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Cell Sci."},{"key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1042\/bj3540047","volume":"354","author":"Riemann D.","year":"2001","journal-title":"Biochem. J."},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"2731","DOI":"10.1083\/jcb.109.6.2731","volume":"109","author":"West M. A.","year":"1989","journal-title":"J. Cell Biol."},{"key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1242\/jcs.102.4.867","volume":"102","author":"Racoosin E. L.","year":"1992","journal-title":"J. Cell Sci."},{"key":"ref30\/cit30","doi-asserted-by":"crossref","first-page":"3453","DOI":"10.1091\/mbc.11.10.3453","volume":"11","author":"Amyere M.","year":"2000","journal-title":"Mol. Biol. Cell"},{"key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1242\/jcs.00235","volume":"116","author":"Araki N.","year":"2003","journal-title":"J. Cell Sci."},{"key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1126\/science.6681676","volume":"219","author":"Spector I.","year":"1983","journal-title":"Science"},{"key":"ref33\/cit33","doi-asserted-by":"crossref","first-page":"6070","DOI":"10.1016\/S0021-9258(18)83314-2","volume":"264","author":"King W. G.","year":"1989","journal-title":"J. Biol. Chem."},{"key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1002\/(SICI)1097-0029(19991001)47:1<67::AID-JEMT7>3.0.CO;2-P","volume":"47","author":"Defilippi P.","year":"1999","journal-title":"Microsc. Res. Tech."},{"key":"ref35\/cit35","doi-asserted-by":"crossref","first-page":"29697","DOI":"10.1016\/S0021-9258(18)43936-1","volume":"269","author":"Oliver J. M.","year":"1994","journal-title":"J. Biol. Chem."},{"key":"ref36\/cit36","doi-asserted-by":"crossref","first-page":"5241","DOI":"10.1016\/S0021-9258(17)37680-9","volume":"269","author":"Vlahos C. 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Chem."},{"key":"ref42\/cit42","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/nrm2447","volume":"9","author":"Swanson J. A.","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref43\/cit43","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1189\/jlb.0106019","volume":"80","author":"Huang Z.-Y.","year":"2006","journal-title":"J. Leukocyte Biol."},{"key":"ref44\/cit44","doi-asserted-by":"crossref","first-page":"2118","DOI":"10.1074\/jbc.M210828200","volume":"278","author":"Haynes M. P.","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref45\/cit45","doi-asserted-by":"crossref","first-page":"32662","DOI":"10.1074\/jbc.274.46.32662","volume":"274","author":"Beitz L. O.","year":"1999","journal-title":"J. Biol. Chem."},{"key":"ref46\/cit46","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1083\/jcb.135.5.1249","volume":"135","author":"Araki N.","year":"1996","journal-title":"J. Cell Biol."},{"key":"ref47\/cit47","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1126\/science.282.5394.1717","volume":"282","author":"Caron E.","year":"1998","journal-title":"Science"},{"key":"ref48\/cit48","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1016\/S0960-9822(02)01069-2","volume":"12","author":"Olazabal I. M.","year":"2002","journal-title":"Curr. Biol."},{"key":"ref49\/cit49","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.yexcr.2005.09.012","volume":"312","author":"Orlando K. A.","year":"2006","journal-title":"Exp. Cell Res."},{"key":"ref50\/cit50","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/S0960-9822(00)00595-9","volume":"10","author":"West M. A.","year":"2000","journal-title":"Curr. Biol."},{"key":"ref51\/cit51","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1006\/bbrc.1998.8521","volume":"245","author":"Takagi T.","year":"1998","journal-title":"Biochem. Biophys. Res. 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