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In preceding work, we disclosed a new class of simplified bryostatin analogs designed for ease of access and tunable activity. Here we describe a final step diversification strategy that provides, in only 25 synthetic steps, simplified and tunable analogs with bryostatin-like PKC modulatory activities.<\/jats:p>","DOI":"10.1021\/ol502492b","type":"journal-article","created":{"date-parts":[[2014,9,19]],"date-time":"2014-09-19T14:29:57Z","timestamp":1411136997000},"page":"5140-5143","source":"Crossref","is-referenced-by-count":21,"title":["Improved Protein Kinase C Affinity through Final Step\nDiversification of a Simplified Salicylate-Derived Bryostatin Analog\nScaffold"],"prefix":"10.1021","volume":"16","author":[{"given":"Paul A.","family":"Wender","sequence":"first","affiliation":[{"name":"Stanford University , , , ,","place":["Stanford, California, United States, 94305"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daryl","family":"Staveness","sequence":"additional","affiliation":[{"name":"Stanford University , , , ,","place":["Stanford, California, United States, 94305"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2014,9,19]]},"reference":[{"key":"2026090121572022000_cit1","doi-asserted-by":"crossref","first-page":"6846","DOI":"10.1021\/ja00388a092","volume":"104","author":"Pettit","year":"1982","journal-title":"J. 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