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Pharmacol."},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1089\/dna.1997.16.871","volume":"16","author":"Gorboulev V.","year":"1997","journal-title":"DNA Cell Biol."},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1038\/sj.bjp.0704785","volume":"136","author":"Hayer-Zillgen M.","year":"2009","journal-title":"Br. J. Pharmacol."},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1124\/dmd.108.020826","volume":"36","author":"Jung N.","year":"2008","journal-title":"Drug Metab. Dispos."},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"41611","DOI":"10.1074\/jbc.M108472200","volume":"276","author":"Sweet D. H.","year":"2001","journal-title":"J. Biol. Chem."},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1124\/mol.104.004713","volume":"67","author":"Suhre W. M.","year":"2005","journal-title":"Mol. 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J."},{"key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1124\/mol.56.6.1254","volume":"56","author":"Gorboulev V.","year":"1999","journal-title":"Mol. Pharmacol."},{"key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1124\/mol.105.012161","volume":"67","author":"Burckhardt G.","year":"2005","journal-title":"Mol. Pharmacol."},{"key":"ref33\/cit33","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/j.neuropharm.2006.01.005","volume":"50","author":"Amphoux A.","year":"2006","journal-title":"Neuropharmacology"},{"key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1124\/dmd.108.024083","volume":"37","author":"Ming X.","year":"2009","journal-title":"Drug Metab. Dispos."},{"key":"ref35\/cit35","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1016\/j.bcp.2005.09.011","volume":"70","author":"M\u00fcller J.","year":"2005","journal-title":"Biochem. 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