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The supplementary crystallographic data can be obtained free of charge via the Internet at www.ccdc.cam.ac.uk\/conts\/retrieving.html or from the Cambridge Crystallographic Data Center, 12 Union Road, Cambridge CB2 1EZ, UK (fax +44 1223 336033; or e-mail deposit@ccdc.cam.ac.uk)."},{"key":"ol047598qb00020\/ol047598qb00020_1","unstructured":"General Procedure.A THF solution of MeMgCl (3.5 equiv) was added to a \u221278 \u00b0C, THF solution (0.1 M) of the oxonitrile1, and the mixture was stirred at \u221278 \u00b0C for 1 h and then warmed to room temperature. After 1.5 h, the electrophile (3 equiv) was added neat either at room temperature or with prior cooling to \u221278 \u00b0C. Subsequent addition of saturated NH4Cl and extraction with EtOAc afforded a crude product that was washed with brine and dried (MgSO4), concentrated, and purified by radial chromatography to afford the pure nitrile."},{"key":"ol047598qb00021\/ol047598qb00021_1","doi-asserted-by":"crossref","first-page":"3344","DOI":"10.1021\/ja9923235","volume":"122","author":"Loss","year":"2000","journal-title":"J. Am. Chem. Soc."},{"key":"ol047598qb00022\/ol047598qb00022_1","doi-asserted-by":"crossref","first-page":"4235","DOI":"10.1021\/jo034174l","volume":"68","author":"For","year":"2003","journal-title":"J. Org. 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