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F.","year":"1998","journal-title":"Science"},{"key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1126\/science.300.5617.243a","volume":"300","author":"Service R. F.","year":"2003","journal-title":"Science"},{"key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1038\/nbt875","volume":"21","author":"Colvin V. L.","year":"2003","journal-title":"Nat. Biotechnol."},{"key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/424246a","volume":"424","author":"Brumfiel G.","year":"2003","journal-title":"Nature"},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/nbt0104-19","volume":"22","author":"Hoet P. H. M.","year":"2004","journal-title":"Nat. Biotechnol."},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1126\/science.305.5685.762b","volume":"305","author":"Proffitt F.","year":"2004","journal-title":"Science"},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1477-3155-2-12","volume":"2","author":"Hoet P. H. M.","year":"2004","journal-title":"J. Nanobiotechnol."},{"key":"ref8\/cit8","first-page":"L696","volume":"289","author":"Kipen H. M.","year":"2005","journal-title":"Am. J. Physiol.: Lung Cell. Mol. Physiol."},{"key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"8985","DOI":"10.1021\/es0506509","volume":"39","author":"Robichaud C. O.","year":"2005","journal-title":"Environ. Sci. Technol."},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1126\/science.1114397","volume":"311","author":"Nel A.","year":"2006","journal-title":"Science"},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1196\/annals.1371.027","volume":"1076","author":"Balbus J. M.","year":"2006","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"ref12\/cit12","first-page":"S2185","volume":"18","author":"Panessa-Warren B. J.","year":"2006","journal-title":"J. Phys.: Condens. Matter"},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1016\/j.carbon.2005.12.023","volume":"44","author":"Hurt R. H.","year":"2006","journal-title":"Carbon"},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1289\/ehp.9652","volume":"115","author":"Helland A.","year":"2007","journal-title":"Environ. Health Perspect."},{"key":"ref15\/cit15","unstructured":"National Institute of Environmental Health Sciences (NIEHS) OPPE Factsheet #03 July 2003 Nanotechnology Safety Assessment.NIEHS:Washington, DC, 2003."},{"key":"ref16\/cit16","unstructured":"Nanoscience and Nanotechnologies: Opportunities and Uncertainties.The Royal Society and Royal Academy of Engineering:London, 2004, (http:\/\/www.nanotec.org.uk\/finalReport.htm)."},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/354056a0","volume":"354","author":"Iijima S.","year":"1991","journal-title":"Nature"},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1081\/FST-100102973","volume":"9","author":"Huczko A.","year":"2001","journal-title":"Fullerene Sci. Technol."},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1093\/toxsci\/kfg228","volume":"77","author":"Warheit D. B.","year":"2004","journal-title":"Toxicol. Sci."},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1093\/toxsci\/kfg243","volume":"77","author":"Lam C.-W.","year":"2004","journal-title":"Toxicol. Sci."},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"L698","DOI":"10.1152\/ajplung.00084.2005","volume":"289","author":"Shvedova A. A.","year":"2005","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.taap.2005.01.008","volume":"207","author":"Muller J.","year":"2005","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1016\/j.carbon.2005.10.019","volume":"44","author":"Muller J.","year":"2006","journal-title":"Carbon"},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1093\/toxsci\/kfj130","volume":"92","author":"Donaldson K.","year":"2006","journal-title":"Toxicol. Sci."},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0009-2614(99)00642-9","volume":"309","author":"Iijima S.","year":"1999","journal-title":"Chem. Phys. Lett."},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"4947","DOI":"10.1021\/jp020387n","volume":"106","author":"Kasuya D.","year":"2002","journal-title":"J. Phys. Chem. B"},{"key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/S0921-4526(02)00871-2","volume":"323","author":"Yoshitake T.","year":"2002","journal-title":"Physica B"},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1002\/adma.200400130","volume":"16","author":"Yuge R.","year":"2004","journal-title":"Adv. Mater."},{"key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"2826","DOI":"10.1016\/j.carbon.2005.05.043","volume":"43","author":"Murata K.","year":"2005","journal-title":"Carbon"},{"key":"ref30\/cit30","doi-asserted-by":"crossref","first-page":"11132","DOI":"10.1021\/jp020583u","volume":"106","author":"Murata K.","year":"2002","journal-title":"J. Phys. Chem. B"},{"key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"4681","DOI":"10.1021\/jp0278263","volume":"107","author":"Bekyarova E.","year":"2003","journal-title":"J. Phys. Chem. B"},{"key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1002\/adma.200400240","volume":"16","author":"Murata K.","year":"2004","journal-title":"Adv. Mater."},{"key":"ref33\/cit33","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1021\/ja065501k","volume":"129","author":"Yang C.-M.","year":"2007","journal-title":"J. Am. Chem. Soc."},{"key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1021\/mp049928e","volume":"1","author":"Murakami T.","year":"2004","journal-title":"Mol. Pharm."},{"key":"ref35\/cit35","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1021\/mp0500566","volume":"2","author":"Ajima K.","year":"2005","journal-title":"Mol. Pharm."},{"key":"ref36\/cit36","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1021\/mp060027a","volume":"3","author":"Murakami T.","year":"2006","journal-title":"Mol. Pharm."},{"key":"ref37\/cit37","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1021\/mp070022t","volume":"4","author":"Matsumura S.","year":"2007","journal-title":"Mol. Pharm."},{"key":"ref38\/cit38","doi-asserted-by":"crossref","first-page":"8939","DOI":"10.1021\/la048968m","volume":"20","author":"Kase D.","year":"2004","journal-title":"Langmuir"},{"key":"ref39\/cit39","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1002\/smll.200500010","volume":"1","author":"Sano K.-I.","year":"2005","journal-title":"Small"},{"key":"ref40\/cit40","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1002\/adma.200502174","volume":"18","author":"Miyawaki J.","year":"2006","journal-title":"Adv. Mater."},{"key":"ref41\/cit41","doi-asserted-by":"crossref","first-page":"6676","DOI":"10.1002\/anie.200601718","volume":"45","author":"Isobe H.","year":"2006","journal-title":"Angew. Chem., Int. Ed."},{"key":"ref42\/cit42","doi-asserted-by":"crossref","first-page":"5773","DOI":"10.1021\/jp056813x","volume":"110","author":"Ajima K.","year":"2006","journal-title":"J. Phys. Chem. B"},{"key":"ref43\/cit43","doi-asserted-by":"crossref","first-page":"19097","DOI":"10.1021\/jp064915x","volume":"110","author":"Ajima K.","year":"2006","journal-title":"J. Phys. Chem. B"},{"key":"ref44\/cit44","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/0165-1110(85)90016-8","volume":"154","author":"Dean B. J.","year":"1985","journal-title":"Mutat. Res."},{"key":"ref45\/cit45","first-page":"3","volume":"85","author":"McMichael A. J.","year":"1988","journal-title":"IARC Sci. Publ."},{"key":"ref46\/cit46","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/0165-1218(88)90024-9","volume":"205","author":"Waters M. D.","year":"1988","journal-title":"Mutat. Res."},{"key":"ref47\/cit47","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1080\/713853956","volume":"66","author":"Shvedova A. A.","year":"2003","journal-title":"J. Toxicol. Environ. Health, Part A"},{"key":"ref48\/cit48","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1039\/b501222h","volume":"1","author":"Sato Y.","year":"2005","journal-title":"Mol. BioSyst."},{"key":"ref49\/cit49","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1039\/b502429c","volume":"1","author":"Sato Y.","year":"2005","journal-title":"Mol. BioSyst."},{"key":"ref50\/cit50","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1021\/es048729l","volume":"39","author":"Jia G.","year":"2005","journal-title":"Environ. Sci. Technol."},{"key":"ref51\/cit51","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1021\/nl0507966","volume":"5","author":"Manna S. K.","year":"2005","journal-title":"Nano Lett."},{"key":"ref52\/cit52","doi-asserted-by":"crossref","first-page":"2448","DOI":"10.1021\/nl051748o","volume":"5","author":"Ding L.","year":"2005","journal-title":"Nano Lett."},{"key":"ref53\/cit53","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.toxlet.2004.08.015","volume":"155","author":"Cui D.","year":"2005","journal-title":"Toxicol. Lett."},{"key":"ref54\/cit54","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.toxlet.2004.11.004","volume":"155","author":"Monteiro-Riviere N. A.","year":"2005","journal-title":"Toxicol. Lett."},{"key":"ref55\/cit55","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1021\/nl060162e","volume":"6","author":"Magrez A.","year":"2006","journal-title":"Nano Lett."},{"key":"ref56\/cit56","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1021\/nl061160x","volume":"6","author":"Dumortier H.","year":"2006","journal-title":"Nano Lett."},{"key":"ref57\/cit57","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1002\/adma.200602667","volume":"19","author":"Becker M. L.","year":"2007","journal-title":"Adv. Mater."},{"key":"ref58\/cit58","doi-asserted-by":"crossref","first-page":"7918","DOI":"10.1021\/ja00070a064","volume":"115","author":"Tokuyama H.","year":"1993","journal-title":"J. Am. Chem. Soc."},{"key":"ref59\/cit59","doi-asserted-by":"crossref","first-page":"2462","DOI":"10.1002\/anie.199424621","volume":"33","author":"Boutorine A. S.","year":"1994","journal-title":"Angew. Chem., Int. Ed. Engl."},{"key":"ref60\/cit60","doi-asserted-by":"crossref","first-page":"5179","DOI":"10.1016\/0040-4020(96)00123-8","volume":"52","author":"An Y.-Z.","year":"1996","journal-title":"Tetrahedron"},{"key":"ref61\/cit61","first-page":"405","volume":"33","author":"Zakharenko L. P.","year":"1997","journal-title":"Genetika"},{"key":"ref62\/cit62","doi-asserted-by":"crossref","first-page":"7394","DOI":"10.1021\/es0609708","volume":"40","author":"Dhawan A.","year":"2006","journal-title":"Environ. Sci. Technol."},{"key":"ref63\/cit63","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.tox.2006.05.001","volume":"225","author":"Mori T.","year":"2006","journal-title":"Toxicology"},{"key":"ref64\/cit64","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1177\/074823379300900405","volume":"9","author":"Nelson M. A.","year":"1993","journal-title":"Toxicol. Ind. Health"},{"key":"ref65\/cit65","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1080\/10641229909351390","volume":"7","author":"Huczko A.","year":"1999","journal-title":"Fullerene Sci. Technol."},{"key":"ref66\/cit66","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1081\/FST-100102972","volume":"9","author":"Huczko A.","year":"2001","journal-title":"Fullerene Sci. Technol."},{"key":"ref67\/cit67","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1021\/nl0489586","volume":"4","author":"Sayes C. M.","year":"2004","journal-title":"Nano Lett."},{"key":"ref68\/cit68","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1177\/019262339802600117","volume":"26","author":"Chen H. H. C.","year":"1998","journal-title":"Toxicol. Pathol."},{"key":"ref69\/cit69","volume-title":"Carbon Black User\u2019s Guide: Safety, Health & Environmental Information","year":"1999"},{"key":"ref70\/cit70","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/0013-9351(76)90107-9","volume":"11","author":"Brain J. D.","year":"1976","journal-title":"Environ. Res."},{"key":"ref71\/cit71","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1093\/toxsci\/55.1.24","volume":"55","author":"Driscoll K. E.","year":"2000","journal-title":"Toxicol. Sci."},{"key":"ref72\/cit72","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1006\/taap.1998.8472","volume":"151","author":"Hesterberg T. W.","year":"1998","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref73\/cit73","doi-asserted-by":"crossref","first-page":"S60","DOI":"10.1007\/PL00014628","volume":"73","author":"Oberd\u00f6rster G.","year":"2000","journal-title":"Int. Arch. Occup. Environ. Health"},{"key":"ref74\/cit74","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/0165-1161(75)90046-1","volume":"31","author":"Ames B. N.","year":"1975","journal-title":"Mutat. Res."},{"key":"ref75\/cit75","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/0027-5107(77)90177-4","volume":"48","author":"Ishidate M.","year":"1977","journal-title":"Mutat. Res."},{"key":"ref76\/cit76","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/0165-1218(79)90089-2","volume":"66","author":"Matsuoka A.","year":"1979","journal-title":"Mutat. Res."},{"key":"ref77\/cit77","volume-title":"Data book of chromosomal aberration test in vitro, Revised edition 1998","author":"Sofuni T.","year":"1999"},{"key":"ref78\/cit78","first-page":"377","volume":"82","author":"Draize J. H.","year":"1944","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref79\/cit79","first-page":"281","volume":"13","author":"Kay J. H.","year":"1962","journal-title":"J. Soc. Cosmet. Chem."},{"key":"ref80\/cit80","volume-title":"Appriaisal of the Safety of Chemicals in Foods, Drugs, and Cosmetics","volume":"46","author":"Draize J. H.","year":"1959"},{"key":"ref81\/cit81","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1038\/jid.1969.42","volume":"52","author":"Magnusson B.","year":"1969","journal-title":"J. Invest. Dermatol."},{"key":"ref82\/cit82","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/j.1600-0536.1981.tb04058.x","volume":"7","author":"Sato Y.","year":"1981","journal-title":"Contact Dermatitis"},{"key":"ref83\/cit83","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1111\/j.1600-0536.1994.tb01921.x","volume":"31","author":"Nakamura A.","year":"1994","journal-title":"Contact Dermatitis"},{"key":"ref84\/cit84","unstructured":"Notification No. 24 of the First Evaluation and Registration DivisionPAB (Pharmaceutical Affairs Bureau, Ministry of Health and Welfare):Tokyo, Japan, September 11, 1989."},{"key":"ref85\/cit85","first-page":"268","volume":"160","author":"Bartlett M. S.","year":"1937","journal-title":"Proc. R. Stat. Soc. A"},{"key":"ref86\/cit86","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1080\/01621459.1955.10501294","volume":"50","author":"Dunnett C. W.","year":"1955","journal-title":"J. Am. Stat. Assoc."},{"key":"ref87\/cit87","unstructured":"We compared two solutions as agents suitable for dispersing SWNHs in the intratracheal instillation test: 0.25% w\/v methyl cellulose (MC, Shin-Etsu Chemical Co., Ltd.)\/saline solution and 0.025% w\/v Tween 80\/saline solution. The latter had less effect on animal health and was thus used in our test. We instilled 0.2 or 0.4 mL\/animal of the 0.25% w\/v MC\/saline or the 0.025% w\/v Tween 80\/saline solution intratracheally into female rats (BrlHan:WIST@Jcl(GALAS), 7 weeks old, 130\u2013143 g, five\/group). The conditions for animal handling and intratracheal instillation were the same as those for the SWNH examination. All animals survived the 2 week test period. Crepitant whistle was observed for all animals in the MC\/saline and Tween 80\/saline groups. Most of the animals in the MC\/saline group recovered within 1 h of the instillation, though two in the high dose group (0.4 mL\/animal) suffered a relapse and did not fully recover until 2\u22125 days after the instillation. Moreover, one of the five animals in the high dose group showed bradypnea at 3 and 4 h after the instillation and a decrease in locomotor activity at 4 h after the instillation; both symptoms were no longer evident the next day. Most of the animals in the Tween 80\/saline group recovered within 30 min or 1 h for the low dose group (0.2 mL\/animal) or within 1 h for the high dose group. The two animals in the high dose group suffered a relapse, but no clinical signs of abnormalities were observed after the second day. There were no statistical differences in body weight gains or organ (lung and bronchus) weight between the control group (syringed only air at 0.4 mL\/animal) and the MC\/saline or Tween 80\/saline group, and no macroscopic pathosis was found in anatomicopathlogical observations of the animals following euthanasia after the 2 week test period. Histopathological examinations showed an increase in foamy macrophages in the intra-alveolar spaces for two and four animals (degree: \u00b1 or +) in the low and high MC\/saline dose groups and for one animal each (degree: \u00b1) at both dose levels in the Tween 80\/saline groups."}],"container-title":["ACS Nano"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/nn700185t","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,7]],"date-time":"2023-04-07T19:10:58Z","timestamp":1680894658000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/nn700185t"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,1,16]]},"references-count":87,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,2,26]]}},"alternative-id":["10.1021\/nn700185t"],"URL":"https:\/\/doi.org\/10.1021\/nn700185t","relation":{},"ISSN":["1936-0851","1936-086X"],"issn-type":[{"value":"1936-0851","type":"print"},{"value":"1936-086X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,1,16]]}}}