{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T13:55:59Z","timestamp":1783518959377,"version":"3.55.0"},"reference-count":20,"publisher":"American Chemical Society (ACS)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Org. 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D.","year":"2000"},{"key":"ol800085ub00004\/ol800085ub00004_2","doi-asserted-by":"crossref","DOI":"10.1201\/9780203503676","volume-title":"Modern Phosphonate Chemistry","author":"Savignac P.","year":"2003"},{"key":"ol800085ub00005\/ol800085ub00005_1","unstructured":"Typical Experimental Procedure.A flame-dried, 50 mL flask was purged with nitrogen and charged with diethyl (chloromethyl)phosphonate4b(4.0 mmol, 746 mg, 1.0 equiv) and dry THF (20 mL). The solution was cooled below \u221290 \u00b0C (liquid nitrogen\/ethanol bath), andn-butyllitium (1.6 M solution in hexane, 2.5 mL, 4.0 mmol, 1.0 equiv) was added slowly by syringe followed by Bu3B (1.0 M solution in diethyl ether, 4.0 mL, 1.0 equiv) in one portion. The reaction mixture was warmed slowly to room temperature and was quenched by addition of water. The resulting biphasic mixture was stirred at reflux for 2 h. 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