{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T18:31:31Z","timestamp":1791916291009,"version":"4.3.4"},"reference-count":45,"publisher":"American Chemical Society (ACS)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Nano"],"published-print":{"date-parts":[[2012,6,26]]},"DOI":"10.1021\/nn301630n","type":"journal-article","created":{"date-parts":[[2012,6,6]],"date-time":"2012-06-06T13:49:23Z","timestamp":1338990563000},"page":"5648-5658","source":"Crossref","is-referenced-by-count":196,"title":["The Effect of Nanoparticle Polyethylene Glycol Surface Density on Ligand-Directed Tumor Targeting Studied<i>in Vivo<\/i>by Dual Modality Imaging"],"prefix":"10.1021","volume":"6","author":[{"given":"Sjoerd","family":"Hak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Helgesen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helga H.","family":"Hektoen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Else Marie","family":"Huuse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter A.","family":"Jarzyna","sequence":"additional","affiliation":[{"name":"Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, New York, New York, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willem J.M.","family":"Mulder","sequence":"additional","affiliation":[{"name":"Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, New York, New York, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olav","family":"Haraldseth","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging, St. Olav\u2019s University Hospital, Trondheim, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catharina de Lange","family":"Davies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2012,6,6]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1038\/nbt1006-1211","volume":"24","author":"Wagner V.","year":"2006","journal-title":"Nat. Biotechnol."},{"issue":"2","key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"S103","DOI":"10.1038\/ncpcardio1242","volume":"5","author":"Mulder W. J.","year":"2008","journal-title":"Nat. Clin. Pract. Cardiovasc. Med."},{"key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1002\/wnan.72","volume":"2","author":"Jarzyna P. A.","year":"2010","journal-title":"Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol."},{"key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1016\/j.addr.2006.09.009","volume":"58","author":"Torchilin V. P.","year":"2006","journal-title":"Adv. Drug Delivery Rev."},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"2877","DOI":"10.1021\/ac103261y","volume":"83","author":"Ali Z.","year":"2011","journal-title":"Anal. Chem."},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0168-3659(03)00240-2","volume":"91","author":"Schiffelers R. M.","year":"2003","journal-title":"J. Controlled Release"},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1517\/17425247.3.3.311","volume":"3","author":"Farokhzad O. C.","year":"2006","journal-title":"Expert Opin. Drug Delivery"},{"key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.ejrad.2009.01.042","volume":"70","author":"Pan D.","year":"2009","journal-title":"Eur. J. Radiol."},{"key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.biotechadv.2010.10.003","volume":"29","author":"Dias A. M.","year":"2011","journal-title":"Biotechnol. Adv."},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1021\/bc0340363","volume":"14","author":"Metselaar J. M.","year":"2003","journal-title":"Bioconjugate Chem."},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"3113","DOI":"10.1002\/smll.201100608","volume":"7","author":"Zhang F.","year":"2011","journal-title":"Small"},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/0005-2736(91)90385-L","volume":"1062","author":"Klibanov A. L.","year":"1991","journal-title":"Biochim. Biophys. Acta"},{"key":"ref13\/cit13","first-page":"5","volume":"57","author":"Bhadra D.","year":"2002","journal-title":"Pharmazie"},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1517\/17425247.5.4.371","volume":"5","author":"Ryan S. M.","year":"2008","journal-title":"Expert Opin. Drug Delivery"},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1166\/jbn.2008.021","volume":"4","author":"Howard M. D.","year":"2008","journal-title":"J. Biomed. Nanotechnol."},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.ejps.2005.08.002","volume":"27","author":"Fang C.","year":"2006","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1007\/s10856-009-3746-9","volume":"20","author":"Sheng Y.","year":"2009","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.ijpharm.2011.02.039","volume":"411","author":"Essa S.","year":"2011","journal-title":"Int. J. Pharm."},{"key":"ref19\/cit19","first-page":"3","volume-title":"Handbook of Experimental Pharmacology","author":"Torchilin V. P.","year":"2010"},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.colsurfb.2007.05.006","volume":"59","author":"Georgiev G. A.","year":"2007","journal-title":"Colloids Surf. B"},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"6947","DOI":"10.1016\/j.biomaterials.2009.09.004","volume":"30","author":"Jarzyna P. A.","year":"2009","journal-title":"Biomaterials"},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1007\/s10555-008-9158-3","volume":"27","author":"Beer A. J.","year":"2008","journal-title":"Cancer Metastasis Rev."},{"key":"ref23\/cit23","first-page":"1475","volume":"27","author":"Tufto I.","year":"2007","journal-title":"Anticancer Res."},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s10456-010-9176-y","volume":"13","author":"Hak S.","year":"2010","journal-title":"Angiogenesis"},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"2476","DOI":"10.1002\/jps.20150","volume":"93","author":"Ashok B.","year":"2004","journal-title":"J. Pharm. Sci."},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1042\/bj20031253","volume":"377","author":"Rejman J.","year":"2004","journal-title":"Biochem. J."},{"key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1016\/S0006-3495(92)81897-0","volume":"61","author":"Woodle M. C.","year":"1992","journal-title":"Biophys. J."},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1002\/jgm.382","volume":"5","author":"Kunath K.","year":"2003","journal-title":"J. Gene. Med."},{"key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1126\/science.7512751","volume":"264","author":"Brooks P. C.","year":"1994","journal-title":"Science"},{"key":"ref30\/cit30","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0001-8686(87)85003-0","volume":"27","author":"Gennes P. A.","year":"1987","journal-title":"Adv. Colloid Interface Sci."},{"key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1021\/bi962148u","volume":"36","author":"Kirpotin D.","year":"1997","journal-title":"Biochemistry"},{"key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"3839","DOI":"10.1016\/S0006-3495(03)74798-5","volume":"85","author":"Johnsson M.","year":"2003","journal-title":"Biophys. J."},{"key":"ref33\/cit33","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.tcb.2008.03.004","volume":"18","author":"Caswell P.","year":"2008","journal-title":"Trends Cell. Biol."},{"key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/nrm2122","volume":"8","author":"Parton R. G.","year":"2007","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"key":"ref35\/cit35","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1021\/bc0700133","volume":"18","author":"Oba M.","year":"2007","journal-title":"Bioconjugate Chem."},{"key":"ref36\/cit36","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1021\/mp800070s","volume":"5","author":"Oba M.","year":"2008","journal-title":"Mol. Pharm."},{"key":"ref37\/cit37","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1111\/j.1600-0854.2005.00362.x","volume":"7","author":"Caswell P. T.","year":"2006","journal-title":"Traffic"},{"key":"ref38\/cit38","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1034\/j.1600-0854.2002.30501.x","volume":"3","author":"Pelkmans L.","year":"2002","journal-title":"Traffic"},{"key":"ref39\/cit39","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/S1286-4579(01)01423-X","volume":"3","author":"Shin J. S.","year":"2001","journal-title":"Microbes Infect."},{"key":"ref40\/cit40","doi-asserted-by":"crossref","first-page":"4422","DOI":"10.1021\/nn103336a","volume":"5","author":"Gianella A.","year":"2011","journal-title":"ACS Nano"},{"key":"ref41\/cit41","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1096\/fj.05-4145fje","volume":"19","author":"Mulder W. J.","year":"2005","journal-title":"FASEB J."},{"key":"ref42\/cit42","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.2967\/jnumed.107.043216","volume":"48","author":"Cai W.","year":"2007","journal-title":"J. Nucl. Med."},{"key":"ref43\/cit43","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1002\/cmmi.361","volume":"5","author":"Oostendorp M.","year":"2010","journal-title":"Contrast Media Mol. Imaging"},{"key":"ref44\/cit44","doi-asserted-by":"crossref","first-page":"263","DOI":"10.7150\/thno\/v01p0263","volume":"1","author":"Kessinger C. W.","year":"2011","journal-title":"Theranostics"},{"key":"ref45\/cit45","first-page":"3557","volume":"28","author":"Erikson A.","year":"2008","journal-title":"Anticancer Res."}],"container-title":["ACS Nano"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/nn301630n","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T00:45:01Z","timestamp":1714005901000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/nn301630n"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6,6]]},"references-count":45,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,6,26]]}},"alternative-id":["10.1021\/nn301630n"],"URL":"https:\/\/doi.org\/10.1021\/nn301630n","relation":{},"ISSN":["1936-0851","1936-086X"],"issn-type":[{"value":"1936-0851","type":"print"},{"value":"1936-086X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,6,6]]}}}