{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T16:17:00Z","timestamp":1791649020662,"version":"4.3.4"},"reference-count":51,"publisher":"American Chemical Society (ACS)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol. Pharmaceutics"],"published-print":{"date-parts":[[2014,8,4]]},"DOI":"10.1021\/mp500196f","type":"journal-article","created":{"date-parts":[[2014,7,15]],"date-time":"2014-07-15T19:42:23Z","timestamp":1405453343000},"page":"2835-2844","source":"Crossref","is-referenced-by-count":55,"title":["Effect of Surfactants, Gastric Emptying, and Dosage Form on Supersaturation of Dipyridamole in an <i>in Vitro<\/i> Model Simulating the Stomach and Duodenum"],"prefix":"10.1021","volume":"11","author":[{"given":"A.","family":"Mitra","sequence":"first","affiliation":[{"name":"Department\rof Pharmaceutical\rSciences, College of Pharmacy and Health Sciences, Butler University, Indianapolis, Indiana 46208, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. M.","family":"Fadda","sequence":"additional","affiliation":[{"name":"Department\rof Pharmaceutical\rSciences, College of Pharmacy and Health Sciences, Butler University, Indianapolis, Indiana 46208, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2014,7,15]]},"reference":[{"issue":"11","key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"4525","DOI":"10.1002\/jps.22154","volume":"99","author":"Bevernage J.","year":"2010","journal-title":"J. Pharm. Sci."},{"issue":"10","key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"2903","DOI":"10.1021\/mp300224h","volume":"9","author":"Carlert S.","year":"2012","journal-title":"Mol. Pharmaceutics"},{"issue":"1","key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.ijpharm.2008.01.049","volume":"357","author":"Mellaerts R.","year":"2008","journal-title":"Int. J. Pharm."},{"issue":"1","key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1211\/0022357022511","volume":"56","author":"Kostewicz E. S.","year":"2004","journal-title":"J. Pharm. Pharmacol."},{"issue":"12","key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"3486","DOI":"10.1007\/s11095-012-0844-z","volume":"29","author":"Psachoulias D.","year":"2012","journal-title":"Pharm. Res."},{"issue":"1","key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/jps.20242","volume":"94","author":"Gu C. H.","year":"2005","journal-title":"J. Pharm. Sci."},{"issue":"10","key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1007\/s11095-010-0213-8","volume":"27","author":"Carlert S.","year":"2010","journal-title":"Pharm. Res."},{"issue":"4","key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1111\/j.1365-2036.1992.tb00558.x","volume":"6","author":"Vatier J.","year":"1992","journal-title":"Aliment. Pharmacol. Ther."},{"issue":"1","key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1002\/jps.20495","volume":"95","author":"Carino S. R.","year":"2006","journal-title":"J. Pharm. Sci."},{"issue":"10","key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1111\/j.1365-2036.2005.02683.x","volume":"22","author":"Schiller C.","year":"2005","journal-title":"Aliment. Pharmacol. Ther."},{"issue":"12","key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1111\/j.1365-2982.2006.00830.x","volume":"18","author":"Gentilcore D.","year":"2006","journal-title":"Neurogastroenterol. Motil."},{"issue":"2","key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1113\/jphysiol.1951.sp004562","volume":"113","author":"Hunt J. N.","year":"1951","journal-title":"J. Physiol."},{"issue":"1","key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/0165-1838(83)90143-1","volume":"9","author":"McHugh P. R.","year":"1983","journal-title":"J. Auton. Nerv. Syst."},{"issue":"12","key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1136\/gut.24.12.1117","volume":"24","author":"Collins P. J.","year":"1983","journal-title":"Gut"},{"issue":"5","key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"726","DOI":"10.2967\/jnumed.108.059790","volume":"50","author":"Ziessman H. A.","year":"2009","journal-title":"J. Nucl. Med."},{"issue":"5","key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1016\/0016-5085(90)91150-5","volume":"99","author":"Oberle R. L.","year":"1990","journal-title":"Gastroenterology"},{"issue":"3","key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1093\/bja\/aer167","volume":"107","author":"Schmitz A.","year":"2011","journal-title":"Br. J. Anaesth."},{"issue":"1","key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/S0016-5085(83)80232-7","volume":"85","author":"Brener W.","year":"1983","journal-title":"Gastroenterology"},{"key":"ref19\/cit19","volume-title":"Biochemists\u2019 handbook","author":"Leach A. A.","year":"1961"},{"issue":"47","key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"2269","DOI":"10.1055\/s-0028-1110923","volume":"93","author":"Ottenjann R.","year":"1968","journal-title":"Dtsch. Med. Wochenschr."},{"issue":"2","key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0016-5085(74)80115-0","volume":"66","author":"Erlinger S.","year":"1974","journal-title":"Gastroenterology"},{"issue":"26","key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1056\/NEJM197612232952606","volume":"295","author":"Javitt N. B.","year":"1976","journal-title":"N. Engl. J. Med."},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1097\/00000658-196412000-00001","volume":"160","author":"Elmslie R. G.","year":"1964","journal-title":"Ann. Surg."},{"key":"ref24\/cit24","volume-title":"Anatomical and physiological differences between various species used in studies on the pharmacokinetics and toxicology of xenobiotics","author":"de Zwart L. L.","year":"1999"},{"issue":"2","key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.jcis.2008.05.034","volume":"325","author":"Lindfors L.","year":"2008","journal-title":"J. Colloid Interface Sci."},{"issue":"5","key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1111\/j.1600-0773.1979.tb02350.x","volume":"44","author":"Nielsen-Kudsk F.","year":"1979","journal-title":"Acta Pharmacol. Toxicol."},{"issue":"4","key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/0016-5085(82)90314-6","volume":"82","author":"Kerlin P.","year":"1982","journal-title":"Gastroenterology"},{"issue":"1","key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.ijpharm.2007.06.018","volume":"347","author":"Aburub A.","year":"2008","journal-title":"Int. J. Pharm."},{"issue":"8","key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1136\/gut.29.8.1035","volume":"29","author":"Evans D. F.","year":"1988","journal-title":"Gut"},{"key":"ref30\/cit30","volume-title":"Guidance for Industry: Bioavailability and bioequivalence studies for orally adminsitered drug products","author":"Food and Drug Administration; Centre for Drug Evaluation and Research","year":"2003"},{"key":"ref31\/cit31","first-page":"1","volume":"41","author":"Finholt P.","year":"1978","journal-title":"Medd. Nor. Farm. Selsk."},{"issue":"2","key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/BF03189322","volume":"23","author":"Efentakis M.","year":"1998","journal-title":"Eur. J. Drug Metab. Pharmacokinet."},{"issue":"7","key":"ref33\/cit33","doi-asserted-by":"crossref","first-page":"2303","DOI":"10.1021\/ma00111a026","volume":"28","author":"Kabanov A. V.","year":"1995","journal-title":"Macromolecules"},{"issue":"1","key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1002\/jps.2600630136","volume":"63","author":"Wan L. S.","year":"1974","journal-title":"J. Pharm. Sci."},{"key":"ref35\/cit35","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/0049-3848(83)90364-X","volume":"4","author":"Bjornsson T. D.","year":"1983","journal-title":"Thromb. Res. Suppl."},{"issue":"1","key":"ref36\/cit36","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1023\/A:1018918316253","volume":"11","author":"Russell T. L.","year":"1994","journal-title":"Pharm. Res."},{"issue":"5","key":"ref37\/cit37","doi-asserted-by":"crossref","first-page":"383","DOI":"10.2133\/dmpk.DMPK-12-RG-139","volume":"28","author":"Taniguchi C.","year":"2013","journal-title":"Drug Metab. Pharmacokinet."},{"issue":"6","key":"ref38\/cit38","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1007\/s11095-006-0207-8","volume":"23","author":"Kalantzi L.","year":"2006","journal-title":"Pharm. Res."},{"issue":"8","key":"ref39\/cit39","doi-asserted-by":"crossref","first-page":"2823","DOI":"10.1021\/mp300576u","volume":"10","author":"Warren D. B.","year":"2013","journal-title":"Mol. Pharmaceutics"},{"issue":"2","key":"ref40\/cit40","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1021\/mp100377m","volume":"8","author":"Bevernage J.","year":"2011","journal-title":"Mol. Pharmaceutics"},{"issue":"10","key":"ref41\/cit41","doi-asserted-by":"crossref","first-page":"704","DOI":"10.3109\/1061186X.2010.525652","volume":"18","author":"Warren D. B.","year":"2010","journal-title":"J. Drug Targeting"},{"issue":"1","key":"ref42\/cit42","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s11095-007-9417-y","volume":"25","author":"Overhoff K. A.","year":"2008","journal-title":"Pharm. Res."},{"issue":"10","key":"ref43\/cit43","doi-asserted-by":"crossref","first-page":"2686","DOI":"10.1002\/jps.20906","volume":"96","author":"Guzman H. R.","year":"2007","journal-title":"J. Pharm. Sci."},{"issue":"11","key":"ref44\/cit44","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1081\/DDC-100100985","volume":"26","author":"Chutimaworapan S.","year":"2000","journal-title":"Drug Dev. Ind. Pharm."},{"issue":"12","key":"ref45\/cit45","doi-asserted-by":"crossref","first-page":"3145","DOI":"10.1007\/s11095-011-0506-6","volume":"28","author":"Psachoulias D.","year":"2011","journal-title":"Pharm. Res."},{"issue":"11","key":"ref46\/cit46","doi-asserted-by":"crossref","first-page":"2346","DOI":"10.1039\/c0nr00628a","volume":"2","author":"Vekilov P. G.","year":"2010","journal-title":"Nanoscale"},{"issue":"11","key":"ref47\/cit47","doi-asserted-by":"crossref","first-page":"2957","DOI":"10.1002\/jps.20886","volume":"96","author":"Dai W. G.","year":"2007","journal-title":"J. Pharm. Sci."},{"issue":"2","key":"ref48\/cit48","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.ejps.2008.02.007","volume":"34","author":"Brewster M. E.","year":"2008","journal-title":"Eur. J. Pharm. Sci."},{"issue":"4","key":"ref49\/cit49","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.colsurfb.2004.09.005","volume":"39","author":"Terayama H.","year":"2004","journal-title":"Colloids Surf., B"},{"issue":"8","key":"ref50\/cit50","doi-asserted-by":"crossref","first-page":"2549","DOI":"10.1002\/jps.21650","volume":"98","author":"Brouwers J.","year":"2009","journal-title":"J. Pharm. Sci."},{"key":"ref51\/cit51","unstructured":"Boehringer Ingelheim, Summary of product characteristcs for Persantin tablets. 2012."}],"container-title":["Molecular Pharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/mp500196f","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,15]],"date-time":"2023-04-15T11:50:54Z","timestamp":1681559454000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/mp500196f"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,15]]},"references-count":51,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2014,8,4]]}},"alternative-id":["10.1021\/mp500196f"],"URL":"https:\/\/doi.org\/10.1021\/mp500196f","relation":{},"ISSN":["1543-8384","1543-8392"],"issn-type":[{"value":"1543-8384","type":"print"},{"value":"1543-8392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,15]]}}}