{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T03:14:31Z","timestamp":1788405271427,"version":"build-2803163510"},"reference-count":32,"publisher":"American Chemical Society (ACS)","issue":"3","license":[{"start":{"date-parts":[[2015,2,4]],"date-time":"2015-02-04T00:00:00Z","timestamp":1423008000000},"content-version":"vor","delay-in-days":365,"URL":"https:\/\/pubs.acs.org\/page\/policy\/authorchoice_termsofuse.html"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,3,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>An extract of Humicola fuscoatra (UCSC strain no. 108111A) was shown to reactivate latent HIV-1 expression in an in vitro model of central memory CD4+ T cells. We report the bioassay-guided isolation and structure determination of several resorcyclic acid lactones, including four known compounds, radicicol (1, aka. monorden) and pochonins B (2), C (3), and N (4), and three new analogues, radicicols B\u2013D (5\u20137). Compounds 1\u20133 and 5 showed moderate activities in the memory T cell model of HIV-1 latency. Radicicol (1) displayed lower potency in reactivating latent HIV-1 (EC50 = 9.1 \u03bcM) relative to the HDAC inhibitors apicidin (EC50 = 0.3 \u03bcM), romidepsin (EC50 = 0.003 \u03bcM), and SAHA (EC50 = 0.6 \u03bcM); however, it achieved equivalent maximum efficacy relative to the positive control compounds (98% of SAHA and romidepsin).<\/jats:p>","DOI":"10.1021\/np400889x","type":"journal-article","created":{"date-parts":[[2014,2,4]],"date-time":"2014-02-04T16:16:08Z","timestamp":1391530568000},"page":"618-624","source":"Crossref","is-referenced-by-count":26,"title":["Study of\nMarine Natural Products Including Resorcyclic\nAcid Lactones from\n                    <i>Humicola fuscoatra<\/i>\n                    That Reactivate\nLatent HIV-1 Expression in an in Vitro Model of Central Memory\nCD4+ T Cells"],"prefix":"10.1021","volume":"77","author":[{"given":"Eric J.","family":"Mejia","sequence":"first","affiliation":[{"name":"University of California , , , ,","place":["Santa Cruz, California, United States, 95064"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven T.","family":"Loveridge","sequence":"additional","affiliation":[{"name":"University of California , , , ,","place":["Santa Cruz, California, United States, 95064"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Stepan","sequence":"additional","affiliation":[{"name":"Gilead Sciences Inc. , , ,","place":["Foster City, California, United States, 94404"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Tsai","sequence":"additional","affiliation":[{"name":"Gilead Sciences Inc. , , ,","place":["Foster City, California, United States, 94404"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregg S.","family":"Jones","sequence":"additional","affiliation":[{"name":"Gilead Sciences Inc. , , ,","place":["Foster City, California, United States, 94404"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiffany","family":"Barnes","sequence":"additional","affiliation":[{"name":"Gilead Sciences Inc. , , ,","place":["Foster City, California, United States, 94404"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly N.","family":"White","sequence":"additional","affiliation":[{"name":"University of California , , , ,","place":["Santa Cruz, California, United States, 95064"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marija","family":"Dras\u030ckovic\u0301","sequence":"additional","affiliation":[{"name":"University of California , , , ,","place":["Santa Cruz, California, United States, 95064"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Tenney","sequence":"additional","affiliation":[{"name":"University of California , , , ,","place":["Santa Cruz, California, United States, 95064"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Tsiang","sequence":"additional","affiliation":[{"name":"Gilead Sciences Inc. , , ,","place":["Foster City, California, United States, 94404"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romas","family":"Geleziunas","sequence":"additional","affiliation":[{"name":"Gilead Sciences Inc. , , ,","place":["Foster City, California, United States, 94404"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas","family":"Cihlar","sequence":"additional","affiliation":[{"name":"Gilead Sciences Inc. , , ,","place":["Foster City, California, United States, 94404"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikos","family":"Pagratis","sequence":"additional","affiliation":[{"name":"Gilead Sciences Inc. , , ,","place":["Foster City, California, United States, 94404"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Tian","sequence":"additional","affiliation":[{"name":"Gilead Sciences Inc. , , ,","place":["Foster City, California, United States, 94404"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Yu","sequence":"additional","affiliation":[{"name":"Gilead Sciences Inc. , , ,","place":["Foster City, California, United States, 94404"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip","family":"Crews","sequence":"additional","affiliation":[{"name":"University of California , , , ,","place":["Santa Cruz, California, United States, 95064"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2014,2,4]]},"reference":[{"key":"2026090222282717600_cit1","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1146\/annurev.med.53.082901.104024","volume":"53","author":"Blankson","year":"2002","journal-title":"Annu. 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