{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T08:30:43Z","timestamp":1793262643282,"version":"4.5.0"},"reference-count":383,"publisher":"American Chemical Society (ACS)","issue":"5","license":[{"start":{"date-parts":[[2015,4,30]],"date-time":"2015-04-30T00:00:00Z","timestamp":1430352000000},"content-version":"vor","delay-in-days":365,"URL":"https:\/\/pubs.acs.org\/page\/policy\/authorchoice_termsofuse.html"}],"funder":[{"DOI":"10.13039\/501100001677","name":"National institute of Health and Medical Research","doi-asserted-by":"publisher","award":["HL087036"],"award-info":[{"award-number":["HL087036"]}],"id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001677","name":"National institute of Health and Medical Research","doi-asserted-by":"publisher","award":["HL091950"],"award-info":[{"award-number":["HL091950"]}],"id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,5,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Targeted nanomedicine holds promise to find clinical use in many medical areas. Endothelial cells that line the luminal surface of blood vessels represent a key target for treatment of inflammation, ischemia, thrombosis, stroke, and other neurological, cardiovascular, pulmonary, and oncological conditions. In other cases, the endothelium is a barrier for tissue penetration or a victim of adverse effects. Several endothelial surface markers including peptidases (e.g., ACE, APP, and APN) and adhesion molecules (e.g., ICAM-1 and PECAM) have been identified as key targets. Binding of nanocarriers to these molecules enables drug targeting and subsequent penetration into or across the endothelium, offering therapeutic effects that are unattainable by their nontargeted counterparts. We analyze diverse aspects of endothelial nanomedicine including (i) circulation and targeting of carriers with diverse geometries, (ii) multivalent interactions of carrier with endothelium, (iii) anchoring to multiple determinants, (iv) accessibility of binding sites and cellular response to their engagement, (v) role of cell phenotype and microenvironment in targeting, (vi) optimization of targeting by lowering carrier avidity, (vii) endocytosis of multivalent carriers via molecules not implicated in internalization of their ligands, and (viii) modulation of cellular uptake and trafficking by selection of specific epitopes on the target determinant, carrier geometry, and hydrodynamic factors. Refinement of these aspects and improving our understanding of vascular biology and pathology is likely to enable the clinical translation of vascular endothelial targeting of nanocarriers.<\/jats:p>","DOI":"10.1021\/nn500136z","type":"journal-article","created":{"date-parts":[[2014,4,30]],"date-time":"2014-04-30T14:49:50Z","timestamp":1398869390000},"page":"4100-4132","source":"Crossref","is-referenced-by-count":193,"title":["Vascular Targeting of Nanocarriers: Perplexing Aspects of the Seemingly Straightforward Paradigm"],"prefix":"10.1021","volume":"8","author":[{"given":"Melissa","family":"Howard","sequence":"first","affiliation":[{"name":"University of Pennsylvania, Perelman School of Medicine , , , ,","place":["Philadelphia, Pennsylvania, United States, 19104"]},{"name":"University of Pennsylvania, Perelman School of Medicine , , , ,","place":["Philadelphia, Pennsylvania, United States, 19104"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blaine J.","family":"Zern","sequence":"additional","affiliation":[{"name":"University of Pennsylvania, Perelman School of Medicine , , , ,","place":["Philadelphia, Pennsylvania, United States, 19104"]},{"name":"University of Pennsylvania, Perelman School of Medicine , , , ,","place":["Philadelphia, Pennsylvania, United States, 19104"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron C.","family":"Anselmo","sequence":"additional","affiliation":[{"name":"University of Pennsylvania, Perelman School of Medicine , , , ,","place":["Philadelphia, Pennsylvania, United States, 19104"]},{"name":"University of California , , , ,","place":["Santa Barbara, California, United States, 93106"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir V.","family":"Shuvaev","sequence":"additional","affiliation":[{"name":"University of Pennsylvania, Perelman School of Medicine , , , ,","place":["Philadelphia, Pennsylvania, United States, 19104"]},{"name":"University of Pennsylvania, Perelman School of Medicine , , , ,","place":["Philadelphia, Pennsylvania, United States, 19104"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samir","family":"Mitragotri","sequence":"additional","affiliation":[{"name":"University of Pennsylvania, Perelman School of Medicine , , , ,","place":["Philadelphia, Pennsylvania, United States, 19104"]},{"name":"University of California , , , ,","place":["Santa Barbara, California, United States, 93106"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Muzykantov","sequence":"additional","affiliation":[{"name":"University of Pennsylvania, Perelman School of Medicine , , , ,","place":["Philadelphia, Pennsylvania, United States, 19104"]},{"name":"University of Pennsylvania, Perelman School of Medicine , , , ,","place":["Philadelphia, Pennsylvania, United States, 19104"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2014,4,30]]},"reference":[{"key":"2026090123533264100_cit1","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1021\/nn900002m","article-title":"Impact of Nanotechnology on Drug Delivery","volume":"3","author":"Farokhzad","year":"2009","journal-title":"ACS Nano"},{"key":"2026090123533264100_cit2","first-page":"5","article-title":"Drug Delivery and Targeting","volume":"392","author":"Langer","year":"1998","journal-title":"Nature"},{"key":"2026090123533264100_cit3","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1021\/bc700408r","article-title":"Tumor-Targeted Gene Delivery Using Molecularly Engineered Hybrid Polymers Functionalized with a Tumor-Homing Peptide","volume":"19","author":"Wood","year":"2008","journal-title":"Bioconjugate Chem."},{"key":"2026090123533264100_cit4","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1021\/mp900015y","article-title":"The First Targeted Delivery of Sirna in Humans via a Self-Assembling, Cyclodextrin Polymer-Based Nanoparticle: From Concept to Clinic","volume":"6","author":"Davis","year":"2009","journal-title":"Mol. Pharmaceutics"},{"key":"2026090123533264100_cit5","doi-asserted-by":"crossref","first-page":"E781","DOI":"10.1002\/ijc.27361","article-title":"Lipid Nanoparticle Sirna Systems for Silencing the Androgen Receptor in Human Prostate Cancer in Vivo","volume":"131","author":"Lee","year":"2012","journal-title":"Int. J. Cancer"},{"key":"2026090123533264100_cit6","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1146\/annurev.bb.07.060178.002251","article-title":"Interactions of Liposomes with Mammalian Cells","volume":"7","author":"Pagano","year":"1978","journal-title":"Annu. Rev. Biophys. Bioeng."},{"key":"2026090123533264100_cit7","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1111\/j.1749-6632.1978.tb22034.x","article-title":"Liposomes in Therapeutic and Preventive Medicine: The Development of the Drug-Carrier Concept","volume":"308","author":"Gregoriadis","year":"1978","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"2026090123533264100_cit8","first-page":"549","article-title":"Liposomes\u2500Methodology and Applications","volume":"48","author":"Ryman","year":"1979","journal-title":"Front. Biol."},{"key":"2026090123533264100_cit9","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1139\/y78-112","article-title":"Drug Delivery Systems: A Brief Review","volume":"56","author":"Juliano","year":"1978","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"2026090123533264100_cit10","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/0142-9612(81)90059-4","article-title":"Present and Future Applications of Biomaterials in Controlled Drug Delivery Systems","volume":"2","author":"Langer","year":"1981","journal-title":"Biomaterials"},{"key":"2026090123533264100_cit11","doi-asserted-by":"crossref","first-page":"2545","DOI":"10.1039\/c2cs15327k","article-title":"Design of Polymeric Nanoparticles for Biomedical Delivery Applications","volume":"41","author":"Elsabahy","year":"2012","journal-title":"Chem. Soc. Rev."},{"key":"2026090123533264100_cit12","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1021\/ar2000315","article-title":"Print: A Novel Platform toward Shape and Size Specific Nanoparticle Theranostics","volume":"44","author":"Perry","year":"2011","journal-title":"Acc. Chem. Res."},{"key":"2026090123533264100_cit13","doi-asserted-by":"crossref","first-page":"232","DOI":"10.3109\/09687688.2010.516276","article-title":"Multifunctionality of Lipid-Core Micelles for Drug Delivery and Tumour Targeting","volume":"27","author":"Sawant","year":"2010","journal-title":"Mol. Membr. Biol."},{"key":"2026090123533264100_cit14","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1016\/j.addr.2011.06.016","article-title":"The Effects of Polymeric Nanostructure Shape on Drug Delivery","volume":"63","author":"Venkataraman","year":"2011","journal-title":"Adv. Drug Delivery Rev."},{"key":"2026090123533264100_cit15","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1021\/bc900553n","article-title":"Design, Synthesis, and Biological Evaluation of a Robust, Biodegradable Dendrimer","volume":"21","author":"van der Poll","year":"2010","journal-title":"Bioconjugate Chem."},{"key":"2026090123533264100_cit16","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1146\/annurev.bb.09.060180.002343","article-title":"Comparative Properties and Methods of Preparation of Lipid Vesicles (Liposomes)","volume":"9","author":"Szoka","year":"1980","journal-title":"Annu. Rev. Biophys. Bioeng."},{"key":"2026090123533264100_cit17","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1126\/science.1185547","article-title":"Self-Assembly of Janus Dendrimers into Uniform Dendrimersomes and Other Complex Architectures","volume":"328","author":"Percec","year":"2010","journal-title":"Science"},{"key":"2026090123533264100_cit18","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.biomaterials.2004.03.003","article-title":"Characterization of Biodegradable Drug Delivery Vehicles with the Adhesive Properties of Leukocytes II: Effect of Degradation on Targeting Activity","volume":"26","author":"Eniola","year":"2005","journal-title":"Biomaterials"},{"key":"2026090123533264100_cit19","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1126\/science.284.5417.1143","article-title":"Polymersomes: Tough Vesicles Made from Diblock Copolymers","volume":"284","author":"Discher","year":"1999","journal-title":"Science"},{"key":"2026090123533264100_cit20","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1021\/nn800072t","article-title":"Multifunctional Inorganic Nanoparticles for Imaging, Targeting, and Drug Delivery","volume":"2","author":"Liong","year":"2008","journal-title":"ACS Nano"},{"key":"2026090123533264100_cit21","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1021\/nn900448g","article-title":"Nanofabrication Beyond Electronics","volume":"3","author":"Wang","year":"2009","journal-title":"ACS Nano"},{"key":"2026090123533264100_cit22","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.jconrel.2008.06.021","article-title":"Advances in Recognitive, Conductive and Responsive Delivery Systems","volume":"132","author":"Bayer","year":"2008","journal-title":"J. Controlled Release"},{"key":"2026090123533264100_cit23","first-page":"130","article-title":"Clinical Developments of Chemotherapeutic Nanomedicines: Polymers and Liposomes for Delivery of Camptothecins and Platinum (II) Drugs","volume":"5","author":"Kieler-Ferguson","year":"2013","journal-title":"Wiley Interdiscip. Rev.: Nanomed. Nanobiotechnol."},{"key":"2026090123533264100_cit24","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.jconrel.2008.04.013","article-title":"Pluronic Block Copolymers: Evolution of Drug Delivery Concept from Inert Nanocarriers to Biological Response Modifiers","volume":"130","author":"Batrakova","year":"2008","journal-title":"J. Controlled Release"},{"key":"2026090123533264100_cit25","doi-asserted-by":"crossref","first-page":"208","DOI":"10.2174\/1567201811310020007","article-title":"Systemic and Biophase Bioavailability and Pharmacokinetics of Nanoparticulate Drug Delivery Systems","volume":"10","author":"Leucuta","year":"2013","journal-title":"Curr. Drug Delivery"},{"key":"2026090123533264100_cit26","first-page":"171","article-title":"Liposomes: The Development of a New Carrier System for Introducing Nucleic Acid into Plant and Animal Cells","volume":"96","author":"Fraley","year":"1982","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"2026090123533264100_cit27","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.jconrel.2012.04.038","article-title":"Macromolecular Therapeutics in Cancer Treatment: The Epr Effect and Beyond","volume":"164","author":"Maeda","year":"2012","journal-title":"J. Controlled Release"},{"key":"2026090123533264100_cit28","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.2967\/jnumed.112.105361","article-title":"From the Angio Suite to the Gamma-Camera: Vascular Mapping and 99mTc-MAA Hepatic Perfusion Imaging before Liver Radioembolization\u2500A Comprehensive Pictorial Review","volume":"53","author":"Uliel","year":"2012","journal-title":"J. Nucl. Med."},{"key":"2026090123533264100_cit29","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.ijpharm.2004.10.017","article-title":"Studies on the Poly(lactic-co-glycolic) Acid Microspheres of Cisplatin for Lung-Targeting","volume":"289","author":"Huo","year":"2005","journal-title":"Int. J. Pharm."},{"key":"2026090123533264100_cit30","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1161\/01.RES.75.6.1039","article-title":"Catheter-Mediated Pulmonary Vascular Gene Transfer and Expression","volume":"75","author":"Muller","year":"1994","journal-title":"Circ. Res."},{"key":"2026090123533264100_cit31","doi-asserted-by":"crossref","first-page":"312","DOI":"10.3109\/09687688.2010.522117","article-title":"Dynamic and Cellular Interactions of Nanoparticles in Vascular-Targeted Drug Delivery","volume":"27","author":"Huang","year":"2010","journal-title":"Mol. Membr. Biol."},{"key":"2026090123533264100_cit32","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1002\/med.20238","article-title":"Targeted Drug Delivery and Penetration into Solid Tumors","volume":"32","author":"Corti","year":"2012","journal-title":"Med. Res. Rev."},{"key":"2026090123533264100_cit33","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1002\/jmri.20866","article-title":"Molecular Imaging and Therapy of Atherosclerosis with Targeted Nanoparticles","volume":"25","author":"Wickline","year":"2007","journal-title":"J. Magn. Reson. Imaging"},{"key":"2026090123533264100_cit34","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1517\/14728222.8.4.335","article-title":"Development of Ligand-Targeted Liposomes for Cancer Therapy","volume":"8","author":"Noble","year":"2004","journal-title":"Expert. Opin. Ther. Targets"},{"key":"2026090123533264100_cit35","doi-asserted-by":"crossref","first-page":"6811","DOI":"10.1021\/jm100509v","article-title":"Folate-Targeted Therapies for Cancer","volume":"53","author":"Xia","year":"2010","journal-title":"J. Med. Chem."},{"key":"2026090123533264100_cit36","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1166\/jbn.2009.030","article-title":"Current Status of Nanoparticle-Based Imaging Agents for Early Diagnosis of Cancer and Atherosclerosis","volume":"5","author":"Saravanakumar","year":"2009","journal-title":"J. Biomed. Nanotechnol."},{"key":"2026090123533264100_cit37","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s00441-008-0676-7","article-title":"Targeted Delivery of Therapeutics to Endothelium","volume":"335","author":"Simone","year":"2009","journal-title":"Cell Tissue Res."},{"key":"2026090123533264100_cit38","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.2174\/1381612054367274","article-title":"Targeting of Antioxidant and Anti-Thrombotic Drugs to Endothelial Cell Adhesion Molecules","volume":"11","author":"Muro","year":"2005","journal-title":"Curr. Pharm. Des."},{"key":"2026090123533264100_cit39","doi-asserted-by":"crossref","first-page":"281","DOI":"10.2174\/1570161043385736","article-title":"Endothelial Endocytic Pathways: Gates for Vascular Drug Delivery","volume":"2","author":"Muro","year":"2004","journal-title":"Curr. Vasc. Pharmacol."},{"key":"2026090123533264100_cit40","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.jconrel.2012.05.052","article-title":"Challenges in Design and Characterization of Ligand-Targeted Drug Delivery Systems","volume":"164","author":"Muro","year":"2012","journal-title":"J. Controlled Release"},{"key":"2026090123533264100_cit41","doi-asserted-by":"crossref","first-page":"70","DOI":"10.2174\/138920012798356916","article-title":"Dynamic Factors Controlling Targeting Nanocarriers to Vascular Endothelium","volume":"13","author":"Muzykantov","year":"2012","journal-title":"Curr. Drug Metab."},{"key":"2026090123533264100_cit42","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1002\/iub.480","article-title":"Targeted Therapeutics and Nanodevices for Vascular Drug Delivery: Quo Vadis?","volume":"63","author":"Muzykantov","year":"2011","journal-title":"IUBMB Life"},{"key":"2026090123533264100_cit43","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1517\/17425247.2.5.909","article-title":"Biomedical Aspects of Targeted Delivery of Drugs to Pulmonary Endothelium","volume":"2","author":"Muzykantov","year":"2005","journal-title":"Expert Opin. Drug Delivery"},{"key":"2026090123533264100_cit44","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.taap.2008.02.007","article-title":"Factors Affecting Toxicity and Efficacy of Polymeric Nanomedicines","volume":"229","author":"Igarashi","year":"2008","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"2026090123533264100_cit45","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.ejpb.2013.01.025","article-title":"Endothelial Cell Response to (Co)Polymer Nanoparticles Depending on the Inflammatory Environment and Comonomer Ratio","volume":"84","author":"Wischke","year":"2013","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"2026090123533264100_cit46","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/978-1-61779-191-8_23","article-title":"Permeability of Endothelial Barrier: Cell Culture and in Vivo Models","volume":"763","author":"Garcia","year":"2011","journal-title":"Methods Mol. Biol. (N.Y., NY, U.S.)"},{"key":"2026090123533264100_cit47","first-page":"139","article-title":"Endothelium in Health and Disease","volume":"60","author":"Aird","year":"2008","journal-title":"Pharmacol. Rep."},{"key":"2026090123533264100_cit48","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1089\/ars.2008.2027","article-title":"Redox Control of Endothelial Function and Dysfunction: Molecular Mechanisms and Therapeutic Opportunities","volume":"10","author":"Thomas","year":"2008","journal-title":"Antioxid. Redox Signaling"},{"key":"2026090123533264100_cit49","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1016\/j.devcel.2012.11.003","article-title":"The Diaphragms of Fenestrated Endothelia: Gatekeepers of Vascular Permeability and Blood Composition","volume":"23","author":"Stan","year":"2011","journal-title":"Dev. Cell"},{"key":"2026090123533264100_cit50","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1111\/j.1582-4934.2007.00075.x","article-title":"Endothelial Stomatal and Fenestral Diaphragms in Normal Vessels and Angiogenesis","volume":"11","author":"Stan","year":"2007","journal-title":"J. Cell. Mol. Med."},{"key":"2026090123533264100_cit51","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1080\/713773925","article-title":"Pathways of Macromolecular Extravasation across Microvascular Endothelium in Response to Vpf\/Vegf and Other Vasoactive Mediators","volume":"6","author":"Feng","year":"1999","journal-title":"Microcirculation"},{"key":"2026090123533264100_cit52","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.2174\/138920112803341842","article-title":"Brain Delivery Systems via Mechanism Independent of Receptor-Mediated Endocytosis and Adsorptive-Mediated Endocytosis","volume":"13","author":"Thomsen","year":"2012","journal-title":"Curr. Pharm. Biotechnol."},{"key":"2026090123533264100_cit53","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1002\/jemt.10087","article-title":"Ultrastructural Studies Define Soluble Macromolecular, Particulate, and Cellular Transendothelial Cell Pathways in Venules, Lymphatic Vessels, and Tumor-Associated Microvessels in Man and Animals","volume":"57","author":"Feng","year":"2002","journal-title":"Microsc. Res. Technol."},{"key":"2026090123533264100_cit54","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1038\/nrc1146","article-title":"Caveolae: Mining Little Caves for New Cancer Targets","volume":"3","author":"Carver","year":"2003","journal-title":"Nat. Rev. Cancer"},{"key":"2026090123533264100_cit55","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1172\/JCI118997","article-title":"Endothelial Adherens Junctions: Implications in the Control of Vascular Permeability and Angiogenesis","volume":"98","author":"Dejana","year":"1996","journal-title":"J. Clin. Invest."},{"key":"2026090123533264100_cit56","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/S0022-3565(24)37616-5","article-title":"Enhanced Endocytosis in Cultured Human Breast Carcinoma Cells and in Vivo Biodistribution in Rats of a Humanized Monoclonal Antibody after Cationization of the Protein","volume":"286","author":"Pardridge","year":"1998","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"2026090123533264100_cit57","first-page":"L895","article-title":"Functional and Morphological Studies of Protein Transcytosis in Continuous Endothelia","volume":"287","author":"Predescu","year":"2004","journal-title":"Am. J. Physiol.: Lung Cell. Mol. Physiol."},{"key":"2026090123533264100_cit58","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1152\/physrev.1983.63.4.1536","article-title":"Cellular Aspects of Transcapillary Exchange","volume":"63","author":"Simionescu","year":"1983","journal-title":"Physiol. Rev."},{"key":"2026090123533264100_cit59","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1002\/iub.485","article-title":"Delivery of Nanoparticle: Complexed Drugs across the Vascular Endothelial Barrier via Caveolae","volume":"63","author":"Wang","year":"2011","journal-title":"IUBMB Life"},{"key":"2026090123533264100_cit60","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1161\/CIRCRESAHA.107.156539","article-title":"Endothelial Mechanisms of Flow-Mediated Athero-Protection and Susceptibility","volume":"101","author":"Davies","year":"2007","journal-title":"Circ. Res."},{"key":"2026090123533264100_cit61","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1002\/iub.487","article-title":"Targeted Sirna Delivery to Diseased Microvascular Endothelial Cells: Cellular and Molecular Concepts","volume":"63","author":"Kowalski","year":"2011","journal-title":"IUBMB Life"},{"key":"2026090123533264100_cit62","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.2217\/nnm.11.92","article-title":"Nanocarriers for Vascular Delivery of Antioxidants","volume":"6","author":"Hood","year":"2011","journal-title":"Nanomedicine (London, U.K.)"},{"key":"2026090123533264100_cit63","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0928-4680(98)00006-6","article-title":"Immunotargeting of Drugs to the Pulmonary Vascular Endothelium as a Therapeutic Strategy","volume":"5","author":"Muzykantov","year":"1998","journal-title":"Pathophysiology"},{"key":"2026090123533264100_cit64","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1038\/nature02580","article-title":"Subtractive Proteomic Mapping of the Endothelial Surface in Lung and Solid Tumours for Tissue-Specific Therapy","volume":"429","author":"Oh","year":"2004","journal-title":"Nature"},{"key":"2026090123533264100_cit65","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1056\/NEJM199808133390711","article-title":"Vascular Targeting as a Strategy for Cancer Therapy","volume":"339","author":"Schnitzer","year":"1998","journal-title":"N. Engl. J. Med."},{"key":"2026090123533264100_cit66","doi-asserted-by":"crossref","first-page":"8795","DOI":"10.1073\/pnas.94.16.8795","article-title":"Immunotargeting of Liposomes to Activated Vascular Endothelial Cells: A Strategy for Site-Selective Delivery in the Cardiovascular System","volume":"94","author":"Spragg","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2026090123533264100_cit67","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0883-2897(90)90147-S","article-title":"Rat Monoclonal Antibody Distribution in Mice: An Epitope inside the Lung Vascular Space Mediates Very Efficient Localization","volume":"17","author":"Kennel","year":"1990","journal-title":"Int. J. Radiat. Appl. Instrum., Part B"},{"key":"2026090123533264100_cit68","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.1073\/pnas.251662398","article-title":"Targeting Endothelium and Its Dynamic Caveolae for Tissue-Specific Transcytosis in Vivo: A Pathway to Overcome Cell Barriers to Drug and Gene Delivery","volume":"99","author":"McIntosh","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2026090123533264100_cit69","first-page":"465","article-title":"Targeting of Radiolabeled Monoclonal Antibody against Ace to the Pulmonary Endothelium","volume-title":"Targeted Delivery of Imaging Agents","author":"Muzykantov","year":"1995"},{"key":"2026090123533264100_cit70","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1002\/(SICI)1097-0215(19960117)65:2<192::AID-IJC11>3.0.CO;2-G","article-title":"Lu-Ecam-1-Mediated Adhesion of Melanoma Cells to Endothelium under Conditions of Flow","volume":"65","author":"Goetz","year":"1996","journal-title":"Int. J. Cancer"},{"key":"2026090123533264100_cit71","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1126\/science.275.5299.547","article-title":"Tumor Infarction in Mice by Antibody-Directed Targeting of Tissue Factor to Tumor Vasculature","volume":"275","author":"Huang","year":"1997","journal-title":"Science"},{"key":"2026090123533264100_cit72","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1083\/jcb.145.6.1189","article-title":"Isolation, Cloning, and Localization of Rat Pv-1, a Novel Endothelial Caveolar Protein","volume":"145","author":"Stan","year":"1999","journal-title":"J. Cell Biol."},{"key":"2026090123533264100_cit73","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1172\/JCI3008","article-title":"Molecular Heterogeneity of the Vascular Endothelium Revealed by in Vivo Phage Display","volume":"102","author":"Rajotte","year":"1998","journal-title":"J. Clin. Invest."},{"key":"2026090123533264100_cit74","first-page":"118","article-title":"Lung Is the Target Organ for a Monoclonal Antibody to Angiotensin-Converting Enzyme","volume":"64","author":"Danilov","year":"1991","journal-title":"Lab. Invest."},{"key":"2026090123533264100_cit75","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1038\/89704","article-title":"Vascular Targeting and Antigen Presentation","volume":"2","author":"Pasqualini","year":"2001","journal-title":"Nat. Immunol."},{"key":"2026090123533264100_cit76","doi-asserted-by":"crossref","first-page":"5213","DOI":"10.1073\/pnas.93.11.5213","article-title":"Immunotargeting of Antioxidant Enzyme to the Pulmonary Endothelium","volume":"93","author":"Muzykantov","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2026090123533264100_cit77","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1038\/nbt0901-838","article-title":"Combined Transductional and Transcriptional Targeting Improves the Specificity of Transgene Expression in Vivo","volume":"19","author":"Reynolds","year":"2001","journal-title":"Nat. Biotechnol."},{"key":"2026090123533264100_cit78","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.jacc.2003.07.048","article-title":"Intravascular Ultrasound Molecular Imaging of Atheroma Components in Vivo","volume":"43","author":"Hamilton","year":"2004","journal-title":"J. Am. Coll. Cardiol."},{"key":"2026090123533264100_cit79","doi-asserted-by":"crossref","first-page":"21444","DOI":"10.1073\/pnas.1217972110","article-title":"Painting Blood Vessels and Atherosclerotic Plaques with an Adhesive Drug Depot","volume":"109","author":"Kastrup","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2026090123533264100_cit80","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1161\/CIRCRESAHA.111.300576","article-title":"Polymeric Nanoparticle Pet\/Mr Imaging Allows Macrophage Detection in Atherosclerotic Plaques","volume":"112","author":"Majmudar","year":"2013","journal-title":"Circ. Res."},{"key":"2026090123533264100_cit81","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s10456-013-9377-2","article-title":"Characterization of Early Neovascular Response to Acute Lung Ischemia Using Simultaneous 19f\/1h Mr Molecular Imaging","volume":"17","author":"Schmieder","year":"2014","journal-title":"Angiogenesis"},{"key":"2026090123533264100_cit82","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1096\/fj.10-171728","article-title":"Molecular Photoacoustic Imaging of Angiogenesis with Integrin-Targeted Gold Nanobeacons","volume":"25","author":"Pan","year":"2011","journal-title":"FASEB J."},{"key":"2026090123533264100_cit83","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s10456-010-9166-0","article-title":"Theragnostics for Tumor and Plaque Angiogenesis with Perfluorocarbon Nanoemulsions","volume":"13","author":"Lanza","year":"2010","journal-title":"Angiogenesis"},{"key":"2026090123533264100_cit84","doi-asserted-by":"crossref","first-page":"51S","DOI":"10.2967\/jnumed.109.068163","article-title":"Imaging Atherosclerosis and Vulnerable Plaque","volume":"51","author":"Sadeghi","year":"2010","journal-title":"J. Nucl. Med."},{"key":"2026090123533264100_cit85","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1073\/pnas.1322725111","article-title":"Probing Nanoparticle Translocation across the Permeable Endothelium in Experimental Atherosclerosis","volume":"111","author":"Kim","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2026090123533264100_cit86","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/nm.3437","article-title":"2-Deoxy-2-[18F] Fluoro-d-Mannose Positron Emission Tomography Imaging in Atherosclerosis","volume":"20","author":"Tahara","year":"2014","journal-title":"Nat. Med."},{"key":"2026090123533264100_cit87","doi-asserted-by":"crossref","first-page":"9975","DOI":"10.1021\/nn4039063","article-title":"Single Step Reconstitution of Multifunctional High-Density Lipoprotein-Derived Nanomaterials Using Microfluidics","volume":"7","author":"Kim","year":"2013","journal-title":"ACS Nano"},{"key":"2026090123533264100_cit88","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1021\/bc400166j","article-title":"Synthesis of Polymer\u2013Lipid Nanoparticles for Image-Guided Delivery of Dual Modality Therapy","volume":"24","author":"Mieszawska","year":"2013","journal-title":"Bioconjugate Chem."},{"key":"2026090123533264100_cit89","first-page":"607","article-title":"Molecular Imaging of Fibrin Deposition in Deep Vein Thrombosis Using Fibrin-Targeted near-Infrared Fluorescence","volume":"5","author":"Hara","year":"2012","journal-title":"JACC"},{"key":"2026090123533264100_cit90","doi-asserted-by":"crossref","first-page":"6991","DOI":"10.1021\/nn2015453","article-title":"Endothelial Targeting of Antibody-Decorated Polymeric Filomicelles","volume":"5","author":"Shuvaev","year":"2011","journal-title":"ACS Nano"},{"key":"2026090123533264100_cit91","doi-asserted-by":"crossref","first-page":"13701","DOI":"10.1021\/la202926m","article-title":"Using Engineered Single-Chain Antibodies to Correlate Molecular Binding Properties and Nanoparticle Adhesion Dynamics","volume":"27","author":"Haun","year":"2011","journal-title":"Langmuir"},{"key":"2026090123533264100_cit92","doi-asserted-by":"crossref","first-page":"8821","DOI":"10.1021\/la8005844","article-title":"Quantifying Nanoparticle Adhesion Mediated by Specific Molecular Interactions","volume":"24","author":"Haun","year":"2008","journal-title":"Langmuir"},{"key":"2026090123533264100_cit93","doi-asserted-by":"crossref","first-page":"3577","DOI":"10.1529\/biophysj.104.057729","article-title":"I-Domain of Lymphocyte Function-Associated Antigen-1 Mediates Rolling of Polystyrene Particles on ICAM-1 under Flow","volume":"89","author":"Eniola","year":"2005","journal-title":"Biophys. J."},{"key":"2026090123533264100_cit94","first-page":"323","article-title":"Flow Dynamics, Binding and Detachment of Spherical Carriers Targeted to ICAM-1 on Endothelial Cells","volume":"46","author":"Calderon","year":"2009","journal-title":"Biorheology"},{"key":"2026090123533264100_cit95","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1124\/jpet.300.3.777","article-title":"Platelet-Endothelial Cell Adhesion Molecule-1-Directed Immunotargeting to Cardiopulmonary Vasculature","volume":"300","author":"Scherpereel","year":"2002","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"2026090123533264100_cit96","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1124\/jpet.107.120535","article-title":"Delivery of Anti-Platelet-Endothelial Cell Adhesion Molecule Single-Chain Variable Fragment-Urokinase Fusion Protein to the Cerebral Vasculature Lyses Arterial Clots and Attenuates Postischemic Brain Edema","volume":"321","author":"Danielyan","year":"2007","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"2026090123533264100_cit97","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1161\/01.RES.0000150373.15149.ff","article-title":"Molecular Imaging of Atherosclerotic Plaques Using a Human Antibody against the Extra-Domain B of Fibronectin","volume":"95","author":"Matter","year":"2004","journal-title":"Circ. Res."},{"key":"2026090123533264100_cit98","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1161\/01.ATV.0000178991.71605.18","article-title":"Atherosclerotic Plaque Progression and Vulnerability to Rupture Angiogenesis as a Source of Intraplaque Hemorrhage","volume":"25","author":"Virmani","year":"2005","journal-title":"Arterioscler., Thromb., Vasc. Biol."},{"key":"2026090123533264100_cit99","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1161\/01.ATV.0000235724.11299.76","article-title":"Endothelial A\u03bd\u03b23 Integrin\u2013Targeted Fumagillin Nanoparticles Inhibit Angiogenesis in Atherosclerosis","volume":"26","author":"Winter","year":"2006","journal-title":"Arterioscler., Thromb., Vasc. Biol."},{"key":"2026090123533264100_cit100","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1161\/CIRCULATIONAHA.105.578955","article-title":"Neovascularization in Human Atherosclerosis","volume":"113","author":"Moreno","year":"2006","journal-title":"Circulation"},{"key":"2026090123533264100_cit101","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1007\/s12350-010-9263-x","article-title":"Molecular Imaging of Inflammation and Intraplaque Vasa Vasorum: A Step Forward to Identification of Vulnerable Plaques?","volume":"17","author":"Gerrit","year":"2010","journal-title":"J. Nucl. Cardiol"},{"key":"2026090123533264100_cit102","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1093\/ejechocard\/jeq048","article-title":"Contrast-Enhanced Ultrasound for Imaging Vasa Vasorum: Comparison with Histopathology in a Swine Model of Atherosclerosis","volume":"11","author":"Schinkel","year":"2010","journal-title":"Eur. J. Echocardiogr."},{"key":"2026090123533264100_cit103","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1126\/science.1217815","article-title":"Shear-Activated Nanotherapeutics for Drug Targeting to Obstructed Blood Vessels","volume":"337","author":"Korin","year":"2012","journal-title":"Science"},{"key":"2026090123533264100_cit104","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.ijpharm.2005.10.010","article-title":"Opsonization, Biodistribution, and Pharmacokinetics of Polymeric Nanoparticles","volume":"307","author":"Owens","year":"2006","journal-title":"Int. J. Pharm."},{"key":"2026090123533264100_cit105","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0939-6411(98)00038-1","article-title":"Surface-Modified Biodegradable Albumin Nano- and Microspheres. II: Effect of Surface Charges on in Vitro Phagocytosis and Biodistribution in Rats","volume":"46","author":"Roser","year":"1998","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"2026090123533264100_cit106","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/0261-5614(92)90006-C","article-title":"Particle Size, Surface Hydrophobicity and Interaction with Serum of Parenteral Fat Emulsions and Model Drug Carriers as Parameters Related to Res Uptake","volume":"11","author":"Carrstensen","year":"1992","journal-title":"Clin. Nutr."},{"key":"2026090123533264100_cit107","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1166\/jbn.2008.021","article-title":"Pegylation of Nanocarrier Drug Delivery Systems: State of the Art","volume":"4","author":"Howard","year":"2008","journal-title":"J. Biomed. Nanotechnol."},{"key":"2026090123533264100_cit108","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1126\/science.8128245","article-title":"Biodegradable Long-Circulating Polymeric Nanospheres","volume":"263","author":"Gref","year":"1994","journal-title":"Science"},{"key":"2026090123533264100_cit109","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/0014-5793(91)80699-4","article-title":"Influence of the Steric Barrier Activity of Amphipathic Poly(Ethyleneglycol) and Ganglioside Gm1 on the Circulation Time of Liposomes and on the Target Binding of Immunoliposomes in Vivo","volume":"284","author":"Mori","year":"1991","journal-title":"FEBS Lett."},{"key":"2026090123533264100_cit110","doi-asserted-by":"crossref","first-page":"2716","DOI":"10.1096\/fasebj.6.9.1612296","article-title":"Targeted Accumulation of Polyethylene Glycol-Coated Immunoliposomes in Infarcted Rabbit Myocardium","volume":"6","author":"Torchilin","year":"1992","journal-title":"FASEB J."},{"key":"2026090123533264100_cit111","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/0005-2736(91)90385-L","article-title":"Activity of Amphipathic Poly(Ethylene Glycol) 5000 to Prolong the Circulation Time of Liposomes Depends on the Liposome Size and Is Unfavorable for Immunoliposome Binding to Target","volume":"1062","author":"Klibanov","year":"1991","journal-title":"Biochim. Biophys. Acta"},{"key":"2026090123533264100_cit112","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1080\/10611860802230240","article-title":"The Architecture of Ligand Attachment to Nanocarriers Controls Their Specific Interaction with Target Cells","volume":"16","author":"Sawant","year":"2008","journal-title":"J. Drug Targeting"},{"key":"2026090123533264100_cit113","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1021\/bc2002133","article-title":"Development of the Novel Peg-Pe-Based Polymer for the Reversible Attachment of Specific Ligands to Liposomes: Synthesis and in Vitro Characterization","volume":"22","author":"Biswas","year":"2011","journal-title":"Bioconjugate Chem."},{"key":"2026090123533264100_cit114","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2013.11.009","article-title":"Ph-Sensitive Nano-Systems for Drug Delivery in Cancer Therapy","author":"Liu","year":"2013","journal-title":"Biotechnol. Adv."},{"key":"2026090123533264100_cit115","first-page":"286","article-title":"The Accelerated Clearance on Repeated Injection of Pegylated Liposomes in Rats: Laboratory and Histopathological Study","volume":"7","author":"Ishida","year":"2002","journal-title":"Cell. Mol. Biol. Lett."},{"key":"2026090123533264100_cit116","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0168-3659(02)00462-5","article-title":"Accelerated Clearance of Pegylated Liposomes in Rats after Repeated Injections","volume":"88","author":"Ishida","year":"2003","journal-title":"J. Controlled Release"},{"key":"2026090123533264100_cit117","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.jconrel.2006.11.015","article-title":"Brain Delivery Property and Accelerated Blood Clearance of Cationic Albumin Conjugated Pegylated Nanoparticle","volume":"118","author":"Lu","year":"2007","journal-title":"J. Controlled Release"},{"key":"2026090123533264100_cit118","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jconrel.2006.01.005","article-title":"Injection of Pegylated Liposomes in Rats Elicits Peg-Specific Igm, Which Is Responsible for Rapid Elimination of a Second Dose of Pegylated Liposomes","volume":"112","author":"Ishida","year":"2006","journal-title":"J. Controlled Release"},{"key":"2026090123533264100_cit119","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1016\/S0022-3565(24)35391-1","article-title":"Accelerated Blood Clearance and Altered Biodistribution of Repeated Injections of Sterically Stabilized Liposomes","volume":"292","author":"Dams","year":"2000","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"2026090123533264100_cit120","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/S0022-3565(24)29419-2","article-title":"Factors Affecting the Accelerated Blood Clearance of Polyethylene Glycol-Liposomes Upon Repeated Injection","volume":"298","author":"Laverman","year":"2001","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"2026090123533264100_cit121","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.jconrel.2006.08.001","article-title":"Spleen Plays an Important Role in the Induction of Accelerated Blood Clearance of Pegylated Liposomes","volume":"115","author":"Ishida","year":"2006","journal-title":"J. Controlled Release"},{"key":"2026090123533264100_cit122","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1046\/j.1365-2249.2002.01953.x","article-title":"The Dual Function of the Splenic Marginal Zone: Essential for Initiation of Anti-Ti-2 Responses but Also Vital in the General First-Line Defense against Blood-Borne Antigens","volume":"130","author":"Zandvoort","year":"2002","journal-title":"Clin. Exp. Immunol."},{"key":"2026090123533264100_cit123","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/pharmaceutics3010001","article-title":"Anti-Peg Igm Response against Pegylated Liposomes in Mice and Rats","volume":"3","author":"Ichihara","year":"2010","journal-title":"Pharmaceutics"},{"key":"2026090123533264100_cit124","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/0005-2760(93)90290-P","article-title":"Effect of Chemically Modified Gm1 and Neoglycolipid Analogs of Gm1 on Liposome Circulation Time: Evidence Supporting the Dysopsonin Hypothesis","volume":"1166","author":"Park","year":"1993","journal-title":"Biochim. Biophys. Acta"},{"key":"2026090123533264100_cit125","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.4049\/jimmunol.140.5.1588","article-title":"Inhibition of the Alternative Pathway of Human Complement by Structural Analogues of Sialic Acid","volume":"140","author":"Michalek","year":"1988","journal-title":"J. Immunol."},{"key":"2026090123533264100_cit126","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/0005-2736(86)90297-X","article-title":"Inhibitory Effects of Gangliosides on Immune Reactions of Antibodies to Neutral Glycolipids in Liposomes","volume":"858","author":"Shichijo","year":"1986","journal-title":"Biochim. Biophys. Acta"},{"key":"2026090123533264100_cit127","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1126\/science.1229568","article-title":"Minimal \u201cSelf\u201d Peptides That Inhibit Phagocytic Clearance and Enhance Delivery of Nanoparticles","volume":"339","author":"Rodriguez","year":"2013","journal-title":"Science"},{"key":"2026090123533264100_cit128","doi-asserted-by":"crossref","first-page":"4317","DOI":"10.1016\/j.biomaterials.2011.02.053","article-title":"The Effect of Cd47 Modified Polymer Surfaces on Inflammatory Cell Attachment and Activation","volume":"32","author":"Stachelek","year":"2011","journal-title":"Biomaterials"},{"key":"2026090123533264100_cit129","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.bcmd.2010.02.016","article-title":"Self Inhibition of Phagocytosis: The Affinity of \u2018Marker of Self\u2019 Cd47 for Sirpalpha Dictates Potency of Inhibition but Only at Low Expression Levels","volume":"45","author":"Tsai","year":"2010","journal-title":"Blood Cells Mol., Dis."},{"key":"2026090123533264100_cit130","doi-asserted-by":"crossref","first-page":"2548","DOI":"10.1182\/blood-2005-04-1463","article-title":"Species- and Cell Type-Specific Interactions between Cd47 and Human Sirpalpha","volume":"107","author":"Subramanian","year":"2006","journal-title":"Blood"},{"key":"2026090123533264100_cit131","doi-asserted-by":"crossref","first-page":"10980","DOI":"10.1073\/pnas.1106634108","article-title":"Erythrocyte Membrane-Camouflaged Polymeric Nanoparticles as a Biomimetic Delivery Platform","volume":"108","author":"Hu","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2026090123533264100_cit132","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/nnano.2012.212","article-title":"Synthetic Nanoparticles Functionalized with Biomimetic Leukocyte Membranes Possess Cell-Like Functions","volume":"8","author":"Parodi","year":"2013","journal-title":"Nat. Nanotechnol."},{"key":"2026090123533264100_cit133","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1038\/nbt1340","article-title":"Renal Clearance of Quantum Dots","volume":"25","author":"Choi","year":"2007","journal-title":"Nat. Biotechnol."},{"key":"2026090123533264100_cit134","first-page":"L823","article-title":"Molecular Determinants of Endothelial Transcytosis and Their Role in Endothelial Permeability","volume":"293","author":"Predescu","year":"2007","journal-title":"Am. J. Physiol.: Lung Cell. Mol. Physiol."},{"key":"2026090123533264100_cit135","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/nbt1292","article-title":"Live Dynamic Imaging of Caveolae Pumping Targeted Antibody Rapidly and Specifically across Endothelium in the Lung","volume":"25","author":"Oh","year":"2007","journal-title":"Nat. Biotechnol."},{"key":"2026090123533264100_cit136","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.jconrel.2010.10.026","article-title":"Modulation of Endothelial Targeting by Size of Antibody-Antioxidant Enzyme Conjugates","volume":"149","author":"Shuvaev","year":"2011","journal-title":"J. Controlled Release"},{"key":"2026090123533264100_cit137","first-page":"52","article-title":"Novel Approaches for Drug Delivery Systems in Nanomedicine: Effects of Particle Design and Shape","volume":"4","author":"Daum","year":"2012","journal-title":"Wiley Interdiscip. Rev.: Nanomed. Nanobiotechnol."},{"key":"2026090123533264100_cit138","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1517\/17425240802567846","article-title":"Polymeric Carriers: Role of Geometry in Drug Delivery","volume":"5","author":"Simone","year":"2008","journal-title":"Expert Opin. Drug Delivery"},{"key":"2026090123533264100_cit139","doi-asserted-by":"crossref","first-page":"181","DOI":"10.4155\/tde.11.156","article-title":"The Shape of Things to Come: Importance of Design in Nanotechnology for Drug Delivery","volume":"3","author":"Liu","year":"2012","journal-title":"Ther. Delivery"},{"key":"2026090123533264100_cit140","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jconrel.2007.03.022","article-title":"Particle Shape: A New Design Parameter for Micro- and Nanoscale Drug Delivery Carriers","volume":"121","author":"Champion","year":"2007","journal-title":"J. Controlled Release"},{"key":"2026090123533264100_cit141","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1007\/s11095-008-9740-y","article-title":"In Drug Delivery, Shape Does Matter","volume":"26","author":"Mitragotri","year":"2009","journal-title":"Pharm. Res."},{"key":"2026090123533264100_cit142","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1021\/nn304439f","article-title":"Nanoparticle Geometry and Surface Orientation Influence Mode of Cellular Uptake","volume":"7","author":"Herd","year":"2013","journal-title":"ACS Nano"},{"key":"2026090123533264100_cit143","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1038\/mt.2008.127","article-title":"Control of Endothelial Targeting and Intracellular Delivery of Therapeutic Enzymes by Modulating the Size and Shape of ICAM-1-Targeted Carriers","volume":"16","author":"Muro","year":"2008","journal-title":"Mol. Ther."},{"key":"2026090123533264100_cit144","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1007\/s11095-008-9626-z","article-title":"Shape Induced Inhibition of Phagocytosis of Polymer Particles","volume":"26","author":"Champion","year":"2009","journal-title":"Pharm. Res."},{"key":"2026090123533264100_cit145","doi-asserted-by":"crossref","first-page":"4930","DOI":"10.1073\/pnas.0600997103","article-title":"Role of Target Geometry in Phagocytosis","volume":"103","author":"Champion","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2026090123533264100_cit146","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1517\/17425241003610633","article-title":"Drug Delivery by Red Blood Cells: Vascular Carriers Designed by Mother Nature","volume":"7","author":"Muzykantov","year":"2010","journal-title":"Expert Opin. Drug Delivery"},{"key":"2026090123533264100_cit147","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1073\/pnas.1010013108","article-title":"Using Mechanobiological Mimicry of Red Blood Cells to Extend Circulation Times of Hydrogel Microparticles","volume":"108","author":"Merkel","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2026090123533264100_cit148","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-4757-2257-4","volume-title":"Biomechanics: Mechanical Properties of Living Tissues","author":"Fung","year":"1993"},{"key":"2026090123533264100_cit149","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.jconrel.2012.06.009","article-title":"The Effect of Particle Size on the Biodistribution of Low-Modulus Hydrogel Print Particles","volume":"162","author":"Merkel","year":"2012","journal-title":"J. Controlled Release"},{"key":"2026090123533264100_cit150","doi-asserted-by":"crossref","first-page":"3914","DOI":"10.1021\/bm700888h","article-title":"Effect of Polymer Amphiphilicity on Loading of a Therapeutic Enzyme into Protective Filamentous and Spherical Polymer Nanocarriers","volume":"8","author":"Simone","year":"2007","journal-title":"Biomacromolecules"},{"key":"2026090123533264100_cit151","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/nnano.2007.70","article-title":"Shape Effects of Filaments versus Spherical Particles in Flow and Drug Delivery","volume":"2","author":"Geng","year":"2007","journal-title":"Nat. Nanotechnol."},{"key":"2026090123533264100_cit152","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1021\/bm049884v","article-title":"Targeted Worm Micelles","volume":"5","author":"Dalhaimer","year":"2004","journal-title":"Biomacromolecules"},{"key":"2026090123533264100_cit153","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.addr.2012.09.038","article-title":"Cancer Nanomedicines: So Many Papers and So Few Drugs!","volume":"65","author":"Venditto","year":"2013","journal-title":"Adv. Drug Delivery Rev."},{"key":"2026090123533264100_cit154","doi-asserted-by":"crossref","first-page":"6115","DOI":"10.1073\/pnas.1220281110","article-title":"Ligand-Functionalized Nanoparticles Target Endothelial Cells in Retinal Capillaries after Systemic Application","volume":"110","author":"Pollinger","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2026090123533264100_cit155","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1021\/bc200578s","article-title":"Size Dependent Biodistribution and Spect Imaging of (111) in-Labeled Polymersomes","volume":"26","author":"Brinkhuis","year":"2012","journal-title":"Bioconjugate Chem."},{"key":"2026090123533264100_cit156","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1021\/nn305773f","article-title":"Reduction of Nanoparticle Avidity Enhances the Selectivity of Vascular Targeting and Pet Detection of Pulmonary Inflammation","volume":"7","author":"Zern","year":"2013","journal-title":"ACS Nano"},{"key":"2026090123533264100_cit157","doi-asserted-by":"crossref","first-page":"103","DOI":"10.2967\/jnumed.107.045302","article-title":"In Vivo Imaging of 64cu-Labeled Polymer Nanoparticles Targeted to the Lung Endothelium","volume":"49","author":"Rossin","year":"2008","journal-title":"J. Nucl. Med."},{"key":"2026090123533264100_cit158","first-page":"1686","article-title":"Radioimmunoimaging of Lung Vessels: An Approach Using Indium-111-Labeled Monoclonal Antibody to Angiotensin-Converting Enzyme","volume":"30","author":"Danilov","year":"1989","journal-title":"J. Nucl. Med."},{"key":"2026090123533264100_cit159","doi-asserted-by":"crossref","first-page":"5406","DOI":"10.1016\/j.biomaterials.2012.04.036","article-title":"Endothelial Targeting of Polymeric Nanoparticles Stably Labeled with the Pet Imaging Radioisotope Iodine-124","volume":"33","author":"Simone","year":"2012","journal-title":"Biomaterials"},{"key":"2026090123533264100_cit160","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.1073\/pnas.96.5.2379","article-title":"Streptavidin Facilitates Internalization and Pulmonary Targeting of an Anti-Endothelial Cell Antibody (Platelet-Endothelial Cell Adhesion Molecule 1): A Strategy for Vascular Immunotargeting of Drugs","volume":"96","author":"Muzykantov","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2026090123533264100_cit161","first-page":"453","article-title":"Endotoxin Reduces Specific Pulmonary Uptake of Radiolabeled Monoclonal Antibody to Angiotensin-Converting Enzyme","volume":"32","author":"Muzykantov","year":"1991","journal-title":"J. Nucl. Med."},{"key":"2026090123533264100_cit162","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1096\/fj.12-218081","article-title":"A. Programmable Nanoparticle Functionalization for in Vivo Targeting","volume":"27","author":"Pan","year":"2013","journal-title":"FASEB J."},{"key":"2026090123533264100_cit163","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1006\/abio.1995.1226","article-title":"The Functional Effects of Biotinylation of Anti-Angiotensin-Converting Enzyme Monoclonal Antibody in Terms of Targeting in Vivo","volume":"226","author":"Muzykantov","year":"1995","journal-title":"Anal. Biochem."},{"key":"2026090123533264100_cit164","doi-asserted-by":"crossref","first-page":"7155","DOI":"10.1021\/nn201950e","article-title":"Nanoparticle Size Is a Critical Physicochemical Determinant of the Human Blood Plasma Corona: A Comprehensive Quantitative Proteomic Analysis","volume":"5","author":"Tenzer","year":"2011","journal-title":"ACS Nano"},{"key":"2026090123533264100_cit165","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1038\/nnano.2012.207","article-title":"Biomolecular Coronas Provide the Biological Identity of Nanosized Materials","volume":"7","author":"Monopoli","year":"2012","journal-title":"Nat. Nanotechnol."},{"key":"2026090123533264100_cit166","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1166\/jbn.2009.1045","article-title":"Complement: Alive and Kicking Nanomedicines","volume":"5","author":"Andersen","year":"2009","journal-title":"J. Biomed. Nanotechnol."},{"key":"2026090123533264100_cit167","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/nnano.2012.237","article-title":"Transferrin-Functionalized Nanoparticles Lose Their Targeting Capabilities When a Biomolecule Corona Adsorbs on the Surface","volume":"8","author":"Salvati","year":"2013","journal-title":"Nat. Nanotechnol."},{"key":"2026090123533264100_cit168","doi-asserted-by":"crossref","first-page":"5845","DOI":"10.1021\/nn300223w","article-title":"Effects of the Presence or Absence of a Protein Corona on Silica Nanoparticle Uptake and Impact on Cells","volume":"6","author":"Lesniak","year":"2012","journal-title":"ACS Nano"},{"key":"2026090123533264100_cit169","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1038\/nnano.2013.181","article-title":"Rapid Formation of Plasma Protein Corona Critically Affects Nanoparticle Pathophysiology","volume":"8","author":"Tenzer","year":"2013","journal-title":"Nat. Nanotechnol."},{"key":"2026090123533264100_cit170","doi-asserted-by":"crossref","first-page":"2611","DOI":"10.1182\/blood.V78.10.2611.2611","article-title":"Avidin Attachment to Biotinylated Erythrocytes Induces Homologous Lysis via the Alternative Pathway of Complement","volume":"78","author":"Muzykantov","year":"1991","journal-title":"Blood"},{"key":"2026090123533264100_cit171","doi-asserted-by":"crossref","first-page":"9511","DOI":"10.1016\/j.biomaterials.2010.09.049","article-title":"Serum Heat Inactivation Affects Protein Corona Composition and Nanoparticle Uptake","volume":"31","author":"Lesniak","year":"2010","journal-title":"Biomaterials"},{"key":"2026090123533264100_cit172","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/0014-5793(91)80216-P","article-title":"Streptavidin-Induced Lysis of Homologous Biotinylated Erythrocytes. Evidence against the Key Role of the Avidin Charge in Complement Activation via the Alternative Pathway","volume":"280","author":"Muzykantov","year":"1991","journal-title":"FEBS Lett."},{"key":"2026090123533264100_cit173","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1038\/nbt993","article-title":"Direct Proteomic Mapping of the Lung Microvascular Endothelial Cell Surface in Vivo and in Cell Culture","volume":"22","author":"Durr","year":"2004","journal-title":"Nat. Biotechnol."},{"key":"2026090123533264100_cit174","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.cell.2006.02.042","article-title":"A Hybrid Vector for Ligand-Directed Tumor Targeting and Molecular Imaging","volume":"125","author":"Hajitou","year":"2006","journal-title":"Cell"},{"key":"2026090123533264100_cit175","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1161\/01.CIR.102.2.231","article-title":"Selective Targeting of Gene Transfer to Vascular Endothelial Cells by Use of Peptides Isolated by Phage Display","volume":"102","author":"Nicklin","year":"2000","journal-title":"Circulation"},{"key":"2026090123533264100_cit176","doi-asserted-by":"crossref","first-page":"47","DOI":"10.2165\/00151829-200605010-00004","article-title":"Antioxidant Strategies in Respiratory Medicine","volume":"5","author":"Christofidou-Solomidou","year":"2006","journal-title":"Treat. Respir. Med."},{"key":"2026090123533264100_cit177","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0168-3659(01)00215-2","article-title":"Targeting of Superoxide Dismutase and Catalase to Vascular Endothelium","volume":"71","author":"Muzykantov","year":"2001","journal-title":"J. Controlled Release"},{"key":"2026090123533264100_cit178","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/S1471-4914(02)02429-2","article-title":"Probing the Structural and Molecular Diversity of Tumor Vasculature","volume":"8","author":"Pasqualini","year":"2002","journal-title":"Trends Mol. Med."},{"key":"2026090123533264100_cit179","first-page":"L1335","article-title":"Lung Uptake of Antibodies to Endothelial Antigens: Key Determinants of Vascular Immunotargeting","volume":"280","author":"Danilov","year":"2001","journal-title":"Am. J. Physiol.: Lung Cell. Mol. Physiol."},{"key":"2026090123533264100_cit180","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.jconrel.2006.12.025","article-title":"Factors Modulating the Delivery and Effect of Enzymatic Cargo Conjugated with Antibodies Targeted to the Pulmonary Endothelium","volume":"118","author":"Shuvaev","year":"2007","journal-title":"J. Controlled Release"},{"key":"2026090123533264100_cit181","first-page":"276","article-title":"Imaging Vascular Endothelial Activation: An Approach Using Radiolabeled Monoclonal Antibodies against the Endothelial Cell Adhesion Molecule E-Selectin","volume":"35","author":"Keelan","year":"1994","journal-title":"J. Nucl. Med."},{"key":"2026090123533264100_cit182","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.mvr.2010.12.003","article-title":"Heterogeneous Distribution of Angiotensin I-Converting Enzyme (Cd143) in the Human and Rat Vascular Systems: Vessel, Organ and Species Specificity","volume":"81","author":"Metzger","year":"2011","journal-title":"Microvasc. Res."},{"key":"2026090123533264100_cit183","doi-asserted-by":"crossref","first-page":"5446","DOI":"10.1016\/S0021-9258(18)42786-X","article-title":"Thrombomodulin Is Preferentially Expressed in Balb\/C Lung Microvessels","volume":"267","author":"Ford","year":"1992","journal-title":"J. Biol. Chem."},{"key":"2026090123533264100_cit184","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1186\/1471-2407-9-417","article-title":"Characterization of Tem1\/Endosialin in Human and Murine Brain Tumors","volume":"9","author":"Carson-Walter","year":"2009","journal-title":"BMC Cancer"},{"key":"2026090123533264100_cit185","first-page":"722","article-title":"Aminopeptidase N Is a Receptor for Tumor-Homing Peptides and a Target for Inhibiting Angiogenesis","volume":"60","author":"Pasqualini","year":"2000","journal-title":"Cancer Res."},{"key":"2026090123533264100_cit186","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1038\/nri2171","article-title":"Evolving Functions of Endothelial Cells in Inflammation","volume":"7","author":"Pober","year":"2007","journal-title":"Nat. Rev. Immunol."},{"key":"2026090123533264100_cit187","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1083\/jcb.138.5.1117","article-title":"Vascular Bed-Specific Expression of an Endothelial Cell Gene Is Programmed by the Tissue Microenvironment","volume":"138","author":"Aird","year":"1997","journal-title":"J. Cell Bio."},{"key":"2026090123533264100_cit188","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1161\/01.RES.0000255691.76142.4a","article-title":"Phenotypic Heterogeneity of the Endothelium: I. Structure, Function, and Mechanisms","volume":"100","author":"Aird","year":"2007","journal-title":"Circ. Res."},{"issue":"Suppl.","key":"2026090123533264100_cit189","first-page":"S9","article-title":"Cellular and Molecular Aspects of PECAM-1","volume":"34","author":"Newman","year":"1992","journal-title":"Nouv. Rev. Fr. Hematol."},{"key":"2026090123533264100_cit190","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.devcel.2013.08.020","article-title":"Ve-Cadherin and Endothelial Adherens Junctions: Active Guardians of Vascular Integrity","volume":"26","author":"Giannotta","year":"2013","journal-title":"Dev. Cell"},{"key":"2026090123533264100_cit191","doi-asserted-by":"crossref","first-page":"2852","DOI":"10.1182\/blood-2004-09-3606","article-title":"Endothelial Tetraspanin Microdomains Regulate Leukocyte Firm Adhesion During Extravasation","volume":"105","author":"Barreiro","year":"2005","journal-title":"Blood"},{"key":"2026090123533264100_cit192","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1089\/ars.2010.3522","article-title":"Vascular Cell Adhesion Molecule-1 Expression and Signaling During Disease: Regulation by Reactive Oxygen Species and Antioxidants","volume":"15","author":"Cook-Mills","year":"2011","journal-title":"Antioxid. Redox Signaling"},{"key":"2026090123533264100_cit193","first-page":"1278","article-title":"Apical Topography and Modulation of ICAM-1 Expression on Activated Endothelium","volume":"147","author":"Almenar-Queralt","year":"1995","journal-title":"Am. J. Pathol."},{"key":"2026090123533264100_cit194","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1111\/j.1399-0039.2004.00321.x","article-title":"Tetraspanin Microdomains in Immune Cell Signalling and Malignant Disease","volume":"64","author":"Wright","year":"2004","journal-title":"Tissue Antigens"},{"key":"2026090123533264100_cit195","doi-asserted-by":"crossref","first-page":"241","DOI":"10.3109\/10623329909053414","article-title":"A Novel, 85 kDa Endothelial Antigen Differentiates Plasma Membrane Macrodomains in Lung Alveolar Capillaries","volume":"6","author":"Ghitescu","year":"1999","journal-title":"Endothelium"},{"key":"2026090123533264100_cit196","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1164\/ajrccm.164.7.2010076","article-title":"Vascular Immunotargeting to Endothelial Surface in a Specific Macrodomain in Alveolar Capillaries","volume":"164","author":"Murciano","year":"2001","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2026090123533264100_cit197","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.jconrel.2008.06.007","article-title":"Differential Intra-Endothelial Delivery of Polymer Nanocarriers Targeted to Distinct PECAM-1 Epitopes","volume":"130","author":"Garnacho","year":"2008","journal-title":"J. Controlled Release"},{"key":"2026090123533264100_cit198","first-page":"H1282","article-title":"Role of Glycocalyx in Leukocyte-Endothelial Cell Adhesion","volume":"283","author":"Mulivor","year":"2002","journal-title":"Am. J. Physiol.: Heart Circ. Physiol."},{"issue":"Suppl 9","key":"2026090123533264100_cit199","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1097\/00005344-199200209-00003","article-title":"Bradykinin-Degrading Enzymes: Structure, Function, Distribution, and Potential Roles in Cardiovascular Pharmacology","volume":"20","author":"Skidgel","year":"1992","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"2026090123533264100_cit200","doi-asserted-by":"crossref","first-page":"5744","DOI":"10.1073\/pnas.87.15.5744","article-title":"Lipid Composition Is Important for Highly Efficient Target Binding and Retention of Immunoliposomes","volume":"87","author":"Maruyama","year":"1990","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2026090123533264100_cit201","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/S0002-9440(10)64935-8","article-title":"Vascular Immunotargeting of Glucose Oxidase to the Endothelial Antigens Induces Distinct Forms of Oxidant Acute Lung Injury: Targeting to Thrombomodulin, but Not to PECAM-1, Causes Pulmonary Thrombosis and Neutrophil Transmigration","volume":"160","author":"Christofidou-Solomidou","year":"2002","journal-title":"Am. J. Pathol."},{"key":"2026090123533264100_cit202","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1096\/fasebj.9.10.7615164","article-title":"Thrombomodulin as a Model of Molecular Mechanisms That Modulate Protease Specificity and Function at the Vessel Surface","volume":"9","author":"Esmon","year":"1995","journal-title":"FASEB J."},{"key":"2026090123533264100_cit203","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1055\/s-0038-1646353","article-title":"Antibodies to Thrombomodulin Induce Receptor-Mediated Endocytosis in Human Saphenous Vein Endothelial Cells","volume":"68","author":"Brisson","year":"1992","journal-title":"Thromb. Haemost."},{"key":"2026090123533264100_cit204","first-page":"553","article-title":"Anti-Thrombomodulin Antibodies and Venous Thrombosis","volume":"15","author":"Guermazi","year":"2004","journal-title":"Blood Coagulation Fibrinolysis"},{"key":"2026090123533264100_cit205","first-page":"L283","article-title":"PECAM-Directed Delivery of Catalase to Endothelium Protects against Pulmonary Vascular Oxidative Stress","volume":"285","author":"Christofidou-Solomidou","year":"2003","journal-title":"Am. J. Physiol.: Lung Cell. Mol. Physiol."},{"key":"2026090123533264100_cit206","first-page":"L271","article-title":"Immunotargeting of Glucose Oxidase: Intracellular Production of H2O2 and Endothelial Oxidative Stress","volume":"277","author":"Gow","year":"1999","journal-title":"Am. J. Physiol."},{"key":"2026090123533264100_cit207","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.cocis.2011.01.008","article-title":"Targeted Nanocarriers for Imaging and Therapy of Vascular Inflammation","volume":"16","author":"Chacko","year":"2011","journal-title":"Curr. Opin. Colloid Interface Sci."},{"key":"2026090123533264100_cit208","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/346425a0","article-title":"Adhesion Receptors of the Immune System","volume":"346","author":"Springer","year":"1990","journal-title":"Nature"},{"key":"2026090123533264100_cit209","doi-asserted-by":"crossref","first-page":"2362","DOI":"10.1172\/JCI118679","article-title":"Role of the Intercellular Adhesion Molecule-1(ICAM-1) in Endotoxin-Induced Pneumonia Evaluated Using ICAM-1 Antisense Oligonucleotides, Anti-ICAM-1 Monoclonal Antibodies, and ICAM-1 Mutant Mice","volume":"97","author":"Kumasaka","year":"1996","journal-title":"J. Clin. Invest."},{"key":"2026090123533264100_cit210","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S1054-3589(08)60431-7","article-title":"Integrins, ICAMs, and Selectins: Role and Regulation of Adhesion Molecules in Neutrophil Recruitment to Inflammatory Sites","volume":"25","author":"Kishimoto","year":"1994","journal-title":"Adv. Pharmacol."},{"key":"2026090123533264100_cit211","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1165\/ajrcmb\/4.3.195","article-title":"Endothelial and Epithelial Cell Adhesion Molecules","volume":"4","author":"Albelda","year":"1991","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"2026090123533264100_cit212","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1161\/01.RES.0000155722.17881.dd","article-title":"Detection of Vascular Adhesion Molecule-1 Expression Using a Novel Multimodal Nanoparticle","volume":"96","author":"Kelly","year":"2005","journal-title":"Circ. Res."},{"key":"2026090123533264100_cit213","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1126\/science.1990440","article-title":"Endothelial Expression of a Mononuclear Leukocyte Adhesion Molecule during Atherogenesis","volume":"251","author":"Cybulsky","year":"1991","journal-title":"Science"},{"key":"2026090123533264100_cit214","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1091\/mbc.2.5.347","article-title":"Tumor Cell Surface Alpha 4 Beta 1 Integrin Mediates Adhesion to Vascular Endothelium: Demonstration of an Interaction with the N-Terminal Domains of Incam-110\/Vcam-1","volume":"2","author":"Taichman","year":"1991","journal-title":"Cell Regul."},{"key":"2026090123533264100_cit215","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1021\/bc050002e","article-title":"In Vivo Imaging of Activated Endothelium Using an Anti-Vcam-1 Magnetooptical Probe","volume":"16","author":"Tsourkas","year":"2005","journal-title":"Bioconjugate Chem."},{"key":"2026090123533264100_cit216","doi-asserted-by":"crossref","first-page":"5060","DOI":"10.4049\/jimmunol.152.10.5060","article-title":"Cytokine-Activated Endothelial Cells Internalize E-Selectin into a Lysosomal Compartment of Vesiculotubular Shape. A Tubulin-Driven Process","volume":"152","author":"Kuijpers","year":"1994","journal-title":"J. Immunol."},{"key":"2026090123533264100_cit217","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1083\/jcb.151.1.107","article-title":"Rapid Transport of Internalized P-Selectin to Late Endosomes and the Tgn: Roles in Regulating Cell Surface Expression and Recycling to Secretory Granules","volume":"151","author":"Straley","year":"2000","journal-title":"J. Cell Biol."},{"key":"2026090123533264100_cit218","doi-asserted-by":"crossref","first-page":"2519","DOI":"10.1002\/eji.1830221009","article-title":"Evidence for Endocytosis of E-Selectin in Human Endothelial Cells","volume":"22","author":"von Asmuth","year":"1992","journal-title":"Eur. J. Immunol."},{"key":"2026090123533264100_cit219","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0005-2736(01)00368-6","article-title":"Investigation of the Cellular Uptake of E-Selectin-Targeted Immunoliposomes by Activated Human Endothelial Cells","volume":"1514","author":"Kessner","year":"2001","journal-title":"Biochim. Biophys. Acta"},{"key":"2026090123533264100_cit220","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1023\/A:1020769716288","article-title":"Cellular Handling of a Dexamethasone-Anti-E-Selectin Immunoconjugate by Activated Endothelial Cells: Comparison with Free Dexamethasone","volume":"19","author":"Kok","year":"2002","journal-title":"Pharm. Res."},{"key":"2026090123533264100_cit221","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1038\/sj.gt.3300898","article-title":"Targeting an Adenoviral Gene Vector to Cytokine-Activated Vascular Endothelium via E-Selectin","volume":"6","author":"Harari","year":"1999","journal-title":"Gene Ther."},{"key":"2026090123533264100_cit222","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1161\/hc4201.097061","article-title":"Ultrasound Assessment of Inflammation and Renal Tissue Injury with Microbubbles Targeted to P-Selectin","volume":"104","author":"Lindner","year":"2001","journal-title":"Circulation"},{"key":"2026090123533264100_cit223","first-page":"149","article-title":"Targeting Inflammation","volume-title":"Biomedical Aspects of Drug Targeting","author":"Lindner","year":"2003"},{"key":"2026090123533264100_cit224","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1083\/jcb.118.5.1223","article-title":"Association of Intercellular Adhesion Molecule-1 (ICAM-1) with Actin-Containing Cytoskeleton and Alpha-Actinin","volume":"118","author":"Carpen","year":"1992","journal-title":"J. Cell Biol."},{"key":"2026090123533264100_cit225","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1038\/nm1297-1405","article-title":"PECAM-1\/Cd31, an Endothelial Receptor for Binding Plasmodium Falciparum-Infected Erythrocytes","volume":"3","author":"Treutiger","year":"1997","journal-title":"Nat. Med."},{"key":"2026090123533264100_cit226","doi-asserted-by":"crossref","first-page":"6582","DOI":"10.4049\/jimmunol.154.12.6582","article-title":"Ifn-Gamma and Tnf-Alpha Induce Redistribution of PECAM-1 (Cd31) on Human Endothelial Cells","volume":"154","author":"Romer","year":"1995","journal-title":"J. Immunol."},{"key":"2026090123533264100_cit227","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1002\/jlb.64.2.163","article-title":"In Vivo Regulation of PECAM-1 Activity During Acute Endothelial Dysfunction in the Rat Mesenteric Microvasculature","volume":"64","author":"Scalia","year":"1998","journal-title":"J. Leukocyte Biol."},{"key":"2026090123533264100_cit228","doi-asserted-by":"crossref","first-page":"C1339","DOI":"10.1152\/ajpcell.00099.2003","article-title":"Slow Intracellular Trafficking of Catalase Nanoparticles Targeted to ICAM-1 Protects Endothelial Cells from Oxidative Stress","volume":"285","author":"Muro","year":"2003","journal-title":"Am. J. Physiol.: Cell Physiol."},{"key":"2026090123533264100_cit229","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1038\/ki.1992.94","article-title":"Role of Intercellular Adhesion Molecule-1 in the Inflammatory Response","volume":"41","author":"Rothlein","year":"1992","journal-title":"Kidney Int."},{"key":"2026090123533264100_cit230","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1016\/S0891-5849(00)00223-9","article-title":"Intercellular Adhesion Molecule-1 (ICAM-1) Expression and Cell Signaling Cascades","volume":"28","author":"Hubbard","year":"2000","journal-title":"Free Radical Biol. Med."},{"key":"2026090123533264100_cit231","doi-asserted-by":"crossref","first-page":"15765","DOI":"10.1074\/jbc.273.25.15765","article-title":"Regulation of Mouse PECAM-1 Tyrosine Phosphorylation by the Src and Csk Families of Protein-Tyrosine Kinases","volume":"273","author":"Cao","year":"1998","journal-title":"J. Biol. Chem."},{"key":"2026090123533264100_cit232","doi-asserted-by":"crossref","first-page":"C1181","DOI":"10.1152\/ajpcell.00524.2001","article-title":"Involvement of Human PECAM-1 in Angiogenesis and in Vitro Endothelial Cell Migration","volume":"282","author":"Cao","year":"2002","journal-title":"Am. J. Physiol.: Cell Physiol."},{"key":"2026090123533264100_cit233","first-page":"671","article-title":"M. Involvement of Endothelial PECAM-1\/Cd31 in Angiogenesis","volume":"151","author":"DeLisser","year":"1997","journal-title":"Am. J. Pathol."},{"key":"2026090123533264100_cit234","doi-asserted-by":"crossref","first-page":"16037","DOI":"10.1016\/S0021-9258(18)82354-7","article-title":"Platelet\/Endothelial Cell Adhesion Molecule-1 (Cd31)-Mediated Cellular Aggregation Involves Cell Surface Glycosaminoglycans","volume":"268","author":"DeLisser","year":"1993","journal-title":"J. Biol. Chem."},{"key":"2026090123533264100_cit235","doi-asserted-by":"crossref","first-page":"3129","DOI":"10.1083\/jcb.111.6.3129","article-title":"ICAM-1 (Cd54): A Counter-Receptor for Mac-1 (Cd11b\/Cd18)","volume":"111","author":"Diamond","year":"1990","journal-title":"J. Cell Biol."},{"key":"2026090123533264100_cit236","doi-asserted-by":"crossref","first-page":"6830","DOI":"10.1073\/pnas.121186998","article-title":"Dimerization and the Effectiveness of ICAM-1 in Mediating Lfa-1-Dependent Adhesion","volume":"98","author":"Jun","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2026090123533264100_cit237","doi-asserted-by":"crossref","first-page":"452","DOI":"10.4049\/jimmunol.164.1.452","article-title":"Antibodies against the First Ig-Like Domain of Human Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1) That Inhibit PECAM-1-Dependent Homophilic Adhesion Block in Vivo Neutrophil Recruitment","volume":"164","author":"Nakada","year":"2000","journal-title":"J. Immunol."},{"key":"2026090123533264100_cit238","doi-asserted-by":"crossref","first-page":"3550","DOI":"10.4049\/jimmunol.156.9.3550","article-title":"Blockade of Platelet Endothelial Cell Adhesion Molecule-1 Protects against Myocardial Ischemia and Reperfusion Injury in Cats","volume":"156","author":"Murohara","year":"1996","journal-title":"J. Immunol."},{"key":"2026090123533264100_cit239","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1182\/blood-2004-05-1714","article-title":"ICAM-1 Recycling in Endothelial Cells: A Novel Pathway for Sustained Intracellular Delivery and Prolonged Effects of Drugs","volume":"105","author":"Muro","year":"2005","journal-title":"Blood"},{"key":"2026090123533264100_cit240","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1053\/gast.1996.v110.pm8608897","article-title":"Portal Hypertension Enhances Endotoxin-Induced Intercellular Adhesion Molecule 1 Up-Regulation in the Rat","volume":"110","author":"Panes","year":"1996","journal-title":"Gastroenterology"},{"key":"2026090123533264100_cit241","doi-asserted-by":"crossref","first-page":"3977","DOI":"10.1182\/blood-2002-09-2853","article-title":"ICAM-Directed Vascular Immunotargeting of Antithrombotic Agents to the Endothelial Luminal Surface","volume":"101","author":"Murciano","year":"2003","journal-title":"Blood"},{"key":"2026090123533264100_cit242","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1096\/fj.00-0022com","article-title":"Cell-Selective Intracellular Delivery of a Foreign Enzyme to Endothelium in Vivo Using Vascular Immunotargeting","volume":"15","author":"Scherpereel","year":"2001","journal-title":"FASEB J."},{"key":"2026090123533264100_cit243","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1124\/jpet.105.098970","article-title":"Endothelial Targeting of High-Affinity Multivalent Polymer Nanocarriers Directed to Intercellular Adhesion Molecule 1","volume":"317","author":"Muro","year":"2006","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"2026090123533264100_cit244","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1124\/jpet.107.133298","article-title":"Delivery of Acid Sphingomyelinase in Normal and Niemann-Pick Disease Mice Using Intercellular Adhesion Molecule-1-Targeted Polymer Nanocarriers","volume":"325","author":"Garnacho","year":"2008","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"2026090123533264100_cit245","doi-asserted-by":"crossref","first-page":"95","DOI":"10.3109\/08982101003754401","article-title":"Targeting of ICAM-1-Directed Immunoliposomes Specifically to Activated Endothelial Cells with Low Cellular Uptake: Use of an Optimized Procedure for the Coupling of Low Concentrations of Antibody to Liposomes","volume":"21","author":"Hua","year":"2011","journal-title":"J. Liposome Res."},{"key":"2026090123533264100_cit246","doi-asserted-by":"crossref","first-page":"4191","DOI":"10.1182\/blood-2005-05-2002","article-title":"Endothelial Targeting of a Recombinant Construct Fusing a PECAM-1 Single-Chain Variable Antibody Fragment (Scfv) with Prourokinase Facilitates Prophylactic Thrombolysis in the Pulmonary Vasculature","volume":"106","author":"Ding","year":"2005","journal-title":"Blood"},{"key":"2026090123533264100_cit247","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.bbrc.2003.08.050","article-title":"Identification of a Murine ICAM-1-Specific Peptide by Subtractive Phage Library Selection on Cells","volume":"309","author":"Belizaire","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2026090123533264100_cit248","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0022-1759(02)00542-2","article-title":"Humanization of an Anti-ICAM-1 Antibody with over 50-fold Affinity and Functional Improvement","volume":"275","author":"Luo","year":"2003","journal-title":"J. Immunol. Methods"},{"key":"2026090123533264100_cit249","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1128\/AAC.47.5.1503-1508.2003","article-title":"Prevention of Human Rhinovirus Infection by Multivalent Fab Molecules Directed against ICAM-1","volume":"47","author":"Charles","year":"2003","journal-title":"Antimicrob. Agents Chemother."},{"key":"2026090123533264100_cit250","doi-asserted-by":"crossref","first-page":"2665","DOI":"10.1161\/hs3211.098535","article-title":"Examination of Several Potential Mechanisms for the Negative Outcome in a Clinical Stroke Trial of Enlimomab, a Murine Anti-Human Intercellular Adhesion Molecule-1 Antibody: A Bedside-to-Bench Study","volume":"32","author":"Furuya","year":"2001","journal-title":"Stroke"},{"key":"2026090123533264100_cit251","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/S0923-2494(93)80058-7","article-title":"Treatment of Inflammation with Anti-ICAM-1","volume":"144","author":"Rothlein","year":"1993","journal-title":"Res. Immunol."},{"key":"2026090123533264100_cit251b","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/S0923-2494(93)80058-7","volume":"144","author":"Rothlein","year":"1993","journal-title":"Res. Immunol."},{"key":"2026090123533264100_cit252","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1124\/jpet.111.185579","article-title":"A Fibrinogen-Derived Peptide Provides Intercellular Adhesion Molecule-1-Specific Targeting and Intraendothelial Transport of Polymer Nanocarriers in Human Cell Cultures and Mice","volume":"340","author":"Garnacho","year":"2012","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"2026090123533264100_cit253","doi-asserted-by":"crossref","first-page":"16530","DOI":"10.1073\/pnas.1006611107","article-title":"Computational Model for Nanocarrier Binding to Endothelium Validated Using in Vivo, in Vitro, and Atomic Force Microscopy Experiments","volume":"107","author":"Liu","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2026090123533264100_cit254","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1016\/j.biomaterials.2009.11.007","article-title":"Potential Role of Size and Hemodynamics in the Efficacy of Vascular-Targeted Spherical Drug Carriers","volume":"31","author":"Charoenphol","year":"2010","journal-title":"Biomaterials"},{"key":"2026090123533264100_cit255","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1114\/1.1376697","article-title":"Ligand Coated Nanosphere Adhesion to E- and P-Selectin under Static and Flow Conditions","volume":"29","author":"Blackwell","year":"2001","journal-title":"Ann. Biomed. Eng."},{"key":"2026090123533264100_cit256","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1002\/iub.475","article-title":"Dynamic Factors Controlling Carrier Anchoring on Vascular Cells","volume":"63","author":"Swaminathan","year":"2011","journal-title":"IUBMB Life"},{"key":"2026090123533264100_cit257","doi-asserted-by":"crossref","first-page":"7136","DOI":"10.1016\/j.biomaterials.2005.05.005","article-title":"In Vitro Characterization of Leukocyte Mimetic for Targeting Therapeutics to the Endothelium Using Two Receptors","volume":"26","author":"Omolola Eniola","year":"2005","journal-title":"Biomaterials"},{"key":"2026090123533264100_cit258","doi-asserted-by":"crossref","first-page":"2822","DOI":"10.1016\/j.jbiomech.2012.08.035","article-title":"Particle-Cell Dynamics in Human Blood Flow: Implications for Vascular-Targeted Drug Delivery","volume":"45","author":"Charoenphol","year":"2012","journal-title":"J. Biomechanics"},{"key":"2026090123533264100_cit259","doi-asserted-by":"crossref","first-page":"2530","DOI":"10.1021\/la304746p","article-title":"Margination Propensity of Vascular-Targeted Spheres from Blood Flow in a Microfluidic Model of Human Microvessels","volume":"29","author":"Namdee","year":"2013","journal-title":"Langmuir"},{"key":"2026090123533264100_cit260","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1023\/A:1020350708672","article-title":"Targeting Microparticles to Select Tissue via Radiation-Induced Upregulation of Endothelial Cell Adhesion Molecules","volume":"19","author":"Kiani","year":"2002","journal-title":"Pharm. Res."},{"key":"2026090123533264100_cit261","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1096\/fj.04-2668fje","article-title":"Enhanced Adhesion of Ligand-Conjugated Biodegradable Particles to Colitic Venules","volume":"19","author":"Sakhalkar","year":"2005","journal-title":"FASEB J."},{"key":"2026090123533264100_cit262","doi-asserted-by":"crossref","first-page":"15895","DOI":"10.1073\/pnas.2631433100","article-title":"Leukocyte-Inspired Biodegradable Particles That Selectively and Avidly Adhere to Inflamed Endothelium in Vitro and in Vivo","volume":"100","author":"Sakhalkar","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2026090123533264100_cit263","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1002\/jbm.a.32592","article-title":"Shear-Regulated Uptake of Nanoparticles by Endothelial Cells and Development of Endothelial-Targeting Nanoparticles","volume":"93A","author":"Lin","year":"2010","journal-title":"J. Biomed. Mater. Res., Part A"},{"key":"2026090123533264100_cit264","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s10439-005-8976-5","article-title":"A Theoretical Model for the Margination of Particles within Blood Vessels","volume":"33","author":"Decuzzi","year":"2005","journal-title":"Ann. Biomed. Eng."},{"key":"2026090123533264100_cit265","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1477-3155-6-9","article-title":"The Margination Propensity of Spherical Particles for Vascular Targeting in the Microcirculation","volume":"6","author":"Gentile","year":"2008","journal-title":"J. Nanobiotechnol."},{"key":"2026090123533264100_cit266","first-page":"H647","article-title":"Heparinase Treatment Suggests a Role for the Endothelial Cell Glycocalyx in Regulation of Capillary Hematocrit","volume":"258","author":"Desjardins","year":"1990","journal-title":"Am. J. Physiol."},{"key":"2026090123533264100_cit267","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/0014-5793(83)80160-4","article-title":"Red Blood Cell Targeting to Collagen-Coated Surfaces","volume":"154","author":"Samokhin","year":"1983","journal-title":"FEBS Lett."},{"key":"2026090123533264100_cit268","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.mvr.2009.01.010","article-title":"Effects of Erythrocyte Deformability and Aggregation on the Cell Free Layer and Apparent Viscosity of Microscopic Blood Flows","volume":"77","author":"Zhang","year":"2009","journal-title":"Microvasc. Res."},{"key":"2026090123533264100_cit269","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1039\/C2SM06391C","article-title":"Influence of Red Blood Cells on Nanoparticle Targeted Delivery in Microcirculation","volume":"8","author":"Tan","year":"2011","journal-title":"Soft Matter"},{"key":"2026090123533264100_cit270","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1159\/000313880","article-title":"Lung Vascular Targeting Using Antibody to Aminopeptidase P: Ct-Spect Imaging, Biodistribution and Pharmacokinetic Analysis","volume":"47","author":"Chrastina","year":"2010","journal-title":"J. Vasc. Res."},{"key":"2026090123533264100_cit271","doi-asserted-by":"crossref","first-page":"10753","DOI":"10.1073\/pnas.1308345110","article-title":"Using Shape Effects to Target Antibody-Coated Nanoparticles to Lung and Brain Endothelium","volume":"110","author":"Kolhar","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2026090123533264100_cit272","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1007\/s10544-008-9170-y","article-title":"Synthetic Microvascular Networks for Quantitative Analysis of Particle Adhesion","volume":"10","author":"Prabhakarpandian","year":"2008","journal-title":"Biomed. Microdevices"},{"key":"2026090123533264100_cit273","doi-asserted-by":"crossref","first-page":"5307","DOI":"10.1016\/j.biomaterials.2006.05.024","article-title":"The Adhesive Strength of Non-Spherical Particles Mediated by Specific Interactions","volume":"27","author":"Decuzzi","year":"2006","journal-title":"Biomaterials"},{"key":"2026090123533264100_cit274","doi-asserted-by":"crossref","first-page":"2915","DOI":"10.1016\/j.biomaterials.2007.02.013","article-title":"The Role of Specific and Non-Specific Interactions in Receptor-Mediated Endocytosis of Nanoparticles","volume":"28","author":"Decuzzi","year":"2007","journal-title":"Biomaterials"},{"key":"2026090123533264100_cit275","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.jconrel.2010.04.007","article-title":"Flow and Adhesion of Drug Carriers in Blood Vessels Depend on Their Shape: A Study Using Model Synthetic Microvascular Networks","volume":"146","author":"Doshi","year":"2010","journal-title":"J. Controlled Release"},{"key":"2026090123533264100_cit276","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1007\/s10544-009-9322-8","article-title":"A Physiologically Realistic in Vitro Model of Microvascular Networks","volume":"11","author":"Rosano","year":"2009","journal-title":"Biomed. Microdevices"},{"key":"2026090123533264100_cit277","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1166\/jnn.2011.3536","article-title":"Modeling Particle Shape-Dependent Dynamics in Nanomedicine","volume":"11","author":"Shah","year":"2011","journal-title":"J. Nanosci. Nanotechnol."},{"key":"2026090123533264100_cit278","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.1016\/j.jbiomech.2008.03.021","article-title":"The Effect of Shape on the Margination Dynamics of Non-Neutrally Buoyant Particles in Two-Dimensional Shear Flows","volume":"41","author":"Gentile","year":"2008","journal-title":"J. Biomechanics"},{"key":"2026090123533264100_cit279","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1016\/j.biomaterials.2009.09.107","article-title":"The Role of Antibody Synergy and Membrane Fluidity in the Vascular Targeting of Immunoliposomes","volume":"31","author":"Gunawan","year":"2010","journal-title":"Biomaterials"},{"key":"2026090123533264100_cit280","doi-asserted-by":"crossref","first-page":"3864","DOI":"10.1002\/adma.201200607","article-title":"Platelet Mimetic Particles for Targeting Thrombi in Flowing Blood","volume":"24","author":"Doshi","year":"2012","journal-title":"Adv. Mater."},{"key":"2026090123533264100_cit281","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1242\/jcs.115.4.849","article-title":"Fc-Receptor-Mediated Phagocytosis Is Regulated by Mechanical Properties of the Target","volume":"115","author":"Beningo","year":"2002","journal-title":"J. Cell Sci."},{"key":"2026090123533264100_cit282","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1021\/bc00022a001","article-title":"Chemically Optimized Antimyosin Fab Conjugates with Chelating Polymers: Importance of the Nature of the Protein-Polymer Single Site Covalent Bond for Biodistribution and Infarction Localization","volume":"4","author":"Trubetskoy","year":"1993","journal-title":"Bioconjugate Chem."},{"key":"2026090123533264100_cit283","first-page":"189","article-title":"New Biotechnological and Nanomedicine Strategies for Treatment of Lysosomal Storage Disorders","volume":"2","author":"Muro","year":"2010","journal-title":"Wiley Interdiscip. Rev.: Nanomed. Nanobiotechnol."},{"key":"2026090123533264100_cit284","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.jconrel.2010.10.025","article-title":"Optimizing Endothelial Targeting by Modulating the Antibody Density and Particle Concentration of Anti-ICAM Coated Carriers","volume":"150","author":"Calderon","year":"2011","journal-title":"J. Controlled Release"},{"key":"2026090123533264100_cit285","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1158\/1078-0432.CCR-05-2217","article-title":"Avidity-Mediated Enhancement of in Vivo Tumor Targeting by Single-Chain Fv Dimers","volume":"12","author":"Adams","year":"2006","journal-title":"Clin. Cancer Res."},{"key":"2026090123533264100_cit286","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1126\/science.1226338","article-title":"Multifunctional Nanoparticles: Cost versus Benefit of Adding Targeting and Imaging Capabilities","volume":"338","author":"Cheng","year":"2012","journal-title":"Science"},{"key":"2026090123533264100_cit287","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1038\/nmat3775","article-title":"Engineering Synthetic Vaccines Using Cues from Natural Immunity","volume":"12","author":"Irvine","year":"2013","journal-title":"Nat. Mater."},{"key":"2026090123533264100_cit288","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/nature12978","article-title":"Structure-Based Programming of Lymph-Node Targeting in Molecular Vaccines","volume":"507","author":"Liu","year":"2014","journal-title":"Nature"},{"key":"2026090123533264100_cit289","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.molmed.2011.11.002","article-title":"Targeted Nanotherapy for Induction of Therapeutic Immune Responses","volume":"18","author":"Metcalfe","year":"2012","journal-title":"Trends Mol. Med."},{"key":"2026090123533264100_cit290","first-page":"4750","article-title":"High Affinity Restricts the Localization and Tumor Penetration of Single-Chain Fv Antibody Molecules","volume":"61","author":"Adams","year":"2001","journal-title":"Cancer Res."},{"key":"2026090123533264100_cit291","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1161\/01.CIR.92.7.1883","article-title":"Superficial Accumulation of Plasminogen During Plasma Clot Lysis","volume":"92","author":"Sakharov","year":"1995","journal-title":"Circulation"},{"key":"2026090123533264100_cit292","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.nano.2012.05.015","article-title":"Effect of Ligand Density, Receptor Density, and Nanoparticle Size on Cell Targeting","volume":"9","author":"Elias","year":"2013","journal-title":"Nanomedicine"},{"key":"2026090123533264100_cit293","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1002\/jps.22342","article-title":"Controlling Ligand Surface Density Optimizes Nanoparticle Binding to ICAM-1","volume":"100","author":"Fakhari","year":"2011","journal-title":"J. Pharm. Sci."},{"key":"2026090123533264100_cit294","doi-asserted-by":"crossref","first-page":"2586","DOI":"10.1073\/pnas.0711714105","article-title":"Precise Engineering of Targeted Nanoparticles by Using Self-Assembled Biointegrated Block Copolymers","volume":"105","author":"Gu","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2026090123533264100_cit295","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/4795","article-title":"Fibrinogen-Coated Albumin Microcapsules Reduce Bleeding in Severely Thrombocytopenic Rabbits","volume":"5","author":"Levi","year":"1999","journal-title":"Nat. Med."},{"key":"2026090123533264100_cit296","doi-asserted-by":"crossref","first-page":"11ra22","DOI":"10.1126\/scitranslmed.3000397","article-title":"Intravenous Hemostat: Nanotechnology to Halt Bleeding","volume":"1","author":"Bertram","year":"2009","journal-title":"Sci. Transl. Med."},{"key":"2026090123533264100_cit297","doi-asserted-by":"crossref","first-page":"3031","DOI":"10.1016\/j.biomaterials.2012.12.045","article-title":"In Vitro and in Vivo Hemostatic Capabilities of a Functionally Integrated Platelet-Mimetic Liposomal Nanoconstruct","volume":"34","author":"Modery-Pawlowski","year":"2013","journal-title":"Biomaterials"},{"key":"2026090123533264100_cit298","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.biomaterials.2012.09.074","article-title":"Approaches to Synthetic Platelet Analogs","volume":"34","author":"Modery-Pawlowski","year":"2012","journal-title":"Biomaterials"},{"key":"2026090123533264100_cit299","doi-asserted-by":"crossref","first-page":"10719","DOI":"10.1039\/c3nr03595f","article-title":"Intravenous Hemostats: Challenges in Translation to Patients","volume":"5","author":"Lashof-Sullivan","year":"2013","journal-title":"Nanoscale"},{"key":"2026090123533264100_cit300","doi-asserted-by":"crossref","first-page":"2790","DOI":"10.1021\/bm400619v","article-title":"Tuning Ligand Density on Intravenous Hemostatic Nanoparticles Dramatically Increases Survival Following Blunt Trauma","volume":"14","author":"Shoffstall","year":"2013","journal-title":"Biomacromolecules"},{"key":"2026090123533264100_cit301","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1096\/fj.09-148981","article-title":"Superior Sensitivity of Novel Molecular Imaging Probe: Simultaneously Targeting Two Types of Endothelial Injury Markers","volume":"24","author":"Sun","year":"2010","journal-title":"FASEB J."},{"key":"2026090123533264100_cit302","doi-asserted-by":"crossref","first-page":"2720","DOI":"10.1016\/S0006-3495(03)74695-5","article-title":"Interplay between Rolling and Firm Adhesion Elucidated with a Cell-Free System Engineered with Two Distinct Receptor-Ligand Pairs","volume":"85","author":"Eniola","year":"2003","journal-title":"Biophys. J."},{"key":"2026090123533264100_cit303","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1021\/mp9003095","article-title":"Immunoliposomes That Target Endothelium in Vitro Are Dependent on Lipid Raft Formation","volume":"7","author":"Gunawan","year":"2010","journal-title":"Mol. Pharmaceutics"},{"key":"2026090123533264100_cit304","doi-asserted-by":"crossref","first-page":"9848","DOI":"10.1016\/j.biomaterials.2011.08.093","article-title":"Complementary Targeting of Liposomes to Il-1alpha and Tnf-Alpha Activated Endothelial Cells via the Transient Expression of Vcam1 and E-Selectin","volume":"32","author":"Gunawan","year":"2011","journal-title":"Biomaterials"},{"key":"2026090123533264100_cit305","doi-asserted-by":"crossref","first-page":"3459","DOI":"10.1016\/j.biomaterials.2013.01.069","article-title":"In Vivo Performance of Polymer Nanocarriers Dually-Targeted to Epitopes of the Same or Different Receptors","volume":"34","author":"Papademetriou","year":"2013","journal-title":"Biomaterials"},{"key":"2026090123533264100_cit306","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1161\/ATVBAHA.107.145466","article-title":"Magnetic Resonance Imaging of Endothelial Adhesion Molecules in Mouse Atherosclerosis Using Dual-Targeted Microparticles of Iron Oxide","volume":"28","author":"McAteer","year":"2008","journal-title":"Arterioscler., Thromb., Vasc. Biol."},{"key":"2026090123533264100_cit307","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1002\/bit.20625","article-title":"Targeted Ultrasound Contrast Agents: In Vitro Assessment of Endothelial Dysfunction and Multi-Targeting to ICAM-1 and Sialyl Lewisx","volume":"92","author":"Weller","year":"2005","journal-title":"Biotechnol. Bioeng."},{"key":"2026090123533264100_cit308","doi-asserted-by":"crossref","first-page":"26806","DOI":"10.1016\/S0021-9258(18)47091-3","article-title":"Structure-Function Analysis of Angiotensin I-Converting Enzyme Using Monoclonal Antibodies. Selective Inhibition of the Amino-Terminal Active Site","volume":"269","author":"Danilov","year":"1994","journal-title":"J. Biol. Chem."},{"key":"2026090123533264100_cit309","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1042\/bj3620585","article-title":"Epitope-Specific Antibody-Induced Cleavage of Angiotensin-Converting Enzyme from the Cell Surface","volume":"362","author":"Balyasnikova","year":"2002","journal-title":"Biochem. J."},{"key":"2026090123533264100_cit310","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1111\/j.1399-0039.2009.01416.x","article-title":"Fine Epitope Mapping of Monoclonal Antibodies 9b9 and 3g8 to the N Domain of Angiotensin-Converting Enzyme (Cd143) Defines a Region Involved in Regulating Angiotensin-Converting Enzyme Dimerization and Shedding","volume":"75","author":"Gordon","year":"2010","journal-title":"Tissue Antigens"},{"key":"2026090123533264100_cit311","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0034958","article-title":"Collaborative Enhancement of Antibody Binding to Distinct PECAM-1 Epitopes Modulates Endothelial Targeting","volume":"7","author":"Chacko","year":"2012","journal-title":"PLoS One"},{"key":"2026090123533264100_cit312","article-title":"Creation of Lung-Targeted Dexamethasone Immunoliposome and Its Therapeutic Effect on Bleomycin-Induced Lung Injury in Rats","volume":"8","author":"Chen","year":"2013","journal-title":"PLoS One"},{"key":"2026090123533264100_cit313","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1055\/s-0030-1253445","article-title":"Under-Recognized Significance of Endothelial Heterogeneity: Hemostasis, Thrombosis, and Beyond","volume":"36","author":"Aird","year":"2010","journal-title":"Semin. Thromb. Hemostasis"},{"key":"2026090123533264100_cit314","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0169-409X(01)00141-7","article-title":"Caveolae: From Basic Trafficking Mechanisms to Targeting Transcytosis for Tissue-Specific Drug and Gene Delivery in Vivo","volume":"49","author":"Schnitzer","year":"2001","journal-title":"Adv. Drug Delivery Rev."},{"key":"2026090123533264100_cit315","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1007\/s11626-998-0114-x","article-title":"Modulation of Angiotensin-Converting Enzyme in Cultured Human Vascular Endothelial Cells","volume":"34","author":"Balyasnikova","year":"1998","journal-title":"In Vitro Cell. Dev. Biol.: Anim."},{"key":"2026090123533264100_cit316","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.addr.2013.11.004","article-title":"Nanopreparations for Organelle-Specific Delivery in Cancer","volume":"66","author":"Biswas","year":"2013","journal-title":"Adv. Drug Delivery Rev."},{"key":"2026090123533264100_cit317","doi-asserted-by":"crossref","first-page":"705","DOI":"10.4155\/tde.13.37","article-title":"Intracellular Delivery of Polymeric Nanocarriers: A Matter of Size, Shape, Charge, Elasticity and Surface Composition","volume":"4","author":"Agarwal","year":"2013","journal-title":"Ther. Delivery"},{"key":"2026090123533264100_cit318","first-page":"L823","article-title":"Molecular Determinants of Endothelial Transcytosis and Their Role in Endothelial Permeability","volume":"293","author":"Predescu","year":"2007","journal-title":"Am. J. Physiol.: Lung Cell. Mol. Physiol."},{"key":"2026090123533264100_cit319","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1152\/physrev.1997.77.3.759","article-title":"Endocytosis","volume":"77","author":"Mukherjee","year":"1997","journal-title":"Physiol. Rev."},{"key":"2026090123533264100_cit320","first-page":"58","volume-title":"Phagocytosis","author":"Caron","year":"2001"},{"key":"2026090123533264100_cit321","doi-asserted-by":"crossref","first-page":"62","DOI":"10.32607\/20758251-2013-5-3-62-73","article-title":"Clathrin-Mediated Endocytosis and Adaptor Proteins","volume":"5","author":"Popova","year":"2013","journal-title":"Acta Nat."},{"key":"2026090123533264100_cit322","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1146\/annurev.cellbio.12.1.575","article-title":"Endocytosis and Molecular Sorting","volume":"12","author":"Mellman","year":"1996","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"2026090123533264100_cit323","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1083\/jcb.150.5.1057","article-title":"Endothelial Cell-Surface Gp60 Activates Vesicle Formation and Trafficking via G(I)-Coupled Src Kinase Signaling Pathway","volume":"150","author":"Minshall","year":"2000","journal-title":"J. Cell Biol."},{"key":"2026090123533264100_cit324","doi-asserted-by":"crossref","first-page":"13932","DOI":"10.1073\/pnas.212253499","article-title":"Transport of Nitrated Albumin across Continuous Vascular Endothelium","volume":"99","author":"Predescu","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2026090123533264100_cit325","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1006\/excr.1998.4110","article-title":"Size of Igg-Opsonized Particles Determines Macrophage Response During Internalization","volume":"242","author":"Koval","year":"1998","journal-title":"Exp. Cell Res."},{"key":"2026090123533264100_cit326","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1182\/blood.V99.3.912","article-title":"Size-Dependent Intracellular Immunotargeting of Therapeutic Cargoes into Endothelial Cells","volume":"99","author":"Wiewrodt","year":"2002","journal-title":"Blood"},{"key":"2026090123533264100_cit327","doi-asserted-by":"crossref","first-page":"883","DOI":"10.4049\/jimmunol.168.2.883","article-title":"Selective Intracellular Delivery of Dexamethasone into Activated Endothelial Cells Using an E-Selectin-Directed Immunoconjugate","volume":"168","author":"Everts","year":"2002","journal-title":"J. Immunol."},{"key":"2026090123533264100_cit328","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1002\/(SICI)1521-4141(199805)28:05<1708::AID-IMMU1708>3.0.CO;2-Y","article-title":"Vcam-1 Is Internalized by a Clathrin-Related Pathway in Human Endothelial Cells but Its Alpha 4 Beta 1 Integrin Counter-Receptor Remains Associated with the Plasma Membrane in Human T Lymphocytes","volume":"28","author":"Ricard","year":"1998","journal-title":"Eur. J. Immunol."},{"key":"2026090123533264100_cit329","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1124\/mi.3.2.90","article-title":"Blood-Brain Barrier Drug Targeting: The Future of Brain Drug Development","volume":"3","author":"Pardridge","year":"2003","journal-title":"Mol. Interventions"},{"key":"2026090123533264100_cit330","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1002\/ijc.2910470625","article-title":"Selection of Monoclonal Antibodies Which Induce Internalization and Phosphorylation of P185her2 and Growth Inhibition of Cells with Her2\/Neu Gene Amplification","volume":"47","author":"Tagliabue","year":"1991","journal-title":"Int. J. Cancer"},{"key":"2026090123533264100_cit331","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1038\/sj.gt.3300453","article-title":"Selection and Use of Ligands for Receptor-Mediated Gene Delivery to Myogenic Cells","volume":"4","author":"Feero","year":"1997","journal-title":"Gene Ther."},{"key":"2026090123533264100_cit332","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.abb.2012.05.007","article-title":"Selection and Characterization of Cell Binding and Internalizing Phage Antibodies","volume":"526","author":"Zhou","year":"2012","journal-title":"Arch. Biochem. Biophys."},{"key":"2026090123533264100_cit333","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.jmb.2010.09.006","article-title":"Internalizing Cancer Antibodies from Phage Libraries Selected on Tumor Cells and Yeast-Displayed Tumor Antigens","volume":"404","author":"Zhou","year":"2010","journal-title":"J. Mol. Biol."},{"key":"2026090123533264100_cit334","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0022-1759(00)00340-9","article-title":"Selection of Cell Binding and Internalizing Epidermal Growth Factor Receptor Antibodies from a Phage Display Library","volume":"248","author":"Heitner","year":"2001","journal-title":"J. Immunol. Methods"},{"key":"2026090123533264100_cit335","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1021\/bc00019a002","article-title":"Enhanced in Vitro Tumor Cell Retention and Internalization of Antibody Derivatized with Synthetic Peptides","volume":"4","author":"Anderson","year":"1993","journal-title":"Bioconjugate Chem."},{"key":"2026090123533264100_cit336","doi-asserted-by":"crossref","first-page":"183ra57","DOI":"10.1126\/scitranslmed.3005338","article-title":"Addressing Safety Liabilities of Tfr Bispecific Antibodies That Cross the Blood-Brain Barrier","volume":"5","author":"Couch","year":"2013","journal-title":"Sci. Transl. Med."},{"key":"2026090123533264100_cit337","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1096\/fj.00-0372com","article-title":"PECAM-1 Shedding During Apoptosis Generates a Membrane-Anchored Truncated Molecule with Unique Signaling Characteristics","volume":"15","author":"Ilan","year":"2001","journal-title":"FASEB J."},{"key":"2026090123533264100_cit338","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1242\/jcs.00367","article-title":"A Novel Endocytic Pathway Induced by Clustering Endothelial ICAM-1 or PECAM-1","volume":"116","author":"Muro","year":"2003","journal-title":"J. Cell Sci."},{"key":"2026090123533264100_cit339","first-page":"21","article-title":"Characterization of Endothelial Internalization and Targeting of Antibody-Enzyme Conjugates in Cell Cultures and in Laboratory Animals","volume":"283","author":"Muro","year":"2004","journal-title":"Methods Mol. Biol."},{"key":"2026090123533264100_cit340","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1164\/rccm.200809-1433OC","article-title":"Anchoring Fusion Thrombomodulin to the Endothelial Lumen Protects against Injury-Induced Lung Thrombosis and Inflammation","volume":"180","author":"Ding","year":"2009","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2026090123533264100_cit341","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1034\/j.1600-0854.2002.30501.x","article-title":"Endocytosis via Caveolae","volume":"3","author":"Pelkmans","year":"2002","journal-title":"Traffic"},{"key":"2026090123533264100_cit342","doi-asserted-by":"crossref","first-page":"3759","DOI":"10.1002\/adfm.201102918","article-title":"Polymer Microparticles Exhibit Size and Shape Dependent Accumulation around the Nucleus after Endocytosis","volume":"22","author":"Kolhar","year":"2012","journal-title":"Adv. Funct. Mater."},{"key":"2026090123533264100_cit343","doi-asserted-by":"crossref","first-page":"2094","DOI":"10.1002\/smll.201100497","article-title":"Polymer Nanoneedle-Mediated Intracellular Drug Delivery","volume":"7","author":"Kolhar","year":"2011","journal-title":"Small"},{"key":"2026090123533264100_cit344","doi-asserted-by":"crossref","first-page":"11613","DOI":"10.1073\/pnas.0801763105","article-title":"The Effect of Particle Design on Cellular Internalization Pathways","volume":"105","author":"Gratton","year":"2008","journal-title":"Proc. Natl. Acad.Sci. U.S.A."},{"key":"2026090123533264100_cit345","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.jconrel.2011.09.067","article-title":"Effect of Flow on Endothelial Endocytosis of Nanocarriers Targeted to ICAM-1","volume":"157","author":"Bhowmick","year":"2012","journal-title":"J. Controlled Release"},{"key":"2026090123533264100_cit346","first-page":"2943","article-title":"Multifactorial Determinants That Govern Nanoparticle Uptake by Human Endothelial Cells under Flow","volume":"7","author":"Samuel","year":"2012","journal-title":"Int. J. Nanomed."},{"key":"2026090123533264100_cit347","doi-asserted-by":"crossref","first-page":"2810","DOI":"10.1111\/j.1538-7836.2010.04088.x","article-title":"Internalization of Microparticles by Endothelial Cells Promotes Platelet\/Endothelial Cell Interaction under Flow","volume":"8","author":"Terrisse","year":"2010","journal-title":"J. Thromb. Haemost."},{"key":"2026090123533264100_cit348","doi-asserted-by":"crossref","first-page":"8824","DOI":"10.1021\/nn302687n","article-title":"Acute and Chronic Shear Stress Differently Regulate Endothelial Internalization of Nanocarriers Targeted to Platelet-Endothelial Cell Adhesion Molecule-1","volume":"6","author":"Han","year":"2012","journal-title":"ACS Nano"},{"key":"2026090123533264100_cit349","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1161\/ATVBAHA.111.244186","article-title":"Intercellular Adhesion Molecule 1 Engagement Modulates Sphingomyelinase and Ceramide, Supporting Uptake of Drug Carriers by the Vascular Endothelium","volume":"32","author":"Serrano","year":"2012","journal-title":"Arterioscler., Thromb., Vasc. Biol."},{"key":"2026090123533264100_cit350","doi-asserted-by":"crossref","first-page":"10597","DOI":"10.1021\/nn404719c","article-title":"Biological Functionalization of Drug Delivery Carriers to Bypass Size Restrictions of Receptor-Mediated Endocytosis Independently from Receptor Targeting","volume":"7","author":"Ansar","year":"2013","journal-title":"ACS Nano"},{"key":"2026090123533264100_cit351","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S1525-0016(02)00018-7","article-title":"Global Non-Viral Gene Transfer to the Primate Brain Following Intravenous Administration","volume":"7","author":"Zhang","year":"2003","journal-title":"Mol. Ther."},{"key":"2026090123533264100_cit352","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1126\/science.274.5285.239","article-title":"Role of Gtp Hydrolysis in Fission of Caveolae Directly from Plasma Membranes","volume":"274","author":"Schnitzer","year":"1996","journal-title":"Science"},{"key":"2026090123533264100_cit353","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1006\/mvre.2000.2274","article-title":"Evidence of Transcellular Permeability Pathway in Microvessels","volume":"61","author":"Vogel","year":"2001","journal-title":"Microvasc. Res."},{"key":"2026090123533264100_cit354","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1177\/002215540104900401","article-title":"The Vesiculo-Vacuolar Organelle (Vvo). A New Endothelial Cell Permeability Organelle","volume":"49","author":"Dvorak","year":"2001","journal-title":"J. Histochem. Cytochem."},{"key":"2026090123533264100_cit355","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1477-3155-10-33","article-title":"Uptake of Ricinb-Quantum Dot Nanoparticles by a Macropinocytosis-Like Mechanism","volume":"10","author":"Iversen","year":"2012","journal-title":"J. Nanobiotechnol."},{"key":"2026090123533264100_cit356","doi-asserted-by":"crossref","first-page":"4110","DOI":"10.1021\/nn9012274","article-title":"Size and Dynamics of Caveolae Studied Using Nanoparticles in Living Endothelial Cells","volume":"3","author":"Wang","year":"2009","journal-title":"ACS Nano"},{"key":"2026090123533264100_cit357","doi-asserted-by":"crossref","first-page":"14399","DOI":"10.1074\/jbc.270.24.14399","article-title":"Endothelial Caveolae Have the Molecular Transport Machinery for Vesicle Budding, Docking, and Fusion Including Vamp, Nsf, Snap, Annexins, and Gtpases","volume":"270","author":"Schnitzer","year":"1995","journal-title":"J. Biol. Chem."},{"key":"2026090123533264100_cit358","first-page":"L1081","article-title":"Integrated Control of Lung Fluid Balance","volume":"287","author":"Mehta","year":"2004","journal-title":"Am. J. Physiol.: Lung Cell. Mol. Physiol."},{"key":"2026090123533264100_cit359","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jconrel.2012.06.007","article-title":"Transport of Nanocarriers across Gastrointestinal Epithelial Cells by a New Transcellular Route Induced by Targeting ICAM-1","volume":"163","author":"Ghaffarian","year":"2012","journal-title":"J. Controlled Release"},{"key":"2026090123533264100_cit360","first-page":"4223","article-title":"Biodistribution and Endocytosis of ICAM-1-Targeting Antibodies versus Nanocarriers in the Gastrointestinal Tract in Mice","volume":"7","author":"Mane","year":"2012","journal-title":"Int. J. Nanomed."},{"key":"2026090123533264100_cit361","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.nano.2010.12.007","article-title":"Propidium Iodide Labeling of Nanoparticles as a Novel Tool for the Quantification of Cellular Binding and Uptake","volume":"7","author":"Neumeyer","year":"2011","journal-title":"Nanomedicine"},{"key":"2026090123533264100_cit362","first-page":"3","article-title":"Streptavidin-Biotin Crosslinking of Therapeutic Enzymes with Carrier Antibodies: Nanoconjugates for Protection against Endothelial Oxidative Stress","volume":"283","author":"Shuvaev","year":"2004","journal-title":"Methods Mol. Biol."},{"key":"2026090123533264100_cit363","doi-asserted-by":"crossref","first-page":"3024","DOI":"10.1182\/blood-2007-06-098657","article-title":"Rhoa Activation and Actin Reorganization Involved in Endothelial Cam-Mediated Endocytosis of Anti-PECAM Carriers: Critical Role for Tyrosine 686 in the Cytoplasmic Tail of PECAM-1","volume":"111","author":"Garnacho","year":"2008","journal-title":"Blood"},{"key":"2026090123533264100_cit364","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/nnano.2011.191","article-title":"Role of Cell Cycle on the Cellular Uptake and Dilution of Nanoparticles in a Cell Population","volume":"7","author":"Kim","year":"2012","journal-title":"Nat. Nanotechnol."},{"key":"2026090123533264100_cit365","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1038\/mt.2010.236","article-title":"Surface Characteristics of Nanoparticles Determine Their Intracellular Fate in and Processing by Human Blood-Brain Barrier Endothelial Cells in Vitro","volume":"19","author":"Georgieva","year":"2011","journal-title":"Mol. Ther."},{"key":"2026090123533264100_cit366","doi-asserted-by":"crossref","first-page":"6605","DOI":"10.1021\/nn306032k","article-title":"Multiple Internalization Pathways of Polyelectrolyte Multilayer Capsules into Mammalian Cells","volume":"7","author":"Kastl","year":"2013","journal-title":"ACS Nano"},{"key":"2026090123533264100_cit367","doi-asserted-by":"crossref","first-page":"7850","DOI":"10.1021\/nn302122h","article-title":"Precision Intracellular Delivery Based on Optofluidic Polymersome Rupture","volume":"6","author":"Vasdekis","year":"2012","journal-title":"ACS Nano"},{"key":"2026090123533264100_cit368","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1007\/s11095-013-1027-2","article-title":"Caveolar Uptake and Endothelial-Protective Effects of Nanostructured Lipid Carriers in Acid Aspiration Murine Acute Lung Injury","volume":"30","author":"Kardara","year":"2013","journal-title":"Pharm. Res."},{"key":"2026090123533264100_cit369","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1042\/bj20031253","article-title":"Size-Dependent Internalization of Particles via the Pathways of Clathrin- and Caveolae-Mediated Endocytosis","volume":"377","author":"Rejman","year":"2004","journal-title":"Biochem. J."},{"key":"2026090123533264100_cit370","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1161\/01.ATV.0000099880.09014.7D","article-title":"Thrombin and Phenotypic Modulation of the Endothelium","volume":"24","author":"Minami","year":"2004","journal-title":"Arterioscler., Thromb., Vasc. Biol."},{"key":"2026090123533264100_cit371","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1165\/rcmb.2011-0416TE","article-title":"Human Primary Lung Endothelial Cells in Culture","volume":"46","author":"Comhair","year":"2012","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"2026090123533264100_cit372","doi-asserted-by":"crossref","first-page":"e32568","DOI":"10.1371\/journal.pone.0032568","article-title":"Uptake Mechanism of Apoe-Modified Nanoparticles on Brain Capillary Endothelial Cells as a Blood-Brain Barrier Model","volume":"7","author":"Wagner","year":"2012","journal-title":"PLoS One"},{"key":"2026090123533264100_cit373","first-page":"1897","article-title":"Vcam-1-Targeted Core\/Shell Nanoparticles for Selective Adhesion and Delivery to Endothelial Cells with Lipopolysaccharide-Induced Inflammation under Shear Flow and Cellular Magnetic Resonance Imaging in Vitro","volume":"8","author":"Yang","year":"2013","journal-title":"Int. J. Nanomed."},{"key":"2026090123533264100_cit374","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1038\/ncpcardio1397","article-title":"Hemodynamic Shear Stress and the Endothelium in Cardiovascular Pathophysiology","volume":"6","author":"Davies","year":"2009","journal-title":"Nat. Clin. Pract. Cardiovasc. Med."},{"key":"2026090123533264100_cit375","doi-asserted-by":"crossref","first-page":"3246","DOI":"10.1039\/c3lc50493j","article-title":"Microfluidics Embedded within Extracellular Matrix to Define Vascular Architectures and Pattern Diffusive Gradients","volume":"13","author":"Baker","year":"2013","journal-title":"Lab Chip"},{"key":"2026090123533264100_cit376","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s10439-012-0634-0","article-title":"Microfluidic System for Facilitated Quantification of Nanoparticle Accumulation to Cells under Laminar Flow","volume":"41","author":"Kusunose","year":"2013","journal-title":"Ann. Biomed. Eng."},{"key":"2026090123533264100_cit377","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1089\/ten.tea.2011.0058","article-title":"Toward an in Vitro Vasculature: Differentiation of Mesenchymal Stromal Cells within an Endothelial Cell-Seeded Modular Construct in a Microfluidic Flow Chamber","volume":"18","author":"Khan","year":"2012","journal-title":"Tissue Eng., Part A"},{"key":"2026090123533264100_cit378","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1039\/B913390A","article-title":"Macro- and Microscale Fluid Flow Systems for Endothelial Cell Biology","volume":"10","author":"Young","year":"2010","journal-title":"Lab Chip"},{"key":"2026090123533264100_cit379","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1038\/nm996","article-title":"Transducible Tat-Ha Fusogenic Peptide Enhances Escape of Tat-Fusion Proteins after Lipid Raft Macropinocytosis","volume":"10","author":"Wadia","year":"2004","journal-title":"Nat. Med."},{"key":"2026090123533264100_cit380","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.2217\/nnm.11.70","article-title":"Quantification of Nanoparticle Uptake by Cells Using an Unbiased Sampling Method and Electron Microscopy","volume":"6","author":"Elsaesser","year":"2011","journal-title":"Nanomedicine (London, U.K.)"},{"key":"2026090123533264100_cit381","doi-asserted-by":"crossref","first-page":"3767","DOI":"10.1021\/nn3049494","article-title":"Mechanism of Polyplex- and Lipoplex-Mediated Delivery of Nucleic Acids: Real-Time Visualization of Transient Membrane Destabilization without Endosomal Lysis","volume":"7","author":"ur Rehman","year":"2013","journal-title":"ACS Nano"},{"key":"2026090123533264100_cit382","doi-asserted-by":"crossref","first-page":"6092","DOI":"10.1021\/nn4018922","article-title":"Assessing the in Vivo Targeting Efficiency of Multifunctional Nanoconstructs Bearing Antibody-Derived Ligands","volume":"7","author":"Fiandra","year":"2013","journal-title":"ACS Nano"}],"container-title":["ACS Nano"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/nn500136z","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/ancac3\/article-pdf\/8\/5\/4100\/13911393\/nn500136z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/ancac3\/article-pdf\/8\/5\/4100\/13911393\/nn500136z.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T04:24:21Z","timestamp":1788323061000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/ancac3\/article\/8\/5\/4100\/1353898\/Vascular-Targeting-of-Nanocarriers-Perplexing"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4,30]]},"references-count":383,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2014,4,30]]},"published-print":{"date-parts":[[2014,5,27]]}},"URL":"https:\/\/doi.org\/10.1021\/nn500136z","relation":{},"ISSN":["1936-0851","1936-086X"],"issn-type":[{"value":"1936-0851","type":"print"},{"value":"1936-086X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,4,30]]}}}