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The salient features of this synthesis include an asymmetric hetero-Diels\u2013Alder reaction to construct the tetrahydropyran ring and a Suzuki cross-coupling to assemble the key segments.<\/jats:p>","DOI":"10.1021\/ol501345d","type":"journal-article","created":{"date-parts":[[2014,5,28]],"date-time":"2014-05-28T10:10:31Z","timestamp":1401271831000},"page":"3154-3157","source":"Crossref","is-referenced-by-count":22,"title":["Total Synthesis of GEX1Q1, Assignment of C-5\nStereoconfiguration and Evaluation of Spliceosome Inhibitory Activity"],"prefix":"10.1021","volume":"16","author":[{"given":"Arun K.","family":"Ghosh","sequence":"first","affiliation":[{"name":"Purdue University , , 560 Oval Drive , , ,","place":["West Lafayette, Indiana, United States, 47907"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nianchun","family":"Ma","sequence":"additional","affiliation":[{"name":"Purdue University , , 560 Oval Drive , , ,","place":["West Lafayette, Indiana, United States, 47907"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin A.","family":"Effenberger","sequence":"additional","affiliation":[{"name":"University of California , , , ,","place":["Santa Cruz, California, United States, 95064"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa S.","family":"Jurica","sequence":"additional","affiliation":[{"name":"University of California , , , ,","place":["Santa Cruz, California, United States, 95064"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2014,5,28]]},"reference":[{"key":"2026090201453400800_cit1a","doi-asserted-by":"crossref","first-page":"863","DOI":"10.7164\/antibiotics.55.863","volume":"55","author":"Sakai","year":"2002","journal-title":"J. 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