{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T05:00:59Z","timestamp":1792299659614,"version":"4.4.0"},"reference-count":50,"publisher":"American Chemical Society (ACS)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol. Pharmaceutics"],"published-print":{"date-parts":[[2008,4,1]]},"DOI":"10.1021\/mp7001285","type":"journal-article","created":{"date-parts":[[2008,1,25]],"date-time":"2008-01-25T01:00:47Z","timestamp":1201222847000},"page":"316-327","source":"Crossref","is-referenced-by-count":613,"title":["Biodistribution, Clearance, and Biocompatibility of Iron Oxide Magnetic Nanoparticles in Rats"],"prefix":"10.1021","volume":"5","author":[{"given":"Tapan K.","family":"Jain","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, Department of Physics & Astronomy and Nebraska Center for Materials and Nanoscience, University of Nebraska\u2212Lincoln, Lincoln, Nebraska 68588-0111, and Department of Pharmaceutical Sciences, College of Pharmacy, Nebraska Medical Center, Omaha, Nebraska 68198-6025"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maram K.","family":"Reddy","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, Department of Physics & Astronomy and Nebraska Center for Materials and Nanoscience, University of Nebraska\u2212Lincoln, Lincoln, Nebraska 68588-0111, and Department of Pharmaceutical Sciences, College of Pharmacy, Nebraska Medical Center, Omaha, Nebraska 68198-6025"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco A.","family":"Morales","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, Department of Physics & Astronomy and Nebraska Center for Materials and Nanoscience, University of Nebraska\u2212Lincoln, Lincoln, Nebraska 68588-0111, and Department of Pharmaceutical Sciences, College of Pharmacy, Nebraska Medical Center, Omaha, Nebraska 68198-6025"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diandra L.","family":"Leslie-Pelecky","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, Department of Physics & Astronomy and Nebraska Center for Materials and Nanoscience, University of Nebraska\u2212Lincoln, Lincoln, Nebraska 68588-0111, and Department of Pharmaceutical Sciences, College of Pharmacy, Nebraska Medical Center, Omaha, Nebraska 68198-6025"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinod","family":"Labhasetwar","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, Department of Physics & Astronomy and Nebraska Center for Materials and Nanoscience, University of Nebraska\u2212Lincoln, Lincoln, Nebraska 68588-0111, and Department of Pharmaceutical Sciences, College of Pharmacy, Nebraska Medical Center, Omaha, Nebraska 68198-6025"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2008,1,25]]},"reference":[{"key":"ref1\/cit1","first-page":"6641","volume":"60","author":"Alexiou C.","year":"2000","journal-title":"Cancer Res."},{"key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"139","DOI":"10.3109\/1061186031000150791","volume":"11","author":"Alexiou C.","year":"2003","journal-title":"J. Drug Target."},{"key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/s00432-006-0076-x","volume":"132","author":"Clement J. H.","year":"2006","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1002\/jcb.10660","volume":"90","author":"Artemov D.","year":"2003","journal-title":"J. Cell. Biochem."},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/0730-725X(95)00024-B","volume":"13","author":"Jung C. W.","year":"1995","journal-title":"Magn. Reson. Imaging"},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1111\/j.1349-7006.2003.tb01438.x","volume":"94","author":"Ito A.","year":"2003","journal-title":"Cancer Sci."},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1021\/mp0500014","volume":"2","author":"Jain T. K.","year":"2005","journal-title":"Mol. Pharm."},{"key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"425","DOI":"10.2174\/187152007781058613","volume":"7","author":"Koning G. A.","year":"2007","journal-title":"Anticancer Agents Med. Chem."},{"key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S1368-7646(03)00026-8","volume":"6","author":"Broxterman H. J.","year":"2003","journal-title":"Drug Resist. Updat."},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"S79","DOI":"10.1007\/s002800051067","volume":"40","author":"Bezwoda W. R.","year":"1997","journal-title":"Cancer Chemother. Pharmacol."},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1148\/radiol.2281020638","volume":"228","author":"Frank J. A.","year":"2003","journal-title":"Radiology"},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"23","DOI":"10.2217\/17435889.2.1.23","volume":"2","author":"Gupta A. K.","year":"2007","journal-title":"Nanomed."},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/73219","volume":"6","author":"Weissleder R.","year":"2000","journal-title":"Nat. Med."},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"245","DOI":"10.3109\/02652049609026013","volume":"13","author":"Chouly C.","year":"1996","journal-title":"J. Microencapsul."},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.ijpharm.2005.10.010","volume":"307","author":"Owens D. E.","year":"2006","journal-title":"Int. J. Pharm."},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"3995","DOI":"10.1016\/j.biomaterials.2004.10.012","volume":"26","author":"Gupta A. K.","year":"2005","journal-title":"Biomaterials"},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1002\/cbf.290020402","volume":"2","author":"Weir M. P.","year":"1984","journal-title":"Cell Biochem. Funct."},{"key":"ref18\/cit18","unstructured":"Jeffery, G. H.; Bassett, J.; Mendham, J.; Denny, R. C.Vogel\u2019s Text Book of Quantitative Chemical Analysis,5th ed.;John Wiley & Sons, Inc.:New York,1989; pp690\u2212692."},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0378-5173(01)00923-1","volume":"233","author":"Davda J.","year":"2002","journal-title":"Int. J. Pharm."},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"6894","DOI":"10.1063\/1.356773","volume":"75","author":"Stearns M. B.","year":"1994","journal-title":"J. Appl. Phys."},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"2494","DOI":"10.1109\/20.92152","volume":"24","author":"Noyau R. H.","year":"1988","journal-title":"IEEE Trans. Magn."},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0891-5849(95)02224-4","volume":"21","author":"Mihaljevic B.","year":"1996","journal-title":"Free Radic. Biol. Med."},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/S1369-7021(05)00893-X","volume":"8","author":"LaConte L.","year":"2005","journal-title":"Mater. Today"},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1111\/j.1753-4887.1996.tb03876.x","volume":"54","author":"McCord J. M.","year":"1996","journal-title":"Nutr. Rev."},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1097\/01.rli.0000197669.80475.dd","volume":"41","author":"Bourrinet P.","year":"2006","journal-title":"Invest. Radiol."},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"167","DOI":"10.2214\/ajr.152.1.167","volume":"152","author":"Weissleder R.","year":"1989","journal-title":"Am. J. Roentgenol."},{"key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.jmmm.2005.01.064","volume":"293","author":"Neuberger T.","year":"2005","journal-title":"J. Magn. Magn. Mater."},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/s00441-004-0884-8","volume":"316","author":"Briley-Saebo K.","year":"2004","journal-title":"Cell Tissue Res."},{"key":"ref29\/cit29","first-page":"895","volume":"71","author":"Okon E.","year":"1994","journal-title":"Lab. Invest."},{"key":"ref30\/cit30","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/0142-9612(93)90004-L","volume":"14","author":"Tan J. S.","year":"1993","journal-title":"Biomaterials"},{"key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S0163-7827(03)00033-X","volume":"42","author":"Moghimi S. M.","year":"2003","journal-title":"Prog. Lipid Res."},{"key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1016\/j.addr.2006.09.013","volume":"58","author":"Corot C.","year":"2006","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref33\/cit33","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1097\/00004424-199510000-00006","volume":"30","author":"Schulze E.","year":"1995","journal-title":"Invest. Radiol."},{"key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"H1149","DOI":"10.1152\/ajpheart.1996.270.4.H1149","volume":"270","author":"Descamps L.","year":"1996","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref35\/cit35","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1007\/s11064-007-9290-4","volume":"32","author":"Gaasch J. A.","year":"2007","journal-title":"Neurochem. Res."},{"key":"ref36\/cit36","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1093\/toxsci\/kfj027","volume":"89","author":"Kim J. S.","year":"2006","journal-title":"Toxicol. Sci."},{"key":"ref37\/cit37","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.bbadis.2007.02.006","volume":"1772","author":"Qian Z. M.","year":"2007","journal-title":"Biochim. Biophys. Acta"},{"key":"ref38\/cit38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0047-6374(98)00005-0","volume":"102","author":"Cook C. I.","year":"1998","journal-title":"Mech. Ageing Dev."},{"key":"ref39\/cit39","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/0730-725X(95)02106-4","volume":"14","author":"Tiefenauer L. X.","year":"1996","journal-title":"Magn. Reson. Imaging"},{"key":"ref40\/cit40","first-page":"63","volume":"52","author":"Thompson J. S.","year":"2002","journal-title":"Comp. Med."},{"key":"ref41\/cit41","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1002\/jgm.868","volume":"8","author":"Jiang X.","year":"2006","journal-title":"J. Gene Med."},{"key":"ref42\/cit42","first-page":"1777","volume-title":"Tietz textbook of clinical chemistry and molecular diagnostics","author":"Dufour D. R.","year":"2006","edition":"4"},{"key":"ref43\/cit43","volume-title":"Guide to the Care and Use of Experimental Animals","author":"Olfert E. D.","year":"1993","edition":"2"},{"key":"ref44\/cit44","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.mam.2005.07.001","volume":"26","author":"Puntarulo S.","year":"2005","journal-title":"Mol. Aspects Med."},{"key":"ref45\/cit45","doi-asserted-by":"crossref","first-page":"R283","DOI":"10.1152\/ajpregu.00446.2002","volume":"286","author":"Mehta S. H.","year":"2004","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref46\/cit46","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1021\/tx00032a001","volume":"6","author":"Minotti G.","year":"1993","journal-title":"Chem. Res. Toxicol."},{"key":"ref47\/cit47","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/j.freeradbiomed.2004.01.016","volume":"36","author":"Stroh A.","year":"2004","journal-title":"Free Radic. Biol. Med."},{"key":"ref48\/cit48","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/S0142-9612(96)00178-0","volume":"18","author":"Fernandez-Urrusuno R.","year":"1997","journal-title":"Biomaterials"},{"key":"ref49\/cit49","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1002\/hep.1840060128","volume":"6","author":"Anthony S.","year":"1986","journal-title":"Hepatology"},{"key":"ref50\/cit50","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1002\/hep.1840060106","volume":"6","author":"Bassett M. L.","year":"1986","journal-title":"Hepatology"}],"container-title":["Molecular Pharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/mp7001285","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,6]],"date-time":"2023-03-06T19:50:46Z","timestamp":1678132246000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/mp7001285"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,1,25]]},"references-count":50,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,4,1]]}},"alternative-id":["10.1021\/mp7001285"],"URL":"https:\/\/doi.org\/10.1021\/mp7001285","relation":{},"ISSN":["1543-8384","1543-8392"],"issn-type":[{"value":"1543-8384","type":"print"},{"value":"1543-8392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,1,25]]}}}