2010","journal-title":"J. Controlled Release"},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S1567-5769(02)00271-0","volume":"3","author":"Maeda H.","year":"2003","journal-title":"Int. Immunopharmacol."},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"5845","DOI":"10.1039\/c0jm03851b","volume":"21","author":"He Q. J.","year":"2011","journal-title":"J. Mater. Chem."},{"key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"464","DOI":"10.2174\/138920309789352001","volume":"10","author":"Chen E.","year":"2009","journal-title":"Curr. Protein Pept. Sci."},{"key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1021\/cm0483137","volume":"17","author":"Wang Y.","year":"2005","journal-title":"Chem. Mater."},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"8845","DOI":"10.1021\/ja0719780","volume":"129","author":"Slowing I. I.","year":"2007","journal-title":"J. Am. Chem. Soc."},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1021\/bc200301a","volume":"23","author":"Mendez J.","year":"2012","journal-title":"Bioconjugate Chem."},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"3209","DOI":"10.1242\/jcs.073643","volume":"123","author":"Bratton S. B.","year":"2010","journal-title":"J. Cell Sci."},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/sj.neo.7900003","volume":"1","author":"Chinnaiyan A. M.","year":"1999","journal-title":"Neoplasia"},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/978-1-60327-017-5_5","volume":"559","author":"Chandra D.","year":"2009","journal-title":"Methods Mol. Biol."},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1021\/mp100043h","volume":"7","author":"Santra S.","year":"2010","journal-title":"Mol. Pharmaceutics"},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"3959","DOI":"10.1016\/j.biomaterials.2012.02.010","volume":"33","author":"Kim S. K.","year":"2012","journal-title":"Biomaterials"},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"e95","DOI":"10.1016\/j.ddtec.2009.01.002","volume":"5","author":"Torchilin V.","year":"2008","journal-title":"Drug Discovery Today: Technol."},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"9","DOI":"10.2165\/11530550-000000000-00000","volume":"24","author":"Sol\u00e1 R. J.","year":"2010","journal-title":"BioDrugs"},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"2184","DOI":"10.1002\/jps.20125","volume":"93","author":"Tang L.","year":"2004","journal-title":"J. Pharm. Sci."},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1158\/0008-5472.CAN-05-2591","volume":"66","author":"Wu W.","year":"2006","journal-title":"Cancer Res."},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"4059","DOI":"10.1091\/mbc.10.12.4059","volume":"10","author":"De Virgilio M.","year":"1999","journal-title":"Mol. Cell Biol."},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1002\/bit.20933","volume":"94","author":"Sol\u00e1 R. J.","year":"2006","journal-title":"Biotechnol. Bioeng."},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1016\/j.febslet.2006.02.001","volume":"580","author":"Sol\u00e1 R. J.","year":"2006","journal-title":"FEBS Lett."},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1002\/bit.22221","volume":"103","author":"Pagan M.","year":"2009","journal-title":"Biotechnol. Bioeng."},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1002\/jps.21504","volume":"98","author":"Sol\u00e1 R. J.","year":"2009","journal-title":"J. Pharm. Sci."},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1002\/bit.260170918","volume":"17","author":"Vegarud G.","year":"1975","journal-title":"Biotechnol. Bioeng."},{"key":"ref27\/cit27","first-page":"1","volume":"218","author":"Lis H.","year":"1993","journal-title":"FEBS J."},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/0003-2697(66)90275-2","volume":"14","author":"Habeeb A. F.","year":"1966","journal-title":"Anal. Biochem."},{"key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","volume":"72","author":"Bradford M. M.","year":"1976","journal-title":"Anal. Biochem."},{"key":"ref30\/cit30","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.1021\/bm2005164","volume":"12","author":"Liu J.","year":"2011","journal-title":"Biomacromolecules"},{"key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"3219","DOI":"10.1039\/b900559e","volume":"22","author":"Mortera R.","year":"2009","journal-title":"Chem. Commun."},{"key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"8845","DOI":"10.1021\/ja0719780","volume":"129","author":"Slowing I. I.","year":"2007","journal-title":"J. Am. Chem. Soc."},{"key":"ref33\/cit33","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1182\/blood.V96.1.307","volume":"96","author":"Shacter E.","year":"2000","journal-title":"Blood"},{"key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1074\/jbc.272.2.1231","volume":"272","author":"Reinhardt D. P.","year":"1997","journal-title":"J. Biol. Chem."},{"key":"ref35\/cit35","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.ijpharm.2008.10.036","volume":"369","author":"Barnes M. P.","year":"2009","journal-title":"Int. J. Pharmaceutics"},{"key":"ref36\/cit36","doi-asserted-by":"crossref","first-page":"11928","DOI":"10.1073\/pnas.220416197","volume":"97","author":"Purring-Koch C.","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref37\/cit37","doi-asserted-by":"crossref","first-page":"13122","DOI":"10.1021\/bi971235z","volume":"36","author":"Pinheiro T. J.","year":"1997","journal-title":"Biochemistry"},{"key":"ref38\/cit38","doi-asserted-by":"crossref","first-page":"3515","DOI":"10.1021\/ja00743a036","volume":"93","author":"Woody R. W.","year":"1971","journal-title":"J. Am. Chem. Soc."},{"key":"ref39\/cit39","doi-asserted-by":"crossref","first-page":"5431","DOI":"10.1021\/bi00071a019","volume":"32","author":"Davies A. M.","year":"1993","journal-title":"Biochemistry"},{"key":"ref40\/cit40","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1021\/bi00842a035","volume":"7","author":"Myer Y. P.","year":"1968","journal-title":"Biochemistry"},{"key":"ref41\/cit41","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1021\/bm1008052","volume":"12","author":"Wei W.","year":"2011","journal-title":"Biomacromolecules"},{"key":"ref42\/cit42","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1021\/bi00842a035","volume":"7","author":"Myer Y. P.","year":"1968","journal-title":"Biochemistry"},{"key":"ref43\/cit43","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1002\/(SICI)1097-0282(2000)57:1<29::AID-BIP5>3.0.CO;2-V","volume":"57","author":"Thomas Y. G.","year":"2000","journal-title":"Biopolymers"},{"key":"ref44\/cit44","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s11051-008-9417-9","volume":"11","author":"Yu K.","year":"2009","journal-title":"J. Nanopart. Res."},{"key":"ref45\/cit45","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.taap.2006.10.004","volume":"217","author":"Lin W.","year":"2006","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref46\/cit46","doi-asserted-by":"crossref","first-page":"14527","DOI":"10.1073\/pnas.0303574101","volume":"101","author":"Robinson M. A.","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref47\/cit47","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1016\/j.carres.2009.06.033","volume":"344","author":"Russell D.","year":"2009","journal-title":"Carbohydr. Res."},{"key":"ref48\/cit48","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/j.bbrc.2004.01.153","volume":"315","author":"Kim B. M.","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref49\/cit49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1752-153X-5-1","volume":"5","author":"Guo H.","year":"2011","journal-title":"Chem. Cent. J."}],"container-title":["Molecular Pharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/mp400400j","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,15]],"date-time":"2023-04-15T11:56:15Z","timestamp":1681559775000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/mp400400j"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12,10]]},"references-count":49,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1,6]]}},"alternative-id":["10.1021\/mp400400j"],"URL":"https:\/\/doi.org\/10.1021\/mp400400j","relation":{},"ISSN":["1543-8384","1543-8392"],"issn-type":[{"value":"1543-8384","type":"print"},{"value":"1543-8392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,10]]}}}