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Three different heterocyclic scaffolds easily accessible from isocyanoacetaldehyde dimethylacetal 1 by multicomponent reaction (MCR) are described. They can be efficiently synthesized by a Ugi tetrazole multicomponent reaction of 1. We discuss the synthesis, 3D structures, and other physicochemical properties.<\/jats:p>","DOI":"10.1021\/ol5024882","type":"journal-article","created":{"date-parts":[[2014,10,29]],"date-time":"2014-10-29T06:29:12Z","timestamp":1414564152000},"page":"5736-5739","source":"Crossref","is-referenced-by-count":24,"title":["A Universal Isocyanide for Diverse Heterocycle Syntheses"],"prefix":"10.1021","volume":"16","author":[{"given":"Pravin","family":"Patil","sequence":"first","affiliation":[{"name":"University of Groningen , , ,","place":["Groningen, The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kareem","family":"Khoury","sequence":"additional","affiliation":[{"name":"University of Pittsburgh , , , ,","place":["Pittsburgh, Pennsylvania, United States, 15261"]},{"name":"Carmolex Inc. , , ,","place":["Pittsburgh, Pennsylvania, United States, 15219"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eberhardt","family":"Herdtweck","sequence":"additional","affiliation":[{"name":"Technische Universita\u0308t Mu\u0308nchen , ,","place":["Mu\u0308nchen, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Do\u0308mling","sequence":"additional","affiliation":[{"name":"University of Groningen , , ,","place":["Groningen, The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2014,10,29]]},"reference":[{"key":"2026090222470875500_cit1","doi-asserted-by":"crossref","first-page":"D1075","DOI":"10.1093\/nar\/gkt978","volume":"42","author":"Wang","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"2026090222470875500_cit2a","doi-asserted-by":"crossref","first-page":"8531","DOI":"10.1074\/jbc.M112.435941","volume":"288","author":"Hong","year":"2013","journal-title":"J. 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