{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T11:30:27Z","timestamp":1787052627710,"version":"build-2736575974"},"reference-count":51,"publisher":"American Chemical Society (ACS)","issue":"6","license":[{"start":{"date-parts":[[2014,5,5]],"date-time":"2014-05-05T00:00:00Z","timestamp":1399248000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2014,5,5]],"date-time":"2014-05-05T00:00:00Z","timestamp":1399248000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2014,5,5]],"date-time":"2014-05-05T00:00:00Z","timestamp":1399248000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,6,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Highly pathogenic avian influenza A viruses are emerging pandemic threats in human beings. Monitoring the in vivo dynamics of avian influenza viruses is extremely important for understanding viral pathogenesis and developing antiviral drugs. Although a number of technologies have been applied for tracking viral infection in vivo, most of them are laborious with unsatisfactory detection sensitivity. Herein we labeled avian influenza H5N1 pseudotype virus (H5N1p) with near-infrared (NIR)-emitting QDs by bioorthogonal chemistry. The conjugation of QDs onto H5N1p was highly efficient with superior stability both in vitro and in vivo. Furthermore, QD-labeled H5N1p (QD-H5N1p) demonstrated bright and sustained fluorescent signals in mouse lung tissues, allowing us to visualize respiratory viral infection in a noninvasive and real-time manner. The fluorescence signals of QD-H5N1p in lung were correlated with the severity of virus infection and significantly attenuated by antiviral agents, such as oseltamivir carboxylate and mouse antiserum against H5N1p. The biodistribution of QD-H5N1p in lungs and other organs could be easily quantified by measuring fluorescent signals and cadmium concentration of virus-conjugated QDs in tissues. Hence, virus labeling with NIR QDs provides a simple, reliable, and quantitative strategy for tracking respiratory viral infection and for antiviral drug screening.<\/jats:p>","DOI":"10.1021\/nn501028b","type":"journal-article","created":{"date-parts":[[2014,5,5]],"date-time":"2014-05-05T14:58:06Z","timestamp":1399301886000},"page":"5468-5477","source":"Crossref","is-referenced-by-count":68,"title":["Noninvasive Visualization of Respiratory Viral Infection Using Bioorthogonal Conjugated Near-Infrared-Emitting Quantum Dots"],"prefix":"10.1021","volume":"8","author":[{"given":"Hong","family":"Pan","sequence":"first","affiliation":[{"name":"Guangdong Key Laboratory of Nanomedicine, CAS Key Laboratory of Health Informatics, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences , ,","place":["Shenzhen, People\u2019s Republic of China, 518055"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengfei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Guangdong Key Laboratory of Nanomedicine, CAS Key Laboratory of Health Informatics, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences , ,","place":["Shenzhen, People\u2019s Republic of China, 518055"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duyang","family":"Gao","sequence":"additional","affiliation":[{"name":"Guangdong Key Laboratory of Nanomedicine, CAS Key Laboratory of Health Informatics, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences , ,","place":["Shenzhen, People\u2019s Republic of China, 518055"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Guangdong Key Laboratory of Nanomedicine, CAS Key Laboratory of Health Informatics, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences , ,","place":["Shenzhen, People\u2019s Republic of China, 518055"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Li","sequence":"additional","affiliation":[{"name":"Guangdong Key Laboratory of Nanomedicine, CAS Key Laboratory of Health Informatics, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences , ,","place":["Shenzhen, People\u2019s Republic of China, 518055"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanlan","family":"Liu","sequence":"additional","affiliation":[{"name":"Guangdong Key Laboratory of Nanomedicine, CAS Key Laboratory of Health Informatics, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences , ,","place":["Shenzhen, People\u2019s Republic of China, 518055"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ce","family":"Wang","sequence":"additional","affiliation":[{"name":"Guangdong Key Laboratory of Nanomedicine, CAS Key Laboratory of Health Informatics, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences , ,","place":["Shenzhen, People\u2019s Republic of China, 518055"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanzhong","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences , ,","place":["Wuhan, People\u2019s Republic of China, 430071"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Ma","sequence":"additional","affiliation":[{"name":"Guangdong Key Laboratory of Nanomedicine, CAS Key Laboratory of Health Informatics, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences , ,","place":["Shenzhen, People\u2019s Republic of China, 518055"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lintao","family":"Cai","sequence":"additional","affiliation":[{"name":"Guangdong Key Laboratory of Nanomedicine, CAS Key Laboratory of Health Informatics, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences , ,","place":["Shenzhen, People\u2019s Republic of China, 518055"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2014,5,5]]},"reference":[{"key":"2026081807152014000_cit1","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1128\/CMR.00037-06","article-title":"Avian Influenza Virus (H5N1): A Threat to Human Health","volume":"20","author":"Peiris","year":"2007","journal-title":"Clin. Microbiol. Rev."},{"key":"2026081807152014000_cit2","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1038\/nm1477","article-title":"Fatal Outcome of Human Influenza A (H5N1) Is Associated with High Viral Load and Hypercytokinemia","volume":"12","author":"de Jong","year":"2006","journal-title":"Nat. Med."},{"key":"2026081807152014000_cit3","doi-asserted-by":"crossref","first-page":"3974","DOI":"10.1128\/JVI.02078-09","article-title":"Dynamics of Influenza Virus Infection and Pathology","volume":"84","author":"Saenz","year":"2010","journal-title":"J. Virol."},{"key":"2026081807152014000_cit4","first-page":"1","article-title":"Distribution and Dynamics of Risk Factors Associated with Highly Pathogenic Avian Influenza H5N1","author":"Zhang","year":"2013","journal-title":"Epidemiol. Infect."},{"key":"2026081807152014000_cit5","doi-asserted-by":"crossref","first-page":"11531","DOI":"10.1073\/pnas.0914994107","article-title":"Analysis of In Vivo Dynamics of Influenza Virus Infection in Mice Using a GFP Reporter Virus","volume":"107","author":"Manicassamy","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2026081807152014000_cit6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/ncomms3369","article-title":"Visualizing Influenza Virus Infection in Living Mice","volume":"4","author":"Pan","year":"2013","journal-title":"Nat. Commun."},{"key":"2026081807152014000_cit7","doi-asserted-by":"crossref","first-page":"e17076","DOI":"10.1371\/journal.pone.0017076","article-title":"Real-Time Dynamic Imaging of Virus Distribution in Vivo","volume":"6","author":"Hofherr","year":"2011","journal-title":"PLoS One"},{"key":"2026081807152014000_cit8","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1038\/nmeth.1248","article-title":"Quantum Dots versus Organic Dyes as Fluorescent Labels","volume":"5","author":"Resch-Genger","year":"2008","journal-title":"Nat. Methods"},{"key":"2026081807152014000_cit9","doi-asserted-by":"crossref","first-page":"3896","DOI":"10.1021\/nn305189n","article-title":"Encapsulating Quantum Dots into Enveloped Virus in Living Cells for Tracking Virus Infection","volume":"7","author":"Zhang","year":"2013","journal-title":"ACS Nano"},{"key":"2026081807152014000_cit10","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1021\/nn8002136","article-title":"Site-Specific Labeling of Enveloped Viruses with Quantum Dots for Single Virus Tracking","volume":"2","author":"Joo","year":"2008","journal-title":"ACS Nano"},{"key":"2026081807152014000_cit11","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1021\/nl048073u","article-title":"Progression of Respiratory Syncytial Virus Infection Monitored by Fluorescent Quantum Dot Probes","volume":"5","author":"Bentzen","year":"2005","journal-title":"Nano Lett."},{"key":"2026081807152014000_cit12","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1021\/nn2031353","article-title":"Effectively and Efficiently Dissecting the Infection of Influenza Virus by Quantum-Dot-Based Single-Particle Tracking","volume":"6","author":"Liu","year":"2012","journal-title":"ACS Nano"},{"key":"2026081807152014000_cit13","doi-asserted-by":"crossref","first-page":"2454","DOI":"10.1039\/c1nr10218d","article-title":"Quantum Dot\u2013Aptamer Nanoprobes for Recognizing and Labeling Influenza A Virus Particles","volume":"3","author":"Cui","year":"2011","journal-title":"Nanoscale"},{"key":"2026081807152014000_cit14","doi-asserted-by":"crossref","first-page":"7828","DOI":"10.1016\/j.biomaterials.2012.07.026","article-title":"High-Efficiency Dual Labeling of Influenza Virus for Single-Virus Imaging","volume":"33","author":"Liu","year":"2012","journal-title":"Biomaterials"},{"key":"2026081807152014000_cit15","doi-asserted-by":"crossref","first-page":"3523","DOI":"10.1021\/nn102651p","article-title":"Enhanced Real-Time Monitoring of Adeno-Associated Virus Trafficking by Virus-Quantum Dot Conjugates","volume":"5","author":"Joo","year":"2011","journal-title":"ACS Nano"},{"key":"2026081807152014000_cit16","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.2147\/IJN.S23348","article-title":"In-Vivo Imaging of Oral Squamous Cell Carcinoma by EGFR Monoclonal Antibody Conjugated Near-Infrared Quantum Dots in Mice","volume":"6","author":"Yang","year":"2011","journal-title":"Int. J. Nanomed."},{"key":"2026081807152014000_cit17","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1038\/nmeth1210-957","article-title":"Nanotechnology Imaging Probes: Smaller and More Stable","volume":"7","author":"Baker","year":"2010","journal-title":"Nat. Methods"},{"key":"2026081807152014000_cit18","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1021\/ja908250r","article-title":"InAs(ZnCdS) Quantum Dots Optimized for Biological Imaging in the Near-Infrared","volume":"132","author":"Allen","year":"2009","journal-title":"J. Am. Chem. Soc."},{"key":"2026081807152014000_cit19","doi-asserted-by":"crossref","first-page":"3695","DOI":"10.1021\/nn301218z","article-title":"Ag2S Quantum Dot: A Bright and Biocompatible Fluorescent Nanoprobe in the Second Near-Infrared Window","volume":"6","author":"Zhang","year":"2012","journal-title":"ACS Nano"},{"key":"2026081807152014000_cit20","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1021\/nl203526f","article-title":"A Novel Clinically Translatable Fluorescent Nanoparticle for Targeted Molecular Imaging of Tumors in Living Subjects","volume":"12","author":"Gao","year":"2012","journal-title":"Nano Lett."},{"key":"2026081807152014000_cit21","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1021\/nn700281b","article-title":"Surfactant-Free, Drug-Quantum-Dot Coloaded Poly(lactide-co-glycolide) Nanoparticles: Towards Multifunctional Nanoparticles","volume":"2","author":"Nehilla","year":"2008","journal-title":"ACS Nano"},{"key":"2026081807152014000_cit22","doi-asserted-by":"crossref","first-page":"9006","DOI":"10.1021\/ja800086u","article-title":"Proton-Sponge Coated Quantum Dots for siRNA Delivery and Intracellular Imaging","volume":"130","author":"Yezhelyev","year":"2008","journal-title":"J. Am. Chem. Soc."},{"key":"2026081807152014000_cit23","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1021\/nn900138d","article-title":"Hyaluronic Acid\u2013Quantum Dot Conjugates for In Vivo Lymphatic Vessel Imaging","volume":"3","author":"Bhang","year":"2009","journal-title":"ACS Nano"},{"key":"2026081807152014000_cit24","doi-asserted-by":"crossref","first-page":"6974","DOI":"10.1002\/anie.200900942","article-title":"Bioorthogonal Chemistry: Fishing for Selectivity in a Sea of Functionality","volume":"48","author":"Sletten","year":"2009","journal-title":"Angew. Chem., Int. Ed."},{"key":"2026081807152014000_cit25","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1021\/bc200065z","article-title":"The Controlled Display of Biomolecules on Nanoparticles: A Challenge Suited to Bioorthogonal Chemistry","volume":"22","author":"Algar","year":"2011","journal-title":"Bioconjugate Chem."},{"key":"2026081807152014000_cit26","doi-asserted-by":"crossref","first-page":"6571","DOI":"10.1021\/bi9007726","article-title":"Click Chemistry and Bioorthogonal Reactions: Unprecedented Selectivity in the Labeling of Biological Molecules","volume":"48","author":"Best","year":"2009","journal-title":"Biochemistry"},{"key":"2026081807152014000_cit27","doi-asserted-by":"crossref","first-page":"8388","DOI":"10.1021\/ja302367s","article-title":"Click-functionalized Compact Quantum Dots Protected by Multidentate-Imidazole Ligands: Conjugation-Ready Nanotags for Living-Virus Labeling and Imaging","volume":"134","author":"Zhang","year":"2012","journal-title":"J. Am. Chem. Soc."},{"key":"2026081807152014000_cit28","doi-asserted-by":"crossref","first-page":"8364","DOI":"10.1021\/ac301918t","article-title":"A Mild and Reliable Method To Label Enveloped Virus with Quantum Dots by Copper-Free Click Chemistry","volume":"84","author":"Hao","year":"2012","journal-title":"Anal. Chem."},{"key":"2026081807152014000_cit29","first-page":"L183","article-title":"Autophagy Mediates Avian Influenza H5N1 Pseudotyped Particle-Induced Lung Inflammation through NF-\u03baB and p38 MAPK Signaling Pathways","volume":"6","author":"Pan","year":"2014","journal-title":"Am. J. Physiol.: Lung Cell. Mol. Physiol."},{"key":"2026081807152014000_cit30","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1586\/eri.11.25","article-title":"Production of Influenza Pseudotyped Lentiviral Particles and Their Use in Influenza Research and Diagnosis: An Update","volume":"9","author":"Garcia","year":"2011","journal-title":"Expert Rev. Anti-Infect. Ther."},{"key":"2026081807152014000_cit31","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1021\/cm8027127","article-title":"Synthesis of Near-Infrared-Emitting, Water-Soluble CdTeSe\/CdZnS Core\/Shell Quantum Dots","volume":"21","author":"Pons","year":"2009","journal-title":"Chem. Mater."},{"key":"2026081807152014000_cit32","doi-asserted-by":"crossref","first-page":"4724","DOI":"10.1039\/c1nr10933b","article-title":"A Fast Synthesis of Near-Infrared Emitting CdTe\/CdSe Quantum Dots with Small Hydrodynamic Diameter for In Vivo Imaging Probes","volume":"3","author":"Hu","year":"2011","journal-title":"Nanoscale"},{"key":"2026081807152014000_cit33","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1007\/s00216-009-3107-z","article-title":"Electrophoretic Properties of BSA-Coated Quantum Dots","volume":"396","author":"Bucking","year":"2010","journal-title":"Anal. Bioanal. Chem."},{"key":"2026081807152014000_cit34","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1002\/smll.201101787","article-title":"Comparing Intracellular Stability and Targeting of Sulfobetaine Quantum Dots with Other Surface Chemistries in Live Cells","volume":"8","author":"Muro","year":"2012","journal-title":"Small"},{"key":"2026081807152014000_cit35","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1038\/nchem.1177","article-title":"Stability of Quantum Dots in Live Cells","volume":"3","author":"Zhu","year":"2011","journal-title":"Nat. Chem."},{"key":"2026081807152014000_cit36","doi-asserted-by":"crossref","first-page":"9804","DOI":"10.1021\/ja102898d","article-title":"Multidentate Poly(ethylene glycol) Ligands Provide Colloidal Stability to Semiconductor and Metallic Nanocrystals in Extreme Conditions","volume":"132","author":"Stewart","year":"2010","journal-title":"J. Am. Chem. Soc."},{"key":"2026081807152014000_cit37","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1021\/ja908137d","article-title":"Compact Biocompatible Quantum Dots via RAFT-Mediated Synthesis of Imidazole-Based Random Copolymer Ligand","volume":"132","author":"Liu","year":"2010","journal-title":"J. Am. Chem. Soc."},{"key":"2026081807152014000_cit38","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1038\/nrd2175","article-title":"Antiviral Agents Active Against Influenza A Viruses","volume":"5","author":"De Clercq","year":"2006","journal-title":"Nat. Rev. Drug Discovery"},{"key":"2026081807152014000_cit39","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1038\/nature07231","article-title":"Neutralizing Antibodies Derived from the B Cells of 1918 Influenza Pandemic Survivors","volume":"455","author":"Yu","year":"2008","journal-title":"Nature"},{"key":"2026081807152014000_cit40","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1093\/infdis\/jit323","article-title":"Highly Pathogenic Avian Influenza A(H5N1) Mutants Transmissible by Air Are Susceptible to Human and Animal Neutralizing Antibodies","volume":"208","author":"Du","year":"2013","journal-title":"Int. J. Infect. Dis."},{"key":"2026081807152014000_cit41","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/j.micinf.2005.12.008","article-title":"Roles of Neuraminidase in the Initial Stage of Influenza Virus Infection","volume":"8","author":"Ohuchi","year":"2006","journal-title":"Microbes Infect."},{"key":"2026081807152014000_cit42","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/j.bbrc.2013.01.019","article-title":"Oseltamivir Inhibits Both Viral Entry and Release but Enhances Apoptosis of Cells Infected with Influenza A H1N1","volume":"431","author":"Gao","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2026081807152014000_cit43","doi-asserted-by":"crossref","first-page":"12665","DOI":"10.1128\/JVI.78.22.12665-12667.2004","article-title":"Neuraminidase Is Important for the Initiation of Influenza Virus Infection in Human Airway Epithelium","volume":"78","author":"Matrosovich","year":"2004","journal-title":"J. Virol."},{"key":"2026081807152014000_cit44","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/nm.3443","article-title":"Broadly Neutralizing Hemagglutinin Stalk-Specific Antibodies Require Fc gamma Interactions for Protection Against Influenza Virus in Vivo","volume":"20","author":"Dilillo","year":"2014","journal-title":"Nat. Med."},{"key":"2026081807152014000_cit45","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1038\/nbt1363","article-title":"The Growth and Potential of Human Antiviral Monoclonal Antibody Therapeutics","volume":"25","author":"Marasco","year":"2007","journal-title":"Nat. Biotechnol."},{"key":"2026081807152014000_cit46","doi-asserted-by":"crossref","first-page":"8156","DOI":"10.1073\/pnas.0402443101","article-title":"H5N1 Influenza: A Protean Pandemic Threat","volume":"101","author":"Guan","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2026081807152014000_cit47","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1056\/NEJMcibr0805865","article-title":"Insights into Inflammation and Influenza","volume":"359","author":"Simmons","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"2026081807152014000_cit48","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.2353\/ajpath.2008.070791","article-title":"Pathology, Molecular Biology, and Pathogenesis of Avian Influenza A (H5N1) Infection in Humans","volume":"172","author":"Korteweg","year":"2008","journal-title":"Am. J. Pathol."},{"key":"2026081807152014000_cit49","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1139\/w2012-006","article-title":"H5N1 Influenza Virus-like Particles Produced by Transient Expression in Mammalian Cells Induce Humoral and Cellular Immune Responses in Mice","volume":"58","author":"Tao","year":"2012","journal-title":"Can. J. Microbiol."},{"key":"2026081807152014000_cit50","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1124\/jpet.107.124719","article-title":"Modulation of Airway Responses to Influenza A\/PR\/8\/34 by \u03949-Tetrahydrocannabinol in C57BL\/6 Mice","volume":"323","author":"Buchweitz","year":"2007","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"2026081807152014000_cit51","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/ncomms3106","article-title":"Bacterial Colonization Dampens Influenza-Mediated Acute Lung Injury via Induction of M2 Alveolar Macrophages","volume":"4","author":"Wang","year":"2013","journal-title":"Nat. Commun."}],"container-title":["ACS Nano"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/nn501028b","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/ancac3\/article-pdf\/8\/6\/5468\/14028830\/nn501028b.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/ancac3\/article-pdf\/8\/6\/5468\/14028830\/nn501028b.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T11:17:19Z","timestamp":1787051839000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/ancac3\/article\/8\/6\/5468\/1360517\/Noninvasive-Visualization-of-Respiratory-Viral"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,5]]},"references-count":51,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2014,5,5]]},"published-print":{"date-parts":[[2014,6,24]]}},"URL":"https:\/\/doi.org\/10.1021\/nn501028b","relation":{},"ISSN":["1936-0851","1936-086X"],"issn-type":[{"value":"1936-0851","type":"print"},{"value":"1936-086X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,5]]}}}