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However, there is a clear need to develop strategies to overcome the critical limitations of peptides, such as poor solubility and the lack of target specificity, which impede their clinical applications. To this end, we report magnetic core\u2013shell nanoparticle (MCNP)-mediated delivery of a mitochondria-targeting pro-apoptotic amphipathic tail-anchoring peptide (ATAP) to malignant brain and metastatic breast cancer cells. Conjugation of ATAP to the MCNPs significantly enhanced the chemotherapeutic efficacy of ATAP, while the presence of targeting ligands afforded selective delivery to cancer cells. Induction of MCNP-mediated hyperthermia further potentiated the efficacy of ATAP. In summary, a combination of MCNP-mediated ATAP delivery and subsequent hyperthermia resulted in an enhanced effect on mitochondrial dysfunction, thus resulting in increased cancer cell apoptosis.<\/jats:p>","DOI":"10.1021\/nn503431x","type":"journal-article","created":{"date-parts":[[2014,8,18]],"date-time":"2014-08-18T13:13:26Z","timestamp":1408367606000},"page":"9379-9387","source":"Crossref","is-referenced-by-count":134,"title":["Core\u2013Shell Nanoparticle-Based Peptide Therapeutics and Combined Hyperthermia for Enhanced Cancer Cell Apoptosis"],"prefix":"10.1021","volume":"8","author":[{"given":"Birju P.","family":"Shah","sequence":"first","affiliation":[{"name":"Rutgers, The State University of New Jersey , , , ,","place":["Piscataway, New Jersey, United States, 08854"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Pasquale","sequence":"additional","affiliation":[{"name":"Rutgers, The State University of New Jersey , , , ,","place":["Piscataway, New Jersey, United States, 08854"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gejing","family":"De","sequence":"additional","affiliation":[{"name":"The Ohio State University Wexner Medical Center , , , ,","place":["Columbus, Ohio, United States, 43210"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Tan","sequence":"additional","affiliation":[{"name":"The Ohio State University Wexner Medical Center , , , ,","place":["Columbus, Ohio, United States, 43210"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianjie","family":"Ma","sequence":"additional","affiliation":[{"name":"The Ohio State University Wexner Medical Center , , , ,","place":["Columbus, Ohio, United States, 43210"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ki-Bum","family":"Lee","sequence":"additional","affiliation":[{"name":"Rutgers, The State University of New Jersey , , , ,","place":["Piscataway, New Jersey, United States, 08854"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2014,8,18]]},"reference":[{"key":"2026090201254066200_cit1","doi-asserted-by":"crossref","first-page":"216rv214","DOI":"10.1126\/scitranslmed.3005872","article-title":"Cancer Nanomedicine: From Drug Delivery to Imaging","volume":"5","author":"Chow","year":"2013","journal-title":"Sci. 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