{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T03:14:09Z","timestamp":1788405249651,"version":"build-2803163510"},"reference-count":20,"publisher":"American Chemical Society (ACS)","issue":"9","license":[{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"vor","delay-in-days":365,"URL":"https:\/\/pubs.acs.org\/page\/policy\/authorchoice_termsofuse.html"}],"funder":[{"DOI":"10.13039\/100000097","name":"National Center for Research Resources","doi-asserted-by":"publisher","award":["C06 RR-14503-01"],"award-info":[{"award-number":["C06 RR-14503-01"]}],"id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/na","name":"Egyptian Government","doi-asserted-by":"publisher","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,9,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Antileishmanial bioassay guided fractionation of Geosmithia langdonii has resulted in the isolation and identification of two new compounds (1 and 2) together with 10 known compounds (3\u201312). The structures of the isolated metabolites were elucidated based on comprehensive 1D and 2D NMR spectroscopic data as well as mass spectrometry. The absolute configuration at C4, C5, and C6 of 2 was determined as R using a modified Mosher esterification method and NOESY correlations. The extracts and the isolated metabolites were evaluated for their antileishmanial activities. Compounds 3, 9, 11, and 12 were found to be active against Leishmania donovani with IC50 values of 6.9, 3.3, 8.5, and 9.2 \u03bcM, respectively, while compounds 1, 5, and 10 showed lower activities against L. donovani with IC50 values of 13.0, 47.3, and 34.0 \u03bcM, respectively.<\/jats:p>","DOI":"10.1021\/np5000473","type":"journal-article","created":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T16:00:30Z","timestamp":1406908830000},"page":"1987-1991","source":"Crossref","is-referenced-by-count":24,"title":["Antileishmanial Metabolites\nfrom\n                    <i>Geosmithia langdonii<\/i>"],"prefix":"10.1021","volume":"77","author":[{"given":"Lourin G.","family":"Malak","sequence":"first","affiliation":[{"name":"The University of Mississippi , , , ,","place":["University, Mississippi, United States, 38677"]},{"name":"Assiut University , , ,","place":["Assiut, Egypt, 71526"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed Ali","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"The University of Mississippi , , , ,","place":["University, Mississippi, United States, 38677"]},{"name":"National Research Center , , Dokki , ,","place":["Cairo, Egypt, 12622"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daoud W.","family":"Bishay","sequence":"additional","affiliation":[{"name":"Assiut University , , ,","place":["Assiut, Egypt, 71526"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afaf M.","family":"Abdel-baky","sequence":"additional","affiliation":[{"name":"Assiut University , , ,","place":["Assiut, Egypt, 71526"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed M.","family":"Moharram","sequence":"additional","affiliation":[{"name":"Assiut University , , ,","place":["Assiut, Egypt, 71515"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Babu","family":"Tekwani","sequence":"additional","affiliation":[{"name":"The University of Mississippi , , , ,","place":["University, Mississippi, United States, 38677"]},{"name":"University of Mississippi , , , ,","place":["University, Mississippi, United States, 38677"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen J.","family":"Cutler","sequence":"additional","affiliation":[{"name":"The University of Mississippi , , , ,","place":["University, Mississippi, United States, 38677"]},{"name":"University of Mississippi , , , ,","place":["University, Mississippi, United States, 38677"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samir A.","family":"Ross","sequence":"additional","affiliation":[{"name":"The University of Mississippi , , , ,","place":["University, Mississippi, United States, 38677"]},{"name":"University of Mississippi , , , ,","place":["University, Mississippi, United States, 38677"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2014,8,1]]},"reference":[{"key":"2026090222285407300_cit1","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/0163-4453(90)93933-J","volume":"21","author":"Montalban","year":"1990","journal-title":"J. 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