{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T09:55:36Z","timestamp":1788515736240,"version":"build-2803163510"},"reference-count":61,"publisher":"American Chemical Society (ACS)","issue":"5","funder":[{"DOI":"10.13039\/100001797","name":"Pharmaceutical Research and Manufacturers of America Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001797","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["GM061390"],"award-info":[{"award-number":["GM061390"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["GM113597"],"award-info":[{"award-number":["GM113597"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol. Pharmaceutics"],"published-print":{"date-parts":[[2015,5,4]]},"DOI":"10.1021\/mp500783g","type":"journal-article","created":{"date-parts":[[2015,3,29]],"date-time":"2015-03-29T14:08:03Z","timestamp":1427638083000},"page":"1456-1466","source":"Crossref","is-referenced-by-count":23,"title":["Predicting the Extent of Metabolism Using<i>in Vitro<\/i>Permeability Rate Measurements and<i>in Silico<\/i>Permeability Rate Predictions"],"prefix":"10.1021","volume":"12","author":[{"given":"Chelsea M.","family":"Hosey","sequence":"first","affiliation":[{"name":"Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, California 94143, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie Z.","family":"Benet","sequence":"additional","affiliation":[{"name":"Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, California 94143, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2015,4,23]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1023\/A:1016212804288","volume":"12","author":"Amidon G. L.","year":"1995","journal-title":"Pharm. Res."},{"key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s11095-004-9004-4","volume":"22","author":"Wu C.-Y.","year":"2005","journal-title":"Pharm. Res."},{"key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1007\/s11095-011-0438-1","volume":"28","author":"Chen M.-L.","year":"2011","journal-title":"Pharm. Res."},{"key":"ref4\/cit4","unstructured":"Food and Drug Administration Center for Drug Evaluation and Research. Guidance for Industry:Waiver of In Vivo Bioavailability and Bioequivalence Studies for Immediate-ReleaseSolid Oral Dosage Forms based on a Biopharmaceutics ClassificationSystem. http:\/\/www.fda.gov\/downloads\/Drugs\/Guidances\/ucm070246.pdf(accessed July 28, 2014) ."},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1021\/mp2004912","volume":"9","author":"Varma M. V.","year":"2012","journal-title":"Mol. Pharmaceutics"},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1002\/jps.21010","volume":"97","author":"Volpe D. A.","year":"2007","journal-title":"J. Pharm. Sci."},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1021\/mp300140h","volume":"9","author":"Dahan A.","year":"2012","journal-title":"Mol. Pharmaceutics"},{"key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1021\/mp500152y","volume":"11","author":"Zur M.","year":"2014","journal-title":"Mol. Pharmaceutics"},{"key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1021\/mp4007858","volume":"11","author":"Larregieu C. A.","year":"2014","journal-title":"Mol. Pharmaceutics"},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1208\/s12248-013-9456-8","volume":"15","author":"Larregieu C. A.","year":"2013","journal-title":"AAPS J."},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1208\/s12248-014-9636-1","volume":"16","author":"Hosey C. M.","year":"2014","journal-title":"AAPS J."},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1208\/s12248-009-9124-1","volume":"11","author":"Yang X.","year":"2009","journal-title":"AAPS J."},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1208\/s12248-011-9290-9","volume":"13","author":"Benet L. Z.","year":"2011","journal-title":"AAPS J."},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1023\/A:1011930411574","volume":"15","author":"Yazdanian M.","year":"1998","journal-title":"Pharm. Res."},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1021\/jm001101a","volume":"44","author":"Stenberg P.","year":"2001","journal-title":"J. Med. Chem."},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"3246","DOI":"10.1002\/jps.22080","volume":"99","author":"Skolnik S.","year":"2010","journal-title":"J. Pharm. Sci."},{"key":"ref17\/cit17","first-page":"317","volume":"6","author":"Camenisch G.","year":"1998","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0928-0987(00)00076-2","volume":"10","author":"Yamashita S.","year":"2000","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1023\/A:1016045820933","volume":"13","author":"Chong S.","year":"1996","journal-title":"Pharm. Res."},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1023\/A:1012102522787","volume":"14","author":"Yee S.","year":"1997","journal-title":"Pharm. Res."},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1021\/js9803205","volume":"88","author":"Irvine J. D.","year":"1999","journal-title":"J. Pharm. Sci."},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1080\/10601330701273669","volume":"24","author":"Volpe D. A.","year":"2007","journal-title":"Clin. Res. Regul. Aff."},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"3756","DOI":"10.1016\/j.bmc.2007.03.040","volume":"15","author":"Fujikawa M.","year":"2007","journal-title":"Bioorg. Med. Chem."},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1208\/s12248-010-9176-2","volume":"12","author":"Teksin Z. S.","year":"2010","journal-title":"AAPS J."},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1007\/978-0-387-74901-3_18","volume-title":"Drug Absorption Studies: In Situ, In Vitro and In Silico Models","author":"Li C.","year":"2008"},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1111\/j.1745-7254.2005.00166.x","volume":"26","author":"Chen L.-L.","year":"2005","journal-title":"Acta Pharmacol. Sin."},{"key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.ijpharm.2004.10.007","volume":"288","author":"Wang Q.","year":"2005","journal-title":"Int. J. Pharm."},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1021\/mp800122b","volume":"6","author":"Thiel-Demby V. E.","year":"2009","journal-title":"Mol. Pharmaceutics"},{"key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/S0223-5234(02)01360-0","volume":"37","author":"Zhu C.","year":"2002","journal-title":"Eur. J. Med. Chem."},{"key":"ref30\/cit30","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1007\/s11095-007-9517-8","volume":"25","author":"Chen X.","year":"2008","journal-title":"Pharm. Res."},{"key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0378-5173(02)00240-5","volume":"241","author":"Sugano K.","year":"2002","journal-title":"Int. J. Pharm."},{"key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0166-1280(99)00360-7","volume":"503","author":"Cruciani C.","year":"2000","journal-title":"J. Mol. Struct.: THEOCHEM"},{"key":"ref33\/cit33","doi-asserted-by":"crossref","first-page":"2204","DOI":"10.1021\/jm990968+","volume":"43","author":"Crivori P.","year":"2000","journal-title":"J. Med. Chem."},{"key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.1021\/mp4000585","volume":"10","author":"Pham-The H.","year":"2013","journal-title":"Mol. Pharmaceutics"},{"key":"ref35\/cit35","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1002\/jps.23359","volume":"102","author":"Benet L. Z.","year":"2012","journal-title":"J. Pharm. Sci."},{"key":"ref36\/cit36","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/S0022-3565(24)36865-X","volume":"282","author":"Proost J. H.","year":"1997","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref37\/cit37","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1124\/dmd.112.044628","volume":"40","author":"Varma M. V. S.","year":"2012","journal-title":"Drug Metab. Dispos."},{"key":"ref38\/cit38","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1208\/s12248-013-9541-z","volume":"16","author":"Sharifi M.","year":"2013","journal-title":"AAPS J."},{"key":"ref39\/cit39","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1023\/A:1008192010023","volume":"15","author":"van de Waterbeemd H.","year":"2001","journal-title":"J. Comput.-Aided Mol. Des."},{"key":"ref40\/cit40","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1021\/jm901371v","volume":"53","author":"Varma M. V. S.","year":"2010","journal-title":"J. Med. Chem."},{"key":"ref41\/cit41","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1124\/dmd.108.020479","volume":"36","author":"Obach R. S.","year":"2008","journal-title":"Drug Metab. Dispos."},{"key":"ref42\/cit42","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1046\/j.1440-1681.2003.03923.x","volume":"30","author":"Smith P. A.","year":"2003","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"ref43\/cit43","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1080\/03602530500205135","volume":"37","author":"Cribb A. E.","year":"2005","journal-title":"Drug Metab. Rev."},{"key":"ref44\/cit44","doi-asserted-by":"crossref","first-page":"e1002083","DOI":"10.1371\/journal.pcbi.1002083","volume":"7","author":"Dolghih E.","year":"2011","journal-title":"PLoS Comput. Biol."},{"key":"ref45\/cit45","unstructured":"Cycloset [Product Insert];Santaurus, Inc.:San Diego, CA, 2010."},{"key":"ref46\/cit46","doi-asserted-by":"crossref","first-page":"155","DOI":"10.2165\/00003088-199834020-00003","volume":"34","author":"Miller D. B.","year":"1998","journal-title":"Clin. Pharmacokinet."},{"key":"ref47\/cit47","volume-title":"Sandimmune [Product Insert]","year":"2013"},{"key":"ref48\/cit48","volume-title":"Vasotec Tablets (Enalapril) [Product Insert]","year":"2011"},{"key":"ref49\/cit49","volume-title":"Invirase [Product Insert]","year":"2004"},{"key":"ref50\/cit50","volume-title":"Azulfidine EN-tabs [Product Insert]","year":"2014"},{"key":"ref51\/cit51","volume-title":"Capoten [Product Insert]","year":"1981"},{"key":"ref52\/cit52","volume-title":"Cephalexin Capsule [Product Insert]","year":"1977"},{"key":"ref53\/cit53","volume-title":"Cipro [Product Insert]","year":"2014"},{"key":"ref54\/cit54","volume-title":"Captapres-TTS [Product Insert]","year":"2012"},{"key":"ref55\/cit55","volume-title":"Norpace [Product Insert]","year":"2006"},{"key":"ref56\/cit56","volume-title":"Flecainide Acetate Tablet [Product Insert]","year":"2013"},{"key":"ref57\/cit57","doi-asserted-by":"crossref","first-page":"523","DOI":"10.2165\/00003088-198308060-00003","volume":"8","author":"Bateman D. N.","year":"1983","journal-title":"Clin Pharmacokinet"},{"key":"ref58\/cit58","volume-title":"Phenazopyridine HCl [Product Insert]","year":"2010"},{"key":"ref59\/cit59","volume-title":"Pindolol Tablet [Product Insert]","year":"2010"},{"key":"ref60\/cit60","volume-title":"Pronestyl SR [Product Insert]","year":"2000"},{"key":"ref61\/cit61","unstructured":"Lexicomp Online.http:\/\/www.crlonline.com\/lco\/action\/doc\/retrieve\/docid\/patch_f\/7826(accessed Oct 15, 2014) ."}],"container-title":["Molecular Pharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/mp500783g","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T18:51:34Z","timestamp":1747853494000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/mp500783g"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,23]]},"references-count":61,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,5,4]]}},"alternative-id":["10.1021\/mp500783g"],"URL":"https:\/\/doi.org\/10.1021\/mp500783g","relation":{},"ISSN":["1543-8384","1543-8392"],"issn-type":[{"value":"1543-8384","type":"print"},{"value":"1543-8392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,23]]}}}