{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T20:09:24Z","timestamp":1778616564410,"version":"3.51.4"},"reference-count":26,"publisher":"American Chemical Society (ACS)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Nat. Prod."],"published-print":{"date-parts":[[2013,3,22]]},"DOI":"10.1021\/np300638f","type":"journal-article","created":{"date-parts":[[2012,11,20]],"date-time":"2012-11-20T19:45:34Z","timestamp":1353440734000},"page":"311-315","source":"Crossref","is-referenced-by-count":10,"title":["8,8-Dialkyldihydroberberines with Potent Antiprotozoal Activity"],"prefix":"10.1021","volume":"76","author":[{"given":"Molla","family":"Endeshaw","sequence":"first","affiliation":[{"name":"Division of Medicinal Chemistry\rand Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohua","family":"Zhu","sequence":"additional","affiliation":[{"name":"Division of Medicinal Chemistry\rand Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanshan","family":"He","sequence":"additional","affiliation":[{"name":"Division of Medicinal Chemistry\rand Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trupti","family":"Pandharkar","sequence":"additional","affiliation":[{"name":"Division of Medicinal Chemistry\rand Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily","family":"Cason","sequence":"additional","affiliation":[{"name":"Department of Microbial Infection\rand Immunity, College of Medicine, The Ohio State University, Columbus, Ohio 43210, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiran V.","family":"Mahasenan","sequence":"additional","affiliation":[{"name":"Division of Medicinal Chemistry\rand Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitesh","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Division of Medicinal Chemistry\rand Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenglong","family":"Li","sequence":"additional","affiliation":[{"name":"Division of Medicinal Chemistry\rand Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manoj","family":"Munde","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Georgia State University, Atlanta, Georgia 30302, United\rStates"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. David","family":"Wilson","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Georgia State University, Atlanta, Georgia 30302, United\rStates"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Bahar","sequence":"additional","affiliation":[{"name":"Division of Medicinal Chemistry\rand Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymond W.","family":"Doskotch","sequence":"additional","affiliation":[{"name":"Division of Medicinal Chemistry\rand Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. Douglas","family":"Kinghorn","sequence":"additional","affiliation":[{"name":"Division of Medicinal Chemistry\rand Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcel","family":"Kaiser","sequence":"additional","affiliation":[{"name":"Department of Medical\rParasitology\rand Infection Biology, Swiss Tropical and Public Health Institute, CH-4002 Basel, Switzerland"},{"name":"University of Basel, CH-4002 Basel, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reto","family":"Brun","sequence":"additional","affiliation":[{"name":"Department of Medical\rParasitology\rand Infection Biology, Swiss Tropical and Public Health Institute, CH-4002 Basel, Switzerland"},{"name":"University of Basel, CH-4002 Basel, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark E.","family":"Drew","sequence":"additional","affiliation":[{"name":"Division of Medicinal Chemistry\rand Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, United States"},{"name":"Department of Microbial Infection\rand Immunity, College of Medicine, The Ohio State University, Columbus, Ohio 43210, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl A.","family":"Werbovetz","sequence":"additional","affiliation":[{"name":"Division of Medicinal Chemistry\rand Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2012,11,20]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1158\/1535-7163.MCT-10-0985","volume":"10","author":"Li J.","year":"2011","journal-title":"Mol. Cancer Ther."},{"key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"8021","DOI":"10.1021\/jf201627w","volume":"59","author":"Chueh W. H.","year":"2011","journal-title":"J. Agric. Food Chem."},{"key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1016\/j.intimp.2011.06.002","volume":"11","author":"Cecil C. E.","year":"2011","journal-title":"Int. Immunopharmacol."},{"key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1021\/jm00401a006","volume":"31","author":"Vennerstrom J. L.","year":"1988","journal-title":"J. Med. Chem."},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1021\/np000144r","volume":"63","author":"Wright C. W.","year":"2000","journal-title":"J. Nat. Prod."},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1128\/AAC.34.5.918","volume":"34","author":"Vennerstrom J. L.","year":"1990","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"e18467","DOI":"10.1371\/journal.pone.0018467","volume":"6","author":"Saha P.","year":"2011","journal-title":"PLoS One"},{"key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1055\/s-2001-17351","volume":"67","author":"Merschjohann K.","year":"2001","journal-title":"Planta Med."},{"key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1124\/dmd.108.021659","volume":"36","author":"Qiu F.","year":"2008","journal-title":"Drug Metab. Dispos."},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.ejphar.2008.12.056","volume":"606","author":"Zhou J.","year":"2009","journal-title":"Eur. J. Pharmacol."},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1002\/jps.2600680613","volume":"68","author":"Moniot J. L.","year":"1979","journal-title":"J. Pharm. Sci."},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"2606","DOI":"10.1016\/j.bmcl.2011.01.101","volume":"21","author":"Bahar M.","year":"2011","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"5915","DOI":"10.1016\/j.bmc.2010.06.085","volume":"18","author":"Cheng Z.","year":"2010","journal-title":"Bioorg. Med. Chem."},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"4185","DOI":"10.1128\/AAC.00225-09","volume":"53","author":"Wenzler T.","year":"2009","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/S0968-0896(02)00466-2","volume":"11","author":"Mazzini S.","year":"2003","journal-title":"Bioorg. Med. Chem."},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"4917","DOI":"10.1039\/c1cc10971e","volume":"47","author":"Ferraroni M.","year":"2011","journal-title":"Chem. Commun."},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"188","DOI":"10.2174\/138620710790596736","volume":"13","author":"McKim J. M. J.","year":"2010","journal-title":"Comb. Chem. High Throughput Screening"},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1016\/j.bbagen.2006.09.007","volume":"1760","author":"Cheng Z.","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1186\/1471-2164-6-127","volume":"6","author":"Parsons M.","year":"2005","journal-title":"BMC Genomics"},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.exppara.2009.07.010","volume":"123","author":"Clemmens C. S.","year":"2009","journal-title":"Exp. Parasitol."},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1074\/jbc.M409740200","volume":"280","author":"Liu J.","year":"2005","journal-title":"J. Biol. Chem."},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1128\/AAC.05412-11","volume":"56","author":"Zhu X.","year":"2012","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1124\/mol.64.6.1325","volume":"64","author":"Werbovetz K. A.","year":"2003","journal-title":"Mol. Pharmacol."},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1021\/np049682k","volume":"68","author":"Salem M. M.","year":"2005","journal-title":"J. Nat. Prod."},{"key":"ref25\/cit25","first-page":"219","volume":"90","author":"Wilson W. D.","year":"1997","journal-title":"Methods Mol. Biol."},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/j.bmc.2008.11.031","volume":"17","author":"Delf\u00edn D. A.","year":"2009","journal-title":"Bioorg. Med. Chem."}],"container-title":["Journal of Natural Products"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/np300638f","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,22]],"date-time":"2023-04-22T08:55:14Z","timestamp":1682153714000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/np300638f"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11,20]]},"references-count":26,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,3,22]]}},"alternative-id":["10.1021\/np300638f"],"URL":"https:\/\/doi.org\/10.1021\/np300638f","relation":{},"ISSN":["0163-3864","1520-6025"],"issn-type":[{"value":"0163-3864","type":"print"},{"value":"1520-6025","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11,20]]}}}