{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T07:10:59Z","timestamp":1789715459908,"version":"4.0.1"},"reference-count":60,"publisher":"American Chemical Society (ACS)","issue":"11","license":[{"start":{"date-parts":[[2015,5,5]],"date-time":"2015-05-05T00:00:00Z","timestamp":1430784000000},"content-version":"vor","delay-in-days":365,"URL":"https:\/\/pubs.acs.org\/page\/policy\/authorchoice_termsofuse.html"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,11,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>N-(2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethyl)-6-fluoronicotinamide ([18F]FNEM), a novel prosthetic agent that is thiol-specific, was synthesized using a one-pot two-step strategy: (1) 18F incorporation by a nucleophilic displacement of trimethylammonium substrate under mild conditions; (2) amidation of the resulting 6-[18F]fluoronicotinic acid 2,3,5,6-tetrafluorophenyl ester with N-(2-aminoethyl)maleimide trifluoroacetate salt. The radiosynthesis of the maleimide tracer was completed in 75 min from [18F]fluoride with 26 \u00b1 5% decay uncorrected radiochemical yield, and specific activity of 19\u201388 GBq\/\u03bcmol (decay uncorrected). The in vitro cell uptake, in vivo biodistribution, and positron emission tomography (PET) imaging properties of its conjugation product with [Cys40]-exendin-4 were described. [18F]FNEM-Cys40-exendin-4 showed specific targeting of glucagon-like peptide 1 receptor (GLP-1R) positive insulinomas and comparable imaging results to our recently reported [18F]FPenM-Cys40-exendin-4.<\/jats:p>","DOI":"10.1021\/mp5001857","type":"journal-article","created":{"date-parts":[[2014,5,5]],"date-time":"2014-05-05T13:52:37Z","timestamp":1399297957000},"page":"3875-3884","source":"Crossref","is-referenced-by-count":31,"title":["One-Pot Two-Step Radiosynthesis of a New 18F-Labeled Thiol Reactive Prosthetic Group and Its Conjugate\nfor Insulinoma Imaging"],"prefix":"10.1021","volume":"11","author":[{"given":"Xuyi","family":"Yue","sequence":"first","affiliation":[{"name":"National Institutes of Health (NIH) , , 35A Convent Drive , , ,","place":["Bethesda, Maryland, United States, 20892"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuefeng","family":"Yan","sequence":"additional","affiliation":[{"name":"National Institutes of Health (NIH) , , 35A Convent Drive , , ,","place":["Bethesda, Maryland, United States, 20892"]},{"name":"The Fourth Hospital of Harbin Medical University , , , ,","place":["Harbin, Heilongjiang, China, 150001"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenxi","family":"Wu","sequence":"additional","affiliation":[{"name":"National Institutes of Health (NIH) , , 35A Convent Drive , , ,","place":["Bethesda, Maryland, United States, 20892"]},{"name":"Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS & PUMC) , , ,","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Niu","sequence":"additional","affiliation":[{"name":"National Institutes of Health (NIH) , , 35A Convent Drive , , ,","place":["Bethesda, Maryland, United States, 20892"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Ma","sequence":"additional","affiliation":[{"name":"National Institutes of Health (NIH) , , 35A Convent Drive , , ,","place":["Bethesda, Maryland, United States, 20892"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orit","family":"Jacobson","sequence":"additional","affiliation":[{"name":"National Institutes of Health (NIH) , , 35A Convent Drive , , ,","place":["Bethesda, Maryland, United States, 20892"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baozhong","family":"Shen","sequence":"additional","affiliation":[{"name":"The Fourth Hospital of Harbin Medical University , , , ,","place":["Harbin, Heilongjiang, China, 150001"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dale O.","family":"Kiesewetter","sequence":"additional","affiliation":[{"name":"National Institutes of Health (NIH) , , 35A Convent Drive , , ,","place":["Bethesda, Maryland, United States, 20892"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyuan","family":"Chen","sequence":"additional","affiliation":[{"name":"National Institutes of Health (NIH) , , 35A Convent Drive , , ,","place":["Bethesda, Maryland, United States, 20892"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2014,5,5]]},"reference":[{"issue":"6056","key":"2026090121195633900_cit1","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1126\/science.1212625","article-title":"A fluoride-derived\nelectrophilic late-stage fluorination reagent for PET imaging","volume":"334","author":"Lee","year":"2011","journal-title":"Science"},{"issue":"3","key":"2026090121195633900_cit2","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.apradiso.2005.03.005","article-title":"Module-assisted synthesis of the\nbifunctional labelling agent N-succinimidyl 4-[18F]fluorobenzoate\n([18F]SFB)","volume":"63","author":"Ma\u0308ding","year":"2005","journal-title":"Appl. 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