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Rev."},{"key":"ref7\/cit7h","doi-asserted-by":"crossref","first-page":"3410","DOI":"10.1002\/anie.200604335","volume":"46","author":"F\u00fcrstner A.","year":"2007","journal-title":"Angew. Chem., Int. Ed."},{"key":"ref8\/cit8","unstructured":"For examples of Au(I)-alkyne-initiated cascade cyclizations, see:"},{"key":"ref8\/cit8a","doi-asserted-by":"crossref","first-page":"2888","DOI":"10.1021\/ol900864n","volume":"11","author":"Toullec P. Y.","year":"2009","journal-title":"Org. Lett."},{"key":"ref8\/cit8b","doi-asserted-by":"crossref","first-page":"5030","DOI":"10.1002\/anie.200800934","volume":"47","author":"F\u00fcrstner A.","year":"2008","journal-title":"Angew. Chem., Int. Ed."},{"key":"ref8\/cit8c","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1002\/chem.200701522","volume":"14","author":"Zriba R.","year":"2008","journal-title":"Chem.\u2014Eur. J."},{"key":"ref8\/cit8d","doi-asserted-by":"crossref","first-page":"12070","DOI":"10.1021\/ja074550+","volume":"129","author":"Yang T.","year":"2007","journal-title":"J. Am. Chem. Soc."},{"key":"ref8\/cit8e","doi-asserted-by":"crossref","first-page":"12070","DOI":"10.1021\/ja074550+","volume":"129","author":"Yang T.","year":"2007","journal-title":"J. Am. Chem. Soc."},{"key":"ref8\/cit8f","doi-asserted-by":"crossref","first-page":"8132","DOI":"10.1021\/ja061344d","volume":"128","author":"Sherry B. D.","year":"2006","journal-title":"J. Am. Chem. Soc."},{"key":"ref8\/cit8g","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1002\/chem.200501088","volume":"12","author":"Nieto-Oberhuber C.","year":"2006","journal-title":"Chem.\u2014Eur. J."},{"key":"ref8\/cit8h","doi-asserted-by":"crossref","first-page":"6726","DOI":"10.1002\/anie.200602270","volume":"45","author":"Couty S.","year":"2006","journal-title":"Angew. Chem., Int. 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J."},{"key":"ref10\/cit10b","doi-asserted-by":"crossref","first-page":"6437","DOI":"10.1016\/j.tetlet.2008.08.093","volume":"49","author":"Dai L.-Z.","year":"2008","journal-title":"Tetrahedron Lett."},{"key":"ref10\/cit10c","doi-asserted-by":"crossref","first-page":"5059","DOI":"10.1021\/ol802047g","volume":"21","author":"Lin G.-Y.","year":"2008","journal-title":"Org. Lett."},{"key":"ref10\/cit10d","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1021\/ol800219k","volume":"10","author":"Cordonnier M. C.","year":"2008","journal-title":"Org. Lett."},{"key":"ref10\/cit10e","doi-asserted-by":"crossref","first-page":"3191","DOI":"10.1021\/ol0713640","volume":"9","author":"Dai L.-Z.","year":"2007","journal-title":"Org. Lett."},{"key":"ref11\/cit11","unstructured":"Previous (unpublished) efforts in our laboratories with \u201ccarbophilic\u201d Lewis acids always resulted in epoxide activation over alkene, which has also been observed by Yang and He under gold(III)\/silver activation catalysis. See for example:"},{"key":"ref11\/cit11a","doi-asserted-by":"crossref","first-page":"4625","DOI":"10.1021\/jo8005649","volume":"73","author":"Liu Y.","year":"2008","journal-title":"J. Org. Chem."},{"key":"ref11\/cit11b","doi-asserted-by":"crossref","first-page":"5964","DOI":"10.1021\/ja031953a","volume":"126","author":"Shi Z.","year":"2004","journal-title":"J. Am. Chem. Soc."},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"4323","DOI":"10.1021\/jo8003875","volume":"73","author":"Li Y.","year":"2008","journal-title":"J. Org. Chem."},{"key":"ref13\/cit13a","doi-asserted-by":"crossref","first-page":"6670","DOI":"10.1002\/anie.200701959","volume":"46","author":"Tarselli M. A.","year":"2007","journal-title":"Angew. Chem., Int. Ed."},{"key":"ref13\/cit13b","doi-asserted-by":"crossref","first-page":"2439","DOI":"10.1021\/jo7024948","volume":"73","author":"Tarselli M. A.","year":"2008","journal-title":"J. Org. Chem."},{"key":"ref13\/cit13c","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1016\/j.tet.2008.10.110","volume":"65","author":"Tarselli M. A.","year":"2009","journal-title":"Tetrahedron"},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.1002\/1521-3773(20000703)39:13<2285::AID-ANIE2285>3.0.CO;2-F","volume":"39","author":"Hashmi A. S. K.","year":"2000","journal-title":"Angew. Chem., Int. Ed."},{"key":"ref15\/cit15","unstructured":"Other silver additives (AgSbF6, AgBF4, AgNTf2,AgClO4,AgOTs) or phosphine ligands (EtPh2P, Cy3P, (4-Cl-Ph)3P, (4-MeO-Ph)3P) led to lower yields of bicyclic product. Other solvents (PhMe, THF) led to complex mixtures."},{"key":"ref16\/cit16","unstructured":"Exposure to AgOTf in the absence of Au(I) did not produce any discernable allene activation. In preliminary (unpublished) reactivity studies for related transition metal-catalyzed cyclization of allenyl esters, Yb(III) and Pd(II) showed negligible levels of desired reactivity."},{"key":"ref17\/cit17","unstructured":"A pseudo-axial preference has been noted in previous electrophilic cyclizations, see for example:"},{"key":"ref17\/cit17a","doi-asserted-by":"crossref","first-page":"2517","DOI":"10.1021\/ja00242a049","volume":"109","author":"Johnson W. S.","year":"1987","journal-title":"J. Am. Chem. Soc."},{"key":"ref17\/cit17b","doi-asserted-by":"crossref","first-page":"3459","DOI":"10.1002\/anie.200453913","volume":"43","author":"Koh J. H.","year":"2004","journal-title":"Angew. Chem., Int. 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Acta"},{"key":"ref21\/cit21","unstructured":"Jamison recently showed that water can overturn this propensity, see ref6afor details."},{"key":"ref22\/cit22a","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1021\/ol9004646","volume":"11","author":"Paton R. S.","year":"2009","journal-title":"Org. Lett."},{"key":"ref22\/cit22b","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1021\/ol800646h","volume":"10","author":"Zhang Z.","year":"2008","journal-title":"Org. Lett."},{"key":"ref22\/cit22c","doi-asserted-by":"crossref","first-page":"4908","DOI":"10.1016\/j.tetlet.2008.05.152","volume":"49","author":"Nishina N.","year":"2008","journal-title":"Tetrahedron Lett."},{"key":"ref22\/cit22d","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1002\/anie.200603260","volume":"46","author":"Zhang Z.","year":"2007","journal-title":"Angew. Chem., Int. 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