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Key to the success of this work was a novel \u03b1-keto ketene macrocyclization that provided an efficient means by which to access two diastereomers of the desired macrolide without the need to employ additional coupling agents or unnecessary oxidation state adjustments.<\/jats:p>","DOI":"10.1021\/ol5025585","type":"journal-article","created":{"date-parts":[[2014,9,23]],"date-time":"2014-09-23T08:37:35Z","timestamp":1411461455000},"page":"5196-5199","source":"Crossref","is-referenced-by-count":14,"title":["The Taumycin A Macrocycle: Asymmetric Total Synthesis\nand Revision of Relative Stereochemistry"],"prefix":"10.1021","volume":"16","author":[{"given":"Justine N.","family":"deGruyter","sequence":"first","affiliation":[{"name":"New Mexico State University , , , ,","place":["Las Cruces, New Mexico, United States, 88003"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William A.","family":"Maio","sequence":"additional","affiliation":[{"name":"New Mexico State University , , , ,","place":["Las Cruces, New Mexico, United States, 88003"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2014,9,23]]},"reference":[{"key":"2026090203033893300_cit1a","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1126\/science.1094318","volume":"303","author":"Walsh","year":"2004","journal-title":"Science"},{"key":"2026090203033893300_cit1b","doi-asserted-by":"crossref","first-page":"3010","DOI":"10.1073\/pnas.0730689100","volume":"100","author":"Hutchinson","year":"2003","journal-title":"Proc. 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