{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T23:18:16Z","timestamp":1788304696982,"version":"build-2803163510"},"reference-count":33,"publisher":"American Chemical Society (ACS)","issue":"8","license":[{"start":{"date-parts":[[2015,7,2]],"date-time":"2015-07-02T00:00:00Z","timestamp":1435795200000},"content-version":"vor","delay-in-days":365,"URL":"https:\/\/pubs.acs.org\/page\/policy\/authorchoice_termsofuse.html"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,8,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We have recently designed and developed a dual-functional drug carrier that is based on poly(ethylene glycol) (PEG)-derivatized farnesylthiosalicylate (FTS, a nontoxic Ras antagonist). PEG5K-FTS2 readily form micelles (20\u201330 nm) and hydrophobic drugs such as paclitaxel (PTX) could be effectively loaded into these micelles. PTX formulated in PEG5K-FTS2 micelles showed an antitumor activity that was more efficacious than Taxol in a syngeneic mouse model of breast cancer (4T1.2). In order to further improve our PEG-FTS micellar system, four PEG-FTS conjugates were developed that vary in the molecular weight of PEG (PEG2K vs PEG5K) and the molar ratio of PEG\/FTS (1\/2 vs 1\/4) in the conjugates. These conjugates were characterized including CMC, drug loading capacity, stability, and their efficacy in delivery of anticancer drug PTX to tumor cells in vitro and in vivo. Our data showed that the conjugates with four FTS molecules were more effective than the conjugates with two molecules of FTS and that FTS conjugates with PEG5K were more effective than the counterparts with PEG2K in forming stable mixed micelles. PTX formulated in PEG5K-FTS4 micelles was the most effective formulation in inhibiting the tumor growth in vivo.<\/jats:p>","DOI":"10.1021\/mp500181x","type":"journal-article","created":{"date-parts":[[2014,7,2]],"date-time":"2014-07-02T17:42:28Z","timestamp":1404322948000},"page":"2807-2814","source":"Crossref","is-referenced-by-count":29,"title":["PEG-Farnesyl Thiosalicylic Acid Telodendrimer Micelles\nas an Improved Formulation for Targeted Delivery of Paclitaxel"],"prefix":"10.1021","volume":"11","author":[{"given":"Xiaolan","family":"Zhang","sequence":"first","affiliation":[{"name":"University of Pittsburgh , , , ,","place":["Pittsburgh, Pennsylvania, United States, 15261"]},{"name":"University of Pittsburgh , , , ,","place":["Pittsburgh, Pennsylvania, United States, 15261"]},{"name":"University of Pittsburgh , , , ,","place":["Pittsburgh, Pennsylvania, United States, 15261"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixian","family":"Huang","sequence":"additional","affiliation":[{"name":"University of Pittsburgh , , , ,","place":["Pittsburgh, Pennsylvania, United States, 15261"]},{"name":"University of Pittsburgh , , , ,","place":["Pittsburgh, Pennsylvania, United States, 15261"]},{"name":"University of Pittsburgh , , , ,","place":["Pittsburgh, Pennsylvania, United States, 15261"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenchen","family":"Zhao","sequence":"additional","affiliation":[{"name":"University of Pittsburgh , , , ,","place":["Pittsburgh, Pennsylvania, United States, 15261"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yichao","family":"Chen","sequence":"additional","affiliation":[{"name":"University of Pittsburgh , , , ,","place":["Pittsburgh, Pennsylvania, United States, 15261"]},{"name":"University of Pittsburgh , , , ,","place":["Pittsburgh, Pennsylvania, United States, 15261"]},{"name":"University of Pittsburgh , , , ,","place":["Pittsburgh, Pennsylvania, United States, 15261"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Zhang","sequence":"additional","affiliation":[{"name":"University of Pittsburgh , , , ,","place":["Pittsburgh, Pennsylvania, United States, 15261"]},{"name":"University of Pittsburgh , , , ,","place":["Pittsburgh, Pennsylvania, United States, 15261"]},{"name":"University of Pittsburgh , , , ,","place":["Pittsburgh, Pennsylvania, United States, 15261"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang","family":"Li","sequence":"additional","affiliation":[{"name":"University of Pittsburgh , , , ,","place":["Pittsburgh, Pennsylvania, United States, 15261"]},{"name":"University of Pittsburgh , , , ,","place":["Pittsburgh, Pennsylvania, United States, 15261"]},{"name":"University of Pittsburgh , , , ,","place":["Pittsburgh, Pennsylvania, United States, 15261"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raman","family":"Venkataramanan","sequence":"additional","affiliation":[{"name":"University of Pittsburgh , , , ,","place":["Pittsburgh, Pennsylvania, United States, 15261"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Li","sequence":"additional","affiliation":[{"name":"University of Pittsburgh , , , ,","place":["Pittsburgh, Pennsylvania, United States, 15261"]},{"name":"University of Pittsburgh , , , ,","place":["Pittsburgh, Pennsylvania, United States, 15261"]},{"name":"University of Pittsburgh , , , ,","place":["Pittsburgh, Pennsylvania, United States, 15261"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2014,7,2]]},"reference":[{"key":"2026090119034217500_cit1","doi-asserted-by":"crossref","first-page":"10435","DOI":"10.1016\/S0021-9258(19)68639-4","article-title":"Taxol-induced\npolymerization of purified tubulin. Mechanism of action","volume":"256","author":"Kumar","year":"1981","journal-title":"J. Biol. Chem."},{"key":"2026090119034217500_cit2","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1200\/JCO.1990.8.7.1263","article-title":"Hypersensitivity reactions from taxol","volume":"8","author":"Weiss","year":"1990","journal-title":"J. Clin. Oncol."},{"key":"2026090119034217500_cit3","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.pharmthera.2006.05.006","article-title":"Current state, achievements, and future prospects of\npolymeric micelles as nanocarriers for drug and gene delivery","volume":"112","author":"Nishiyama","year":"2006","journal-title":"Pharmacol. Ther."},{"key":"2026090119034217500_cit4","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0169-409X(00)00124-1","article-title":"Block copolymer micelles for drug\ndelivery: design, characterization and biological significance","volume":"47","author":"Kataoka","year":"2012","journal-title":"Adv. Drug Delivery Rev."},{"key":"2026090119034217500_cit5","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1002\/jps.10397","article-title":"Amphiphilic block copolymers for\ndrug delivery","volume":"92","author":"Adams","year":"2003","journal-title":"J. Pharm. Sci."},{"key":"2026090119034217500_cit6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11095-006-9132-0","article-title":"Micellar\nnanocarriers: pharmaceutical perspectives","volume":"24","author":"Torchilin","year":"2007","journal-title":"Pharm.\nRes."},{"key":"2026090119034217500_cit7","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.progpolymsci.2012.07.002","article-title":"Design\nand development of polymeric\nmicelles with cleavable links for intracellular drug delivery","volume":"38","author":"Wei","year":"2013","journal-title":"Prog. Polym. Sci."},{"key":"2026090119034217500_cit8","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1021\/nl900031y","article-title":"Mediating\ntumor targeting efficiency of nanoparticles through design","volume":"9","author":"Perrault","year":"2009","journal-title":"Nano Lett."},{"key":"2026090119034217500_cit9","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0168-3659(99)00248-5","article-title":"Tumor vascular permeability\nand the EPR effect in macromolecular therapeutics: a review","volume":"65","author":"Maeda","year":"2000","journal-title":"J. Controlled Release"},{"key":"2026090119034217500_cit10","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1021\/bc1000033","article-title":"Well-defined, size-tunable,\nmultifunctional micelles\nfor efficient paclitaxel delivery for cancer treatment","volume":"21","author":"Luo","year":"2010","journal-title":"Bioconjugate Chem."},{"key":"2026090119034217500_cit11","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1038\/nnano.2011.166","article-title":"Accumulation of sub-100\nnm polymeric micelles in poorly permeable tumours depends on size","volume":"6","author":"Cabral","year":"2011","journal-title":"Nat. Nanotechnol."},{"key":"2026090119034217500_cit12","doi-asserted-by":"crossref","first-page":"53","DOI":"10.4155\/tde.13.135","article-title":"Nanomicellar carriers for targeted\ndelivery of anticancer agents","volume":"5","author":"Zhang","year":"2014","journal-title":"Ther. Delivery"},{"key":"2026090119034217500_cit13","doi-asserted-by":"crossref","first-page":"S58","DOI":"10.1038\/491S58a","article-title":"Nanotechnology:\nCarrying drugs","volume":"491","author":"Bourzac","year":"2012","journal-title":"Nature"},{"key":"2026090119034217500_cit14","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1021\/bc300608h","article-title":"PEG-farnesylthiosalicylate\nconjugate\nas a nanomicellar carrier for delivery of paclitaxel","volume":"24","author":"Zhang","year":"2013","journal-title":"Bioconjugate Chem."},{"key":"2026090119034217500_cit15","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.2174\/0929867311320100002","article-title":"Immunomodulatory properties\nof farnesoids: the new steroids?","volume":"20","author":"Mor","year":"2013","journal-title":"Curr. Med.\nChem."},{"key":"2026090119034217500_cit16","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.4155\/fmc.11.121","article-title":"Inhibition of Ras for cancer treatment: the search\ncontinues","volume":"3","author":"Baines","year":"2011","journal-title":"Future Med. Chem."},{"key":"2026090119034217500_cit17","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1021\/bi972032d","article-title":"Dislodgment and accelerated\ndegradation of Ras","volume":"37","author":"Haklai","year":"1998","journal-title":"Biochemistry"},{"key":"2026090119034217500_cit18","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/S0076-6879(07)00432-6","article-title":"The Ras inhibitor farnesylthiosalicylic\nacid (Salirasib) disrupts the spatiotemporal localization of active\nRas: a potential treatment for cancer","volume":"439","author":"Rotblat","year":"2008","journal-title":"Methods\nEnzymol."},{"key":"2026090119034217500_cit19","doi-asserted-by":"crossref","first-page":"14019","DOI":"10.1073\/pnas.96.24.14019","article-title":"Novel Ras\nantagonist blocks human melanoma growth","volume":"96","author":"Jansen","year":"1996","journal-title":"Proc.\nNatl. Acad. Sci. U. S. A."},{"key":"2026090119034217500_cit20","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1074\/jbc.274.3.1606","article-title":"Membrane interactions\nof a constitutively active GFP-Ki-Ras 4B and their role in signaling.\nEvidence from lateral mobility studies","volume":"274","author":"Niv","year":"1999","journal-title":"J. Biol.\nChem."},{"key":"2026090119034217500_cit21","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1517\/13543784.8.12.2121","article-title":"Concepts in\nRas-directed therapy","volume":"8","author":"Kloog","year":"1999","journal-title":"Expert Opin. Invest. Drugs"},{"key":"2026090119034217500_cit22","doi-asserted-by":"crossref","first-page":"2880","DOI":"10.1021\/mp300729y","article-title":"Design and characterization\nof PEG-derivatized vitamin E as a nanomicellar formulation for delivery\nof paclitaxel","volume":"10","author":"Lu","year":"2013","journal-title":"Mol. Pharmacol."},{"key":"2026090119034217500_cit23","doi-asserted-by":"crossref","first-page":"6877","DOI":"10.1016\/j.biomaterials.2012.06.019","article-title":"Star-shape copolymer\nof lysine-linked\ndi-tocopherol polyethylene glycol 2000 succinate for doxorubicin delivery\nwith reversal of multidrug resistance","volume":"33","author":"Wang","year":"2012","journal-title":"Biomaterials"},{"key":"2026090119034217500_cit24","doi-asserted-by":"crossref","first-page":"4058","DOI":"10.1016\/j.biomaterials.2011.02.022","article-title":"Formulation\nof Docetaxel by folic acid-conjugated d-alpha-tocopheryl\npolyethylene glycol succinate 2000 (Vitamin E TPGS(2k)) micelles for\ntargeted and synergistic chemotherapy","volume":"32","author":"Mi","year":"2011","journal-title":"Biomaterials"},{"key":"2026090119034217500_cit25","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1021\/bc3000468","article-title":"PEG-derivatized\nembelin as a dual functional carrier for the delivery of paclitaxel","volume":"23","author":"Huang","year":"2012","journal-title":"Bioconjugate Chem."},{"key":"2026090119034217500_cit26","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1016\/j.biomaterials.2012.10.073","article-title":"PEG-derivatized\nembelin as a nanomicellar carrier for delivery of paclitaxel to breast\nand prostate cancers","volume":"34","author":"Lu","year":"2013","journal-title":"Biomaterials"},{"key":"2026090119034217500_cit27","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1021\/jm00008a004","article-title":"Selective\ninhibition of Ras-dependent cell growth by farnesylthiosalicylic\nacid","volume":"38","author":"Marciano","year":"1995","journal-title":"J. Med. Chem."},{"key":"2026090119034217500_cit28","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.colsurfb.2009.12.007","article-title":"Fabrication\nof cationic\nnanomicelle from chitosan-graft-polycaprolactone as the carrier of\n7-ethyl-10-hydroxy-camptothecin","volume":"76","author":"Duan","year":"2010","journal-title":"Colloids Surf.,\nB"},{"key":"2026090119034217500_cit29","doi-asserted-by":"crossref","first-page":"3435","DOI":"10.1016\/j.biomaterials.2011.01.021","article-title":"The effect of surface charge on in vivo biodistribution of PEG-oligocholic acid based micellar\nnanoparticles","volume":"32","author":"Xiao","year":"2011","journal-title":"Biomaterials"},{"key":"2026090119034217500_cit30","doi-asserted-by":"crossref","first-page":"5815","DOI":"10.1016\/j.biomaterials.2009.06.057","article-title":"Amine-modified hyperbranched\npolyesters\nas non-toxic, biodegradable gene delivery systems","volume":"30","author":"Reul","year":"2009","journal-title":"Biomaterials"},{"key":"2026090119034217500_cit31","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1183\/09031936.06.00103805","article-title":"Negligble clearance of ultrafine particles retained\nin healthy and affected human lungs","volume":"28","author":"Wiebert","year":"2006","journal-title":"Eur. Respir.\nJ."},{"key":"2026090119034217500_cit32","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1093\/jnci\/djj070","article-title":"Tumor vascular\npermeability, accumulation, and penetration of macromolecular drug\ncarriers","volume":"98","author":"Dreher","year":"2006","journal-title":"J. Natl. Cancer Inst."},{"key":"2026090119034217500_cit34","doi-asserted-by":"crossref","first-page":"232","DOI":"10.3109\/09687688.2010.516276","article-title":"Multifunctionality\nof lipid core micelles for drug\ndelivery and tumor targeting","volume":"27","author":"Sawant","year":"2010","journal-title":"Mol. Membr. Biol."}],"container-title":["Molecular Pharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/mp500181x","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/mpohbp\/article-pdf\/11\/8\/2807\/14367427\/mp500181x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/mpohbp\/article-pdf\/11\/8\/2807\/14367427\/mp500181x.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T23:03:51Z","timestamp":1788303831000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/mpohbp\/article\/11\/8\/2807\/1379208\/PEG-Farnesyl-Thiosalicylic-Acid-Telodendrimer"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,2]]},"references-count":33,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2014,7,2]]},"published-print":{"date-parts":[[2014,8,4]]}},"URL":"https:\/\/doi.org\/10.1021\/mp500181x","relation":{},"ISSN":["1543-8384","1543-8392"],"issn-type":[{"value":"1543-8384","type":"print"},{"value":"1543-8392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,2]]}}}