{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,8]],"date-time":"2026-11-08T11:40:35Z","timestamp":1794138035246,"version":"4.8.0"},"reference-count":37,"publisher":"American Chemical Society (ACS)","issue":"12","license":[{"start":{"date-parts":[[2015,11,6]],"date-time":"2015-11-06T00:00:00Z","timestamp":1446768000000},"content-version":"vor","delay-in-days":365,"URL":"https:\/\/pubs.acs.org\/page\/policy\/authorchoice_termsofuse.html"}],"funder":[{"DOI":"10.13039\/100000900","name":"California Institute for Regenerative Medicine","doi-asserted-by":"publisher","award":["TG2-01150"],"award-info":[{"award-number":["TG2-01150"]}],"id":[{"id":"10.13039\/100000900","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000983","name":"Mary Kay Foundation","doi-asserted-by":"publisher","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/100000983","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001880","name":"Stop Cancer","doi-asserted-by":"publisher","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/100001880","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/na","name":"Alvarez Family Foundation","doi-asserted-by":"publisher","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,12,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Plasmonic photothermal therapy utilizes biologically inert gold nanorods (AuNRs) as tumor-localized antennas that convert light into heat capable of eliminating cancerous tissue. This approach has lower morbidity than surgical resection and can potentially synergize with other treatment modalities including chemotherapy and immunotherapy. Despite these advantages, it is still challenging to obtain heating of the entire tumor mass while avoiding unnecessary collateral damage to surrounding healthy tissue. It is therefore critical to identify innovative methods to distribute an effective concentration of AuNRs throughout tumors without depositing them in surrounding healthy tissue. Here we demonstrate that AuNR-loaded, tumor-tropic neural stem cells (NSCs) can be used to improve the intratumoral distribution of AuNRs. A simple UV\u2013vis technique for measuring AuNR loading within NSCs was established. It was then confirmed that NSC viability is unimpaired following AuNR loading and that NSCs retain AuNRs long enough to migrate throughout tumors. We then demonstrate that intratumoral injections of AuNR-loaded NSCs are more efficacious than free AuNR injections, as evidenced by reduced recurrence rates of triple-negative breast cancer (MDA-MB-231) xenografts following NIR exposure. Finally, we demonstrate that the distribution of AuNRs throughout the tumors is improved when transported by NSCs, likely resulting in the improved efficacy of AuNR-loaded NSCs as compared to free AuNRs. These findings highlight the advantage of combining cellular therapies and nanotechnology to generate more effective cancer treatments.<\/jats:p>","DOI":"10.1021\/nn505147w","type":"journal-article","created":{"date-parts":[[2014,11,6]],"date-time":"2014-11-06T19:08:10Z","timestamp":1415300890000},"page":"12450-12460","source":"Crossref","is-referenced-by-count":154,"title":["Neural Stem Cell-Mediated Intratumoral Delivery of Gold Nanorods Improves Photothermal Therapy"],"prefix":"10.1021","volume":"8","author":[{"given":"Rachael","family":"Mooney","sequence":"first","affiliation":[{"name":"Beckman Research Institute at City of Hope , , 1500 East Duarte Road , , ,","place":["Duarte, California, United States, 91010"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luella","family":"Roma","sequence":"additional","affiliation":[{"name":"Beckman Research Institute at City of Hope , , 1500 East Duarte Road , , ,","place":["Duarte, California, United States, 91010"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donghong","family":"Zhao","sequence":"additional","affiliation":[{"name":"Beckman Research Institute at City of Hope , , 1500 East Duarte Road , , ,","place":["Duarte, California, United States, 91010"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Desiree","family":"Van Haute","sequence":"additional","affiliation":[{"name":"Beckman Research Institute at City of Hope , , 1500 East Duarte Road , , ,","place":["Duarte, California, United States, 91010"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Garcia","sequence":"additional","affiliation":[{"name":"Beckman Research Institute at City of Hope , , 1500 East Duarte Road , , ,","place":["Duarte, California, United States, 91010"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung U.","family":"Kim","sequence":"additional","affiliation":[{"name":"University of British Columbia , , , ,","place":["Vancouver, British Columbia, Canada, V6T2B5"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander J.","family":"Annala","sequence":"additional","affiliation":[{"name":"Beckman Research Institute at City of Hope , , 1500 East Duarte Road , , ,","place":["Duarte, California, United States, 91010"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen S.","family":"Aboody","sequence":"additional","affiliation":[{"name":"Beckman Research Institute at City of Hope , , 1500 East Duarte Road , , ,","place":["Duarte, California, United States, 91010"]},{"name":"Beckman Research Institute at City of Hope , , 1500 East Duarte Road , , ,","place":["Duarte, California, United States, 91010"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob M.","family":"Berlin","sequence":"additional","affiliation":[{"name":"Beckman Research Institute at City of Hope , , 1500 East Duarte Road , , ,","place":["Duarte, California, United States, 91010"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2014,11,6]]},"reference":[{"key":"2026090203003406700_cit1","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/nrc3672","article-title":"Thermal Ablation of Tumours: Biological Mechanisms and Advances in Therapy","volume":"14","author":"Chu","year":"2014","journal-title":"Nat. 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Nanomed."}],"container-title":["ACS Nano"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/nn505147w","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/ancac3\/article-pdf\/8\/12\/12450\/14048195\/nn505147w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/ancac3\/article-pdf\/8\/12\/12450\/14048195\/nn505147w.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T07:00:44Z","timestamp":1788332444000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/ancac3\/article\/8\/12\/12450\/1361941\/Neural-Stem-Cell-Mediated-Intratumoral-Delivery-of"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,6]]},"references-count":37,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2014,11,6]]},"published-print":{"date-parts":[[2014,12,23]]}},"URL":"https:\/\/doi.org\/10.1021\/nn505147w","relation":{},"ISSN":["1936-0851","1936-086X"],"issn-type":[{"value":"1936-0851","type":"print"},{"value":"1936-086X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11,6]]}}}