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Chem."},{"key":"ol034077eb00005\/ol034077eb00005_1","unstructured":"Schl\u00fcntzen, F.; Zarlvach, R.; Harms, J.; Bashan, A.; Tocijl, A.; Albrecht, R.; Yonath, A.; Franceschl, F.\n                      Nature\n                      2001\n                      413\n                      , 814."},{"key":"ol034077eb00006\/ol034077eb00006_1","first-page":"1969","volume":"287","author":"Schreiber S. L.","year":"2001","journal-title":"Science"},{"key":"ol034077eb00007\/ol034077eb00007_1","doi-asserted-by":"crossref","first-page":"4751","DOI":"10.1016\/S0040-4039(00)00711-5","volume":"41","year":"2000","journal-title":"Tetrahedron Lett."},{"key":"ol034077eb00008\/ol034077eb00008_1","doi-asserted-by":"crossref","first-page":"3321","DOI":"10.1002\/1521-3765(20000915)6:18<3321::AID-CHEM3321>3.0.CO;2-A","volume":"6","author":"Bienaym\u00e9 H.","year":"2000","journal-title":"Chem. Eur. J."},{"key":"ol034077eb00009\/ol034077eb00009_1","doi-asserted-by":"crossref","first-page":"3168","DOI":"10.1002\/1521-3773(20000915)39:18<3168::AID-ANIE3168>3.0.CO;2-U","volume":"39","author":"D\u00f6mling A.","year":"2000","journal-title":"Angew. Chem., Int. Ed."},{"key":"ol034077eb00010\/ol034077eb00010_1","unstructured":"Number of stable compounds below 500 Dalton built from the atoms, C, N, O, H, S, F, Cl, Br, and P has been judged to be in excess of 10\n                      63\n                      (Bohacek, R. S.; McMartin, C.; Guida, W. C.\n                      Med. Res. Rev\n                      .\n                      1996\n                      ,\n                      16,\n                      3). Very large search spaces therefore are of a similar order of magnitude. All known traditional two-component reactions can only afford much smaller numbers. As early as 1959, Ivar Ugi noticed (Ugi, I., et al.\n                      Chem. Ber\n                      .\n                      1961\n                      ,\n                      94\n                      , 734.) that, \u201cIf, for example, 40 each of the different components are reacted with one another, the result is 40\n                      4\n                      = 2\u2009560\u2009000 reaction products\u201d. With today's commercial availability of several hundred isocyanides (e.g., www.priaton.de) and the broad accessibility of the other functional groups of isocyanide-based MCRs, it is clear that only this reaction type can theoretically cover such large chemical spaces."},{"key":"ol034077eb00011\/ol034077eb00011_1","doi-asserted-by":"crossref","first-page":"4959","DOI":"10.1016\/S0040-4039(01)00919-4","volume":"42","author":"Tempest P.","year":"2001","journal-title":"Tetrahedron Lett."},{"key":"ol034077eb00011\/ol034077eb00011_2","doi-asserted-by":"crossref","first-page":"8021","DOI":"10.1021\/jo980622r","volume":"63","author":"Hulme C.","year":"1998","journal-title":"J. Org. 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