{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T02:40:47Z","timestamp":1789180847574,"version":"build-2803163510"},"reference-count":18,"publisher":"American Chemical Society (ACS)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Org. Lett."],"published-print":{"date-parts":[[2001,6,1]]},"DOI":"10.1021\/ol015933u","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T04:58:44Z","timestamp":1027659524000},"page":"1841-1844","source":"Crossref","is-referenced-by-count":29,"title":["Dithiane- and Trithiane-Based Photolabile Scaffolds for Molecular Recognition"],"prefix":"10.1021","volume":"3","author":[{"given":"Oleg D.","family":"Mitkin","sequence":"first","affiliation":[{"name":"Department of Chemistry and Biochemistry, University of Denver, Denver, Colorado 80208-2436"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexei N.","family":"Kurchan","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, University of Denver, Denver, Colorado 80208-2436"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongqin","family":"Wan","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, University of Denver, Denver, Colorado 80208-2436"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian F.","family":"Schiwal","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, University of Denver, Denver, Colorado 80208-2436"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrei G.","family":"Kutateladze","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, University of Denver, Denver, Colorado 80208-2436"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2001,5,15]]},"reference":[{"key":"ol015933ub00001\/ol015933ub00001_1","doi-asserted-by":"crossref","unstructured":"For recent reviews on various aspects of molecular recognition, see special issue ofChem. Rev.1997,97, issue 5, Gellman, S. H., Guest Editor.","DOI":"10.1021\/cr970328j"},{"key":"ol015933ub00002\/ol015933ub00002_1","doi-asserted-by":"crossref","first-page":"2931","DOI":"10.1021\/ol006157d","volume":"2","author":"Mertz E.","year":"2000","journal-title":"Org. Lett."},{"key":"ol015933ub00002\/ol015933ub00002_2","doi-asserted-by":"crossref","first-page":"3779","DOI":"10.1021\/ja992830m","volume":"122","author":"Corbin P. S.","year":"2000","journal-title":"J. Am. Chem. Soc."},{"key":"ol015933ub00002\/ol015933ub00002_3","doi-asserted-by":"crossref","first-page":"9860","DOI":"10.1021\/ja001851+","volume":"122","author":"Mak T. C. W.","year":"2000","journal-title":"J. Am. Chem. Soc."},{"key":"ol015933ub00002\/ol015933ub00002_4","doi-asserted-by":"crossref","first-page":"9526","DOI":"10.1021\/ja981722h","volume":"120","author":"Suarez M.","year":"1998","journal-title":"J. Am. Chem. 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D.","year":"2001"},{"key":"ol015933ub00005\/ol015933ub00005_1","unstructured":"Typical Experimental Procedure.A solution of 4.56 g (28 mmol) of 1,1,1,3,3,3-hexamethyldisilazane in 100 mL of freshly distilled THF was cooled to 0 \u00b0C, and 19.4 mL ofn-butyllithium (1.6 M solution in hexanes, 30 mmol) was added with stirring under N2atmosphere. The reaction mixture was stirred at this temperature for 1.5 h. Next, 3 g (28 mmol) of benzaldehyde was slowly added, and the resulting mixture was stirred at 0 \u00b0C for 1 h. Lithiated dithiane was prepared by adding 19.4 mL of 1.6 Mn-butyllithium (30 mmol) to a solution of 3.39 g (28 mmol) of 1,3-dithiane in 100 mL of freshly distilled THF at \u221220 to \u221225 \u00b0C and stirring at this temperature for 2 h. The solution of lithiodithiane was added slowly to the solution of silylated benzaldimine, the cooling bath was removed, and the reaction mixture was stirred overnight at room temperature. The resulting red solution was washed with 100 mL of saturated NH4Cl, and THF was removed in a vacuum, producing a yellow oil, which was dissolved in 200 mL of EtOAc and extracted with 2 \u00d7 100 mL of 10% HCl. The acid extracts were combined, pH was adjusted to 12 with 20% NaOH, and the water layer was extracted with 3 \u00d7 100 mL of EtOAc. Organic extracts were combined and washed with water 3 \u00d7 100 mL. The organic layer was dried over anhydrous MgSO4, and the solvent was removed in a vacuum, furnishing1a(Ar = Ph, 6.2 g, 97%) as a yellow oil, which was used without further purification.1H NMR (CDCl3) \u03b4 (ppm) 7.42\u22127.22 (5H, m), 4.25 (1H, d,J= 6.6 Hz), 4.22 (1H, d,J= 6.6 Hz), 2.92\u22122.73 (4H, m), 2.12\u22122.04 (1H, m), 1.82\u22121.92 (1H, m)."},{"key":"ol015933ub00006\/ol015933ub00006_1","doi-asserted-by":"crossref","first-page":"2824","DOI":"10.1021\/jo971061r","volume":"63","author":"Gyenes F.","year":"1998","journal-title":"J. Org. 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