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The synthesis proceeds via a longest linear sequence of 14 steps from an Evans \u03b2-ketoimide and enabled preliminary evaluations of the effects of late-stage intermediates on S. mutans biofilms. These studies suggest that further investigations into carolacton\u2019s structure\u2013function relationships are warranted.<\/jats:p>","DOI":"10.1021\/ol500004k","type":"journal-article","created":{"date-parts":[[2014,1,31]],"date-time":"2014-01-31T10:05:50Z","timestamp":1391162750000},"page":"1148-1151","source":"Crossref","is-referenced-by-count":36,"title":["A Concise Synthesis of Carolacton"],"prefix":"10.1021","volume":"16","author":[{"given":"Michal S.","family":"Hallside","sequence":"first","affiliation":[{"name":"Yale University , , , ,","place":["New Haven, Connecticut, United States, 06511"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard S.","family":"Brzozowski","sequence":"additional","affiliation":[{"name":"Temple University , , , ,","place":["Philadelphia, Pennsylvania, United States, 19122"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William M.","family":"Wuest","sequence":"additional","affiliation":[{"name":"Temple University , , , ,","place":["Philadelphia, Pennsylvania, United States, 19122"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Phillips","sequence":"additional","affiliation":[{"name":"Yale University , , , ,","place":["New Haven, Connecticut, United States, 06511"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2014,1,31]]},"reference":[{"key":"2026090309053132000_cit1","first-page":"3","volume":"22","author":"Bagramian","year":"2009","journal-title":"Am. 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