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Microbiol."},{"key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"3542","DOI":"10.1093\/emboj\/17.13.3542","volume":"17","author":"Lorenz P.","year":"1998","journal-title":"EMBO J."},{"key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"35299","DOI":"10.1074\/jbc.M301811200","volume":"278","author":"Voncken F.","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref33\/cit33","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1046\/j.1365-2958.2001.02333.x","volume":"39","author":"Maier A.","year":"2001","journal-title":"Mol. Microbiol."},{"key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.1242\/jcs.064907","volume":"123","author":"Koch J.","year":"2010","journal-title":"J. Cell Sci."},{"key":"ref35\/cit35","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1111\/j.1600-0854.2011.01290.x","volume":"13","author":"Huber A.","year":"2012","journal-title":"Traffic"},{"key":"ref36\/cit36","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/emboj.2010.299","volume":"30","author":"Opalinski L.","year":"2011","journal-title":"EMBO J."},{"key":"ref37\/cit37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S0031182012001278","volume":"140","author":"Gualdron-Lopez M.","year":"2013","journal-title":"Parasitology"},{"key":"ref38\/cit38","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1002\/anie.200702070","volume":"47","author":"Ulrich G.","year":"2008","journal-title":"Angew. Chem., Int. Ed."},{"key":"ref39\/cit39","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.pharmthera.2003.08.001","volume":"100","author":"Daly C. J.","year":"2003","journal-title":"Pharmacol. 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