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This result is consistent with our previous report (see ref30) that showed that the conductance of ions through heterodimeric gramicidin channels comprising a negatively charged and an uncharged derivative of gA adopts approximately the same conductance as homodimeric gramicidin channels (at potentials of \u2265|\u00b150 mV|); this conductance depends on the charge of the group at the entrance of the pore. The conductance through these heterodimeric channels does not depend on the charge presented near the exit of the pore. Due to the absence of an intermediate conductance from heterodimeric channels, the conversion of\n                      3\n                      to\n                      4\n                      by AP can be monitored unambiguously."},{"key":"ref73\/cit73","doi-asserted-by":"crossref","first-page":"4599","DOI":"10.1002\/1521-3773(20001215)39:24<4599::AID-ANIE4599>3.0.CO;2-Y","volume":"39","author":"Meier W.","year":"2000","journal-title":"Angew. Chem., Int. 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At high concentrations of peptide (1 nM), we observe single ion channel activity from\n                      6\n                      . Analysis of single channel currents through\n                      6\n                      (1 nM)\n                      versus\n                      applied potential resulted in Ohmic behavior (\n                      R\n                      2\n                      of a linear fit was 0.97,\n                      N\n                      = 6) over the complete voltage range from \u2212120 to +120 mV. The absence of rectifying behavior indicated that electrostatically driven closure of the channels due movement of the charged residues in\n                      6\n                      into the pore did not occur to a detectable extent over this applied potential range."},{"key":"ref90\/cit90","unstructured":"We have observed previously that gA derivatives carrying one positive charge readily partition into membranes and form ion pores; see ref30."},{"key":"ref91\/cit91","doi-asserted-by":"crossref","first-page":"3056","DOI":"10.1016\/S0006-3495(02)75646-4","volume":"82","author":"Fertig N.","year":"2002","journal-title":"Biophys. J."},{"key":"ref92\/cit92","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1021\/ja056901v","volume":"128","author":"Jeon T. J.","year":"2006","journal-title":"J. Am. Chem. 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